Loss of expression of BAP1 is a useful adjunct, which strongly supports the diagnosis of mesothelioma in effusion cytology View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2015-10

AUTHORS

Juliana Andrici, Amy Sheen, Loretta Sioson, Kathryn Wardell, Adele Clarkson, Nicole Watson, Mahsa S Ahadi, Mahtab Farzin, Christopher W Toon, Anthony J Gill

ABSTRACT

Although most mesotheliomas present with pleural effusions, it is controversial whether mesothelioma can be diagnosed with confidence in effusion cytology. Therefore, an ancillary marker of malignant mesothelial cells applicable in effusions would be clinically valuable. BRCA-1-associated protein (BAP1) is a tumor suppressor gene, which shows biallelic inactivation in approximately half of all mesotheliomas. We investigated whether loss of BAP1 expression by immunohistochemistry can be used to support a diagnosis of mesothelioma in effusion cytology. Immunohistochemistry for BAP1 was performed on cell blocks and interpreted blinded. 43 of 75 (57%) effusions associated with confirmed mesothelioma showed negative staining with positive internal controls. Of 57 effusions considered to have atypical mesothelial cells in the absence of a definitive diagnosis of mesothelioma, 8 cases demonstrated negative staining for BAP1. On follow-up six of these patients received a definitive diagnosis of mesothelioma in the subsequent 14 months (two were lost to follow-up immediately, and mesothelioma could not be excluded). Only 5 of 100 consecutive benign effusions were interpreted as BAP1 negative. One of these patients died soon after and mesothelioma could not be excluded. On unblinded review the four other patients with apparently negative BAP1 staining but no malignancy lacked convincing positive staining in non-neoplastic cells suggesting that BAP1 immunohistochemistry may have initially been misinterpreted. 47 effusions with adenocarcinoma were BAP1 positive. We conclude that loss of BAP1 expression, while not definitive, can be used to support the diagnosis of mesothelioma in effusion cytology. We caution that interpretation of BAP1 immunohistochemistry on cell block may be difficult and that convincing positive staining in non-neoplastic cells is required before atypical cells are considered negative. We also note that BAP1 loss is not a sensitive test as it occurs in only half of all mesotheliomas and cannot be used to exclude the diagnosis. More... »

