Role of HERG1 potassium channel in both malignant transformation and disease progression in head and neck carcinomas View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2012-08

AUTHORS

Sofía T Menéndez, Juan P Rodrigo, Saúl Álvarez-Teijeiro, M Ángeles Villaronga, Eva Allonca, Aitana Vallina, Aurora Astudillo, Francisco Barros, Carlos Suárez, Juana M García-Pedrero

ABSTRACT

Evidence indicates that human ether à-go-go-related gene 1 (HERG1) voltage-gated potassium channels could represent new valuable membrane therapeutic targets and diagnostic/prognostic biomarkers in various cancers. This study is the first to investigate the expression pattern of HERG1 potassium channel subunit in both primary tumors and precancerous lesions to establish its clinical and biological role during the development and progression of head and neck squamous cell carcinomas. HERG1 protein expression was evaluated by immunohistochemistry in paraffin-embedded tissue specimens from 133 patients with laryngeal/hypopharyngeal squamous cell carcinomas and 75 patients with laryngeal dysplasia, and correlated with clinical data. Our findings demonstrate that HERG1 is frequently aberrantly expressed in a high percentage of primary tumors (87%), whereas expression was negligible in both stromal cells and normal-adjacent epithelia. HERG1 expression increased during head and neck squamous cell carcinoma progression and was significantly associated with lymph node metastasis (P=0.04), advanced disease stages (P<0.001), regional tumor recurrence (P=0.004), distant metastasis (P=0.03) and reduced disease-specific survival (P=0.012, log-rank test). HERG1-positive expression was also detected in 31 (41%) of 75 laryngeal dysplasias. Interestingly, HERG1 expression increased with the grade of dysplasia; however, HERG1 expression but not histology correlated significantly with increased laryngeal cancer risk (P=0.007). In addition, functional studies in head and neck squamous cell carcinoma-derived cell lines further revealed that HERG1 expression promotes anchorage-dependent and -independent cell growth and invasive capability, although independently of its ion-conducting function. Our data demonstrate that HERG1 expression is a biologically and clinically relevant feature in head and neck squamous cell carcinoma progression and also during malignant transformation, and a promising candidate as cancer risk marker and therapeutic target for head and neck squamous cell carcinoma prevention and treatment. More... »

PAGES

1069

References to SciGraph publications

  • 2010. Physical and Functional Interaction between Integrins and hERG1 Channels in Cancer Cells in INTEGRINS AND ION CHANNELS
  • 2004-06. Roles of K+ channels in regulating tumour cell proliferation and apoptosis in PFLÜGERS ARCHIV - EUROPEAN JOURNAL OF PHYSIOLOGY
  • 2006-10. Non-conducting functions of voltage-gated ion channels in NATURE REVIEWS NEUROSCIENCE
  • 2011-01. The molecular biology of head and neck cancer in NATURE REVIEWS CANCER
  • 2009-12. Voltage-gated potassium channels as therapeutic targets in NATURE REVIEWS DRUG DISCOVERY
  • 2010-04. Prognostic Significance of hERG1 Expression in Gastric Cancer in DIGESTIVE DISEASES AND SCIENCES
  • 2012-02. Inhibition of HERG1 K+ channel protein expression decreases cell proliferation of human small cell lung cancer cells in PFLÜGERS ARCHIV - EUROPEAN JOURNAL OF PHYSIOLOGY
  • 2006-03. hERG potassium channels and cardiac arrhythmia in NATURE
  • 2010-12. Eag and HERG potassium channels as novel therapeutic targets in cancer in WORLD JOURNAL OF SURGICAL ONCOLOGY
  • 2002. Head and Neck Cancers in HUMAN CELL CULTURE
  • 2005-10. hERG1 channels are overexpressed in glioblastoma multiforme and modulate VEGF secretion in glioblastoma cell lines in BRITISH JOURNAL OF CANCER
  • 2002-09. HERG potassium channels are constitutively expressed in primary human acute myeloid leukemias and regulate cell proliferation of normal and leukemic hemopoietic progenitors in LEUKEMIA
  • 2011-08. Novel roles for hERG K+ channels in cell proliferation and apoptosis in CELL DEATH & DISEASE
  • 2000-12. HERG potassium channels are more frequently expressed in human endometrial cancer as compared to non-cancerous endometrium in BRITISH JOURNAL OF CANCER
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/modpathol.2012.63

    DOI

    http://dx.doi.org/10.1038/modpathol.2012.63

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1047335023

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/22460808


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