ERG gene rearrangements are common in prostatic small cell carcinomas View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2011-06

AUTHORS

Tamara L Lotan, Nilesh S Gupta, Wenle Wang, Antoun Toubaji, Michael C Haffner, Alcides Chaux, Jessica L Hicks, Alan K Meeker, Charles J Bieberich, Angelo M De Marzo, Jonathan I Epstein, George J Netto

ABSTRACT

Small cell carcinoma of the prostate is a rare subtype with an aggressive clinical course. Despite the frequent occurrence of ERG gene rearrangements in acinar carcinoma, the incidence of these rearrangements in prostatic small cell carcinoma is unclear. In addition, molecular markers to distinguish prostatic small cell carcinomas from lung and bladder small cell carcinomas may be clinically useful. We examined the occurrence of ERG gene rearrangements by fluorescence in situ hybridization in prostatic, bladder and lung small cell carcinomas. We also examined the expression of ERG, androgen receptor (AR) and NKX3-1 by immunohistochemistry in prostatic cases. Overall, 45% (10/22) of prostatic small cell carcinoma cases harbored ERG rearrangements, whereas no cases of bladder or lung small cell carcinomas showed ERG rearrangement (0/12 and 0/13, respectively). Of prostatic small cell carcinoma cases, 80% (8/10) showed ERG deletion and 20% (2/10) showed ERG translocation. In 83% (5/6) of prostatic small cell carcinoma cases in which a concurrent conventional prostatic acinar carcinoma component was available for analysis, there was concordance for the presence/absence of ERG gene rearrangement between the different subtypes. ERG, AR and NKX3-1 protein expression was detected in a minority of prostatic small cell carcinoma cases (23, 27 and 18%, respectively), while these markers were positive in the majority of concurrent acinar carcinoma cases (66, 83 and 83%, respectively). The presence of ERG rearrangements in nearly half of the prostatic small cell carcinomas is a similar rate of rearrangement to that found in prostatic acinar carcinomas. Furthermore, the high concordance rate of ERG rearrangement between the small cell and acinar components in a given patient supports a common origin for these two subtypes of prostate cancer. Finally, the absence of ERG rearrangement in bladder or lung small cell carcinomas highlights the utility of detecting ERG rearrangement in small cell carcinomas of unknown primary for establishing prostatic origin. More... »

