A panel of antibodies to determine site of origin and malignancy in smooth muscle tumors View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2009-12

AUTHORS

Cheng-Han Lee, Dmitry A Turbin, Y-C Vanessa Sung, Inigo Espinosa, Kelli Montgomery, Matt van de Rijn, C Blake Gilks

ABSTRACT

Leiomyosarcomas are malignant smooth muscle tumors that occur most commonly in the gynecologic tract and soft tissue. There are different diagnostic criteria of malignancy for smooth muscle tumors arising at gynecologic and soft tissue sites and they may be managed differently but determining the primary site of a smooth muscle tumor can be difficult in some cases. In addition, the distinction between malignant and benign gynecologic tract smooth muscle tumors on morphologic grounds can be challenging. Using a series of tissue microarrays that contain 245 cases of leiomyosarcomas (102 gynecologic) with survival data, and 49 cases of uterine leiomyoma, we examined the ability of selected immune-markers (estrogen receptor (ER) and WT1) to distinguish between leiomyosarcomas of gynecologic and nongynecologic origin. In addition, we examined whether immunostains for p16, p53 and Ki-67 could distinguish between malignant and benign gynecologic smooth muscle tumors. ER nuclear positivity was observed in 3 and 50% of the nongynecologic and gynecologic leiomyosarcomas, respectively (P<0.001). Nuclear WT1 positivity was seen in 0 and 8% of the nongynecologic and gynecologic leiomyosarcomas, respectively (P<0.001). 87% of primary gynecologic leiomyosarcomas and 2% of uterine leiomyomas showed diffuse (>or=50% of cells) p16 staining (P<0.001). 23% of gynecologic leiomyosarcomas showed p53 immunopositivity (>or=50% of cells) whereas none of the leiomyomas were positive for p53 (P<0.001). 65% of the gynecologic leiomyosarcomas and 0% of the leiomyomas exhibited >10% Ki-67 proliferation index (P<0.001). Diffuse p16 and p53 immunopositivity and high Ki-67 proliferation index, singly or in combination, yielded an overall sensitivity of 92% and specificity of 98% for distinguishing between gynecologic leiomyosarcomas and leiomyomas and can be used as indicators of malignancy for gynecologic smooth muscle tumors. Although ER positivity can be used to support the gynecologic origin of a leiomyosarcomas, nuclear WT1 immunostaining is of little use. More... »