PAGES

1360-1368

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/modpathol.2015.87

DOI

http://dx.doi.org/10.1038/modpathol.2015.87

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1009676602

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/26226841


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1199", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Other Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Adult", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Aged", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Aged, 80 and over", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Biomarkers, Tumor", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cytodiagnosis", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Female", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Immunohistochemistry", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Male", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Mesothelioma", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Middle Aged", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Pleural Effusion, Malignant", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Pleural Neoplasms", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Tumor Suppressor Proteins", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Ubiquitin Thiolesterase", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Young Adult", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "University of Sydney", 
          "id": "https://www.grid.ac/institutes/grid.1013.3", 
          "name": [
            "Cancer Diagnosis and Pathology Research Group, Kolling Institute of Medical Research, Sydney, NSW, Australia.", 
            "Sydney Medical School, University of Sydney, Sydney, NSW, Australia."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Andrici", 
        "givenName": "Juliana", 
        "id": "sg:person.0711044326.86", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0711044326.86"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Sydney", 
          "id": "https://www.grid.ac/institutes/grid.1013.3", 
          "name": [
            "Cancer Diagnosis and Pathology Research Group, Kolling Institute of Medical Research, Sydney, NSW, Australia.", 
            "Sydney Medical School, University of Sydney, Sydney, NSW, Australia."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Sheen", 
        "givenName": "Amy", 
        "id": "sg:person.01214202001.49", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01214202001.49"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Sydney", 
          "id": "https://www.grid.ac/institutes/grid.1013.3", 
          "name": [
            "Cancer Diagnosis and Pathology Research Group, Kolling Institute of Medical Research, Sydney, NSW, Australia.", 
            "Sydney Medical School, University of Sydney, Sydney, NSW, Australia."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Sioson", 
        "givenName": "Loretta", 
        "id": "sg:person.0640756006.45", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0640756006.45"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Sydney", 
          "id": "https://www.grid.ac/institutes/grid.1013.3", 
          "name": [
            "Sydney Medical School, University of Sydney, Sydney, NSW, Australia."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Wardell", 
        "givenName": "Kathryn", 
        "id": "sg:person.01330430401.33", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01330430401.33"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Royal North Shore Hospital", 
          "id": "https://www.grid.ac/institutes/grid.412703.3", 
          "name": [
            "Cancer Diagnosis and Pathology Research Group, Kolling Institute of Medical Research, Sydney, NSW, Australia.", 
            "Department of Anatomical Pathology, Royal North Shore Hospital, Sydney, NSW, Australia."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Clarkson", 
        "givenName": "Adele", 
        "id": "sg:person.0763063114.08", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0763063114.08"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Sydney", 
          "id": "https://www.grid.ac/institutes/grid.1013.3", 
          "name": [
            "Cancer Diagnosis and Pathology Research Group, Kolling Institute of Medical Research, Sydney, NSW, Australia."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Watson", 
        "givenName": "Nicole", 
        "id": "sg:person.0707071206.52", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0707071206.52"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Royal North Shore Hospital", 
          "id": "https://www.grid.ac/institutes/grid.412703.3", 
          "name": [
            "Cancer Diagnosis and Pathology Research Group, Kolling Institute of Medical Research, Sydney, NSW, Australia.", 
            "Department of Anatomical Pathology, Royal North Shore Hospital, Sydney, NSW, Australia."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Ahadi", 
        "givenName": "Mahsa S", 
        "id": "sg:person.0721252701.85", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0721252701.85"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Royal North Shore Hospital", 
          "id": "https://www.grid.ac/institutes/grid.412703.3", 
          "name": [
            "Cancer Diagnosis and Pathology Research Group, Kolling Institute of Medical Research, Sydney, NSW, Australia.", 
            "Department of Anatomical Pathology, Royal North Shore Hospital, Sydney, NSW, Australia."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Farzin", 
        "givenName": "Mahtab", 
        "id": "sg:person.0727416674.76", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0727416674.76"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Sydney", 
          "id": "https://www.grid.ac/institutes/grid.1013.3", 
          "name": [
            "Cancer Diagnosis and Pathology Research Group, Kolling Institute of Medical Research, Sydney, NSW, Australia.", 
            "Sydney Medical School, University of Sydney, Sydney, NSW, Australia.", 
            "Histopath Pathology, Sydney, NSW, Australia."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Toon", 
        "givenName": "Christopher W", 
        "id": "sg:person.01040413736.70", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01040413736.70"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Royal North Shore Hospital", 
          "id": "https://www.grid.ac/institutes/grid.412703.3", 
          "name": [
            "Cancer Diagnosis and Pathology Research Group, Kolling Institute of Medical Research, Sydney, NSW, Australia.", 
            "Sydney Medical School, University of Sydney, Sydney, NSW, Australia.", 
            "Department of Anatomical Pathology, Royal North Shore Hospital, Sydney, NSW, Australia.", 
            "Sydney Vital Translational Research Centre, Royal North Shore Hospital, Pacific Highway St Leonards, Sydney, NSW, Australia."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Gill", 
        "givenName": "Anthony J", 
        "id": "sg:person.01160073674.20", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01160073674.20"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.1309/ajcpwfw7o1fvflkt", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1001563737"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/modpathol.3800732", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1003680743", 
          "https://doi.org/10.1038/modpathol.3800732"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/modpathol.3800732", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1003680743", 
          "https://doi.org/10.1038/modpathol.3800732"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ng.912", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1006344582", 
          "https://doi.org/10.1038/ng.912"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ng.912", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1006344582", 
          "https://doi.org/10.1038/ng.912"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1136/jclinpath-2012-201303", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1006688026"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1349-7006.2012.02223.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1007628309"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1349-7006.2012.02223.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1007628309"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ng.855", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1016007156", 
          "https://doi.org/10.1038/ng.855"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ng.855", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1016007156", 
          "https://doi.org/10.1038/ng.855"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.jtcvs.2012.09.023", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1017234835"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/pat.0000000000000250", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1017393286"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/pat.0000000000000250", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1017393286"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/pat.0000000000000250", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1017393286"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/pat.0000000000000250", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1017393286"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/jcp.22724", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1018547055"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/jto.0000000000000471", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1018839824"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/jto.0000000000000471", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1018839824"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1309/ajcpp5r2zjzkclwn", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1019827765"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/pas.0b013e31826ab1c0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1020243774"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/pas.0b013e31826ab1c0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1020243774"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/pas.0b013e31826ab1c0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1020243774"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.5858/arpa.2012-0214-oa", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1022193197"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nrc2068", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1023263359", 