PAGES

820

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/modpathol.2011.7

DOI

http://dx.doi.org/10.1038/modpathol.2011.7

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1035407645

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/21336263


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1112", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Oncology and Carcinogenesis", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Aged", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Aged, 80 and over", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Carcinoma, Small Cell", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "DNA, Neoplasm", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Gene Rearrangement", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Homeodomain Proteins", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Immunoenzyme Techniques", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "In Situ Hybridization, Fluorescence", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Male", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Middle Aged", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Prostatic Neoplasms", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Receptors, Androgen", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Tissue Array Analysis", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Trans-Activators", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Transcription Factors", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Transcriptional Regulator ERG", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Johns Hopkins University", 
          "id": "https://www.grid.ac/institutes/grid.21107.35", 
          "name": [
            "Department of Pathology, Johns Hopkins Medical Institutions, Baltimore, MD, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Lotan", 
        "givenName": "Tamara L", 
        "id": "sg:person.01361572070.78", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01361572070.78"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Henry Ford Hospital", 
          "id": "https://www.grid.ac/institutes/grid.413103.4", 
          "name": [
            "Department of Pathology, Henry Ford Hospital, Detroit, MI, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Gupta", 
        "givenName": "Nilesh S", 
        "id": "sg:person.01210551701.06", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01210551701.06"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Johns Hopkins University", 
          "id": "https://www.grid.ac/institutes/grid.21107.35", 
          "name": [
            "Department of Pathology, Johns Hopkins Medical Institutions, Baltimore, MD, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Wang", 
        "givenName": "Wenle", 
        "id": "sg:person.0673134012.07", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0673134012.07"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Johns Hopkins University", 
          "id": "https://www.grid.ac/institutes/grid.21107.35", 
          "name": [
            "Department of Pathology, Johns Hopkins Medical Institutions, Baltimore, MD, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Toubaji", 
        "givenName": "Antoun", 
        "id": "sg:person.01205174365.84", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01205174365.84"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Johns Hopkins University", 
          "id": "https://www.grid.ac/institutes/grid.21107.35", 
          "name": [
            "Department of Oncology, Johns Hopkins Medical Institutions, Baltimore, MD, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Haffner", 
        "givenName": "Michael C", 
        "id": "sg:person.01236740114.23", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01236740114.23"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Johns Hopkins University", 
          "id": "https://www.grid.ac/institutes/grid.21107.35", 
          "name": [
            "Department of Pathology, Johns Hopkins Medical Institutions, Baltimore, MD, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Chaux", 
        "givenName": "Alcides", 
        "id": "sg:person.01340356077.05", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01340356077.05"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Johns Hopkins University", 
          "id": "https://www.grid.ac/institutes/grid.21107.35", 
          "name": [
            "Department of Pathology, Johns Hopkins Medical Institutions, Baltimore, MD, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Hicks", 
        "givenName": "Jessica L", 
        "id": "sg:person.01321422765.91", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01321422765.91"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Johns Hopkins University", 
          "id": "https://www.grid.ac/institutes/grid.21107.35", 
          "name": [
            "Department of Pathology, Johns Hopkins Medical Institutions, Baltimore, MD, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Meeker", 
        "givenName": "Alan K", 
        "id": "sg:person.01223312623.32", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01223312623.32"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Maryland, Baltimore County", 
          "id": "https://www.grid.ac/institutes/grid.266673.0", 
          "name": [
            "Department of Biological Sciences, University of Maryland Baltimore County, Baltimore, MD, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Bieberich", 
        "givenName": "Charles J", 
        "id": "sg:person.0774645232.78", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0774645232.78"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Johns Hopkins University", 
          "id": "https://www.grid.ac/institutes/grid.21107.35", 
          "name": [
            "Department of Pathology, Johns Hopkins Medical Institutions, Baltimore, MD, USA", 
            "Department of Oncology, Johns Hopkins Medical Institutions, Baltimore, MD, USA", 
            "Department of Urology, Johns Hopkins Medical Institutions, Baltimore, MD, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "De Marzo", 
        "givenName": "Angelo M", 
        "id": "sg:person.01261765353.31", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01261765353.31"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Johns Hopkins University", 
          "id": "https://www.grid.ac/institutes/grid.21107.35", 
          "name": [
            "Department of Pathology, Johns Hopkins Medical Institutions, Baltimore, MD, USA", 
            "Department of Oncology, Johns Hopkins Medical Institutions, Baltimore, MD, USA", 
            "Department of Urology, Johns Hopkins Medical Institutions, Baltimore, MD, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Epstein", 
        "givenName": "Jonathan I", 
        "id": "sg:person.0773612331.05", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0773612331.05"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Johns Hopkins University", 
          "id": "https://www.grid.ac/institutes/grid.21107.35", 
          "name": [
            "Department of Pathology, Johns Hopkins Medical Institutions, Baltimore, MD, USA", 
            "Department of Oncology, Johns Hopkins Medical Institutions, Baltimore, MD, USA", 
            "Department of Urology, Johns Hopkins Medical Institutions, Baltimore, MD, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Netto", 
        "givenName": "George J", 
        "id": "sg:person.0712550525.22", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0712550525.22"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.1158/1078-0432.ccr-07-0700", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1002726379"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.cell.2009.11.030", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1003685710"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/modpathol.2010.120", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1004027416", 
          "https://doi.org/10.1038/modpathol.2010.120"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/modpathol.2010.120", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1004027416", 
          "https://doi.org/10.1038/modpathol.2010.120"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.humpath.2010.05.026", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1004435631"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00000478-200606000-00005", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1007133124"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00000478-200606000-00005", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1007133124"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00000478-200606000-00005", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1007133124"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ng.613", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1017624697", 
          "https://doi.org/10.1038/ng.613"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ng.613", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1017624697", 
