Interobserver reliability in the histopathological diagnosis of cartilaginous tumors in patients with multiple osteochondromas View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2012-09

AUTHORS

Carlos E de Andrea, Herman M Kroon, Ron Wolterbeek, Salvatore Romeo, Andrew E Rosenberg, Barry R De Young, Bernadette Liegl, Carrie Y Inwards, Esther Hauben, Edward F McCarthy, Miguel Idoate, Nicholas A Athanasou, Kevin B Jones, Pancras CW Hogendoorn, Judith V M G Bovée

ABSTRACT

The distinction between benign and malignant cartilaginous tumors located peripherally in the bone may be a challenging task in surgical pathology. The aim of this study was to investigate interobserver reliability in histological diagnosis of cartilaginous tumors in the setting of multiple osteochondromas and to evaluate possible histological parameters that could differentiate among osteochondroma, low- and high-grade secondary peripheral chondrosarcoma. Interobserver reliability was assessed by 12 specialized bone-tumor pathologists in a set of 38 cases. Substantial agreement on diagnosis among all the reviewers was observed (intraclass correlation coefficient=0.78). Our study confirmed that mitotic figures and nuclear pleomorphism are hallmarks of high-grade secondary peripheral chondrosarcoma. However, despite the substantial agreement, we demonstrated that histology alone cannot distinguish osteochondroma from low-grade secondary peripheral chondrosarcoma in the setting of multiple osteochondromas, as nodularity, the presence of binucleated cells, irregular calcification, cystic/mucoid changes and necrosis were not helpful to indicate malignant transformation of an osteochondroma. On the other hand, among the concordant cases, the cartilage cap in osteochondroma was significantly less thicker than in low- and high-grade secondary peripheral chondrosarcoma. Therefore, our study showed that a multidisciplinary approach integrating clinical and radiographical features and the size of the cartilaginous cap in combination with a histological assessment are crucial to the diagnosis of cartilaginous tumors. More... »