          "https://doi.org/10.1038/nrc2068"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/gcc.22218", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1024347279"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/gcc.22218", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1024347279"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/pas.0b013e3182498be5", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1026441037"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/pas.0b013e3182498be5", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1026441037"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/pas.0b013e3182498be5", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1026441037"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/modpathol.2014.43", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1029253249", 
          "https://doi.org/10.1038/modpathol.2014.43"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/modpathol.2014.43", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1029253249", 
          "https://doi.org/10.1038/modpathol.2014.43"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.4137/cmo.s15239", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1031036106"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/pat.0b013e32835d0efb", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1031538966"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/pat.0b013e32835d0efb", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1031538966"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/pat.0b013e32835d0efb", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1031538966"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/cge.12472", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035642810"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/cge.12472", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035642810"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ng.2323", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1043591147", 
          "https://doi.org/10.1038/ng.2323"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ng.2323", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1043591147", 
          "https://doi.org/10.1038/ng.2323"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ng.910", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1043671664", 
          "https://doi.org/10.1038/ng.910"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ng.910", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1043671664", 
          "https://doi.org/10.1038/ng.910"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/pas.0000000000000394", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1043919406"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/pas.0000000000000394", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1043919406"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/pas.0000000000000394", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1043919406"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/gcc.22129", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1047607128"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/gcc.22129", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1047607128"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/pas.0b013e318218985b", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1047885898"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/pas.0b013e318218985b", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1047885898"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/cge.12501", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1048880090"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/cge.12501", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1048880090"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ng.2813", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1049645772", 
          "https://doi.org/10.1038/ng.2813"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ng.2813", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1049645772", 
          "https://doi.org/10.1038/ng.2813"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1136/jmedgenet-2011-100156", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1051723503"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1136/jmedgenet-2011-100156", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1051723503"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/bjc.2012.245", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1052944382", 
          "https://doi.org/10.1038/bjc.2012.245"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/ajcp/110.3.397", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1053107321"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1043/1543-2165-133.8.1317", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1077940552"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3978/j.issn.2225-319x.2012.11.04", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1078776398"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2015-10", 
    "datePublishedReg": "2015-10-01", 
    "description": "Although most mesotheliomas present with pleural effusions, it is controversial whether mesothelioma can be diagnosed with confidence in effusion cytology. Therefore, an ancillary marker of malignant mesothelial cells applicable in effusions would be clinically valuable. BRCA-1-associated protein (BAP1) is a tumor suppressor gene, which shows biallelic inactivation in approximately half of all mesotheliomas. We investigated whether loss of BAP1 expression by immunohistochemistry can be used to support a diagnosis of mesothelioma in effusion cytology. Immunohistochemistry for BAP1 was performed on cell blocks and interpreted blinded. 43 of 75 (57%) effusions associated with confirmed mesothelioma showed negative staining with positive internal controls. Of 57 effusions considered to have atypical mesothelial cells in the absence of a definitive diagnosis of mesothelioma, 8 cases demonstrated negative staining for BAP1. On follow-up six of these patients received a definitive diagnosis of mesothelioma in the subsequent 14 months (two were lost to follow-up immediately, and mesothelioma could not be excluded). Only 5 of 100 consecutive benign effusions were interpreted as BAP1 negative. One of these patients died soon after and mesothelioma could not be excluded. On unblinded review the four other patients with apparently negative BAP1 staining but no malignancy lacked convincing positive staining in non-neoplastic cells suggesting that BAP1 immunohistochemistry may have initially been misinterpreted. 47 effusions with adenocarcinoma were BAP1 positive. We conclude that loss of BAP1 expression, while not definitive, can be used to support the diagnosis of mesothelioma in effusion cytology. We caution that interpretation of BAP1 immunohistochemistry on cell block may be difficult and that convincing positive staining in non-neoplastic cells is required before atypical cells are considered negative. We also note that BAP1 loss is not a sensitive test as it occurs in only half of all mesotheliomas and cannot be used to exclude the diagnosis. ", 
    "genre": "research_article", 
    "id": "sg:pub.10.1038/modpathol.2015.87", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": true, 
    "isPartOf": [
      {
        "id": "sg:journal.1098208", 
        "issn": [
          "0893-3952", 
          "1530-0285"
        ], 
        "name": "Modern Pathology", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "10", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "28"
      }
    ], 
    "name": "Loss of expression of BAP1 is a useful adjunct, which strongly supports the diagnosis of mesothelioma in effusion cytology", 
    "pagination": "1360-1368", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "2e190acdada36654712110fb72b979811faee966a0a3948bbd650e274254ac26"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "26226841"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "8806605"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1038/modpathol.2015.87"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1009676602"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1038/modpathol.2015.87", 
      "https://app.dimensions.ai/details/publication/pub.1009676602"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-11T13:51", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000371_0000000371/records_130801_00000000.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "http://www.nature.com/modpathol/journal/v28/n10/full/modpathol201587a.html"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/modpathol.2015.87'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/modpathol.2015.87'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/modpathol.2015.87'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/modpathol.2015.87'