          "https://doi.org/10.1038/ng.613"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/modpathol.3800769", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1020552100", 
          "https://doi.org/10.1038/modpathol.3800769"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/1097-0142(197708)40:2<773::aid-cncr2820400226>3.0.co;2-i", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1022663596"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/cncr.22971", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1023773294"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0090-4295(92)90235-o", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1024046908"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1158/0008-5472.can-06-0168", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1026516082"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/science.1117679", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1028743308"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/modpathol.2009.79", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1029125989", 
          "https://doi.org/10.1038/modpathol.2009.79"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1158/0008-5472.can-06-0963", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1029588619"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1158/0008-5472.can-08-2467", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035256247"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/pros.20910", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037214945"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/pros.20910", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037214945"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1365-2559.2010.03564.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1038786871"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1365-2559.2010.03564.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1038786871"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/modpathol.2010.87", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1043402921", 
          "https://doi.org/10.1038/modpathol.2010.87"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/modpathol.2010.87", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1043402921", 
          "https://doi.org/10.1038/modpathol.2010.87"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.onc.1210640", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1043696319", 
          "https://doi.org/10.1038/sj.onc.1210640"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1158/0008-5472.can-06-1482", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1044043611"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/1097-0142(19870515)59:10<1803::aid-cncr2820591019>3.0.co;2-x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1044209841"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s004280050357", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1044674266", 
          "https://doi.org/10.1007/s004280050357"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1593/neo.07103", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1046098769"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.onc.1210237", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1048310050", 
          "https://doi.org/10.1038/sj.onc.1210237"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1053/j.seminoncol.2006.10.026", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1049265878"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0090-4295(85)90060-3", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1050917134"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/pas.0b013e318058a96b", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1051290544"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/pas.0b013e318058a96b", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1051290544"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/maj.0b013e3181731e58", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1051467372"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/maj.0b013e3181731e58", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1051467372"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00000421-199708000-00011", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1060113613"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00000421-199708000-00011", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1060113613"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00000421-199708000-00011", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1060113613"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00000421-199708000-00011", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1060113613"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/science.1178124", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1062460474"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1200/jco.2002.12.065", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1064203205"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0022-5347(17)32417-5", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1082571308"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2011-06", 
    "datePublishedReg": "2011-06-01", 
    "description": "Small cell carcinoma of the prostate is a rare subtype with an aggressive clinical course. Despite the frequent occurrence of ERG gene rearrangements in acinar carcinoma, the incidence of these rearrangements in prostatic small cell carcinoma is unclear. In addition, molecular markers to distinguish prostatic small cell carcinomas from lung and bladder small cell carcinomas may be clinically useful. We examined the occurrence of ERG gene rearrangements by fluorescence in situ hybridization in prostatic, bladder and lung small cell carcinomas. We also examined the expression of ERG, androgen receptor (AR) and NKX3-1 by immunohistochemistry in prostatic cases. Overall, 45% (10/22) of prostatic small cell carcinoma cases harbored ERG rearrangements, whereas no cases of bladder or lung small cell carcinomas showed ERG rearrangement (0/12 and 0/13, respectively). Of prostatic small cell carcinoma cases, 80% (8/10) showed ERG deletion and 20% (2/10) showed ERG translocation. In 83% (5/6) of prostatic small cell carcinoma cases in which a concurrent conventional prostatic acinar carcinoma component was available for analysis, there was concordance for the presence/absence of ERG gene rearrangement between the different subtypes. ERG, AR and NKX3-1 protein expression was detected in a minority of prostatic small cell carcinoma cases (23, 27 and 18%, respectively), while these markers were positive in the majority of concurrent acinar carcinoma cases (66, 83 and 83%, respectively). The presence of ERG rearrangements in nearly half of the prostatic small cell carcinomas is a similar rate of rearrangement to that found in prostatic acinar carcinomas. Furthermore, the high concordance rate of ERG rearrangement between the small cell and acinar components in a given patient supports a common origin for these two subtypes of prostate cancer. Finally, the absence of ERG rearrangement in bladder or lung small cell carcinomas highlights the utility of detecting ERG rearrangement in small cell carcinomas of unknown primary for establishing prostatic origin.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1038/modpathol.2011.7", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": true, 
    "isFundedItemOf": [
      {
        "id": "sg:grant.2440140", 
        "type": "MonetaryGrant"
      }
    ], 
    "isPartOf": [
      {
        "id": "sg:journal.1098208", 
        "issn": [
          "0893-3952", 
          "1530-0285"
        ], 
        "name": "Modern Pathology", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "6", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "24"
      }
    ], 
    "name": "ERG gene rearrangements are common in prostatic small cell carcinomas", 
    "pagination": "820", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "a8aa71029c1c296705bde5d1af7aa7ed8d0a38b0307e233b9dd55e07f959c49f"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "21336263"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "8806605"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1038/modpathol.2011.7"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1035407645"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1038/modpathol.2011.7", 
      "https://app.dimensions.ai/details/publication/pub.1035407645"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-10T21:26", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8687_00000436.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://www.nature.com/articles/modpathol20117"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/modpathol.2011.7'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/modpathol.2011.7'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/modpathol.2011.7'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/modpathol.2011.7'