PAGES

1275

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/modpathol.2012.78

DOI

http://dx.doi.org/10.1038/modpathol.2012.78

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1010479670

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/22555180


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1103", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Clinical Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Adolescent", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Adult", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Bone Neoplasms", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cartilage", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cell Nucleus", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Child", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Chondrocytes", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Chondrosarcoma", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Exostoses, Multiple Hereditary", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Female", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Male", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Middle Aged", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Observer Variation", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Radiography", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Reproducibility of Results", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Young Adult", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "University of Navarra", 
          "id": "https://www.grid.ac/institutes/grid.5924.a", 
          "name": [
            "Department of Pathology, Leiden University Medical Center, Leiden, The Netherlands", 
            "Department of Pathology, University of Navarra, Pamplona, Spain"
          ], 
          "type": "Organization"
        }, 
        "familyName": "de Andrea", 
        "givenName": "Carlos E", 
        "id": "sg:person.01252676113.88", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01252676113.88"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Leiden University Medical Center", 
          "id": "https://www.grid.ac/institutes/grid.10419.3d", 
          "name": [
            "Department of Radiology, Leiden University Medical Center, Leiden, The Netherlands"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Kroon", 
        "givenName": "Herman M", 
        "id": "sg:person.01044737077.94", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01044737077.94"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Leiden University Medical Center", 
          "id": "https://www.grid.ac/institutes/grid.10419.3d", 
          "name": [
            "Department of Statistics, Leiden University Medical Center, Leiden, The Netherlands"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Wolterbeek", 
        "givenName": "Ron", 
        "id": "sg:person.01005403414.07", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01005403414.07"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Ca' Foncello Hospital", 
          "id": "https://www.grid.ac/institutes/grid.413196.8", 
          "name": [
            "Department of Pathology, Treviso Regional Hospital, Treviso, Italy"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Romeo", 
        "givenName": "Salvatore", 
        "id": "sg:person.0710125620.29", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0710125620.29"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Miami Hospital", 
          "id": "https://www.grid.ac/institutes/grid.413057.4", 
          "name": [
            "Department of Pathology, University of Miami Hospital, Miami, FL, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Rosenberg", 
        "givenName": "Andrew E", 
        "id": "sg:person.012137015137.64", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012137015137.64"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Iowa", 
          "id": "https://www.grid.ac/institutes/grid.214572.7", 
          "name": [
            "Department of Pathology, University of Iowa Carver College of Medicine, Iowa City, IA, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "De Young", 
        "givenName": "Barry R", 
        "id": "sg:person.01126432700.89", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01126432700.89"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Medical University of Graz", 
          "id": "https://www.grid.ac/institutes/grid.11598.34", 
          "name": [
            "Institute of Pathology, Medical University of Graz, Graz, Austria"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Liegl", 
        "givenName": "Bernadette", 
        "id": "sg:person.01002305760.58", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01002305760.58"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Mayo Clinic", 
          "id": "https://www.grid.ac/institutes/grid.66875.3a", 
          "name": [
            "Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Inwards", 
        "givenName": "Carrie Y", 
        "id": "sg:person.0600570630.22", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0600570630.22"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Universitaire Ziekenhuizen Leuven", 
          "id": "https://www.grid.ac/institutes/grid.410569.f", 
          "name": [
            "Department of Pathology, University Hospitals Leuven, Leuven, Belgium"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Hauben", 
        "givenName": "Esther", 
        "id": "sg:person.0775060525.36", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0775060525.36"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Johns Hopkins University", 
          "id": "https://www.grid.ac/institutes/grid.21107.35", 
          "name": [
            "Department of Pathology and Orthopaedic Surgery, The Johns Hopkins Hospital and Johns Hopkins University School of Medicine, Baltimore, MD, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "McCarthy", 
        "givenName": "Edward F", 
        "id": "sg:person.01347521400.22", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01347521400.22"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Navarra", 
          "id": "https://www.grid.ac/institutes/grid.5924.a", 
          "name": [
            "Department of Pathology, University of Navarra, Pamplona, Spain"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Idoate", 
        "givenName": "Miguel", 
        "id": "sg:person.01164607654.11", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01164607654.11"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Oxford", 
          "id": "https://www.grid.ac/institutes/grid.4991.5", 
          "name": [
            "Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford, Nuffield Orthopaedic Centre, Oxford, UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Athanasou", 
        "givenName": "Nicholas A", 
        "id": "sg:person.013046236517.87", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013046236517.87"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Utah", 
          "id": "https://www.grid.ac/institutes/grid.223827.e", 
          "name": [
            "Department of Orthopaedic Surgery, Center for Children's Cancer Research, Huntsman Cancer Institute, Primary Children's Medical Center, University of Utah, Salt Lake City, UT, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Jones", 
        "givenName": "Kevin B", 
        "id": "sg:person.014111512767.32", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.014111512767.32"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Leiden University Medical Center", 
          "id": "https://www.grid.ac/institutes/grid.10419.3d", 
          "name": [
            "Department of Pathology, Leiden University Medical Center, Leiden, The Netherlands"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Hogendoorn", 
        "givenName": "Pancras CW", 
        "id": "sg:person.0577703344.59", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0577703344.59"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Leiden University Medical Center", 
          "id": "https://www.grid.ac/institutes/grid.10419.3d", 
          "name": [