 

This table displays all metadata directly associated to this object as RDF triples.

309 TRIPLES      21 PREDICATES      77 URIs      37 LITERALS      25 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1038/modpathol.2015.87 schema:about N0dedb6a0af124538a88cac3f7a2eade1
2 N120e4e97cc15412fbdfa3bc5ca6354a0
3 N1fd108d780be4b2582d113a16220b301
4 N3ef0eaaf62464fefa147e8d8d5c32059
5 N42bc19b32ecc4814830820ac5be173b9
6 N466d454e484e428fad01d4ec2b054d32
7 N7fa71fcc79384bd1bbb07375c55fb0b5
8 Na10b58c27c4c498fadef861e0cf4be76
9 Na8f6f2fe2cf14b1aa358d0236117cd3f
10 Naf3f716b732f48af90b1200c1b195a34
11 Nb0d0ebd59bea42ee81d347a1fc1ae0ba
12 Nba071e127f4b4a1abdeab5a2fd5974f4
13 Nc0f79acad6324684a58f52894ef8a1ca
14 Nc26afcba32684449bf46f7774d3ad7a9
15 Nc47d13f2dc1f470cbcf79125a8add80d
16 Ned4d7266602d4f49a90259b18cd14cff
17 anzsrc-for:11
18 anzsrc-for:1199
19 schema:author N7970037704224f909d850d91981b3ae7
20 schema:citation sg:pub.10.1038/bjc.2012.245
21 sg:pub.10.1038/modpathol.2014.43
22 sg:pub.10.1038/modpathol.3800732
23 sg:pub.10.1038/ng.2323
24 sg:pub.10.1038/ng.2813
25 sg:pub.10.1038/ng.855
26 sg:pub.10.1038/ng.910
27 sg:pub.10.1038/ng.912
28 sg:pub.10.1038/nrc2068
29 https://doi.org/10.1002/gcc.22129
30 https://doi.org/10.1002/gcc.22218
31 https://doi.org/10.1002/jcp.22724
32 https://doi.org/10.1016/j.jtcvs.2012.09.023
33 https://doi.org/10.1043/1543-2165-133.8.1317
34 https://doi.org/10.1093/ajcp/110.3.397
35 https://doi.org/10.1097/jto.0000000000000471
36 https://doi.org/10.1097/pas.0000000000000394
37 https://doi.org/10.1097/pas.0b013e318218985b
38 https://doi.org/10.1097/pas.0b013e3182498be5
39 https://doi.org/10.1097/pas.0b013e31826ab1c0
40 https://doi.org/10.1097/pat.0000000000000250
41 https://doi.org/10.1097/pat.0b013e32835d0efb
42 https://doi.org/10.1111/cge.12472
43 https://doi.org/10.1111/cge.12501
44 https://doi.org/10.1111/j.1349-7006.2012.02223.x
45 https://doi.org/10.1136/jclinpath-2012-201303
46 https://doi.org/10.1136/jmedgenet-2011-100156
47 https://doi.org/10.1309/ajcpp5r2zjzkclwn
48 https://doi.org/10.1309/ajcpwfw7o1fvflkt
49 https://doi.org/10.3978/j.issn.2225-319x.2012.11.04
50 https://doi.org/10.4137/cmo.s15239
51 https://doi.org/10.5858/arpa.2012-0214-oa
52 schema:datePublished 2015-10
53 schema:datePublishedReg 2015-10-01
54 schema:description Although most mesotheliomas present with pleural effusions, it is controversial whether mesothelioma can be diagnosed with confidence in effusion cytology. Therefore, an ancillary marker of malignant mesothelial cells applicable in effusions would be clinically valuable. BRCA-1-associated protein (BAP1) is a tumor suppressor gene, which shows biallelic inactivation in approximately half of all mesotheliomas. We investigated whether loss of BAP1 expression by immunohistochemistry can be used to support a diagnosis of mesothelioma in effusion cytology. Immunohistochemistry for BAP1 was performed on cell blocks and interpreted blinded. 43 of 75 (57%) effusions associated with confirmed mesothelioma showed negative staining with positive internal controls. Of 57 effusions considered to have atypical mesothelial cells in the absence of a definitive diagnosis of mesothelioma, 8 cases demonstrated negative staining for BAP1. On follow-up six of these patients received a definitive diagnosis of mesothelioma in the subsequent 14 months (two were lost to follow-up immediately, and mesothelioma could not be excluded). Only 5 of 100 consecutive benign effusions were interpreted as BAP1 negative. One of these patients died soon after and mesothelioma could not be excluded. On unblinded review the four other patients with apparently negative BAP1 staining but no malignancy lacked convincing positive staining in non-neoplastic cells suggesting that BAP1 immunohistochemistry may have initially been misinterpreted. 