Interobserver reliability in the histopathological diagnosis of cartilaginous tumors in patients with multiple osteochondromas View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2012-09

AUTHORS

Carlos E de Andrea, Herman M Kroon, Ron Wolterbeek, Salvatore Romeo, Andrew E Rosenberg, Barry R De Young, Bernadette Liegl, Carrie Y Inwards, Esther Hauben, Edward F McCarthy, Miguel Idoate, Nicholas A Athanasou, Kevin B Jones, Pancras CW Hogendoorn, Judith V M G Bovée

ABSTRACT

The distinction between benign and malignant cartilaginous tumors located peripherally in the bone may be a challenging task in surgical pathology. The aim of this study was to investigate interobserver reliability in histological diagnosis of cartilaginous tumors in the setting of multiple osteochondromas and to evaluate possible histological parameters that could differentiate among osteochondroma, low- and high-grade secondary peripheral chondrosarcoma. Interobserver reliability was assessed by 12 specialized bone-tumor pathologists in a set of 38 cases. Substantial agreement on diagnosis among all the reviewers was observed (intraclass correlation coefficient=0.78). Our study confirmed that mitotic figures and nuclear pleomorphism are hallmarks of high-grade secondary peripheral chondrosarcoma. However, despite the substantial agreement, we demonstrated that histology alone cannot distinguish osteochondroma from low-grade secondary peripheral chondrosarcoma in the setting of multiple osteochondromas, as nodularity, the presence of binucleated cells, irregular calcification, cystic/mucoid changes and necrosis were not helpful to indicate malignant transformation of an osteochondroma. On the other hand, among the concordant cases, the cartilage cap in osteochondroma was significantly less thicker than in low- and high-grade secondary peripheral chondrosarcoma. Therefore, our study showed that a multidisciplinary approach integrating clinical and radiographical features and the size of the cartilaginous cap in combination with a histological assessment are crucial to the diagnosis of cartilaginous tumors. More... »

PAGES

1275

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/modpathol.2012.78

DOI

http://dx.doi.org/10.1038/modpathol.2012.78

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1010479670

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/22555180


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299 Department of Statistics, Leiden University Medical Center, Leiden, The Netherlands
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301 https://www.grid.ac/institutes/grid.11598.34 schema:alternateName Medical University of Graz
302 schema:name Institute of Pathology, Medical University of Graz, Graz, Austria
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304 https://www.grid.ac/institutes/grid.21107.35 schema:alternateName Johns Hopkins University
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311 schema:name Department of Orthopaedic Surgery, Center for Children's Cancer Research, Huntsman Cancer Institute, Primary Children's Medical Center, University of Utah, Salt Lake City, UT, USA
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320 schema:name Department of Pathology, Treviso Regional Hospital, Treviso, Italy
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325 https://www.grid.ac/institutes/grid.5924.a schema:alternateName University of Navarra
326 schema:name Department of Pathology, Leiden University Medical Center, Leiden, The Netherlands
327 Department of Pathology, University of Navarra, Pamplona, Spain
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329 https://www.grid.ac/institutes/grid.66875.3a schema:alternateName Mayo Clinic
330 schema:name Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN, USA
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