            "Department of Pathology, Leiden University Medical Center, Leiden, The Netherlands"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Bov\u00e9e", 
        "givenName": "Judith V M G", 
        "id": "sg:person.0675664562.78", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0675664562.78"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.1002/jor.1100090303", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1008495528"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1148/radiographics.20.5.g00se171407", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1010502431"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/01.blo.0000069888.31220.2b", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030458529"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/01.blo.0000069888.31220.2b", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030458529"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/1097-0142(197708)40:2<818::aid-cncr2820400234>3.0.co;2-b", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1034738239"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/pap.0b013e3181b506a1", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035673099"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/pap.0b013e3181b506a1", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035673099"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/pap.0b013e3181b506a1", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035673099"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1037/0033-2909.86.2.420", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1038345864"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nrc2869", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1038423235", 
          "https://doi.org/10.1038/nrc2869"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/pas.0b013e31817eec2b", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1038605431"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/pas.0b013e31817eec2b", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1038605431"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1148/radiol.10082120", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1039983234"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1044182599", 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/978-3-7091-3846-5", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1044182599", 
          "https://doi.org/10.1007/978-3-7091-3846-5"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/978-3-7091-3846-5", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1044182599", 
          "https://doi.org/10.1007/978-3-7091-3846-5"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/annonc/mdq223", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1047390272"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/annonc/mdq223", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1047390272"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00003072-200209000-00002", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1050326722"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00003072-200209000-00002", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1050326722"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00003086-198512000-00035", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1060161400"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00003086-198512000-00035", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1060161400"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00003086-198512000-00035", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1060161400"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.2106/00004623-199407000-00005", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1068891803"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.2106/00004623-200710000-00003", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1068898004"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.2106/jbjs.f.01530", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1068900403"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.2106/jbjs.f.01530", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1068900403"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.2106/jbjs.f.01530", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1068900403"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.2307/2529786", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1069975393"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1148/radiology.139.1.6937887", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1082051567"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1302/0301-620x.75b3.8496214", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1082831329"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2012-09", 
    "datePublishedReg": "2012-09-01", 
    "description": "The distinction between benign and malignant cartilaginous tumors located peripherally in the bone may be a challenging task in surgical pathology. The aim of this study was to investigate interobserver reliability in histological diagnosis of cartilaginous tumors in the setting of multiple osteochondromas and to evaluate possible histological parameters that could differentiate among osteochondroma, low- and high-grade secondary peripheral chondrosarcoma. Interobserver reliability was assessed by 12 specialized bone-tumor pathologists in a set of 38 cases. Substantial agreement on diagnosis among all the reviewers was observed (intraclass correlation coefficient=0.78). Our study confirmed that mitotic figures and nuclear pleomorphism are hallmarks of high-grade secondary peripheral chondrosarcoma. However, despite the substantial agreement, we demonstrated that histology alone cannot distinguish osteochondroma from low-grade secondary peripheral chondrosarcoma in the setting of multiple osteochondromas, as nodularity, the presence of binucleated cells, irregular calcification, cystic/mucoid changes and necrosis were not helpful to indicate malignant transformation of an osteochondroma. On the other hand, among the concordant cases, the cartilage cap in osteochondroma was significantly less thicker than in low- and high-grade secondary peripheral chondrosarcoma. Therefore, our study showed that a multidisciplinary approach integrating clinical and radiographical features and the size of the cartilaginous cap in combination with a histological assessment are crucial to the diagnosis of cartilaginous tumors.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1038/modpathol.2012.78", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": true, 
    "isFundedItemOf": [
      {
        "id": "sg:grant.2411210", 
        "type": "MonetaryGrant"
      }
    ], 
    "isPartOf": [
      {
        "id": "sg:journal.1098208", 
        "issn": [
          "0893-3952", 
          "1530-0285"
        ], 
        "name": "Modern Pathology", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "9", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "25"
      }
    ], 
    "name": "Interobserver reliability in the histopathological diagnosis of cartilaginous tumors in patients with multiple osteochondromas", 
    "pagination": "1275", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "31ecf220a84c309f8941365a091b5d80fd351c95babedcede68042038ab3019a"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "22555180"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "8806605"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1038/modpathol.2012.78"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1010479670"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1038/modpathol.2012.78", 
      "https://app.dimensions.ai/details/publication/pub.1010479670"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-10T23:13", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8693_00000435.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://www.nature.com/articles/modpathol201278"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/modpathol.2012.78'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/modpathol.2012.78'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/modpathol.2012.78'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/modpathol.2012.78'


