Ovarian and endometrial endometrioid carcinomas have distinct CTNNB1 and PTEN mutation profiles View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2014-01

AUTHORS

Melissa K McConechy, Jiarui Ding, Janine Senz, Winnie Yang, Nataliya Melnyk, Alicia A Tone, Leah M Prentice, Kimberly C Wiegand, Jessica N McAlpine, Sohrab P Shah, Cheng-Han Lee, Paul J Goodfellow, C Blake Gilks, David G Huntsman

ABSTRACT

Ovarian endometrioid carcinomas and endometrial endometrioid carcinomas share many histological and molecular alterations. These similarities are likely due to a common endometrial epithelial precursor cell of origin, with most ovarian endometrioid carcinomas arising from endometriosis. To directly compare the mutation profiles of two morphologically similar tumor types, endometrial endometrioid carcinomas (n=307) and ovarian endometrioid carcinomas (n=33), we performed select exon capture sequencing on a panel of genes: ARID1A, PTEN, PIK3CA, KRAS, CTNNB1, PPP2R1A, TP53. We found that PTEN mutations are more frequent in low-grade endometrial endometrioid carcinomas (67%) compared with low-grade ovarian endometrioid carcinomas (17%) (P<0.0001). By contrast, CTNNB1 mutations are significantly different in low-grade ovarian endometrioid carcinomas (53%) compared with low-grade endometrial endometrioid carcinomas (28%) (P<0.0057). This difference in CTNNB1 mutation frequency may be reflective of the distinct microenvironments; the epithelial cells lining an endometriotic cyst within the ovary are exposed to a highly oxidative environment that promotes tumorigenesis. Understanding the distinct mutation patterns found in the PI3K and Wnt pathways of ovarian and endometrial endometrioid carcinomas may provide future opportunities for stratifying patients for targeted therapeutics. More... »