47 effusions with adenocarcinoma were BAP1 positive. We conclude that loss of BAP1 expression, while not definitive, can be used to support the diagnosis of mesothelioma in effusion cytology. We caution that interpretation of BAP1 immunohistochemistry on cell block may be difficult and that convincing positive staining in non-neoplastic cells is required before atypical cells are considered negative. We also note that BAP1 loss is not a sensitive test as it occurs in only half of all mesotheliomas and cannot be used to exclude the diagnosis.
55 schema:genre research_article
56 schema:inLanguage en
57 schema:isAccessibleForFree true
58 schema:isPartOf N6afa92901bce4abbbecbe0b69f28003c
59 N9d122f696c264af38efb84f17b46e836
60 sg:journal.1098208
61 schema:name Loss of expression of BAP1 is a useful adjunct, which strongly supports the diagnosis of mesothelioma in effusion cytology
62 schema:pagination 1360-1368
63 schema:productId N52e70e10828c400d9fe21edd3a4cdd8e
64 N80e7fac9fe024df39bd1b1b2e4a16c99
65 Nccbb256e6af1485f97ce1cc7343442f2
66 Nd34c9953750241c2beb8bc749a63f025
67 Ne525e6fa25ee4bf5a1d2415b49092c8b
68 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009676602
69 https://doi.org/10.1038/modpathol.2015.87
70 schema:sdDatePublished 2019-04-11T13:51
71 schema:sdLicense https://scigraph.springernature.com/explorer/license/
72 schema:sdPublisher Nb8eebcb7c72f4c11a02ae61dd518b77d
73 schema:url http://www.nature.com/modpathol/journal/v28/n10/full/modpathol201587a.html
74 sgo:license sg:explorer/license/
75 sgo:sdDataset articles
76 rdf:type schema:ScholarlyArticle
77 N0dedb6a0af124538a88cac3f7a2eade1 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
78 schema:name Male
79 rdf:type schema:DefinedTerm
80 N120e4e97cc15412fbdfa3bc5ca6354a0 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
81 schema:name Humans
82 rdf:type schema:DefinedTerm
83 N1fd108d780be4b2582d113a16220b301 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
84 schema:name Aged
85 rdf:type schema:DefinedTerm
86 N35f6c5dd686b48e99a893e3410b118fc rdf:first sg:person.0707071206.52
87 rdf:rest N974dcfaa6dae4915aba641fa8a8c24db
88 N3ed1a5ff600941dea3b62a41dc6af8c1 rdf:first sg:person.01214202001.49
89 rdf:rest Nd30dbe5fd6954f918a762f1954281c15
90 N3ef0eaaf62464fefa147e8d8d5c32059 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
91 schema:name Pleural Neoplasms
92 rdf:type schema:DefinedTerm
93 N42bc19b32ecc4814830820ac5be173b9 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
94 schema:name Tumor Suppressor Proteins
95 rdf:type schema:DefinedTerm
96 N466d454e484e428fad01d4ec2b054d32 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
97 schema:name Mesothelioma
98 rdf:type schema:DefinedTerm
99 N52e70e10828c400d9fe21edd3a4cdd8e schema:name nlm_unique_id
100 schema:value 8806605
101 rdf:type schema:PropertyValue
102 N6afa92901bce4abbbecbe0b69f28003c schema:issueNumber 10
103 rdf:type schema:PublicationIssue
104 N7970037704224f909d850d91981b3ae7 rdf:first sg:person.0711044326.86
105 rdf:rest N3ed1a5ff600941dea3b62a41dc6af8c1
106 N7fa71fcc79384bd1bbb07375c55fb0b5 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
107 schema:name Female
108 rdf:type schema:DefinedTerm
109 N80e7fac9fe024df39bd1b1b2e4a16c99 schema:name doi
110 schema:value 10.1038/modpathol.2015.87
111 rdf:type schema:PropertyValue
112 N92756d3f7ea44200b735a48dd8a87714 rdf:first sg:person.01330430401.33
113 rdf:rest Nf2cefa6f28ec4e0da2786727e605a844
114 N974dcfaa6dae4915aba641fa8a8c24db rdf:first sg:person.0721252701.85
115 rdf:rest Ndb0870203d9a4487811f1bb653141c56
116 N9d122f696c264af38efb84f17b46e836 schema:volumeNumber 28