 

This table displays all metadata directly associated to this object as RDF triples.

331 TRIPLES      21 PREDICATES      66 URIs      38 LITERALS      26 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1038/modpathol.2012.78 schema:about N0a2247264ae040b6858d7a6dfbe3448f
2 N159b8a69baf642f181e534fc5be3e12e
3 N1bedde68330f43e2ade08d62c339f0ec
4 N2320b6d1a3dd4c848700d5d2784550e6
5 N5c88a50e7bf64ce189ebf6088cfd6fbe
6 N5e69cb449db44270bbc9372a81be3f4d
7 N850d8b28d2634f9fa16fd5a4b3e18e3b
8 N8af8ed3cb2124963b6f667d09b1dce64
9 N8c848ce4e53e4216bc91af554767d95c
10 N9ba81e49f3ae498b836d8f98c0240824
11 Na4ee281495c24f0899c6bf21dcf01442
12 Nad6e578ae83c430a9474a80be893429e
13 Nc41fd5068e3643bb8d589d94753e9222
14 Ncba209cb61f3498cbb825e7c055892fb
15 Ne2c1e2ecbb224710b1acd51e55d59124
16 Ne7fd60a7e78e4ea8870bef91a46c7755
17 Neb534b04032246618405cb380a63aec2
18 anzsrc-for:11
19 anzsrc-for:1103
20 schema:author Na5345571c2d84fe284b5d6ec0c561837
21 schema:citation sg:pub.10.1007/978-3-7091-3846-5
22 sg:pub.10.1038/nrc2869
23 https://app.dimensions.ai/details/publication/pub.1044182599
24 https://doi.org/10.1002/1097-0142(197708)40:2<818::aid-cncr2820400234>3.0.co;2-b
25 https://doi.org/10.1002/jor.1100090303
26 https://doi.org/10.1037/0033-2909.86.2.420
27 https://doi.org/10.1093/annonc/mdq223
28 https://doi.org/10.1097/00003072-200209000-00002
29 https://doi.org/10.1097/00003086-198512000-00035
30 https://doi.org/10.1097/01.blo.0000069888.31220.2b
31 https://doi.org/10.1097/pap.0b013e3181b506a1
32 https://doi.org/10.1097/pas.0b013e31817eec2b
33 https://doi.org/10.1148/radiographics.20.5.g00se171407
34 https://doi.org/10.1148/radiol.10082120
35 https://doi.org/10.1148/radiology.139.1.6937887
36 https://doi.org/10.1302/0301-620x.75b3.8496214
37 https://doi.org/10.2106/00004623-199407000-00005
38 https://doi.org/10.2106/00004623-200710000-00003
39 https://doi.org/10.2106/jbjs.f.01530
40 https://doi.org/10.2307/2529786
41 schema:datePublished 2012-09
42 schema:datePublishedReg 2012-09-01
43 schema:description The distinction between benign and malignant cartilaginous tumors located peripherally in the bone may be a challenging task in surgical pathology. The aim of this study was to investigate interobserver reliability in histological diagnosis of cartilaginous tumors in the setting of multiple osteochondromas and to evaluate possible histological parameters that could differentiate among osteochondroma, low- and high-grade secondary peripheral chondrosarcoma. Interobserver reliability was assessed by 12 specialized bone-tumor pathologists in a set of 38 cases. Substantial agreement on diagnosis among all the reviewers was observed (intraclass correlation coefficient=0.78). Our study confirmed that mitotic figures and nuclear pleomorphism are hallmarks of high-grade secondary peripheral chondrosarcoma. However, despite the substantial agreement, we demonstrated that histology alone cannot distinguish osteochondroma from low-grade secondary peripheral chondrosarcoma in the setting of multiple osteochondromas, as nodularity, the presence of binucleated cells, irregular calcification, cystic/mucoid changes and necrosis were not helpful to indicate malignant transformation of an osteochondroma. On the other hand, among the concordant cases, the cartilage cap in osteochondroma was significantly less thicker than in low- and high-grade secondary peripheral chondrosarcoma. Therefore, our study showed that a multidisciplinary approach integrating clinical and radiographical features and the size of the cartilaginous cap in combination with a histological assessment are crucial to the diagnosis of cartilaginous tumors.
44 schema:genre research_article
45 schema:inLanguage en
46 schema:isAccessibleForFree true
47 schema:isPartOf N3e3e54a5650541278420184e0a0d8aa2
48 Na48aea20df9d4e458926ccaaeb6957f7
49 sg:journal.1098208
50 schema:name Interobserver reliability in the histopathological diagnosis of cartilaginous tumors in patients with multiple osteochondromas
51 schema:pagination 1275