 

This table displays all metadata directly associated to this object as RDF triples.

328 TRIPLES      21 PREDICATES      78 URIs      38 LITERALS      26 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1038/modpathol.2011.7 schema:about N0581c8365f2745a1933afebcb298a851
2 N0e160e1711dd46c2bf00260256d2f09b
3 N0f71448da951494480910e4322c02e05
4 N1c1d22eb20cc4c49883fa16dbdebae22
5 N354189b06680448c9e91d6cf75873cb6
6 N3792edb41da948bfbaa46b29df44d74f
7 N4bcac1e797c8419fa361aacbc480204c
8 N53b4a8bdab084071bb0b22982471d63d
9 N5515b0ea7b494624b17da8a08c3e7d91
10 N5eaedaa57a2e47b4abde00e2c634f8bd
11 N769c6f4bfc5d4b57881e25b014f2cd83
12 N88ab61edd2c1416ca6e904c5b1b549f0
13 N9cc9c44018f44fe19889821f06d17069
14 Na1a079602bf44c809400741282f19409
15 Na2b01b3bc6a94a33b860c152e0981b3b
16 Ne07ce2a74ba0495db7a0e12b15f3f952
17 Ne9c7a5cf98e84f509080d0567b3b1d97
18 anzsrc-for:11
19 anzsrc-for:1112
20 schema:author Nc3cd10dfd7c04323a658d5d83af2b974
21 schema:citation sg:pub.10.1007/s004280050357
22 sg:pub.10.1038/modpathol.2009.79
23 sg:pub.10.1038/modpathol.2010.120
24 sg:pub.10.1038/modpathol.2010.87
25 sg:pub.10.1038/modpathol.3800769
26 sg:pub.10.1038/ng.613
27 sg:pub.10.1038/sj.onc.1210237
28 sg:pub.10.1038/sj.onc.1210640
29 https://doi.org/10.1002/1097-0142(197708)40:2<773::aid-cncr2820400226>3.0.co;2-i
30 https://doi.org/10.1002/1097-0142(19870515)59:10<1803::aid-cncr2820591019>3.0.co;2-x
31 https://doi.org/10.1002/cncr.22971
32 https://doi.org/10.1002/pros.20910
33 https://doi.org/10.1016/0090-4295(85)90060-3
34 https://doi.org/10.1016/0090-4295(92)90235-o
35 https://doi.org/10.1016/j.cell.2009.11.030
36 https://doi.org/10.1016/j.humpath.2010.05.026
37 https://doi.org/10.1016/s0022-5347(17)32417-5
38 https://doi.org/10.1053/j.seminoncol.2006.10.026
39 https://doi.org/10.1097/00000421-199708000-00011
40 https://doi.org/10.1097/00000478-200606000-00005
41 https://doi.org/10.1097/maj.0b013e3181731e58
42 https://doi.org/10.1097/pas.0b013e318058a96b
43 https://doi.org/10.1111/j.1365-2559.2010.03564.x
44 https://doi.org/10.1126/science.1117679
45 https://doi.org/10.1126/science.1178124
46 https://doi.org/10.1158/0008-5472.can-06-0168
47 https://doi.org/10.1158/0008-5472.can-06-0963
48 https://doi.org/10.1158/0008-5472.can-06-1482
49 https://doi.org/10.1158/0008-5472.can-08-2467
50 https://doi.org/10.1158/1078-0432.ccr-07-0700
51 https://doi.org/10.1200/jco.2002.12.065
52 https://doi.org/10.1593/neo.07103
53 schema:datePublished 2011-06
54 schema:datePublishedReg 2011-06-01
55 schema:description Small cell carcinoma of the prostate is a rare subtype with an aggressive clinical course. Despite the frequent occurrence of ERG gene rearrangements in acinar carcinoma, the incidence of these rearrangements in prostatic small cell carcinoma is unclear. In addition, molecular markers to distinguish prostatic small cell carcinomas from lung and bladder small cell carcinomas may be clinically useful. We examined the occurrence of ERG gene rearrangements by fluorescence in situ hybridization in prostatic, bladder and lung small cell carcinomas. We also examined the expression of ERG, androgen receptor (AR) and NKX3-1 by immunohistochemistry in prostatic cases. Overall, 45% (10/22) of prostatic small cell carcinoma cases harbored ERG rearrangements, whereas no cases of bladder or lung small cell carcinomas showed ERG rearrangement (0/12 and 0/13, respectively). Of prostatic small cell carcinoma cases, 80% (8/10) showed ERG deletion and 20% (2/10) showed ERG translocation. In 83% (5/6) of prostatic small cell carcinoma cases in which a concurrent conventional prostatic acinar carcinoma component was available for analysis, there was concordance for the presence/absence of ERG gene rearrangement between the different subtypes. ERG, AR and NKX3-1 protein expression was detected in a minority of prostatic small cell carcinoma cases (23, 27 and 18%, respectively), while these markers were positive in the majority of concurrent acinar carcinoma cases (66, 83 