Carbonic anhydrase II. A novel biomarker for gastrointestinal stromal tumors View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2010-05

AUTHORS

Seppo Parkkila, Jerzy Lasota, Jonathan A Fletcher, Wen-bin Ou, Antti J Kivelä, Kyösti Nuorva, Anna-Kaisa Parkkila, Jyrki Ollikainen, William S Sly, Abdul Waheed, Silvia Pastorekova, Jaromir Pastorek, Jorma Isola, Markku Miettinen

ABSTRACT

Gastrointestinal stromal tumors (GISTs) are clinically distinct mesenchymal tumors, which generally result from expression of mutant KIT or PDGFRA receptor tyrosine kinase oncogenes. Most GISTs feature strong expression of KIT that serves as a crucial diagnostic adjunct. However, a subset of tumors lacks KIT expression and otherwise may also be difficult to distinguish from other sarcomas, including leiomyosarcoma. Because various carbonic anhydrase (CA) isozymes have been identified as potential treatment targets against different cancers, we evaluated CA II expression in 175 GISTs. Western blotting experiments indicated that CA II is highly expressed in GIST cell lines. Immunohistochemically, 95% of GISTs showed positive signal. The CA II expression in GISTs did not correlate with particular KIT or PDGFRA mutation types. CA II immunoreactivity was absent or low in other mesenchymal tumor categories analyzed. High CA II expression was associated with a better disease-specific survival rate than low or no expression (Mantel-Cox test, P<0.0001). The present results indicate that CA II is overexpressed in most GISTs, is quite selective to this tumor type among mesenchymal tumors, and therefore might be a useful biomarker in diagnostics. More... »

PAGES

743

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/modpathol.2009.189

DOI

http://dx.doi.org/10.1038/modpathol.2009.189

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1040318597

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/20081808


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Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/modpathol.2009.189'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/modpathol.2009.189'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/modpathol.2009.189'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/modpathol.2009.189'


 

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302 https://www.grid.ac/institutes/grid.426602.4 schema:alternateName Institute of Virology
303 schema:name Center of Molecular Medicine, Institute of Virology, Slovak Academy of Sciences, Bratislava, Slovak Republic
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306 schema:name Department of Pathology, Jyväskylä Central Hospital, Jyväskylä, Finland
307 Department of Surgery, Jyväskylä Central Hospital, Jyväskylä, Finland
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309 https://www.grid.ac/institutes/grid.496749.1 schema:alternateName Armed Forces Institute of Pathology
310 schema:name Department of Soft Tissue Pathology, Armed Forces Institute of Pathology, Washington, DC, USA
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312 https://www.grid.ac/institutes/grid.5509.9 schema:alternateName University of Tampere
313 schema:name Department of Mathematics and Statistics, University of Tampere, Tampere, Finland
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