52 schema:productId N34c0162702274b95af00514f18f352c1
53 N6eac9bdcc08a4f378f1a43cb2f8c7e1f
54 N85dca966b1444d7797a60e17138d0c52
55 Na0227367af3a4cb7892a33ab5bae2dca
56 Nf81bfe39a2e8421b988ff3e371a5a261
57 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010479670
58 https://doi.org/10.1038/modpathol.2012.78
59 schema:sdDatePublished 2019-04-10T23:13
60 schema:sdLicense https://scigraph.springernature.com/explorer/license/
61 schema:sdPublisher N97b7a05048e041e1901c12fd88e5118a
62 schema:url https://www.nature.com/articles/modpathol201278
63 sgo:license sg:explorer/license/
64 sgo:sdDataset articles
65 rdf:type schema:ScholarlyArticle
66 N040acfeee08c4efcbe20f56d8100abf5 rdf:first sg:person.01044737077.94
67 rdf:rest N06526144400a4e86a620e039a9db912c
68 N06526144400a4e86a620e039a9db912c rdf:first sg:person.01005403414.07
69 rdf:rest N0d0765e02a294ffcbfbe2172f6b151b6
70 N0a2247264ae040b6858d7a6dfbe3448f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
71 schema:name Cartilage
72 rdf:type schema:DefinedTerm
73 N0d0765e02a294ffcbfbe2172f6b151b6 rdf:first sg:person.0710125620.29
74 rdf:rest Ne82b3c6737cf46e09813ac89e0f60ec1
75 N159b8a69baf642f181e534fc5be3e12e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
76 schema:name Reproducibility of Results
77 rdf:type schema:DefinedTerm
78 N1bedde68330f43e2ade08d62c339f0ec schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
79 schema:name Adult
80 rdf:type schema:DefinedTerm
81 N2320b6d1a3dd4c848700d5d2784550e6 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
82 schema:name Humans
83 rdf:type schema:DefinedTerm
84 N2f4183f4e88c45a69e3d77fc4b6bdbfd rdf:first sg:person.0600570630.22
85 rdf:rest Nd82dca72081a40b49107db690bf97c83
86 N308116175f3043329493277096bd39bf rdf:first sg:person.013046236517.87
87 rdf:rest Nfe6a3bab843641d7a194c2b25d8e5a92
88 N34c0162702274b95af00514f18f352c1 schema:name nlm_unique_id
89 schema:value 8806605
90 rdf:type schema:PropertyValue
91 N3e3e54a5650541278420184e0a0d8aa2 schema:volumeNumber 25
92 rdf:type schema:PublicationVolume
93 N3f529b32d3e44da4bd82802f67b4b9c2 rdf:first sg:person.0675664562.78
94 rdf:rest rdf:nil
95 N57bf83b4e8af45caa540d139bf237c61 rdf:first sg:person.01347521400.22
96 rdf:rest Nefefe03e3c2b4b1697c0e977b34de571
97 N5c88a50e7bf64ce189ebf6088cfd6fbe schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
98 schema:name Observer Variation
99 rdf:type schema:DefinedTerm
100 N5e69cb449db44270bbc9372a81be3f4d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
101 schema:name Middle Aged
102 rdf:type schema:DefinedTerm
103 N6eac9bdcc08a4f378f1a43cb2f8c7e1f schema:name readcube_id
104 schema:value 31ecf220a84c309f8941365a091b5d80fd351c95babedcede68042038ab3019a
105 rdf:type schema:PropertyValue
106 N71ab8af6f9a54f3fbc9ff426a8b7bb52 rdf:first sg:person.01126432700.89
107 rdf:rest Nf2919a85edca4ecda8ebb85736b49a4e
108 N83f6ff6597284edf8a62a66b9264bed1 rdf:first sg:person.0577703344.59
109 rdf:rest N3f529b32d3e44da4bd82802f67b4b9c2
110 N850d8b28d2634f9fa16fd5a4b3e18e3b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
111 schema:name Child
112 rdf:type schema:DefinedTerm
113 N85dca966b1444d7797a60e17138d0c52 schema:name doi
114 schema:value 10.1038/modpathol.2012.78
115 rdf:type schema:PropertyValue
116 N8af8ed3cb2124963b6f667d09b1dce64 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
117 schema:name Exostoses, Multiple Hereditary
118 rdf:type schema:DefinedTerm
119 N8c848ce4e53e4216bc91af554767d95c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
120 schema:name Young Adult
121 rdf:type schema:DefinedTerm
122 N97b7a05048e041e1901c12fd88e5118a schema:name Springer Nature - SN SciGraph project
123 rdf:type schema:Organization
124 N9ba81e49f3ae498b836d8f98c0240824 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
125 schema:name Chondrocytes
126 rdf:type schema:DefinedTerm
127 Na0227367af3a4cb7892a33ab5bae2dca schema:name pubmed_id
128 schema:value 22555180
129 rdf:type schema:PropertyValue
130 Na48aea20df9d4e458926ccaaeb6957f7 schema:issueNumber 9
