Towards an international pediatric liver tumor consensus classification: proceedings of the Los Angeles COG liver tumors symposium View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2013-09-06

AUTHORS

Dolores López-Terrada, Rita Alaggio, Maria T de Dávila, Piotr Czauderna, Eiso Hiyama, Howard Katzenstein, Ivo Leuschner, Marcio Malogolowkin, Rebecka Meyers, Sarangarajan Ranganathan, Yukichi Tanaka, Gail Tomlinson, Monique Fabrè, Arthur Zimmermann, Milton J Finegold

ABSTRACT

Liver tumors are rare in children, and their diagnoses may be challenging particularly because of the lack of a current consensus classification system. Systematic central histopathological review of these tumors performed as part of the pediatric collaborative therapeutic protocols has allowed the identification of histologic subtypes with distinct clinical associations. As a result, histopathology has been incorporated within the Children’s Oncology Group (COG) protocols, and only in the United States, as a risk-stratification parameter and for patient management. Therefore, the COG Liver Tumor Committee sponsored an International Pathology Symposium in March 2011 to discuss the histopathology and classification of pediatric liver tumors, and hepatoblastoma in particular, and work towards an International Pediatric Liver Tumors Consensus Classification that would be required for international collaborative projects. Twenty-two pathologists and experts in pediatric liver tumors, including those serving as central reviewers for the COG, European Société Internationale d’Oncologie Pédiatrique, Gesellschaft für Pädiatrische Onkologie und Hämatologie, and Japanese Study Group for Pediatric Liver Tumors protocols, as well as pediatric oncologists and surgeons specialized in this field, reviewed more than 50 pediatric liver tumor cases and discussed classic and newly reported entities, as well as criteria for their classification. This symposium represented the first collaborative step to develop a classification that may lead to a common treatment-stratification system incorporating tumor histopathology. A standardized, clinically meaningful classification will also be necessary to allow the integration of new biological parameters and to move towards clinical algorithms based on patient characteristics and tumor genetics, which should improve future patient management and outcome. More... »

PAGES

472-491

Journal

TITLE

Modern Pathology

ISSUE

3

VOLUME

27

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/modpathol.2013.80

DOI

http://dx.doi.org/10.1038/modpathol.2013.80

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1031527752

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/24008558


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20 schema:description Liver tumors are rare in children, and their diagnoses may be challenging particularly because of the lack of a current consensus classification system. Systematic central histopathological review of these tumors performed as part of the pediatric collaborative therapeutic protocols has allowed the identification of histologic subtypes with distinct clinical associations. As a result, histopathology has been incorporated within the Children’s Oncology Group (COG) protocols, and only in the United States, as a risk-stratification parameter and for patient management. Therefore, the COG Liver Tumor Committee sponsored an International Pathology Symposium in March 2011 to discuss the histopathology and classification of pediatric liver tumors, and hepatoblastoma in particular, and work towards an International Pediatric Liver Tumors Consensus Classification that would be required for international collaborative projects. Twenty-two pathologists and experts in pediatric liver tumors, including those serving as central reviewers for the COG, European Société Internationale d’Oncologie Pédiatrique, Gesellschaft für Pädiatrische Onkologie und Hämatologie, and Japanese Study Group for Pediatric Liver Tumors protocols, as well as pediatric oncologists and surgeons specialized in this field, reviewed more than 50 pediatric liver tumor cases and discussed classic and newly reported entities, as well as criteria for their classification. This symposium represented the first collaborative step to develop a classification that may lead to a common treatment-stratification system incorporating tumor histopathology. A standardized, clinically meaningful classification will also be necessary to allow the integration of new biological parameters and to move towards clinical algorithms based on patient characteristics and tumor genetics, which should improve future patient management and outcome.
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27 Children's Oncology Group protocols
28 Committee
29 Gesellschaft für Pädiatrische Onkologie und Hämatologie
30 Japanese Study Group
31 Tumor Committee
32 United States
33 algorithm
34 association
35 biological parameters
36 cases
37 central histopathological review
38 central reviewers
39 characteristics
40 children
41 classification
42 classification system
43 clinical algorithm
44 clinical associations
45 collaborative project
46 collaborative steps
47 consensus classification
48 consensus classification system
49 criteria
50 diagnosis
51 distinct clinical associations
52 entities
53 experts
54 field
55 future patient management
56 genetics
57 group
58 group protocol
59 hepatoblastoma
60 histologic subtype
61 histopathological review
62 histopathology
63 identification
64 integration
65 international collaborative project
66 lack
67 liver tumor cases
68 liver tumors
69 management
70 meaningful classification
71 new biological parameters
72 oncologists
73 outcomes
74 parameters
75 part
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77 patient characteristics
78 patient management
79 pediatric liver tumors
80 pediatric oncologists
81 proceedings
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84 results
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87 risk stratification parameters
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