Reovirus-associated reduction of microRNA-let-7d is related to the increased apoptotic death of cancer cells in clinical samples View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2012-10

AUTHORS

Gerard J Nuovo, Michela Garofalo, Nicola Valeri, Vicki Roulstone, Stefano Volinia, David E Cohn, Mitch Phelps, Kevin J Harrington, Richard Vile, Alan Melcher, Evanthia Galanis, Sarah Sehl, Rob Adair, Karen Scott, Ailsa Rose, Giles Toogood, Matthew C Coffey

ABSTRACT

We analyzed the in situ molecular correlates of infection from cancer patients treated with reovirus. Melanoma, colorectal, and ovarian cancer samples from such patients showed variable infection of the cancer cells but not the intermingled benign cells. RT in situ PCR showed most cancer cells contained the viral genome with threefold less having productive viral infection as documented by either tubulin or reoviral protein co-expression. Productive infection in the cancer cells was strongly correlated with co-expression of p38 and caspase-3 as well as apoptosis-related death (P<0.001). The cancer cell apoptotic death was due to a marked viral-induced inhibition of microRNA-let-7d that, in turn, upregulated caspase-3 activity. In summary, reovirus shows a striking tropism to cancer cells in clinical samples. A rate-limiting factor of reovirus-induced cancer cell death is productive viral infection that operates via the marked reduction of microRNA-let-7d and concomitant elevated caspase-3 expression. More... »

PAGES

1333

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/modpathol.2012.95

DOI

http://dx.doi.org/10.1038/modpathol.2012.95

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1051526491

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/22699519


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Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

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curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/modpathol.2012.95'

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Turtle is a human-readable linked data format.

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RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/modpathol.2012.95'


 

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