131 rdf:type schema:PublicationIssue
132 Na4ee281495c24f0899c6bf21dcf01442 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
133 schema:name Radiography
134 rdf:type schema:DefinedTerm
135 Na5345571c2d84fe284b5d6ec0c561837 rdf:first sg:person.01252676113.88
136 rdf:rest N040acfeee08c4efcbe20f56d8100abf5
137 Nad6e578ae83c430a9474a80be893429e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
138 schema:name Chondrosarcoma
139 rdf:type schema:DefinedTerm
140 Nc41fd5068e3643bb8d589d94753e9222 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
141 schema:name Adolescent
142 rdf:type schema:DefinedTerm
143 Ncba209cb61f3498cbb825e7c055892fb schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
144 schema:name Female
145 rdf:type schema:DefinedTerm
146 Nd82dca72081a40b49107db690bf97c83 rdf:first sg:person.0775060525.36
147 rdf:rest N57bf83b4e8af45caa540d139bf237c61
148 Ne2c1e2ecbb224710b1acd51e55d59124 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
149 schema:name Male
150 rdf:type schema:DefinedTerm
151 Ne7fd60a7e78e4ea8870bef91a46c7755 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
152 schema:name Bone Neoplasms
153 rdf:type schema:DefinedTerm
154 Ne82b3c6737cf46e09813ac89e0f60ec1 rdf:first sg:person.012137015137.64
155 rdf:rest N71ab8af6f9a54f3fbc9ff426a8b7bb52
156 Neb534b04032246618405cb380a63aec2 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
157 schema:name Cell Nucleus
158 rdf:type schema:DefinedTerm
159 Nefefe03e3c2b4b1697c0e977b34de571 rdf:first sg:person.01164607654.11
160 rdf:rest N308116175f3043329493277096bd39bf
161 Nf2919a85edca4ecda8ebb85736b49a4e rdf:first sg:person.01002305760.58
162 rdf:rest N2f4183f4e88c45a69e3d77fc4b6bdbfd
163 Nf81bfe39a2e8421b988ff3e371a5a261 schema:name dimensions_id
164 schema:value pub.1010479670
165 rdf:type schema:PropertyValue
166 Nfe6a3bab843641d7a194c2b25d8e5a92 rdf:first sg:person.014111512767.32
167 rdf:rest N83f6ff6597284edf8a62a66b9264bed1
168 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
169 schema:name Medical and Health Sciences
170 rdf:type schema:DefinedTerm
171 anzsrc-for:1103 schema:inDefinedTermSet anzsrc-for:
172 schema:name Clinical Sciences
173 rdf:type schema:DefinedTerm
174 sg:grant.2411210 http://pending.schema.org/fundedItem sg:pub.10.1038/modpathol.2012.78
175 rdf:type schema:MonetaryGrant
176 sg:journal.1098208 schema:issn 0893-3952
177 1530-0285
178 schema:name Modern Pathology
179 rdf:type schema:Periodical
180 sg:person.01002305760.58 schema:affiliation https://www.grid.ac/institutes/grid.11598.34
181 schema:familyName Liegl
182 schema:givenName Bernadette
183 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01002305760.58
184 rdf:type schema:Person
185 sg:person.01005403414.07 schema:affiliation https://www.grid.ac/institutes/grid.10419.3d
186 schema:familyName Wolterbeek
187 schema:givenName Ron
188 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01005403414.07
189 rdf:type schema:Person
190 sg:person.01044737077.94 schema:affiliation https://www.grid.ac/institutes/grid.10419.3d
191 schema:familyName Kroon
192 schema:givenName Herman M
193 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01044737077.94
194 rdf:type schema:Person
195 sg:person.01126432700.89 schema:affiliation https://www.grid.ac/institutes/grid.214572.7
196 schema:familyName De Young
197 schema:givenName Barry R
198 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01126432700.89
199 rdf:type schema:Person
200 sg:person.01164607654.11 schema:affiliation https://www.grid.ac/institutes/grid.5924.a
201 schema:familyName Idoate
202 schema:givenName Miguel
203 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01164607654.11
204 rdf:type schema:Person
205 sg:person.012137015137.64 schema:affiliation https://www.grid.ac/institutes/grid.413057.4
206 schema:familyName Rosenberg
207 schema:givenName Andrew E
208 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012137015137.64
209 rdf:type schema:Person
210 sg:person.01252676113.88 schema:affiliation https://www.grid.ac/institutes/grid.5924.a