117 rdf:type schema:PublicationVolume
118 Na10b58c27c4c498fadef861e0cf4be76 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
119 schema:name Adult
120 rdf:type schema:DefinedTerm
121 Na471a6fa19f1439eafd76fd019bc7e54 rdf:first sg:person.01160073674.20
122 rdf:rest rdf:nil
123 Na8f6f2fe2cf14b1aa358d0236117cd3f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
124 schema:name Middle Aged
125 rdf:type schema:DefinedTerm
126 Naf3f716b732f48af90b1200c1b195a34 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
127 schema:name Cytodiagnosis
128 rdf:type schema:DefinedTerm
129 Nb0d0ebd59bea42ee81d347a1fc1ae0ba schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
130 schema:name Aged, 80 and over
131 rdf:type schema:DefinedTerm
132 Nb40e4ae588684bab9e0e89d1150eb567 rdf:first sg:person.01040413736.70
133 rdf:rest Na471a6fa19f1439eafd76fd019bc7e54
134 Nb8eebcb7c72f4c11a02ae61dd518b77d schema:name Springer Nature - SN SciGraph project
135 rdf:type schema:Organization
136 Nba071e127f4b4a1abdeab5a2fd5974f4 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
137 schema:name Pleural Effusion, Malignant
138 rdf:type schema:DefinedTerm
139 Nc0f79acad6324684a58f52894ef8a1ca schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
140 schema:name Young Adult
141 rdf:type schema:DefinedTerm
142 Nc26afcba32684449bf46f7774d3ad7a9 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
143 schema:name Immunohistochemistry
144 rdf:type schema:DefinedTerm
145 Nc47d13f2dc1f470cbcf79125a8add80d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
146 schema:name Biomarkers, Tumor
147 rdf:type schema:DefinedTerm
148 Nccbb256e6af1485f97ce1cc7343442f2 schema:name dimensions_id
149 schema:value pub.1009676602
150 rdf:type schema:PropertyValue
151 Nd30dbe5fd6954f918a762f1954281c15 rdf:first sg:person.0640756006.45
152 rdf:rest N92756d3f7ea44200b735a48dd8a87714
153 Nd34c9953750241c2beb8bc749a63f025 schema:name readcube_id
154 schema:value 2e190acdada36654712110fb72b979811faee966a0a3948bbd650e274254ac26
155 rdf:type schema:PropertyValue
156 Ndb0870203d9a4487811f1bb653141c56 rdf:first sg:person.0727416674.76
157 rdf:rest Nb40e4ae588684bab9e0e89d1150eb567
158 Ne525e6fa25ee4bf5a1d2415b49092c8b schema:name pubmed_id
159 schema:value 26226841
160 rdf:type schema:PropertyValue
161 Ned4d7266602d4f49a90259b18cd14cff schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
162 schema:name Ubiquitin Thiolesterase
163 rdf:type schema:DefinedTerm
164 Nf2cefa6f28ec4e0da2786727e605a844 rdf:first sg:person.0763063114.08
165 rdf:rest N35f6c5dd686b48e99a893e3410b118fc
166 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
167 schema:name Medical and Health Sciences
168 rdf:type schema:DefinedTerm
169 anzsrc-for:1199 schema:inDefinedTermSet anzsrc-for:
170 schema:name Other Medical and Health Sciences
171 rdf:type schema:DefinedTerm
172 sg:journal.1098208 schema:issn 0893-3952
173 1530-0285
174 schema:name Modern Pathology
175 rdf:type schema:Periodical
176 sg:person.01040413736.70 schema:affiliation https://www.grid.ac/institutes/grid.1013.3
177 schema:familyName Toon
178 schema:givenName Christopher W
179 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01040413736.70
180 rdf:type schema:Person
181 sg:person.01160073674.20 schema:affiliation https://www.grid.ac/institutes/grid.412703.3
182 schema:familyName Gill
183 schema:givenName Anthony J
184 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01160073674.20
185 rdf:type schema:Person
186 sg:person.01214202001.49 schema:affiliation https://www.grid.ac/institutes/grid.1013.3
187 schema:familyName Sheen
188 schema:givenName Amy
189 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01214202001.49
190 rdf:type schema:Person