PAGES

128

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/modpathol.2013.107

DOI

http://dx.doi.org/10.1038/modpathol.2013.107

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1026225969

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/23765252


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1112", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Oncology and Carcinogenesis", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Biomarkers, Tumor", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Carcinoma, Endometrioid", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "DNA Mutational Analysis", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Endometrial Neoplasms", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Exons", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Female", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Genetic Predisposition to Disease", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Mutation", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Neoplasm Grading", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Ovarian Neoplasms", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "PTEN Phosphohydrolase", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Phenotype", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Tumor Microenvironment", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "beta Catenin", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "University of British Columbia", 
          "id": "https://www.grid.ac/institutes/grid.17091.3e", 
          "name": [
            "Department of Pathology and Laboratory Medicine, University of British Columbia, BC Cancer Agency, Centre for Translational and Applied Genomics, Vancouver, BC, Canada"
          ], 
          "type": "Organization"
        }, 
        "familyName": "McConechy", 
        "givenName": "Melissa K", 
        "id": "sg:person.01322426561.61", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01322426561.61"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of British Columbia", 
          "id": "https://www.grid.ac/institutes/grid.17091.3e", 
          "name": [
            "Department of Molecular Oncology, BC Cancer Agency, Vancouver, BC, Canada", 
            "Department of Computer Science, University of British Columbia, Vancouver, BC, Canada"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Ding", 
        "givenName": "Jiarui", 
        "id": "sg:person.01370541761.21", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01370541761.21"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of British Columbia", 
          "id": "https://www.grid.ac/institutes/grid.17091.3e", 
          "name": [
            "Department of Pathology and Laboratory Medicine, University of British Columbia, BC Cancer Agency, Centre for Translational and Applied Genomics, Vancouver, BC, Canada"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Senz", 
        "givenName": "Janine", 
        "id": "sg:person.01030542013.51", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01030542013.51"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of British Columbia", 
          "id": "https://www.grid.ac/institutes/grid.17091.3e", 
          "name": [
            "Department of Pathology and Laboratory Medicine, University of British Columbia, BC Cancer Agency, Centre for Translational and Applied Genomics, Vancouver, BC, Canada"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Yang", 
        "givenName": "Winnie", 
        "id": "sg:person.01173143626.10", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01173143626.10"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of British Columbia", 
          "id": "https://www.grid.ac/institutes/grid.17091.3e", 
          "name": [
            "Department of Pathology and Laboratory Medicine, University of British Columbia, BC Cancer Agency, Centre for Translational and Applied Genomics, Vancouver, BC, Canada"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Melnyk", 
        "givenName": "Nataliya", 
        "id": "sg:person.01320367375.39", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01320367375.39"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Princess Margaret Cancer Centre", 
          "id": "https://www.grid.ac/institutes/grid.415224.4", 
          "name": [
            "Division of Gynecology Oncology, Princess Margaret Cancer Centre, Toronto, ON, Canada"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Tone", 
        "givenName": "Alicia A", 
        "id": "sg:person.0656753501.43", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0656753501.43"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of British Columbia", 
          "id": "https://www.grid.ac/institutes/grid.17091.3e", 
          "name": [
            "Department of Pathology and Laboratory Medicine, University of British Columbia, BC Cancer Agency, Centre for Translational and Applied Genomics, Vancouver, BC, Canada"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Prentice", 
        "givenName": "Leah M", 
        "id": "sg:person.0714313413.19", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0714313413.19"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of British Columbia", 
          "id": "https://www.grid.ac/institutes/grid.17091.3e", 
          "name": [
            "Department of Pathology and Laboratory Medicine, University of British Columbia, BC Cancer Agency, Centre for Translational and Applied Genomics, Vancouver, BC, Canada"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Wiegand", 
        "givenName": "Kimberly C", 
        "id": "sg:person.0645441121.08", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0645441121.08"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of British Columbia", 
          "id": "https://www.grid.ac/institutes/grid.17091.3e", 
          "name": [
            "Division of Gynaecologic Oncology, Department of Obstetrics and Gynaecology, Vancouver General Hospital, University of British Columbia, Vancouver, BC, Canada"
          ], 
          "type": "Organization"
        }, 
        "familyName": "McAlpine", 
        "givenName": "Jessica N", 
        "id": "sg:person.01323165653.10", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01323165653.10"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of British Columbia", 
          "id": "https://www.grid.ac/institutes/grid.17091.3e", 
          "name": [
            "Department of Molecular Oncology, BC Cancer Agency, Vancouver, BC, Canada", 
            "Department of Computer Science, University of British Columbia, Vancouver, BC, Canada"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Shah", 
        "givenName": "Sohrab P", 
        "id": "sg:person.01201274527.46", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01201274527.46"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of British Columbia", 
          "id": "https://www.grid.ac/institutes/grid.17091.3e", 
          "name": [
            "Department of Pathology and Laboratory Medicine, Vancouver General Hospital and University of British Columbia, Vancouver, BC, Canada"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Lee", 
        "givenName": "Cheng-Han", 
        "id": "sg:person.0777615543.62", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0777615543.62"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "The Ohio State University", 
          "id": "https://www.grid.ac/institutes/grid.261331.4", 
          "name": [
            "Department of Obstetrics and Gynecology, College of Medicine, Ohio State University, Columbus, OH, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Goodfellow", 
        "givenName": "Paul J", 
        "id": "sg:person.013270471324.04", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013270471324.04"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of British Columbia", 
          "id": "https://www.grid.ac/institutes/grid.17091.3e", 
          "name": [
            "Department of Pathology and Laboratory Medicine, Vancouver General Hospital and University of British Columbia, Vancouver, BC, Canada"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Gilks", 
        "givenName": "C Blake", 
        "id": "sg:person.01120560217.98", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01120560217.98"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "BC Cancer Agency", 
          "id": "https://www.grid.ac/institutes/grid.248762.d", 
          "name": [
            "Department of Pathology and Laboratory Medicine, University of British Columbia, BC Cancer Agency, Centre for Translational and Applied Genomics, Vancouver, BC, Canada", 
            "Department of Molecular Oncology, BC Cancer Agency, Vancouver, BC, Canada"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Huntsman", 
        "givenName": "David G", 
        "id": "sg:person.015140454124.62", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015140454124.62"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.1097/pat.0b013e328348a6e7", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1000654232"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/pat.0b013e328348a6e7", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1000654232"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/pat.0b013e328348a6e7", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1000654232"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature10166", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1000736346", 
          "https://doi.org/10.1038/nature10166"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/path.856", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1003545720"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/path.2848", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1003569676"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0002-9440(10)65148-6", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1003592570"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.humpath.2004.02.007", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1004018900"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/modpathol.3800699", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1004375601", 
          "https://doi.org/10.1038/modpathol.3800699"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/modpathol.3800699", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1004375601", 
          "https://doi.org/10.1038/modpathol.3800699"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/nar/gkq929", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1005486377"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00019606-200106000-00008", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1007828050"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00019606-200106000-00008", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1007828050"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ng.2455", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1009004517", 