and 83%, respectively). The presence of ERG rearrangements in nearly half of the prostatic small cell carcinomas is a similar rate of rearrangement to that found in prostatic acinar carcinomas. Furthermore, the high concordance rate of ERG rearrangement between the small cell and acinar components in a given patient supports a common origin for these two subtypes of prostate cancer. Finally, the absence of ERG rearrangement in bladder or lung small cell carcinomas highlights the utility of detecting ERG rearrangement in small cell carcinomas of unknown primary for establishing prostatic origin.
56 schema:genre research_article
57 schema:inLanguage en
58 schema:isAccessibleForFree true
59 schema:isPartOf N338c1d7cb7c940fc85e517c65a7be0ea
60 Nde30750ecb054c0ca4539e3aa8036034
61 sg:journal.1098208
62 schema:name ERG gene rearrangements are common in prostatic small cell carcinomas
63 schema:pagination 820
64 schema:productId N42241cd23f964225b623ecf06f836788
65 N535f4087055a477dbb0e2d9ff40408d5
66 N720f9428fa8245dcb09e6af6278542a4
67 Nc4e3aa93da5743dc9e884b915ffdb17c
68 Ncfe10799361d4c19bcf99a341cd63eec
69 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035407645
70 https://doi.org/10.1038/modpathol.2011.7
71 schema:sdDatePublished 2019-04-10T21:26
72 schema:sdLicense https://scigraph.springernature.com/explorer/license/
73 schema:sdPublisher N4a7005d01d134d138b1ff06abe2d2c02
74 schema:url https://www.nature.com/articles/modpathol20117
75 sgo:license sg:explorer/license/
76 sgo:sdDataset articles
77 rdf:type schema:ScholarlyArticle
78 N0581c8365f2745a1933afebcb298a851 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
79 schema:name Immunoenzyme Techniques
80 rdf:type schema:DefinedTerm
81 N0e160e1711dd46c2bf00260256d2f09b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
82 schema:name In Situ Hybridization, Fluorescence
83 rdf:type schema:DefinedTerm
84 N0f71448da951494480910e4322c02e05 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
85 schema:name Transcription Factors
86 rdf:type schema:DefinedTerm
87 N15da9d6e306049289c1e3d490deb3171 rdf:first sg:person.01210551701.06
88 rdf:rest N7dfce67f85e9479bab2dd43b2a4af678
89 N1c1d22eb20cc4c49883fa16dbdebae22 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
90 schema:name Aged
91 rdf:type schema:DefinedTerm
92 N338c1d7cb7c940fc85e517c65a7be0ea schema:volumeNumber 24
93 rdf:type schema:PublicationVolume
94 N354189b06680448c9e91d6cf75873cb6 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
95 schema:name Receptors, Androgen
96 rdf:type schema:DefinedTerm
97 N3792edb41da948bfbaa46b29df44d74f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
98 schema:name Middle Aged
99 rdf:type schema:DefinedTerm
100 N42241cd23f964225b623ecf06f836788 schema:name dimensions_id
101 schema:value pub.1035407645
102 rdf:type schema:PropertyValue
103 N4a7005d01d134d138b1ff06abe2d2c02 schema:name Springer Nature - SN SciGraph project
104 rdf:type schema:Organization
105 N4bcac1e797c8419fa361aacbc480204c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
106 schema:name DNA, Neoplasm
107 rdf:type schema:DefinedTerm
108 N535f4087055a477dbb0e2d9ff40408d5 schema:name nlm_unique_id
109 schema:value 8806605
110 rdf:type schema:PropertyValue
111 N53b4a8bdab084071bb0b22982471d63d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
112 schema:name Homeodomain Proteins
113 rdf:type schema:DefinedTerm
114 N5515b0ea7b494624b17da8a08c3e7d91 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
115 schema:name Trans-Activators
116 rdf:type schema:DefinedTerm
117 N567f26e4d009484fbc3dc12c6bd5fa68 rdf:first sg:person.01223312623.32
118 rdf:rest Nf53bfe6336b44f4a8bfc7d32de7de8e5
119 N5eaedaa57a2e47b4abde00e2c634f8bd schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
120 schema:name Aged, 80 and over
121 rdf:type schema:DefinedTerm
122 N6e0eb7e49a9e40719d995c23644e337e rdf:first sg:person.01236740114.23
123 rdf:rest Na179582c39d7488d88e0775ae34fd782
124 N710dcd9d4ec04ff9b1da1ebcc9c80dc3 rdf:first sg:person.0773612331.05