191 sg:person.01330430401.33 schema:affiliation https://www.grid.ac/institutes/grid.1013.3
192 schema:familyName Wardell
193 schema:givenName Kathryn
194 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01330430401.33
195 rdf:type schema:Person
196 sg:person.0640756006.45 schema:affiliation https://www.grid.ac/institutes/grid.1013.3
197 schema:familyName Sioson
198 schema:givenName Loretta
199 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0640756006.45
200 rdf:type schema:Person
201 sg:person.0707071206.52 schema:affiliation https://www.grid.ac/institutes/grid.1013.3
202 schema:familyName Watson
203 schema:givenName Nicole
204 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0707071206.52
205 rdf:type schema:Person
206 sg:person.0711044326.86 schema:affiliation https://www.grid.ac/institutes/grid.1013.3
207 schema:familyName Andrici
208 schema:givenName Juliana
209 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0711044326.86
210 rdf:type schema:Person
211 sg:person.0721252701.85 schema:affiliation https://www.grid.ac/institutes/grid.412703.3
212 schema:familyName Ahadi
213 schema:givenName Mahsa S
214 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0721252701.85
215 rdf:type schema:Person
216 sg:person.0727416674.76 schema:affiliation https://www.grid.ac/institutes/grid.412703.3
217 schema:familyName Farzin
218 schema:givenName Mahtab
219 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0727416674.76
220 rdf:type schema:Person
221 sg:person.0763063114.08 schema:affiliation https://www.grid.ac/institutes/grid.412703.3
222 schema:familyName Clarkson
223 schema:givenName Adele
224 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0763063114.08
225 rdf:type schema:Person
226 sg:pub.10.1038/bjc.2012.245 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052944382
227 https://doi.org/10.1038/bjc.2012.245
228 rdf:type schema:CreativeWork
229 sg:pub.10.1038/modpathol.2014.43 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029253249
230 https://doi.org/10.1038/modpathol.2014.43
231 rdf:type schema:CreativeWork
232 sg:pub.10.1038/modpathol.3800732 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003680743
233 https://doi.org/10.1038/modpathol.3800732
234 rdf:type schema:CreativeWork
235 sg:pub.10.1038/ng.2323 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043591147
236 https://doi.org/10.1038/ng.2323
237 rdf:type schema:CreativeWork
238 sg:pub.10.1038/ng.2813 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049645772
239 https://doi.org/10.1038/ng.2813
240 rdf:type schema:CreativeWork
241 sg:pub.10.1038/ng.855 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016007156
242 https://doi.org/10.1038/ng.855
243 rdf:type schema:CreativeWork
244 sg:pub.10.1038/ng.910 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043671664
245 https://doi.org/10.1038/ng.910
246 rdf:type schema:CreativeWork
247 sg:pub.10.1038/ng.912 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006344582
248 https://doi.org/10.1038/ng.912
249 rdf:type schema:CreativeWork
250 sg:pub.10.1038/nrc2068 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023263359
251 https://doi.org/10.1038/nrc2068
252 rdf:type schema:CreativeWork
253 https://doi.org/10.1002/gcc.22129 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047607128
254 rdf:type schema:CreativeWork
255 https://doi.org/10.1002/gcc.22218 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024347279
256 rdf:type schema:CreativeWork
257 https://doi.org/10.1002/jcp.22724 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018547055
258 rdf:type schema:CreativeWork
259 https://doi.org/10.1016/j.jtcvs.2012.09.023 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017234835
260 rdf:type schema:CreativeWork