          "https://doi.org/10.1038/ng.2455"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3322/caac.20107", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1009055747"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/modpathol.3800366", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1010196299", 
          "https://doi.org/10.1038/modpathol.3800366"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/modpathol.3800366", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1010196299", 
          "https://doi.org/10.1038/modpathol.3800366"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1155/2010/162363", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1010551793"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/bioinformatics/btr629", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1011156122"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.ajpath.2011.01.009", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1012812273"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1158/1078-0432.ccr-04-2061", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1013347264"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1371/journal.pone.0030801", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1014953441"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/(sici)1097-0215(19990827)82:5<625::aid-ijc1>3.0.co;2-2", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1015648147"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.18632/oncotarget.652", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1017977209"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/igc.0b013e31821b2568", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1021333604"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/igc.0b013e31821b2568", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1021333604"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/igc.0b013e31821b2568", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1021333604"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.2147/agg.s28953", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1022278215"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0015-0282(01)03211-3", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1022929556"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/path.4056", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1023283092"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/pas.0b013e3181a902e1", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1025573271"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/pas.0b013e3181a902e1", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1025573271"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/pas.0b013e3181a902e1", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1025573271"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/modpathol.3800306", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1027289274", 
          "https://doi.org/10.1038/modpathol.3800306"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/modpathol.3800306", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1027289274", 
          "https://doi.org/10.1038/modpathol.3800306"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nrc2389", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1028228628", 
          "https://doi.org/10.1038/nrc2389"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/molehr/gar049", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1029371988"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1158/2159-8290.cd-11-0039", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1033852076"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.humpath.2004.07.019", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1034387931"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1349-7006.1999.tb00777.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1036659484"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1349-7006.1999.tb00777.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1036659484"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/jnci/djs345", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037640504"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1158/1078-0432.ccr-07-1614", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1038160120"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/bioinformatics/btp324", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1038266369"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1056/nejmcp1000274", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1040924773"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.humpath.2011.03.003", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1042393446"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.humpath.2011.03.003", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1042393446"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nrc1819", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1044083124", 
          "https://doi.org/10.1038/nrc1819"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nrc1819", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1044083124", 
          "https://doi.org/10.1038/nrc1819"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.mpdhp.2009.09.002", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1045313078"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/science.1096502", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1049080424"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0090-8258(74)90012-2", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1050091648"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/ijc.21845", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1051646178"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/ijc.21845", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1051646178"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/bjc.1988.44", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1052791314", 
          "https://doi.org/10.1038/bjc.1988.44"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/bjc.1988.44", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1052791314", 
          "https://doi.org/10.1038/bjc.1988.44"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1158/0008-5472.can-11-0549", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1053740385"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/science.8259518", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1062653866"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/science.8259519", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1062653867"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3892/or_00000417", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1071537222"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3892/or_00000429", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1071537234"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1074750468", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1074957461", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1083241009", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1083251670", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1083269026", 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2014-01", 
    "datePublishedReg": "2014-01-01", 
    "description": "Ovarian endometrioid carcinomas and endometrial endometrioid carcinomas share many histological and molecular alterations. These similarities are likely due to a common endometrial epithelial precursor cell of origin, with most ovarian endometrioid carcinomas arising from endometriosis. To directly compare the mutation profiles of two morphologically similar tumor types, endometrial endometrioid carcinomas (n=307) and ovarian endometrioid carcinomas (n=33), we performed select exon capture sequencing on a panel of genes: ARID1A, PTEN, PIK3CA, KRAS, CTNNB1, PPP2R1A, TP53. We found that PTEN mutations are more frequent in low-grade endometrial endometrioid carcinomas (67%) compared with low-grade ovarian endometrioid carcinomas (17%) (P<0.0001). By contrast, CTNNB1 mutations are significantly different in low-grade ovarian endometrioid carcinomas (53%) compared with low-grade endometrial endometrioid carcinomas (28%) (P<0.0057). This difference in CTNNB1 mutation frequency may be reflective of the distinct microenvironments; the epithelial cells lining an endometriotic cyst within the ovary are exposed to a highly oxidative environment that promotes tumorigenesis. Understanding the distinct mutation patterns found in the PI3K and Wnt pathways of ovarian and endometrial endometrioid carcinomas may provide future opportunities for stratifying patients for targeted therapeutics. ", 
    "genre": "research_article", 
    "id": "sg:pub.10.1038/modpathol.2013.107", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": true, 
    "isFundedItemOf": [
      {
        "id": "sg:grant.2472787", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.2440232", 
        "type": "MonetaryGrant"
      }
    ], 
    "isPartOf": [
      {
        "id": "sg:journal.1098208", 
        "issn": [
          "0893-3952", 
          "1530-0285"
        ], 
        "name": "Modern Pathology", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "1", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "27"
      }
    ], 
    "name": "Ovarian and endometrial endometrioid carcinomas have distinct CTNNB1 and PTEN mutation profiles", 
    "pagination": "128", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "7cf031721b52f58a2751db1cab5b79d74450dcbb730b3b17efb2925cae2bac8f"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "23765252"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "8806605"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1038/modpathol.2013.107"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1026225969"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1038/modpathol.2013.107", 
      "https://app.dimensions.ai/details/publication/pub.1026225969"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-10T16:30", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8669_00000435.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://www.nature.com/articles/modpathol2013107"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/modpathol.2013.107'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/modpathol.2013.107'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/modpathol.2013.107'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/modpathol.2013.107'