211 schema:familyName de Andrea
212 schema:givenName Carlos E
213 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01252676113.88
214 rdf:type schema:Person
215 sg:person.013046236517.87 schema:affiliation https://www.grid.ac/institutes/grid.4991.5
216 schema:familyName Athanasou
217 schema:givenName Nicholas A
218 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013046236517.87
219 rdf:type schema:Person
220 sg:person.01347521400.22 schema:affiliation https://www.grid.ac/institutes/grid.21107.35
221 schema:familyName McCarthy
222 schema:givenName Edward F
223 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01347521400.22
224 rdf:type schema:Person
225 sg:person.014111512767.32 schema:affiliation https://www.grid.ac/institutes/grid.223827.e
226 schema:familyName Jones
227 schema:givenName Kevin B
228 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.014111512767.32
229 rdf:type schema:Person
230 sg:person.0577703344.59 schema:affiliation https://www.grid.ac/institutes/grid.10419.3d
231 schema:familyName Hogendoorn
232 schema:givenName Pancras CW
233 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0577703344.59
234 rdf:type schema:Person
235 sg:person.0600570630.22 schema:affiliation https://www.grid.ac/institutes/grid.66875.3a
236 schema:familyName Inwards
237 schema:givenName Carrie Y
238 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0600570630.22
239 rdf:type schema:Person
240 sg:person.0675664562.78 schema:affiliation https://www.grid.ac/institutes/grid.10419.3d
241 schema:familyName Bovée
242 schema:givenName Judith V M G
243 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0675664562.78
244 rdf:type schema:Person
245 sg:person.0710125620.29 schema:affiliation https://www.grid.ac/institutes/grid.413196.8
246 schema:familyName Romeo
247 schema:givenName Salvatore
248 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0710125620.29
249 rdf:type schema:Person
250 sg:person.0775060525.36 schema:affiliation https://www.grid.ac/institutes/grid.410569.f
251 schema:familyName Hauben
252 schema:givenName Esther
253 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0775060525.36
254 rdf:type schema:Person
255 sg:pub.10.1007/978-3-7091-3846-5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044182599
256 https://doi.org/10.1007/978-3-7091-3846-5
257 rdf:type schema:CreativeWork
258 sg:pub.10.1038/nrc2869 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038423235
259 https://doi.org/10.1038/nrc2869
260 rdf:type schema:CreativeWork
261 https://app.dimensions.ai/details/publication/pub.1044182599 schema:CreativeWork
262 https://doi.org/10.1002/1097-0142(197708)40:2<818::aid-cncr2820400234>3.0.co;2-b schema:sameAs https://app.dimensions.ai/details/publication/pub.1034738239
263 rdf:type schema:CreativeWork
264 https://doi.org/10.1002/jor.1100090303 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008495528
265 rdf:type schema:CreativeWork
266 https://doi.org/10.1037/0033-2909.86.2.420 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038345864
267 rdf:type schema:CreativeWork
268 https://doi.org/10.1093/annonc/mdq223 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047390272
269 rdf:type schema:CreativeWork
270 https://doi.org/10.1097/00003072-200209000-00002 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050326722
271 rdf:type schema:CreativeWork
272 https://doi.org/10.1097/00003086-198512000-00035 schema:sameAs https://app.dimensions.ai/details/publication/pub.1060161400
273 rdf:type schema:CreativeWork
274 https://doi.org/10.1097/01.blo.0000069888.31220.2b schema:sameAs https://app.dimensions.ai/details/publication/pub.1030458529
275 rdf:type schema:CreativeWork
276 https://doi.org/10.1097/pap.0b013e3181b506a1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035673099
277 rdf:type schema:CreativeWork
278 https://doi.org/10.1097/pas.0b013e31817eec2b schema:sameAs https://app.dimensions.ai/details/publication/pub.1038605431
279 rdf:type schema:CreativeWork