125 rdf:rest Ne47bce74b0a5463ebba0c2b51941adea
126 N720f9428fa8245dcb09e6af6278542a4 schema:name doi
127 schema:value 10.1038/modpathol.2011.7
128 rdf:type schema:PropertyValue
129 N769c6f4bfc5d4b57881e25b014f2cd83 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
130 schema:name Male
131 rdf:type schema:DefinedTerm
132 N7dfce67f85e9479bab2dd43b2a4af678 rdf:first sg:person.0673134012.07
133 rdf:rest Ne6d481def0ad43d3b024cbc86e71008f
134 N88ab61edd2c1416ca6e904c5b1b549f0 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
135 schema:name Transcriptional Regulator ERG
136 rdf:type schema:DefinedTerm
137 N9cc9c44018f44fe19889821f06d17069 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
138 schema:name Prostatic Neoplasms
139 rdf:type schema:DefinedTerm
140 Na0782c961a5142c291dc51149b6f5412 rdf:first sg:person.01321422765.91
141 rdf:rest N567f26e4d009484fbc3dc12c6bd5fa68
142 Na179582c39d7488d88e0775ae34fd782 rdf:first sg:person.01340356077.05
143 rdf:rest Na0782c961a5142c291dc51149b6f5412
144 Na1a079602bf44c809400741282f19409 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
145 schema:name Gene Rearrangement
146 rdf:type schema:DefinedTerm
147 Na2b01b3bc6a94a33b860c152e0981b3b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
148 schema:name Humans
149 rdf:type schema:DefinedTerm
150 Nc3cd10dfd7c04323a658d5d83af2b974 rdf:first sg:person.01361572070.78
151 rdf:rest N15da9d6e306049289c1e3d490deb3171
152 Nc4e3aa93da5743dc9e884b915ffdb17c schema:name readcube_id
153 schema:value a8aa71029c1c296705bde5d1af7aa7ed8d0a38b0307e233b9dd55e07f959c49f
154 rdf:type schema:PropertyValue
155 Ncb2bef4de17e47308b9b132ee963d788 rdf:first sg:person.01261765353.31
156 rdf:rest N710dcd9d4ec04ff9b1da1ebcc9c80dc3
157 Ncfe10799361d4c19bcf99a341cd63eec schema:name pubmed_id
158 schema:value 21336263
159 rdf:type schema:PropertyValue
160 Nde30750ecb054c0ca4539e3aa8036034 schema:issueNumber 6
161 rdf:type schema:PublicationIssue
162 Ne07ce2a74ba0495db7a0e12b15f3f952 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
163 schema:name Carcinoma, Small Cell
164 rdf:type schema:DefinedTerm
165 Ne47bce74b0a5463ebba0c2b51941adea rdf:first sg:person.0712550525.22
166 rdf:rest rdf:nil
167 Ne6d481def0ad43d3b024cbc86e71008f rdf:first sg:person.01205174365.84
168 rdf:rest N6e0eb7e49a9e40719d995c23644e337e
169 Ne9c7a5cf98e84f509080d0567b3b1d97 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
170 schema:name Tissue Array Analysis
171 rdf:type schema:DefinedTerm
172 Nf53bfe6336b44f4a8bfc7d32de7de8e5 rdf:first sg:person.0774645232.78
173 rdf:rest Ncb2bef4de17e47308b9b132ee963d788
174 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
175 schema:name Medical and Health Sciences
176 rdf:type schema:DefinedTerm
177 anzsrc-for:1112 schema:inDefinedTermSet anzsrc-for:
178 schema:name Oncology and Carcinogenesis
179 rdf:type schema:DefinedTerm
180 sg:grant.2440140 http://pending.schema.org/fundedItem sg:pub.10.1038/modpathol.2011.7
181 rdf:type schema:MonetaryGrant
182 sg:journal.1098208 schema:issn 0893-3952
183 1530-0285
184 schema:name Modern Pathology
185 rdf:type schema:Periodical
186 sg:person.01205174365.84 schema:affiliation https://www.grid.ac/institutes/grid.21107.35
187 schema:familyName Toubaji
188 schema:givenName Antoun
189 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01205174365.84
190 rdf:type schema:Person
191 sg:person.01210551701.06 schema:affiliation https://www.grid.ac/institutes/grid.413103.4
192 schema:familyName Gupta
193 schema:givenName Nilesh S
194 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01210551701.06
195 rdf:type schema:Person
196 sg:person.01223312623.32 schema:affiliation https://www.grid.ac/institutes/grid.21107.35
197 schema:familyName Meeker
198 schema:givenName Alan K
199 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01223312623.32
200 rdf:type schema:Person
201 sg:person.01236740114.23 schema:affiliation https://www.grid.ac/institutes/grid.21107.35
202 schema:familyName Haffner
