Ontology type: schema:ScholarlyArticle Open Access: True
2011-09
AUTHORSElizabeth G Demicco, Alton B Farris, Yoshifumi Baba, Brian Agbor-Etang, Kristin Bergethon, Rajni Mandal, Diane Daives, Junya Fukuoka, Michio Shimizu, Dora Dias-Santagata, Shuji Ogino, A John Iafrate, Henning A Gaissert, Mari Mino-Kenudson
ABSTRACTAdenocarcinoma of the distal esophagus and esophagogastric junction continues to rise in incidence. An intestinal metaplasia (Barrett esophagus)-dysplasia-carcinoma sequence induced by gastroesophageal reflux disease is well established. However, a significant number of adenocarcinomas in the vicinity of the esophagogastric junction are seen in the background of gastric/cardiac-type mucosa without intestinal metaplasia. Thus, the aim of this study was to investigate the role of Barrett esophagus (intestinal-type mucosa) in the classification and prognosis of tumors of the distal esophagus and esophagogastric junction. Clinicopathological and molecular characteristics were examined in 157 consecutively resected adenocarcinomas of the distal esophagus and esophagogastric junction and were compared between tumors arising in association with intestinal-type and cardiac-type mucosa. Intestinal-type mucosa-associated adenocarcinomas were more likely to be associated with younger age (P=0.0057), reflux symptoms (P<0.0001), proximal location (P=0.0009), lower T stage (P<0.0001), fewer nodal metastases (P=0.0001), absence of lymphatic (P<0.0001), venous (P=0.0060) or perineural (P<0.0001) invasion. Histologically, intestinal-type mucosa-associated tumors were more likely to be low-grade glandular tumors (P=0.0095) of intestinal or mixed immunophenotype (P=0.015) and express nuclear β-catenin (P=0.0080), whereas tumors arising in a background of cardiac-type mucosa were more frequently associated with EGFR amplification (P=0.0051). Five-year overall survival rate was significantly higher in patients with intestinal-type mucosa-associated tumors (28 vs 9%, P=0.0015), although no survival benefit was seen after adjusting for potential confounders. Our findings support the theory that multiple distinct pathways of tumorigenesis exist in the vicinity of the esophagogastric junction, including one in which tumors arise from dysplastic intestinal metaplasia (intestinal pathway), and one potentially involving dysplasia of the cardiac-type mucosa (non-intestinal pathway). Additional studies are warranted to further clarify their pathogenesis and the molecular mechanisms involved. More... »
PAGES1177
http://scigraph.springernature.com/pub.10.1038/modpathol.2011.77
DOIhttp://dx.doi.org/10.1038/modpathol.2011.77
DIMENSIONShttps://app.dimensions.ai/details/publication/pub.1047905121
PUBMEDhttps://www.ncbi.nlm.nih.gov/pubmed/21572404
JSON-LD is the canonical representation for SciGraph data.
TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT
[
{
"@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json",
"about": [
{
"id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1103",
"inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/",
"name": "Clinical Sciences",
"type": "DefinedTerm"
},
{
"id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11",
"inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/",
"name": "Medical and Health Sciences",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Adenocarcinoma",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Adult",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Aged",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Aged, 80 and over",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Barrett Esophagus",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Cardia",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Esophageal Neoplasms",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Esophagogastric Junction",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Female",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Humans",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Immunohistochemistry",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Intestinal Mucosa",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Kaplan-Meier Estimate",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Male",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Middle Aged",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Precancerous Conditions",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Stomach Neoplasms",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Tissue Array Analysis",
"type": "DefinedTerm"
}
],
"author": [
{
"affiliation": {
"alternateName": "Massachusetts General Hospital",
"id": "https://www.grid.ac/institutes/grid.32224.35",
"name": [
"Department of Pathology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA"
],
"type": "Organization"
},
"familyName": "Demicco",
"givenName": "Elizabeth G",
"id": "sg:person.0751521705.20",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0751521705.20"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Emory University",
"id": "https://www.grid.ac/institutes/grid.189967.8",
"name": [
"Department of Pathology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA",
"Department of Pathology, Emory University School of Medicine, Atlanta, GA, USA"
],
"type": "Organization"
},
"familyName": "Farris",
"givenName": "Alton B",
"id": "sg:person.011615561504.71",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011615561504.71"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Dana\u2013Farber Cancer Institute",
"id": "https://www.grid.ac/institutes/grid.65499.37",
"name": [
"Department of Medical Oncology, Dana-Farber Cancer Institute and Harvard Medical School, Boston, MA, USA"
],
"type": "Organization"
},
"familyName": "Baba",
"givenName": "Yoshifumi",
"id": "sg:person.0671655525.01",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0671655525.01"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Harvard University",
"id": "https://www.grid.ac/institutes/grid.38142.3c",
"name": [
"Thoracic Surgery, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA"
],
"type": "Organization"
},
"familyName": "Agbor-Etang",
"givenName": "Brian",
"id": "sg:person.0733770455.03",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0733770455.03"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Massachusetts General Hospital",
"id": "https://www.grid.ac/institutes/grid.32224.35",
"name": [