 

This table displays all metadata directly associated to this object as RDF triples.

394 TRIPLES      21 PREDICATES      95 URIs      36 LITERALS      24 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1038/modpathol.2013.107 schema:about N15366ccc525d4b62b7bf10a83bd41a66
2 N2f1b57366b8d4b52b0344bc7ec096a84
3 N30f4d70cb36b438589b114374be49be3
4 N3a7e4d5917734ca388a609631a451bfa
5 N3b8d602cf5934297b1e4c0e68de7067b
6 N4c603cf1bbc34d0d82ef206c39baa564
7 N688df65939b347d798f003061160ae70
8 N6e60f75d62cd4534bb9499bf32e9e45d
9 N83d7e33001ad4e599da8cc1aa3a7a6af
10 N85ac86cb9e6445a782d266207d8ab14c
11 Na374bf486ef04cc3a870f84b670d6466
12 Nc56ee6b56f2247b29646fee8cf97c58b
13 Nde97d7cc808a430dbcb9d7cdf8602432
14 Nec8fdac0960f40fdaad8bc8968c5fb81
15 Nf9e2f18524014a04a73216a8648b2390
16 anzsrc-for:11
17 anzsrc-for:1112
18 schema:author N332bc25efecd4c909a24fdeb0d292b6a
19 schema:citation sg:pub.10.1038/bjc.1988.44
20 sg:pub.10.1038/modpathol.3800306
21 sg:pub.10.1038/modpathol.3800366
22 sg:pub.10.1038/modpathol.3800699
23 sg:pub.10.1038/nature10166
24 sg:pub.10.1038/ng.2455
25 sg:pub.10.1038/nrc1819
26 sg:pub.10.1038/nrc2389
27 https://app.dimensions.ai/details/publication/pub.1074750468
28 https://app.dimensions.ai/details/publication/pub.1074957461
29 https://app.dimensions.ai/details/publication/pub.1083241009
30 https://app.dimensions.ai/details/publication/pub.1083251670
31 https://app.dimensions.ai/details/publication/pub.1083269026
32 https://doi.org/10.1002/(sici)1097-0215(19990827)82:5<625::aid-ijc1>3.0.co;2-2
33 https://doi.org/10.1002/ijc.21845
34 https://doi.org/10.1002/path.2848
35 https://doi.org/10.1002/path.4056
36 https://doi.org/10.1002/path.856
37 https://doi.org/10.1016/0090-8258(74)90012-2
38 https://doi.org/10.1016/j.ajpath.2011.01.009
39 https://doi.org/10.1016/j.humpath.2004.02.007
40 https://doi.org/10.1016/j.humpath.2004.07.019
41 https://doi.org/10.1016/j.humpath.2011.03.003
42 https://doi.org/10.1016/j.mpdhp.2009.09.002
43 https://doi.org/10.1016/s0002-9440(10)65148-6
44 https://doi.org/10.1016/s0015-0282(01)03211-3
45 https://doi.org/10.1056/nejmcp1000274
46 https://doi.org/10.1093/bioinformatics/btp324
47 https://doi.org/10.1093/bioinformatics/btr629
48 https://doi.org/10.1093/jnci/djs345
49 https://doi.org/10.1093/molehr/gar049
50 https://doi.org/10.1093/nar/gkq929
51 https://doi.org/10.1097/00019606-200106000-00008
52 https://doi.org/10.1097/igc.0b013e31821b2568
53 https://doi.org/10.1097/pas.0b013e3181a902e1
54 https://doi.org/10.1097/pat.0b013e328348a6e7
55 https://doi.org/10.1111/j.1349-7006.1999.tb00777.x
56 https://doi.org/10.1126/science.1096502
57 https://doi.org/10.1126/science.8259518
58 https://doi.org/10.1126/science.8259519
59 https://doi.org/10.1155/2010/162363
60 https://doi.org/10.1158/0008-5472.can-11-0549
61 https://doi.org/10.1158/1078-0432.ccr-04-2061
62 https://doi.org/10.1158/1078-0432.ccr-07-1614
63 https://doi.org/10.1158/2159-8290.cd-11-0039
64 https://doi.org/10.1371/journal.pone.0030801
65 https://doi.org/10.18632/oncotarget.652
66 https://doi.org/10.2147/agg.s28953
67 https://doi.org/10.3322/caac.20107
68 https://doi.org/10.3892/or_00000417
69 https://doi.org/10.3892/or_00000429
70 schema:datePublished 2014-01
71 schema:datePublishedReg 2014-01-01
72 schema:description Ovarian endometrioid carcinomas and endometrial endometrioid carcinomas share many histological and molecular alterations. These similarities are likely due to a common endometrial epithelial precursor cell of origin, with most ovarian endometrioid carcinomas arising from endometriosis. To directly compare the mutation profiles of two morphologically similar tumor types, endometrial endometrioid carcinomas (n=307) and ovarian endometrioid carcinomas (n=33), we performed select exon capture sequencing on a panel of genes: ARID1A, PTEN, PIK3CA, KRAS, CTNNB1, PPP2R1A, TP53. We found that PTEN mutations are more frequent in low-grade endometrial endometrioid carcinomas (67%) compared with low-grade ovarian endometrioid carcinomas (17%) (P<0.0001). By contrast, CTNNB1 mutations are significantly different in low-grade ovarian endometrioid carcinomas (53%) compared with low-grade endometrial endometrioid carcinomas (28%) (P<0.0057). This difference in CTNNB1 mutation frequency may be reflective of the distinct microenvironments; the epithelial cells lining an endometriotic cyst within the ovary are exposed to a highly oxidative environment that promotes tumorigenesis. Understanding the distinct mutation patterns found in the PI3K and Wnt pathways of ovarian and endometrial endometrioid carcinomas may provide future opportunities for stratifying patients for targeted therapeutics.
73 schema:genre research_article
74 schema:inLanguage en