261 https://doi.org/10.1043/1543-2165-133.8.1317 schema:sameAs https://app.dimensions.ai/details/publication/pub.1077940552
262 rdf:type schema:CreativeWork
263 https://doi.org/10.1093/ajcp/110.3.397 schema:sameAs https://app.dimensions.ai/details/publication/pub.1053107321
264 rdf:type schema:CreativeWork
265 https://doi.org/10.1097/jto.0000000000000471 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018839824
266 rdf:type schema:CreativeWork
267 https://doi.org/10.1097/pas.0000000000000394 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043919406
268 rdf:type schema:CreativeWork
269 https://doi.org/10.1097/pas.0b013e318218985b schema:sameAs https://app.dimensions.ai/details/publication/pub.1047885898
270 rdf:type schema:CreativeWork
271 https://doi.org/10.1097/pas.0b013e3182498be5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026441037
272 rdf:type schema:CreativeWork
273 https://doi.org/10.1097/pas.0b013e31826ab1c0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020243774
274 rdf:type schema:CreativeWork
275 https://doi.org/10.1097/pat.0000000000000250 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017393286
276 rdf:type schema:CreativeWork
277 https://doi.org/10.1097/pat.0b013e32835d0efb schema:sameAs https://app.dimensions.ai/details/publication/pub.1031538966
278 rdf:type schema:CreativeWork
279 https://doi.org/10.1111/cge.12472 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035642810
280 rdf:type schema:CreativeWork
281 https://doi.org/10.1111/cge.12501 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048880090
282 rdf:type schema:CreativeWork
283 https://doi.org/10.1111/j.1349-7006.2012.02223.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1007628309
284 rdf:type schema:CreativeWork
285 https://doi.org/10.1136/jclinpath-2012-201303 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006688026
286 rdf:type schema:CreativeWork
287 https://doi.org/10.1136/jmedgenet-2011-100156 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051723503
288 rdf:type schema:CreativeWork
289 https://doi.org/10.1309/ajcpp5r2zjzkclwn schema:sameAs https://app.dimensions.ai/details/publication/pub.1019827765
290 rdf:type schema:CreativeWork
291 https://doi.org/10.1309/ajcpwfw7o1fvflkt schema:sameAs https://app.dimensions.ai/details/publication/pub.1001563737
292 rdf:type schema:CreativeWork
293 https://doi.org/10.3978/j.issn.2225-319x.2012.11.04 schema:sameAs https://app.dimensions.ai/details/publication/pub.1078776398
294 rdf:type schema:CreativeWork
295 https://doi.org/10.4137/cmo.s15239 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031036106
296 rdf:type schema:CreativeWork
297 https://doi.org/10.5858/arpa.2012-0214-oa schema:sameAs https://app.dimensions.ai/details/publication/pub.1022193197
298 rdf:type schema:CreativeWork
299 https://www.grid.ac/institutes/grid.1013.3 schema:alternateName University of Sydney
300 schema:name Cancer Diagnosis and Pathology Research Group, Kolling Institute of Medical Research, Sydney, NSW, Australia.
301 Histopath Pathology, Sydney, NSW, Australia.
302 Sydney Medical School, University of Sydney, Sydney, NSW, Australia.
303 rdf:type schema:Organization
304 https://www.grid.ac/institutes/grid.412703.3 schema:alternateName Royal North Shore Hospital
305 schema:name Cancer Diagnosis and Pathology Research Group, Kolling Institute of Medical Research, Sydney, NSW, Australia.
306 Department of Anatomical Pathology, Royal North Shore Hospital, Sydney, NSW, Australia.
307 Sydney Medical School, University of Sydney, Sydney, NSW, Australia.
308 Sydney Vital Translational Research Centre, Royal North Shore Hospital, Pacific Highway St Leonards, Sydney, NSW, Australia.
309 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...