"Department of Pathology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA"
],
"type": "Organization"
},
"familyName": "Bergethon",
"givenName": "Kristin",
"id": "sg:person.0727421754.64",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0727421754.64"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Massachusetts General Hospital",
"id": "https://www.grid.ac/institutes/grid.32224.35",
"name": [
"Department of Pathology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA"
],
"type": "Organization"
},
"familyName": "Mandal",
"givenName": "Rajni",
"id": "sg:person.0713657733.23",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0713657733.23"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Harvard University",
"id": "https://www.grid.ac/institutes/grid.38142.3c",
"name": [
"Thoracic Surgery, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA"
],
"type": "Organization"
},
"familyName": "Daives",
"givenName": "Diane",
"type": "Person"
},
{
"affiliation": {
"alternateName": "University of Toyama",
"id": "https://www.grid.ac/institutes/grid.267346.2",
"name": [
"Department of Pathology, Toyama Medical University, Toyama, Japan"
],
"type": "Organization"
},
"familyName": "Fukuoka",
"givenName": "Junya",
"id": "sg:person.0616033724.80",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0616033724.80"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Saitama Medical University",
"id": "https://www.grid.ac/institutes/grid.410802.f",
"name": [
"Department of Pathology, Saitama Medical University, International Medical Center, Saitama, Japan"
],
"type": "Organization"
},
"familyName": "Shimizu",
"givenName": "Michio",
"id": "sg:person.010447225752.09",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.010447225752.09"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Massachusetts General Hospital",
"id": "https://www.grid.ac/institutes/grid.32224.35",
"name": [
"Department of Pathology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA"
],
"type": "Organization"
},
"familyName": "Dias-Santagata",
"givenName": "Dora",
"id": "sg:person.01023302000.48",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01023302000.48"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Brigham and Women's Hospital",
"id": "https://www.grid.ac/institutes/grid.62560.37",
"name": [
"Department of Medical Oncology, Dana-Farber Cancer Institute and Harvard Medical School, Boston, MA, USA",
"Department of Pathology, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA"
],
"type": "Organization"
},
"familyName": "Ogino",
"givenName": "Shuji",
"id": "sg:person.01006336021.57",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01006336021.57"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Massachusetts General Hospital",
"id": "https://www.grid.ac/institutes/grid.32224.35",
"name": [
"Department of Pathology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA"
],
"type": "Organization"
},
"familyName": "Iafrate",
"givenName": "A John",
"id": "sg:person.01015244475.19",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01015244475.19"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Harvard University",
"id": "https://www.grid.ac/institutes/grid.38142.3c",
"name": [
"Thoracic Surgery, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA"
],
"type": "Organization"
},
"familyName": "Gaissert",
"givenName": "Henning A",
"id": "sg:person.01054606275.75",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01054606275.75"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Massachusetts General Hospital",
"id": "https://www.grid.ac/institutes/grid.32224.35",
"name": [
"Department of Pathology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA"
],
"type": "Organization"
},
"familyName": "Mino-Kenudson",
"givenName": "Mari",
"id": "sg:person.0716744366.62",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0716744366.62"
],
"type": "Person"
}
],
"citation": [
{
"id": "https://doi.org/10.1080/00365520701420735",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1001686212"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1002/1097-0142(20000601)88:11<2520::aid-cncr13>3.0.co;2-l",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1001940742"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/j.ejca.2005.10.017",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1004330696"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/ajg.2009.85",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1005444719",
"https://doi.org/10.1038/ajg.2009.85"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/s0016-5085(89)80011-3",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1007859991"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1093/jnci/djn211",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1008555467"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1007/s00432-003-0519-6",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1008689893",
"https://doi.org/10.1007/s00432-003-0519-6"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/s0046-8177(00)80195-1",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1010274468"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/s0046-8177(00)80195-1",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1010274468"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1002/ijc.2910540209",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1011037504"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1007/bf01359557",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1012355048",
"https://doi.org/10.1007/bf01359557"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1007/bf01359557",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1012355048",
"https://doi.org/10.1007/bf01359557"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/j.dld.2007.01.011",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1013509609"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1001/archsurg.135.7.831",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1014357854"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1002/cncr.10868",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1014517884"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1111/j.1572-0241.2006.00379.x",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1015908821",
"https://doi.org/10.1111/j.1572-0241.2006.00379.x"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1111/j.1572-0241.2006.00379.x",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1015908821",