75 schema:isAccessibleForFree true
76 schema:isPartOf N04d1bb095e714297927b2d9547750dfb
77 N2c182e89e280448ea67017c5d0af0541
78 sg:journal.1098208
79 schema:name Ovarian and endometrial endometrioid carcinomas have distinct CTNNB1 and PTEN mutation profiles
80 schema:pagination 128
81 schema:productId N22cb43aad2114badbfdaa3b6770b7a8a
82 N32c81e7f873f401b8bd3f236b772f974
83 N5703e4bd7a634091bdc535aaebde7a71
84 N71398c1a152e4f7ead1d127af268852b
85 Nad91127e5d124f6e8beebd89bf7979d3
86 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026225969
87 https://doi.org/10.1038/modpathol.2013.107
88 schema:sdDatePublished 2019-04-10T16:30
89 schema:sdLicense https://scigraph.springernature.com/explorer/license/
90 schema:sdPublisher N9b8503168173407fa8d804f44c0864d1
91 schema:url https://www.nature.com/articles/modpathol2013107
92 sgo:license sg:explorer/license/
93 sgo:sdDataset articles
94 rdf:type schema:ScholarlyArticle
95 N04d1bb095e714297927b2d9547750dfb schema:issueNumber 1
96 rdf:type schema:PublicationIssue
97 N15366ccc525d4b62b7bf10a83bd41a66 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
98 schema:name Mutation
99 rdf:type schema:DefinedTerm
100 N22cb43aad2114badbfdaa3b6770b7a8a schema:name doi
101 schema:value 10.1038/modpathol.2013.107
102 rdf:type schema:PropertyValue
103 N25512bddb76145d08f4c004b86806cd1 rdf:first sg:person.0656753501.43
104 rdf:rest Na494a190fbf14f6d98dc11962db0d8bf
105 N2c182e89e280448ea67017c5d0af0541 schema:volumeNumber 27
106 rdf:type schema:PublicationVolume
107 N2f1b57366b8d4b52b0344bc7ec096a84 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
108 schema:name Neoplasm Grading
109 rdf:type schema:DefinedTerm
110 N30f4d70cb36b438589b114374be49be3 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
111 schema:name Genetic Predisposition to Disease
112 rdf:type schema:DefinedTerm
113 N32c81e7f873f401b8bd3f236b772f974 schema:name nlm_unique_id
114 schema:value 8806605
115 rdf:type schema:PropertyValue
116 N332bc25efecd4c909a24fdeb0d292b6a rdf:first sg:person.01322426561.61
117 rdf:rest N5397ae3f0ed14d45b749d01a69a5910b
118 N3a7e4d5917734ca388a609631a451bfa schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
119 schema:name Humans
120 rdf:type schema:DefinedTerm
121 N3b8d602cf5934297b1e4c0e68de7067b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
122 schema:name Phenotype
123 rdf:type schema:DefinedTerm
124 N4c603cf1bbc34d0d82ef206c39baa564 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
125 schema:name Tumor Microenvironment
126 rdf:type schema:DefinedTerm
127 N4d2c423882444283a9fa5979f943ddcc rdf:first sg:person.013270471324.04
128 rdf:rest N81e1a6e08836477b961c8cdbc5bcb9e7
129 N5397ae3f0ed14d45b749d01a69a5910b rdf:first sg:person.01370541761.21
130 rdf:rest Naa2395d119c74d4cb3eefd0a00bd17af
131 N5703e4bd7a634091bdc535aaebde7a71 schema:name readcube_id
132 schema:value 7cf031721b52f58a2751db1cab5b79d74450dcbb730b3b17efb2925cae2bac8f
133 rdf:type schema:PropertyValue
134 N688df65939b347d798f003061160ae70 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
135 schema:name Biomarkers, Tumor
136 rdf:type schema:DefinedTerm
137 N6b061737f33945be8f8a85bb4255436e rdf:first sg:person.0645441121.08
138 rdf:rest Ndbf43a30df524ead97968b7f06e2906a
139 N6c1b7a7abc1441b0b65bf2d5d1821424 rdf:first sg:person.0777615543.62
140 rdf:rest N4d2c423882444283a9fa5979f943ddcc
141 N6e60f75d62cd4534bb9499bf32e9e45d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
142 schema:name Exons
143 rdf:type schema:DefinedTerm
144 N71398c1a152e4f7ead1d127af268852b schema:name pubmed_id
145 schema:value 23765252
146 rdf:type schema:PropertyValue
147 N81e1a6e08836477b961c8cdbc5bcb9e7 rdf:first sg:person.01120560217.98
148 rdf:rest Ne3434c85fa9d4afb906d4501e7fdb171
149 N83d7e33001ad4e599da8cc1aa3a7a6af schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
150 schema:name Female
151 rdf:type schema:DefinedTerm
152 N85ac86cb9e6445a782d266207d8ab14c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
153 schema:name Carcinoma, Endometrioid
154 rdf:type schema:DefinedTerm
155 N88f9d49a318a406a837720417b7843ac rdf:first sg:person.01173143626.10
156 rdf:rest Na6216eda01fd4406b968d01ed6a070d0
157 N9b8503168173407fa8d804f44c0864d1 schema:name Springer Nature - SN SciGraph project
158 rdf:type schema:Organization
159 Na374bf486ef04cc3a870f84b670d6466 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
160 schema:name Ovarian Neoplasms
161 rdf:type schema:DefinedTerm
162 Na494a190fbf14f6d98dc11962db0d8bf rdf:first sg:person.0714313413.19
163 rdf:rest N6b061737f33945be8f8a85bb4255436e
164 Na6216eda01fd4406b968d01ed6a070d0 rdf:first sg:person.01320367375.39
165 rdf:rest N25512bddb76145d08f4c004b86806cd1
166 Naa2395d119c74d4cb3eefd0a00bd17af rdf:first sg:person.01030542013.51
