Ontology type: schema:ScholarlyArticle Open Access: True
2012-02
AUTHORSElizabeth G Demicco, Keila E Torres, Markus P Ghadimi, Chiara Colombo, Svetlana Bolshakov, Aviad Hoffman, Tingsheng Peng, Judith V M G Bovée, Wei-Lien Wang, Dina Lev, Alexander J Lazar
ABSTRACTThe molecular determinants involved in the progression of myxoid liposarcoma to increased cellularity/round cell change are poorly understood. We studied the PI3K/Akt pathway in myxoid and round cell liposarcomas using a tissue microarray composed of 165 tumors from 111 patients, and mutational analysis of PIK3CA in 44 cases. Activating PIK3CA mutations were found in 6/44 cases, 14%; mutations were more frequent in round cell vs myxoid tumors (5/15, 33% vs 1/29, 3%; P=0.013). Complete loss of PTEN, an alternative mechanism for PI3K/Akt activation, was found in 13/111 (12%) cases and was mutually exclusive with PIK3CA mutation. Strong IGF1R expression was demonstrated in 14/39 (36%) of round cell and 11/58 (19%) of myxoid tumors (P=0.062). Activation of the PI3K pathway was confirmed using immunohistochemical analysis for downstream targets phospho-S6 ribosomal protein and phospho-4EBP1. Phospho-4EBP1 was increased in round cell tumors compared with myxoid tumors (24/30, 80% vs 25/44, 57%; P=0.038) or tumors with treatment effect (10/24, 42%; P=0.02). Phospho-S6 was highly expressed in both myxoid and round cell tumors (29/47, 62% and 14/30, 47%, respectively; P=0.2). In tumors with PIK3CA mutation, any IGF1R expression, or loss of PTEN expression, phospho-4EBP1 was more frequently elevated compared with tumors without a known activating event in the PI3K pathway (55/72; 76% vs 3/8, 38%; P=0.033). These findings suggest that activation of the PI3K/Akt pathway via activating mutation of PIK3CA, loss of PTEN, or IGF1R expression have a role in round cell transformation. The PI3K/Akt pathway may therefore provide a therapeutic target in round cell liposarcoma. More... »
PAGESmodpathol2011148
http://scigraph.springernature.com/pub.10.1038/modpathol.2011.148
DOIhttp://dx.doi.org/10.1038/modpathol.2011.148
DIMENSIONShttps://app.dimensions.ai/details/publication/pub.1025747772
PUBMEDhttps://www.ncbi.nlm.nih.gov/pubmed/22020193
JSON-LD is the canonical representation for SciGraph data.
TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT
[
{
"@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json",
"about": [
{
"id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/0601",
"inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/",
"name": "Biochemistry and Cell Biology",
"type": "DefinedTerm"
},
{
"id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/06",
"inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/",
"name": "Biological Sciences",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Adolescent",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Adult",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Aged",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Cell Transformation, Neoplastic",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Class I Phosphatidylinositol 3-Kinases",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Female",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Genotype",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Humans",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Liposarcoma, Myxoid",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Male",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Membrane Proteins",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Middle Aged",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Mutation",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "PTEN Phosphohydrolase",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Phosphatidylinositol 3-Kinases",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Proto-Oncogene Proteins c-akt",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Receptor, IGF Type 1",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Signal Transduction",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Soft Tissue Neoplasms",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Young Adult",
"type": "DefinedTerm"
}
],
"author": [
{
"affiliation": {
"alternateName": "The University of Texas MD Anderson Cancer Center",
"id": "https://www.grid.ac/institutes/grid.240145.6",
"name": [
"Department of Pathology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA"
],
"type": "Organization"
},
"familyName": "Demicco",
"givenName": "Elizabeth G",
"id": "sg:person.0751521705.20",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0751521705.20"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "The University of Texas MD Anderson Cancer Center",
"id": "https://www.grid.ac/institutes/grid.240145.6",
"name": [
"Sarcoma Research Center, The University of Texas MD Anderson Cancer Center, Houston, TX, USA"
],
"type": "Organization"
},
"familyName": "Torres",
"givenName": "Keila E",
"id": "sg:person.01017635105.71",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01017635105.71"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "The University of Texas MD Anderson Cancer Center",
"id": "https://www.grid.ac/institutes/grid.240145.6",
"name": [
"Sarcoma Research Center, The University of Texas MD Anderson Cancer Center, Houston, TX, USA"
],
"type": "Organization"
},
"familyName": "Ghadimi",
"givenName": "Markus P",
"id": "sg:person.01065750305.94",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01065750305.94"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "The University of Texas MD Anderson Cancer Center",
"id": "https://www.grid.ac/institutes/grid.240145.6",
"name": [
"Sarcoma Research Center, The University of Texas MD Anderson Cancer Center, Houston, TX, USA"
],
"type": "Organization"
},
"familyName": "Colombo",
"givenName": "Chiara",
"id": "sg:person.01134063505.32",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01134063505.32"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "The University of Texas MD Anderson Cancer Center",
"id": "https://www.grid.ac/institutes/grid.240145.6",
"name": [
"Sarcoma Research Center, The University of Texas MD Anderson Cancer Center, Houston, TX, USA"