PAGES

1519

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/modpathol.2009.122

DOI

http://dx.doi.org/10.1038/modpathol.2009.122

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1002470538

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/19734847


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1116", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical Physiology", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Adult", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Antibodies", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Biomarkers, Tumor", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Canada", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cell Nucleus", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cyclin-Dependent Kinase Inhibitor p16", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Diagnosis, Differential", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Europe", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Female", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Immunohistochemistry", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Kaplan-Meier Estimate", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Ki-67 Antigen", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Leiomyoma", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Leiomyosarcoma", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Male", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Middle Aged", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Muscle Neoplasms", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Muscle, Smooth", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Predictive Value of Tests", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Receptors, Estrogen", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Sensitivity and Specificity", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Tissue Array Analysis", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Tumor Suppressor Protein p53", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "United States", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Uterine Neoplasms", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "WT1 Proteins", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "University of British Columbia", 
          "id": "https://www.grid.ac/institutes/grid.17091.3e", 
          "name": [
            "Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver General Hospital, Vancouver, BC, Canada"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Lee", 
        "givenName": "Cheng-Han", 
        "id": "sg:person.0777615543.62", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0777615543.62"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of British Columbia", 
          "id": "https://www.grid.ac/institutes/grid.17091.3e", 
          "name": [
            "Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver General Hospital, Vancouver, BC, Canada"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Turbin", 
        "givenName": "Dmitry A", 
        "id": "sg:person.01134051654.56", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01134051654.56"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of British Columbia", 
          "id": "https://www.grid.ac/institutes/grid.17091.3e", 
          "name": [
            "Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver General Hospital, Vancouver, BC, Canada"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Sung", 
        "givenName": "Y-C Vanessa", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Hospital de Sant Pau", 
          "id": "https://www.grid.ac/institutes/grid.413396.a", 
          "name": [
            "Department of Pathology, Hospital de la Santa Creu i Sant Pau, Barcelona, Spain"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Espinosa", 
        "givenName": "Inigo", 
        "id": "sg:person.01264471130.83", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01264471130.83"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Stanford Medicine", 
          "id": "https://www.grid.ac/institutes/grid.240952.8", 
          "name": [
            "Department of Pathology, Stanford University Medical Center, Stanford, CA, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Montgomery", 
        "givenName": "Kelli", 
        "id": "sg:person.0673466335.52", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0673466335.52"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Stanford Medicine", 
          "id": "https://www.grid.ac/institutes/grid.240952.8", 
          "name": [
            "Department of Pathology, Stanford University Medical Center, Stanford, CA, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "van de Rijn", 
        "givenName": "Matt", 
        "id": "sg:person.0737427052.58", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0737427052.58"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of British Columbia", 
          "id": "https://www.grid.ac/institutes/grid.17091.3e", 
          "name": [
            "Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver General Hospital, Vancouver, BC, Canada"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Gilks", 
        "givenName": "C Blake", 
        "id": "sg:person.01120560217.98", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01120560217.98"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.1016/0046-8177(95)90136-1", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1001721310"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1369/jhc.7a7333.2007", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1002926949"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1369/jhc.7a7333.2007", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1002926949"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/pgp.0b013e31815ea7f5", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1005549403"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/pgp.0b013e31815ea7f5", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1005549403"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1365-2559.2005.02292.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1006026850"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1365-2559.2005.02292.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1006026850"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0046-8177(98)90393-8", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1007381179"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.ygyno.2003.10.028", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1007898506"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.ejca.2007.04.008", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1008531325"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1365-2559.2007.02699.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1009400753"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.fertnstert.2004.02.130", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1009507818"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1006/gyno.1997.4653", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1010681420"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00004347-199504000-00007", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1012157117"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00004347-199504000-00007", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1012157117"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00129039-200412000-00008", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1015661960"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00129039-200412000-00008", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1015661960"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/pas.0b013e3181574d1e", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1022322284"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/pas.0b013e3181574d1e", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1022322284"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1159/000080933", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1024798060"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.fertnstert.2003.08.043", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1025308626"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1006/gyno.1997.4634", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1026367828"