167 rdf:rest N88f9d49a318a406a837720417b7843ac
168 Nad91127e5d124f6e8beebd89bf7979d3 schema:name dimensions_id
169 schema:value pub.1026225969
170 rdf:type schema:PropertyValue
171 Nc56ee6b56f2247b29646fee8cf97c58b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
172 schema:name PTEN Phosphohydrolase
173 rdf:type schema:DefinedTerm
174 Ndbf43a30df524ead97968b7f06e2906a rdf:first sg:person.01323165653.10
175 rdf:rest Nf22e61f195ae4055a0ca9888e5d825aa
176 Nde97d7cc808a430dbcb9d7cdf8602432 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
177 schema:name Endometrial Neoplasms
178 rdf:type schema:DefinedTerm
179 Ne3434c85fa9d4afb906d4501e7fdb171 rdf:first sg:person.015140454124.62
180 rdf:rest rdf:nil
181 Nec8fdac0960f40fdaad8bc8968c5fb81 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
182 schema:name DNA Mutational Analysis
183 rdf:type schema:DefinedTerm
184 Nf22e61f195ae4055a0ca9888e5d825aa rdf:first sg:person.01201274527.46
185 rdf:rest N6c1b7a7abc1441b0b65bf2d5d1821424
186 Nf9e2f18524014a04a73216a8648b2390 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
187 schema:name beta Catenin
188 rdf:type schema:DefinedTerm
189 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
190 schema:name Medical and Health Sciences
191 rdf:type schema:DefinedTerm
192 anzsrc-for:1112 schema:inDefinedTermSet anzsrc-for:
193 schema:name Oncology and Carcinogenesis
194 rdf:type schema:DefinedTerm
195 sg:grant.2440232 http://pending.schema.org/fundedItem sg:pub.10.1038/modpathol.2013.107
196 rdf:type schema:MonetaryGrant
197 sg:grant.2472787 http://pending.schema.org/fundedItem sg:pub.10.1038/modpathol.2013.107
198 rdf:type schema:MonetaryGrant
199 sg:journal.1098208 schema:issn 0893-3952
200 1530-0285
201 schema:name Modern Pathology
202 rdf:type schema:Periodical
203 sg:person.01030542013.51 schema:affiliation https://www.grid.ac/institutes/grid.17091.3e
204 schema:familyName Senz
205 schema:givenName Janine
206 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01030542013.51
207 rdf:type schema:Person
208 sg:person.01120560217.98 schema:affiliation https://www.grid.ac/institutes/grid.17091.3e
209 schema:familyName Gilks
210 schema:givenName C Blake
211 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01120560217.98
212 rdf:type schema:Person
213 sg:person.01173143626.10 schema:affiliation https://www.grid.ac/institutes/grid.17091.3e
214 schema:familyName Yang
215 schema:givenName Winnie
216 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01173143626.10
217 rdf:type schema:Person
218 sg:person.01201274527.46 schema:affiliation https://www.grid.ac/institutes/grid.17091.3e
219 schema:familyName Shah
220 schema:givenName Sohrab P
221 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01201274527.46
222 rdf:type schema:Person
223 sg:person.01320367375.39 schema:affiliation https://www.grid.ac/institutes/grid.17091.3e
224 schema:familyName Melnyk
225 schema:givenName Nataliya
226 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01320367375.39
227 rdf:type schema:Person
228 sg:person.01322426561.61 schema:affiliation https://www.grid.ac/institutes/grid.17091.3e
229 schema:familyName McConechy
230 schema:givenName Melissa K
231 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01322426561.61
232 rdf:type schema:Person
233 sg:person.01323165653.10 schema:affiliation https://www.grid.ac/institutes/grid.17091.3e
234 schema:familyName McAlpine
235 schema:givenName Jessica N
236 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01323165653.10
237 rdf:type schema:Person
238 sg:person.013270471324.04 schema:affiliation https://www.grid.ac/institutes/grid.261331.4
239 schema:familyName Goodfellow
240 schema:givenName Paul J
241 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013270471324.04
242 rdf:type schema:Person
243 sg:person.01370541761.21 schema:affiliation https://www.grid.ac/institutes/grid.17091.3e
244 schema:familyName Ding
245 schema:givenName Jiarui
246 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01370541761.21
247 rdf:type schema:Person
248 sg:person.015140454124.62 schema:affiliation https://www.grid.ac/institutes/grid.248762.d
249 schema:familyName Huntsman
250 schema:givenName David G
251 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015140454124.62
252 rdf:type schema:Person
253 sg:person.0645441121.08 schema:affiliation https://www.grid.ac/institutes/grid.17091.3e
254 schema:familyName Wiegand
255 schema:givenName Kimberly C
256 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0645441121.08
257 rdf:type schema:Person
258 sg:person.0656753501.43 schema:affiliation https://www.grid.ac/institutes/grid.415224.4
259 schema:familyName Tone
260 schema:givenName Alicia A