"https://doi.org/10.1111/j.1572-0241.2006.00379.x"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1097/00000478-200311000-00006",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1016630592"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1097/00000478-200311000-00006",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1016630592"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1056/nejm199903183401101",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1019422943"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.3109/00365529209165436",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1020135082"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.3322/caac.20006",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1022825825"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1111/j.1365-2559.2006.02560.x",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1025069580"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1136/gut.52.10.1465",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1025271521"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1097/pas.0b013e318078ce91",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1025426760"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1097/pas.0b013e318078ce91",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1025426760"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/labinvest.3780232",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1026209961",
"https://doi.org/10.1038/labinvest.3780232"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/labinvest.3780232",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1026209961",
"https://doi.org/10.1038/labinvest.3780232"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1309/1db6-gfvh-ra6w-q07y",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1027121516"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1111/j.1365-2036.2006.02813.x",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1030090007"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1111/j.1365-2036.2006.02813.x",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1030090007"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1111/j.1349-7006.2003.tb01409.x",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1030890933"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1111/j.1349-7006.2003.tb01409.x",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1030890933"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1053/j.seminoncol.2004.04.021",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1031576130"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1001/archsurg.140.6.570",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1033277619"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/modpathol.3800946",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1033449193",
"https://doi.org/10.1038/modpathol.3800946"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/386084a0",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1033922193",
"https://doi.org/10.1038/386084a0"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/s0003-4975(97)01178-8",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1036135954"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/j.jtcvs.2009.04.011",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1036680541"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1245/aso.2005.12.025",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1038345220",
"https://doi.org/10.1245/aso.2005.12.025"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1245/aso.2005.12.025",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1038345220",
"https://doi.org/10.1245/aso.2005.12.025"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1136/gut.33.11.1454",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1038603581"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1053/gast.2000.18142",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1039433564"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1007/s00428-001-0548-y",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1039951685",
"https://doi.org/10.1007/s00428-001-0548-y"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1309/3qlc-5mf1-jyxu-a5xx",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1041021110"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1016/j.gassur.2004.01.006",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1042583457",
"https://doi.org/10.1016/j.gassur.2004.01.006"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1002/ijc.2910600103",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1042799373"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1136/gut.2009.186825",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1043090209"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1046/j.1365-2168.1998.00940.x",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1043122418"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1177/145749690609500409",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1043186204"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1177/145749690609500409",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1043186204"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1073/pnas.96.13.7318",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1044286488"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1002/path.1246",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1044788373"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/s0960-7404(00)00021-9",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1044865135"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1111/j.1442-2050.2007.00638.x",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1045671661"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/s0006-291x(02)02935-2",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1046932864"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/s0006-291x(02)02935-2",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1046932864"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1002/1097-0142(19940401)73:7<1785::aid-cncr2820730703>3.0.co;2-0",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1048150838"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1177/002215540004800307",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1048703797"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1177/002215540004800307",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1048703797"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/j.humpath.2008.06.008",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1049186107"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1053/j.gastro.2010.01.002",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1049815626"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1042/cs0810663",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1056726526"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1042/cs0810663",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1056726526"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.3748/wjg.v8.i6.987",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1071375368"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.3892/ijo.24.2.257",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1071515252"