],
"type": "Organization"
},
"familyName": "Bolshakov",
"givenName": "Svetlana",
"id": "sg:person.01202176705.31",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01202176705.31"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "The University of Texas MD Anderson Cancer Center",
"id": "https://www.grid.ac/institutes/grid.240145.6",
"name": [
"Sarcoma Research Center, The University of Texas MD Anderson Cancer Center, Houston, TX, USA"
],
"type": "Organization"
},
"familyName": "Hoffman",
"givenName": "Aviad",
"id": "sg:person.0731612450.73",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0731612450.73"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "The University of Texas MD Anderson Cancer Center",
"id": "https://www.grid.ac/institutes/grid.240145.6",
"name": [
"Sarcoma Research Center, The University of Texas MD Anderson Cancer Center, Houston, TX, USA"
],
"type": "Organization"
},
"familyName": "Peng",
"givenName": "Tingsheng",
"id": "sg:person.01145211627.10",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01145211627.10"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Leiden University Medical Center",
"id": "https://www.grid.ac/institutes/grid.10419.3d",
"name": [
"Department of Pathology, Leiden University Medical Center, Leiden, The Netherlands"
],
"type": "Organization"
},
"familyName": "Bov\u00e9e",
"givenName": "Judith V M G",
"id": "sg:person.0675664562.78",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0675664562.78"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "The University of Texas MD Anderson Cancer Center",
"id": "https://www.grid.ac/institutes/grid.240145.6",
"name": [
"Department of Pathology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA"
],
"type": "Organization"
},
"familyName": "Wang",
"givenName": "Wei-Lien",
"id": "sg:person.010331373604.53",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.010331373604.53"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "The University of Texas MD Anderson Cancer Center",
"id": "https://www.grid.ac/institutes/grid.240145.6",
"name": [
"Sarcoma Research Center, The University of Texas MD Anderson Cancer Center, Houston, TX, USA"
],
"type": "Organization"
},
"familyName": "Lev",
"givenName": "Dina",
"id": "sg:person.0707247605.98",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0707247605.98"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "The University of Texas MD Anderson Cancer Center",
"id": "https://www.grid.ac/institutes/grid.240145.6",
"name": [
"Department of Pathology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA",
"Sarcoma Research Center, The University of Texas MD Anderson Cancer Center, Houston, TX, USA"
],
"type": "Organization"
},
"familyName": "Lazar",
"givenName": "Alexander J",
"id": "sg:person.010255222337.53",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.010255222337.53"
],
"type": "Person"
}
],
"citation": [
{
"id": "sg:pub.10.1186/1476-4598-9-257",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1000191570",
"https://doi.org/10.1186/1476-4598-9-257"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/modpathol.3800995",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1004189527",
"https://doi.org/10.1038/modpathol.3800995"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1245/s10434-006-9043-7",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1004217425",
"https://doi.org/10.1245/s10434-006-9043-7"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1097/00000478-197912000-00004",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1005237630"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1097/00000478-197912000-00004",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1005237630"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/ng.619",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1006757412",
"https://doi.org/10.1038/ng.619"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/ng.619",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1006757412",
"https://doi.org/10.1038/ng.619"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/s1937-6448(08)00801-0",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1007373011"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1101/gad.12.4.502",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1007558707"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/ncponc0934",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1013383026",
"https://doi.org/10.1038/ncponc0934"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/nrc839",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1014023118",
"https://doi.org/10.1038/nrc839"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/nrc839",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1014023118",
"https://doi.org/10.1038/nrc839"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1371/journal.pone.0017791",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1016879781"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/modpathol.2009.104",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1017010059",
"https://doi.org/10.1038/modpathol.2009.104"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1158/1078-0432.ccr-09-2912",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1019463215"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1073/pnas.171301998",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1023536159"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/modpathol.3800834",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1026740772",
"https://doi.org/10.1038/modpathol.3800834"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1242/jcs.01311",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1028982687"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1097/pas.0b013e3181963c9c",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1029545791"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1097/pas.0b013e3181963c9c",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1029545791"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1097/pas.0b013e3181963c9c",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1029545791"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/sj.onc.1204018",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1030547160",
