Improved demonstration of immunohistochemical prognostic markers for survival in follicular lymphoma cells View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2011-01-14

AUTHORS

Francisca I Camacho, Carmen Bellas, Cesáreo Corbacho, Alexia Caleo, Reyes Arranz-Sáez, Jimena Cannata, Javier Menárguez, Lydia Sánchez-Verde, Leocricia González-Camacho, Ma Elena Pérez-Martín, Miguel A Martínez-González, Tomás Álvaro, Manuela Mollejo, Carmen Ruíz-Marcellán, Carlos Montalbán, Miguel A Piris

ABSTRACT

Follicular lymphoma (FL) is one of the most common forms of the low-grade non-Hodgkin's lymphoma in adults, with a characteristic translocation, t(14;18)(q32;q21) that deregulates the expression of the BCL2 gene. The clinical course of FL patients is variable, whereby a subset of patients survive for long periods even without relapses, whereas the majority have frequent relapses with shorter survival. We have analyzed a series of 186 FLs, studying the correlation between clinical outcome and the tumor cell expression of a set of immunohistochemical markers, using an automated procedure for tissue microarrays to reduce the subjectivity of scoring. The results identified several markers associated with differences in overall survival (OS) in univariate analyses, such as Cyclin E, Mdm2, CD10, p21, IgD, Bcl-xL, CD30, and E2F6. Cases with a higher level of expression of Cyclin E, Mdm2, p21, IgD, Bcl-xL, CD30, and E2F6 were associated with a significantly shorter OS. On the other hand, strong CD10 expression was linked to a significantly better outcome. A Cox model was then constructed, integrating the Follicular Lymphoma International Prognostic Index (FLIPI) score and a restricted selection of three immunohistochemical markers: Cyclin E, Mdm2, and CD10 expression. A potentially useful finding is that the integrated FLIPI plus immunohistochemical model can be used to identify a subset of 26 patients (almost 20% of the total series), with a survival probability of 100% at 5 years. This not only confirms that a group of FL cases may have a very good clinical course, but also indicates that this group can be identified using this integrated clinical and immunohistochemical approach. More... »

PAGES

698-707

Journal

TITLE

Modern Pathology

ISSUE

5

VOLUME

24

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/modpathol.2010.237

DOI

http://dx.doi.org/10.1038/modpathol.2010.237

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1001828190

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/21240256


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