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/pas.0b013e3181a02d1c", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1026660231"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/pas.0b013e3181a02d1c", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1026660231"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/pas.0b013e3181a02d1c", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1026660231"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00129039-200106000-00009", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1027482177"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00129039-200106000-00009", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1027482177"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1006/gyno.1997.4889", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1028056874"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/cncr.20521", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1029319376"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/pai.0b013e31815c2e02", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1033013464"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/pai.0b013e31815c2e02", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1033013464"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.0001-6349.2004.00502.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035636778"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00022744-200106000-00009", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035778966"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00022744-200106000-00009", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035778966"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1006/gyno.1994.1194", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1036529698"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.ygyno.2005.05.019", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1036631690"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.2353/ajpath.2009.081037", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1038843671"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.2353/ajpath.2009.081037", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1038843671"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1365-2559.1996.tb01394.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1042295721"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00004347-199901000-00004", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1043696805"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00004347-199901000-00004", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1043696805"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1525-1438.2006.00542.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1043808912"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1158/1078-0432.ccr-07-1712", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1045614116"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.ygyno.2004.09.026", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1046120823"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/01.cco.0000127721.55676.f6", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1046439205"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/01.cco.0000127721.55676.f6", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1046439205"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1053/hupa.2001.27113", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1052754799"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/pgp.0b013e3180ca954f", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1053308295"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/pgp.0b013e3180ca954f", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1053308295"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1074554941", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1074584391", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1075265123", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1177/107327480501200102", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1076997996"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1177/107327480501200102", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1076997996"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1077583720", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1043/1543-2165(2008)132[175:iigp]2.0.co;2", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1077603614"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1083080422", 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2009-12", 
    "datePublishedReg": "2009-12-01", 
    "description": "Leiomyosarcomas are malignant smooth muscle tumors that occur most commonly in the gynecologic tract and soft tissue. There are different diagnostic criteria of malignancy for smooth muscle tumors arising at gynecologic and soft tissue sites and they may be managed differently but determining the primary site of a smooth muscle tumor can be difficult in some cases. In addition, the distinction between malignant and benign gynecologic tract smooth muscle tumors on morphologic grounds can be challenging. Using a series of tissue microarrays that contain 245 cases of leiomyosarcomas (102 gynecologic) with survival data, and 49 cases of uterine leiomyoma, we examined the ability of selected immune-markers (estrogen receptor (ER) and WT1) to distinguish between leiomyosarcomas of gynecologic and nongynecologic origin. In addition, we examined whether immunostains for p16, p53 and Ki-67 could distinguish between malignant and benign gynecologic smooth muscle tumors. ER nuclear positivity was observed in 3 and 50% of the nongynecologic and gynecologic leiomyosarcomas, respectively (P<0.001). Nuclear WT1 positivity was seen in 0 and 8% of the nongynecologic and gynecologic leiomyosarcomas, respectively (P<0.001). 87% of primary gynecologic leiomyosarcomas and 2% of uterine leiomyomas showed diffuse (>or=50% of cells) p16 staining (P<0.001). 23% of gynecologic leiomyosarcomas showed p53 immunopositivity (>or=50% of cells) whereas none of the leiomyomas were positive for p53 (P<0.001). 65% of the gynecologic leiomyosarcomas and 0% of the leiomyomas exhibited >10% Ki-67 proliferation index (P<0.001). Diffuse p16 and p53 immunopositivity and high Ki-67 proliferation index, singly or in combination, yielded an overall sensitivity of 92% and specificity of 98% for distinguishing between gynecologic leiomyosarcomas and leiomyomas and can be used as indicators of malignancy for gynecologic smooth muscle tumors. Although ER positivity can be used to support the gynecologic origin of a leiomyosarcomas, nuclear WT1 immunostaining is of little use.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1038/modpathol.2009.122", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": true, 
    "isFundedItemOf": [
      {
        "id": "sg:grant.2477881", 
        "type": "MonetaryGrant"
      }
    ], 
    "isPartOf": [
      {
        "id": "sg:journal.1098208", 
        "issn": [
          "0893-3952", 
          "1530-0285"
        ], 
        "name": "Modern Pathology", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "12", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "22"
      }
    ], 
    "name": "A panel of antibodies to determine site of origin and malignancy in smooth muscle tumors", 
    "pagination": "1519", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "0bc3186eadc791487e82975e5288ac4f58f6379c369a612c8bde8ec83f37a236"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "19734847"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "8806605"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1038/modpathol.2009.122"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1002470538"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1038/modpathol.2009.122", 
      "https://app.dimensions.ai/details/publication/pub.1002470538"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-11T09:32", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000346_0000000346/records_99809_00000000.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://www.nature.com/articles/modpathol2009122"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/modpathol.2009.122'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/modpathol.2009.122'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/modpathol.2009.122'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/modpathol.2009.122'