261 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0656753501.43
262 rdf:type schema:Person
263 sg:person.0714313413.19 schema:affiliation https://www.grid.ac/institutes/grid.17091.3e
264 schema:familyName Prentice
265 schema:givenName Leah M
266 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0714313413.19
267 rdf:type schema:Person
268 sg:person.0777615543.62 schema:affiliation https://www.grid.ac/institutes/grid.17091.3e
269 schema:familyName Lee
270 schema:givenName Cheng-Han
271 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0777615543.62
272 rdf:type schema:Person
273 sg:pub.10.1038/bjc.1988.44 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052791314
274 https://doi.org/10.1038/bjc.1988.44
275 rdf:type schema:CreativeWork
276 sg:pub.10.1038/modpathol.3800306 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027289274
277 https://doi.org/10.1038/modpathol.3800306
278 rdf:type schema:CreativeWork
279 sg:pub.10.1038/modpathol.3800366 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010196299
280 https://doi.org/10.1038/modpathol.3800366
281 rdf:type schema:CreativeWork
282 sg:pub.10.1038/modpathol.3800699 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004375601
283 https://doi.org/10.1038/modpathol.3800699
284 rdf:type schema:CreativeWork
285 sg:pub.10.1038/nature10166 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000736346
286 https://doi.org/10.1038/nature10166
287 rdf:type schema:CreativeWork
288 sg:pub.10.1038/ng.2455 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009004517
289 https://doi.org/10.1038/ng.2455
290 rdf:type schema:CreativeWork
291 sg:pub.10.1038/nrc1819 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044083124
292 https://doi.org/10.1038/nrc1819
293 rdf:type schema:CreativeWork
294 sg:pub.10.1038/nrc2389 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028228628
295 https://doi.org/10.1038/nrc2389
296 rdf:type schema:CreativeWork
297 https://app.dimensions.ai/details/publication/pub.1074750468 schema:CreativeWork
298 https://app.dimensions.ai/details/publication/pub.1074957461 schema:CreativeWork
299 https://app.dimensions.ai/details/publication/pub.1083241009 schema:CreativeWork
300 https://app.dimensions.ai/details/publication/pub.1083251670 schema:CreativeWork
301 https://app.dimensions.ai/details/publication/pub.1083269026 schema:CreativeWork
302 https://doi.org/10.1002/(sici)1097-0215(19990827)82:5<625::aid-ijc1>3.0.co;2-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015648147
303 rdf:type schema:CreativeWork
304 https://doi.org/10.1002/ijc.21845 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051646178
305 rdf:type schema:CreativeWork
306 https://doi.org/10.1002/path.2848 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003569676
307 rdf:type schema:CreativeWork
308 https://doi.org/10.1002/path.4056 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023283092
309 rdf:type schema:CreativeWork
310 https://doi.org/10.1002/path.856 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003545720
311 rdf:type schema:CreativeWork
312 https://doi.org/10.1016/0090-8258(74)90012-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050091648
313 rdf:type schema:CreativeWork
314 https://doi.org/10.1016/j.ajpath.2011.01.009 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012812273
315 rdf:type schema:CreativeWork
316 https://doi.org/10.1016/j.humpath.2004.02.007 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004018900
317 rdf:type schema:CreativeWork
318 https://doi.org/10.1016/j.humpath.2004.07.019 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034387931
319 rdf:type schema:CreativeWork
320 https://doi.org/10.1016/j.humpath.2011.03.003 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042393446
321 rdf:type schema:CreativeWork
322 https://doi.org/10.1016/j.mpdhp.2009.09.002 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045313078
323 rdf:type schema:CreativeWork
324 https://doi.org/10.1016/s0002-9440(10)65148-6 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003592570
325 rdf:type schema:CreativeWork
326 https://doi.org/10.1016/s0015-0282(01)03211-3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022929556
327 rdf:type schema:CreativeWork
328 https://doi.org/10.1056/nejmcp1000274 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040924773
329 rdf:type schema:CreativeWork
330 https://doi.org/10.1093/bioinformatics/btp324 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038266369
331 rdf:type schema:CreativeWork
332 https://doi.org/10.1093/bioinformatics/btr629 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011156122
333 rdf:type schema:CreativeWork
334 https://doi.org/10.1093/jnci/djs345 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037640504