"https://doi.org/10.1038/sj.onc.1204018"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/sj.onc.1204018",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1030547160",
"https://doi.org/10.1038/sj.onc.1204018"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/j.humpath.2009.01.011",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1030998025"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/j.semcdb.2004.01.002",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1033280784"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1002/(sici)1097-0142(19960415)77:8<1450::aid-cncr5>3.0.co;2-g",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1033796679"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/onc.2008.245",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1038283584",
"https://doi.org/10.1038/onc.2008.245"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1002/bies.950161107",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1048243483"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1158/0008-5472.can-05-3979",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1053345698"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1097/00000478-199602000-00005",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1060121977"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1126/science.1135394",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1062454933"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.4161/cbt.3.8.994",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1072293464"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.4161/cc.3.10.1164",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1072297742"
],
"type": "CreativeWork"
},
{
"id": "https://app.dimensions.ai/details/publication/pub.1074963961",
"type": "CreativeWork"
},
{
"id": "https://app.dimensions.ai/details/publication/pub.1083141934",
"type": "CreativeWork"
}
],
"datePublished": "2012-02",
"datePublishedReg": "2012-02-01",
"description": "The molecular determinants involved in the progression of myxoid liposarcoma to increased cellularity/round cell change are poorly understood. We studied the PI3K/Akt pathway in myxoid and round cell liposarcomas using a tissue microarray composed of 165 tumors from 111 patients, and mutational analysis of PIK3CA in 44 cases. Activating PIK3CA mutations were found in 6/44 cases, 14%; mutations were more frequent in round cell vs myxoid tumors (5/15, 33% vs 1/29, 3%; P=0.013). Complete loss of PTEN, an alternative mechanism for PI3K/Akt activation, was found in 13/111 (12%) cases and was mutually exclusive with PIK3CA mutation. Strong IGF1R expression was demonstrated in 14/39 (36%) of round cell and 11/58 (19%) of myxoid tumors (P=0.062). Activation of the PI3K pathway was confirmed using immunohistochemical analysis for downstream targets phospho-S6 ribosomal protein and phospho-4EBP1. Phospho-4EBP1 was increased in round cell tumors compared with myxoid tumors (24/30, 80% vs 25/44, 57%; P=0.038) or tumors with treatment effect (10/24, 42%; P=0.02). Phospho-S6 was highly expressed in both myxoid and round cell tumors (29/47, 62% and 14/30, 47%, respectively; P=0.2). In tumors with PIK3CA mutation, any IGF1R expression, or loss of PTEN expression, phospho-4EBP1 was more frequently elevated compared with tumors without a known activating event in the PI3K pathway (55/72; 76% vs 3/8, 38%; P=0.033). These findings suggest that activation of the PI3K/Akt pathway via activating mutation of PIK3CA, loss of PTEN, or IGF1R expression have a role in round cell transformation. The PI3K/Akt pathway may therefore provide a therapeutic target in round cell liposarcoma.",
"genre": "research_article",
"id": "sg:pub.10.1038/modpathol.2011.148",
"inLanguage": [
"en"
],
"isAccessibleForFree": true,
"isFundedItemOf": [
{
"id": "sg:grant.2480275",
"type": "MonetaryGrant"
}
],
"isPartOf": [
{
"id": "sg:journal.1098208",
"issn": [
"0893-3952",
"1530-0285"
],
"name": "Modern Pathology",
"type": "Periodical"
},
{
"issueNumber": "2",
"type": "PublicationIssue"
},
{
"type": "PublicationVolume",
"volumeNumber": "25"
}
],
"name": "Involvement of the PI3K/Akt pathway in myxoid/round cell liposarcoma",
"pagination": "modpathol2011148",
"productId": [
{
"name": "readcube_id",
"type": "PropertyValue",
"value": [
"7aaa330dc268a9fd289f1a70bcd8839e4967cd77b15abefa00b72ae2ba8eaa4c"
]
},
{
"name": "pubmed_id",
"type": "PropertyValue",
"value": [
"22020193"
]
},
{
"name": "nlm_unique_id",
"type": "PropertyValue",
"value": [
"8806605"
]
},
{
"name": "doi",
"type": "PropertyValue",
"value": [
"10.1038/modpathol.2011.148"
]
},
{
"name": "dimensions_id",
"type": "PropertyValue",
"value": [
"pub.1025747772"
]
}
],
"sameAs": [
"https://doi.org/10.1038/modpathol.2011.148",
"https://app.dimensions.ai/details/publication/pub.1025747772"
],
"sdDataset": "articles",
"sdDatePublished": "2019-04-10T20:34",
"sdLicense": "https://scigraph.springernature.com/explorer/license/",
"sdPublisher": {
"name": "Springer Nature - SN SciGraph project",
"type": "Organization"
},
"sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8684_00000424.jsonl",
"type": "ScholarlyArticle",
"url": "http://www.nature.com/articles/modpathol2011148"
}
]
Download the RDF metadata as: json-ld nt turtle xml License info
JSON-LD is a popular format for linked data which is fully compatible with JSON.
curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/modpathol.2011.148'
N-Triples is a line-based linked data format ideal for batch operations.
curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/modpathol.2011.148'
Turtle is a human-readable linked data format.
curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/modpathol.2011.148'
RDF/XML is a standard XML format for linked data.
curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/modpathol.2011.148'
This table displays all metadata directly associated to this object as RDF triples.
320 TRIPLES
21 PREDICATES
78 URIs
41 LITERALS
29 BLANK NODES