280 https://doi.org/10.1148/radiographics.20.5.g00se171407 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010502431
281 rdf:type schema:CreativeWork
282 https://doi.org/10.1148/radiol.10082120 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039983234
283 rdf:type schema:CreativeWork
284 https://doi.org/10.1148/radiology.139.1.6937887 schema:sameAs https://app.dimensions.ai/details/publication/pub.1082051567
285 rdf:type schema:CreativeWork
286 https://doi.org/10.1302/0301-620x.75b3.8496214 schema:sameAs https://app.dimensions.ai/details/publication/pub.1082831329
287 rdf:type schema:CreativeWork
288 https://doi.org/10.2106/00004623-199407000-00005 schema:sameAs https://app.dimensions.ai/details/publication/pub.1068891803
289 rdf:type schema:CreativeWork
290 https://doi.org/10.2106/00004623-200710000-00003 schema:sameAs https://app.dimensions.ai/details/publication/pub.1068898004
291 rdf:type schema:CreativeWork
292 https://doi.org/10.2106/jbjs.f.01530 schema:sameAs https://app.dimensions.ai/details/publication/pub.1068900403
293 rdf:type schema:CreativeWork
294 https://doi.org/10.2307/2529786 schema:sameAs https://app.dimensions.ai/details/publication/pub.1069975393
295 rdf:type schema:CreativeWork
296 https://www.grid.ac/institutes/grid.10419.3d schema:alternateName Leiden University Medical Center
297 schema:name Department of Pathology, Leiden University Medical Center, Leiden, The Netherlands
298 Department of Radiology, Leiden University Medical Center, Leiden, The Netherlands
299 Department of Statistics, Leiden University Medical Center, Leiden, The Netherlands
300 rdf:type schema:Organization
301 https://www.grid.ac/institutes/grid.11598.34 schema:alternateName Medical University of Graz
302 schema:name Institute of Pathology, Medical University of Graz, Graz, Austria
303 rdf:type schema:Organization
304 https://www.grid.ac/institutes/grid.21107.35 schema:alternateName Johns Hopkins University
305 schema:name Department of Pathology and Orthopaedic Surgery, The Johns Hopkins Hospital and Johns Hopkins University School of Medicine, Baltimore, MD, USA
306 rdf:type schema:Organization
307 https://www.grid.ac/institutes/grid.214572.7 schema:alternateName University of Iowa
308 schema:name Department of Pathology, University of Iowa Carver College of Medicine, Iowa City, IA, USA
309 rdf:type schema:Organization
310 https://www.grid.ac/institutes/grid.223827.e schema:alternateName University of Utah
311 schema:name Department of Orthopaedic Surgery, Center for Children's Cancer Research, Huntsman Cancer Institute, Primary Children's Medical Center, University of Utah, Salt Lake City, UT, USA
312 rdf:type schema:Organization
313 https://www.grid.ac/institutes/grid.410569.f schema:alternateName Universitaire Ziekenhuizen Leuven
314 schema:name Department of Pathology, University Hospitals Leuven, Leuven, Belgium
315 rdf:type schema:Organization
316 https://www.grid.ac/institutes/grid.413057.4 schema:alternateName University of Miami Hospital
317 schema:name Department of Pathology, University of Miami Hospital, Miami, FL, USA
318 rdf:type schema:Organization
319 https://www.grid.ac/institutes/grid.413196.8 schema:alternateName Ca' Foncello Hospital
320 schema:name Department of Pathology, Treviso Regional Hospital, Treviso, Italy
321 rdf:type schema:Organization
322 https://www.grid.ac/institutes/grid.4991.5 schema:alternateName University of Oxford
323 schema:name Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford, Nuffield Orthopaedic Centre, Oxford, UK
324 rdf:type schema:Organization
325 https://www.grid.ac/institutes/grid.5924.a schema:alternateName University of Navarra
326 schema:name Department of Pathology, Leiden University Medical Center, Leiden, The Netherlands
327 Department of Pathology, University of Navarra, Pamplona, Spain
328 rdf:type schema:Organization
329 https://www.grid.ac/institutes/grid.66875.3a schema:alternateName Mayo Clinic
330 schema:name Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN, USA
331 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...