203 schema:givenName Michael C
204 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01236740114.23
205 rdf:type schema:Person
206 sg:person.01261765353.31 schema:affiliation https://www.grid.ac/institutes/grid.21107.35
207 schema:familyName De Marzo
208 schema:givenName Angelo M
209 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01261765353.31
210 rdf:type schema:Person
211 sg:person.01321422765.91 schema:affiliation https://www.grid.ac/institutes/grid.21107.35
212 schema:familyName Hicks
213 schema:givenName Jessica L
214 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01321422765.91
215 rdf:type schema:Person
216 sg:person.01340356077.05 schema:affiliation https://www.grid.ac/institutes/grid.21107.35
217 schema:familyName Chaux
218 schema:givenName Alcides
219 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01340356077.05
220 rdf:type schema:Person
221 sg:person.01361572070.78 schema:affiliation https://www.grid.ac/institutes/grid.21107.35
222 schema:familyName Lotan
223 schema:givenName Tamara L
224 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01361572070.78
225 rdf:type schema:Person
226 sg:person.0673134012.07 schema:affiliation https://www.grid.ac/institutes/grid.21107.35
227 schema:familyName Wang
228 schema:givenName Wenle
229 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0673134012.07
230 rdf:type schema:Person
231 sg:person.0712550525.22 schema:affiliation https://www.grid.ac/institutes/grid.21107.35
232 schema:familyName Netto
233 schema:givenName George J
234 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0712550525.22
235 rdf:type schema:Person
236 sg:person.0773612331.05 schema:affiliation https://www.grid.ac/institutes/grid.21107.35
237 schema:familyName Epstein
238 schema:givenName Jonathan I
239 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0773612331.05
240 rdf:type schema:Person
241 sg:person.0774645232.78 schema:affiliation https://www.grid.ac/institutes/grid.266673.0
242 schema:familyName Bieberich
243 schema:givenName Charles J
244 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0774645232.78
245 rdf:type schema:Person
246 sg:pub.10.1007/s004280050357 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044674266
247 https://doi.org/10.1007/s004280050357
248 rdf:type schema:CreativeWork
249 sg:pub.10.1038/modpathol.2009.79 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029125989
250 https://doi.org/10.1038/modpathol.2009.79
251 rdf:type schema:CreativeWork
252 sg:pub.10.1038/modpathol.2010.120 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004027416
253 https://doi.org/10.1038/modpathol.2010.120
254 rdf:type schema:CreativeWork
255 sg:pub.10.1038/modpathol.2010.87 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043402921
256 https://doi.org/10.1038/modpathol.2010.87
257 rdf:type schema:CreativeWork
258 sg:pub.10.1038/modpathol.3800769 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020552100
259 https://doi.org/10.1038/modpathol.3800769
260 rdf:type schema:CreativeWork
261 sg:pub.10.1038/ng.613 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017624697
262 https://doi.org/10.1038/ng.613
263 rdf:type schema:CreativeWork
264 sg:pub.10.1038/sj.onc.1210237 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048310050
265 https://doi.org/10.1038/sj.onc.1210237
266 rdf:type schema:CreativeWork
267 sg:pub.10.1038/sj.onc.1210640 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043696319
268 https://doi.org/10.1038/sj.onc.1210640
269 rdf:type schema:CreativeWork
270 https://doi.org/10.1002/1097-0142(197708)40:2<773::aid-cncr2820400226>3.0.co;2-i schema:sameAs https://app.dimensions.ai/details/publication/pub.1022663596
271 rdf:type schema:CreativeWork
272 https://doi.org/10.1002/1097-0142(19870515)59:10<1803::aid-cncr2820591019>3.0.co;2-x schema:sameAs https://app.dimensions.ai/details/publication/pub.1044209841
273 rdf:type schema:CreativeWork
274 https://doi.org/10.1002/cncr.22971 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023773294