335 rdf:type schema:CreativeWork
336 https://doi.org/10.1093/molehr/gar049 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029371988
337 rdf:type schema:CreativeWork
338 https://doi.org/10.1093/nar/gkq929 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005486377
339 rdf:type schema:CreativeWork
340 https://doi.org/10.1097/00019606-200106000-00008 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007828050
341 rdf:type schema:CreativeWork
342 https://doi.org/10.1097/igc.0b013e31821b2568 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021333604
343 rdf:type schema:CreativeWork
344 https://doi.org/10.1097/pas.0b013e3181a902e1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025573271
345 rdf:type schema:CreativeWork
346 https://doi.org/10.1097/pat.0b013e328348a6e7 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000654232
347 rdf:type schema:CreativeWork
348 https://doi.org/10.1111/j.1349-7006.1999.tb00777.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1036659484
349 rdf:type schema:CreativeWork
350 https://doi.org/10.1126/science.1096502 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049080424
351 rdf:type schema:CreativeWork
352 https://doi.org/10.1126/science.8259518 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062653866
353 rdf:type schema:CreativeWork
354 https://doi.org/10.1126/science.8259519 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062653867
355 rdf:type schema:CreativeWork
356 https://doi.org/10.1155/2010/162363 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010551793
357 rdf:type schema:CreativeWork
358 https://doi.org/10.1158/0008-5472.can-11-0549 schema:sameAs https://app.dimensions.ai/details/publication/pub.1053740385
359 rdf:type schema:CreativeWork
360 https://doi.org/10.1158/1078-0432.ccr-04-2061 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013347264
361 rdf:type schema:CreativeWork
362 https://doi.org/10.1158/1078-0432.ccr-07-1614 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038160120
363 rdf:type schema:CreativeWork
364 https://doi.org/10.1158/2159-8290.cd-11-0039 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033852076
365 rdf:type schema:CreativeWork
366 https://doi.org/10.1371/journal.pone.0030801 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014953441
367 rdf:type schema:CreativeWork
368 https://doi.org/10.18632/oncotarget.652 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017977209
369 rdf:type schema:CreativeWork
370 https://doi.org/10.2147/agg.s28953 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022278215
371 rdf:type schema:CreativeWork
372 https://doi.org/10.3322/caac.20107 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009055747
373 rdf:type schema:CreativeWork
374 https://doi.org/10.3892/or_00000417 schema:sameAs https://app.dimensions.ai/details/publication/pub.1071537222
375 rdf:type schema:CreativeWork
376 https://doi.org/10.3892/or_00000429 schema:sameAs https://app.dimensions.ai/details/publication/pub.1071537234
377 rdf:type schema:CreativeWork
378 https://www.grid.ac/institutes/grid.17091.3e schema:alternateName University of British Columbia
379 schema:name Department of Computer Science, University of British Columbia, Vancouver, BC, Canada
380 Department of Molecular Oncology, BC Cancer Agency, Vancouver, BC, Canada
381 Department of Pathology and Laboratory Medicine, University of British Columbia, BC Cancer Agency, Centre for Translational and Applied Genomics, Vancouver, BC, Canada
382 Department of Pathology and Laboratory Medicine, Vancouver General Hospital and University of British Columbia, Vancouver, BC, Canada
383 Division of Gynaecologic Oncology, Department of Obstetrics and Gynaecology, Vancouver General Hospital, University of British Columbia, Vancouver, BC, Canada
384 rdf:type schema:Organization
385 https://www.grid.ac/institutes/grid.248762.d schema:alternateName BC Cancer Agency
386 schema:name Department of Molecular Oncology, BC Cancer Agency, Vancouver, BC, Canada
387 Department of Pathology and Laboratory Medicine, University of British Columbia, BC Cancer Agency, Centre for Translational and Applied Genomics, Vancouver, BC, Canada
388 rdf:type schema:Organization
389 https://www.grid.ac/institutes/grid.261331.4 schema:alternateName The Ohio State University
390 schema:name Department of Obstetrics and Gynecology, College of Medicine, Ohio State University, Columbus, OH, USA
391 rdf:type schema:Organization
392 https://www.grid.ac/institutes/grid.415224.4 schema:alternateName Princess Margaret Cancer Centre
393 schema:name Division of Gynecology Oncology, Princess Margaret Cancer Centre, Toronto, ON, Canada
394 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...