],
"type": "CreativeWork"
},
{
"id": "https://app.dimensions.ai/details/publication/pub.1074262072",
"type": "CreativeWork"
},
{
"id": "https://app.dimensions.ai/details/publication/pub.1077000475",
"type": "CreativeWork"
},
{
"id": "https://app.dimensions.ai/details/publication/pub.1078204495",
"type": "CreativeWork"
},
{
"id": "https://app.dimensions.ai/details/publication/pub.1082561638",
"type": "CreativeWork"
},
{
"id": "https://app.dimensions.ai/details/publication/pub.1082586609",
"type": "CreativeWork"
},
{
"id": "https://app.dimensions.ai/details/publication/pub.1083080424",
"type": "CreativeWork"
},
{
"id": "https://app.dimensions.ai/details/publication/pub.1083194191",
"type": "CreativeWork"
},
{
"id": "https://app.dimensions.ai/details/publication/pub.1083324284",
"type": "CreativeWork"
},
{
"id": "https://app.dimensions.ai/details/publication/pub.1083390009",
"type": "CreativeWork"
}
],
"datePublished": "2011-09",
"datePublishedReg": "2011-09-01",
"description": "Adenocarcinoma of the distal esophagus and esophagogastric junction continues to rise in incidence. An intestinal metaplasia (Barrett esophagus)-dysplasia-carcinoma sequence induced by gastroesophageal reflux disease is well established. However, a significant number of adenocarcinomas in the vicinity of the esophagogastric junction are seen in the background of gastric/cardiac-type mucosa without intestinal metaplasia. Thus, the aim of this study was to investigate the role of Barrett esophagus (intestinal-type mucosa) in the classification and prognosis of tumors of the distal esophagus and esophagogastric junction. Clinicopathological and molecular characteristics were examined in 157 consecutively resected adenocarcinomas of the distal esophagus and esophagogastric junction and were compared between tumors arising in association with intestinal-type and cardiac-type mucosa. Intestinal-type mucosa-associated adenocarcinomas were more likely to be associated with younger age (P=0.0057), reflux symptoms (P<0.0001), proximal location (P=0.0009), lower T stage (P<0.0001), fewer nodal metastases (P=0.0001), absence of lymphatic (P<0.0001), venous (P=0.0060) or perineural (P<0.0001) invasion. Histologically, intestinal-type mucosa-associated tumors were more likely to be low-grade glandular tumors (P=0.0095) of intestinal or mixed immunophenotype (P=0.015) and express nuclear \u03b2-catenin (P=0.0080), whereas tumors arising in a background of cardiac-type mucosa were more frequently associated with EGFR amplification (P=0.0051). Five-year overall survival rate was significantly higher in patients with intestinal-type mucosa-associated tumors (28 vs 9%, P=0.0015), although no survival benefit was seen after adjusting for potential confounders. Our findings support the theory that multiple distinct pathways of tumorigenesis exist in the vicinity of the esophagogastric junction, including one in which tumors arise from dysplastic intestinal metaplasia (intestinal pathway), and one potentially involving dysplasia of the cardiac-type mucosa (non-intestinal pathway). Additional studies are warranted to further clarify their pathogenesis and the molecular mechanisms involved.",
"genre": "research_article",
"id": "sg:pub.10.1038/modpathol.2011.77",
"inLanguage": [
"en"
],
"isAccessibleForFree": true,
"isPartOf": [
{
"id": "sg:journal.1098208",
"issn": [
"0893-3952",
"1530-0285"
],
"name": "Modern Pathology",
"type": "Periodical"
},
{
"issueNumber": "9",
"type": "PublicationIssue"
},
{
"type": "PublicationVolume",
"volumeNumber": "24"
}
],
"name": "The dichotomy in carcinogenesis of the distal esophagus and esophagogastric junction: intestinal-type vs cardiac-type mucosa-associated adenocarcinoma",
"pagination": "1177",
"productId": [
{
"name": "readcube_id",
"type": "PropertyValue",
"value": [
"e4355f3798902a38cb9c818b4f8faef6e499d8e6e7b79ec512f3572e292b3240"
]
},
{
"name": "pubmed_id",
"type": "PropertyValue",
"value": [
"21572404"
]
},
{
"name": "nlm_unique_id",
"type": "PropertyValue",
"value": [
"8806605"
]
},
{
"name": "doi",
"type": "PropertyValue",
"value": [
"10.1038/modpathol.2011.77"
]
},
{
"name": "dimensions_id",
"type": "PropertyValue",
"value": [
"pub.1047905121"
]
}
],
"sameAs": [
"https://doi.org/10.1038/modpathol.2011.77",
"https://app.dimensions.ai/details/publication/pub.1047905121"
],
"sdDataset": "articles",
"sdDatePublished": "2019-04-11T00:05",
"sdLicense": "https://scigraph.springernature.com/explorer/license/",
"sdPublisher": {
"name": "Springer Nature - SN SciGraph project",
"type": "Organization"
},
"sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8695_00000438.jsonl",
"type": "ScholarlyArticle",
"url": "https://www.nature.com/articles/modpathol201177"
}
]Download the RDF metadata as: json-ld nt turtle xml License info
JSON-LD is a popular format for linked data which is fully compatible with JSON.
curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/modpathol.2011.77'
N-Triples is a line-based linked data format ideal for batch operations.
curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/modpathol.2011.77'
Turtle is a human-readable linked data format.
curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/modpathol.2011.77'
RDF/XML is a standard XML format for linked data.
curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/modpathol.2011.77'
This table displays all metadata directly associated to this object as RDF triples.
438 TRIPLES
21 PREDICATES
109 URIs
39 LITERALS
27 BLANK NODES