275 rdf:type schema:CreativeWork
276 https://doi.org/10.1002/pros.20910 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037214945
277 rdf:type schema:CreativeWork
278 https://doi.org/10.1016/0090-4295(85)90060-3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050917134
279 rdf:type schema:CreativeWork
280 https://doi.org/10.1016/0090-4295(92)90235-o schema:sameAs https://app.dimensions.ai/details/publication/pub.1024046908
281 rdf:type schema:CreativeWork
282 https://doi.org/10.1016/j.cell.2009.11.030 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003685710
283 rdf:type schema:CreativeWork
284 https://doi.org/10.1016/j.humpath.2010.05.026 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004435631
285 rdf:type schema:CreativeWork
286 https://doi.org/10.1016/s0022-5347(17)32417-5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1082571308
287 rdf:type schema:CreativeWork
288 https://doi.org/10.1053/j.seminoncol.2006.10.026 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049265878
289 rdf:type schema:CreativeWork
290 https://doi.org/10.1097/00000421-199708000-00011 schema:sameAs https://app.dimensions.ai/details/publication/pub.1060113613
291 rdf:type schema:CreativeWork
292 https://doi.org/10.1097/00000478-200606000-00005 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007133124
293 rdf:type schema:CreativeWork
294 https://doi.org/10.1097/maj.0b013e3181731e58 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051467372
295 rdf:type schema:CreativeWork
296 https://doi.org/10.1097/pas.0b013e318058a96b schema:sameAs https://app.dimensions.ai/details/publication/pub.1051290544
297 rdf:type schema:CreativeWork
298 https://doi.org/10.1111/j.1365-2559.2010.03564.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1038786871
299 rdf:type schema:CreativeWork
300 https://doi.org/10.1126/science.1117679 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028743308
301 rdf:type schema:CreativeWork
302 https://doi.org/10.1126/science.1178124 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062460474
303 rdf:type schema:CreativeWork
304 https://doi.org/10.1158/0008-5472.can-06-0168 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026516082
305 rdf:type schema:CreativeWork
306 https://doi.org/10.1158/0008-5472.can-06-0963 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029588619
307 rdf:type schema:CreativeWork
308 https://doi.org/10.1158/0008-5472.can-06-1482 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044043611
309 rdf:type schema:CreativeWork
310 https://doi.org/10.1158/0008-5472.can-08-2467 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035256247
311 rdf:type schema:CreativeWork
312 https://doi.org/10.1158/1078-0432.ccr-07-0700 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002726379
313 rdf:type schema:CreativeWork
314 https://doi.org/10.1200/jco.2002.12.065 schema:sameAs https://app.dimensions.ai/details/publication/pub.1064203205
315 rdf:type schema:CreativeWork
316 https://doi.org/10.1593/neo.07103 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046098769
317 rdf:type schema:CreativeWork
318 https://www.grid.ac/institutes/grid.21107.35 schema:alternateName Johns Hopkins University
319 schema:name Department of Oncology, Johns Hopkins Medical Institutions, Baltimore, MD, USA
320 Department of Pathology, Johns Hopkins Medical Institutions, Baltimore, MD, USA
321 Department of Urology, Johns Hopkins Medical Institutions, Baltimore, MD, USA
322 rdf:type schema:Organization
323 https://www.grid.ac/institutes/grid.266673.0 schema:alternateName University of Maryland, Baltimore County
324 schema:name Department of Biological Sciences, University of Maryland Baltimore County, Baltimore, MD, USA
325 rdf:type schema:Organization
326 https://www.grid.ac/institutes/grid.413103.4 schema:alternateName Henry Ford Hospital
327 schema:name Department of Pathology, Henry Ford Hospital, Detroit, MI, USA
328 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...