 

This table displays all metadata directly associated to this object as RDF triples.

344 TRIPLES      21 PREDICATES      97 URIs      48 LITERALS      36 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1038/modpathol.2009.122 schema:about N00a931acb5be424b97c77255890fb5b2
2 N116dd99f5cd14e3181fa160f10801838
3 N2af29bb471c5442a9538e283608c628b
4 N45468fc1ed554f0098cc627815f49436
5 N4f8ab2a29a964ab0a69f2c6bef0ea2c0
6 N506519789db04253b77f7c4c7f0b135d
7 N5a69ca2333ea4cdfbded30a274c472d1
8 N5ab49ceedcdc419da865b41ce0eb1d5c
9 N5b86f678c80c437d832afc5706c2a46b
10 N696adb0800234846901a34be2f027f62
11 N6d6d8a6412c34b12a7da4b2811410215
12 N7ab5ac2330ae44f488e35bf73a0cf4bf
13 N8b0d14ac1c964614a71831509dae776a
14 N92955933f7914d1bbbfa62af3ff30ca3
15 Na46ea91bb87e438ab2f2da41034a8f6f
16 Na53236ae5a144f77be9de60439520172
17 Naea9036376ad437e9b53cfaa518dc6cb
18 Nbd87c37f34c442708211e6be9a7d88b4
19 Nc2d8318f05aa4ef4b1e5ea10f6b75809
20 Nc503042a24864abb88cce7d36be389a8
21 Nd73c1b99ec144ed39196de91a25993c4
22 Ne94a7b2820214912a9cc0c31c205c55f
23 Nef14837c2d8344039ba73db969ea3916
24 Nf05beceb826549679baef1510f250ea3
25 Nf521665b6d8d49e49cc59cefd0c637c4
26 Nf9ae3f2dd63d44609e3eeccc2903b5b1
27 Nfd3eaafd9ffc4719a0d45160cb524922
28 anzsrc-for:11
29 anzsrc-for:1116
30 schema:author Nd1c17777371046bbb7e4154dd711403b
31 schema:citation https://app.dimensions.ai/details/publication/pub.1074554941
32 https://app.dimensions.ai/details/publication/pub.1074584391
33 https://app.dimensions.ai/details/publication/pub.1075265123
34 https://app.dimensions.ai/details/publication/pub.1077583720
35 https://app.dimensions.ai/details/publication/pub.1083080422
36 https://doi.org/10.1002/cncr.20521
37 https://doi.org/10.1006/gyno.1994.1194
38 https://doi.org/10.1006/gyno.1997.4634
39 https://doi.org/10.1006/gyno.1997.4653
40 https://doi.org/10.1006/gyno.1997.4889
41 https://doi.org/10.1016/0046-8177(95)90136-1
42 https://doi.org/10.1016/j.ejca.2007.04.008
43 https://doi.org/10.1016/j.fertnstert.2003.08.043
44 https://doi.org/10.1016/j.fertnstert.2004.02.130
45 https://doi.org/10.1016/j.ygyno.2003.10.028
46 https://doi.org/10.1016/j.ygyno.2004.09.026
47 https://doi.org/10.1016/j.ygyno.2005.05.019
48 https://doi.org/10.1016/s0046-8177(98)90393-8
49 https://doi.org/10.1043/1543-2165(2008)132[175:iigp]2.0.co;2
50 https://doi.org/10.1053/hupa.2001.27113
51 https://doi.org/10.1097/00004347-199504000-00007
52 https://doi.org/10.1097/00004347-199901000-00004
53 https://doi.org/10.1097/00022744-200106000-00009
54 https://doi.org/10.1097/00129039-200106000-00009
55 https://doi.org/10.1097/00129039-200412000-00008
56 https://doi.org/10.1097/01.cco.0000127721.55676.f6
57 https://doi.org/10.1097/pai.0b013e31815c2e02
58 https://doi.org/10.1097/pas.0b013e3181574d1e
59 https://doi.org/10.1097/pas.0b013e3181a02d1c
60 https://doi.org/10.1097/pgp.0b013e3180ca954f
61 https://doi.org/10.1097/pgp.0b013e31815ea7f5
62 https://doi.org/10.1111/j.0001-6349.2004.00502.x
63 https://doi.org/10.1111/j.1365-2559.1996.tb01394.x
64 https://doi.org/10.1111/j.1365-2559.2005.02292.x
65 https://doi.org/10.1111/j.1365-2559.2007.02699.x
66 https://doi.org/10.1111/j.1525-1438.2006.00542.x
67 https://doi.org/10.1158/1078-0432.ccr-07-1712
68 https://doi.org/10.1159/000080933
69 https://doi.org/10.1177/107327480501200102
70 https://doi.org/10.1369/jhc.7a7333.2007
71 https://doi.org/10.2353/ajpath.2009.081037
72 schema:datePublished 2009-12
73 schema:datePublishedReg 2009-12-01
74 schema:description Leiomyosarcomas are malignant smooth muscle tumors that occur most commonly in the gynecologic tract and soft tissue. There are different diagnostic criteria of malignancy for smooth muscle tumors arising at gynecologic and soft tissue sites and they may be managed differently but determining the primary site of a smooth muscle tumor can be difficult in some cases. In addition, the distinction between malignant and benign gynecologic tract smooth muscle tumors on morphologic grounds can be challenging. Using a series of tissue microarrays that contain 245 cases of leiomyosarcomas (102 gynecologic) with survival data, and 49 cases of uterine leiomyoma, we examined the ability of selected immune-markers (estrogen receptor (ER) and WT1) to distinguish between leiomyosarcomas of gynecologic and nongynecologic origin. In addition, we examined whether immunostains for p16, p53 and Ki-67 could distinguish between malignant and benign gynecologic smooth muscle tumors. ER nuclear positivity was observed in 3 and 50% of the nongynecologic and gynecologic leiomyosarcomas, respectively (P<0.001). Nuclear WT1 positivity was seen in 0 and 8% of the nongynecologic and gynecologic leiomyosarcomas, respectively (P<0.001). 87% of primary gynecologic leiomyosarcomas and 2% of uterine leiomyomas showed diffuse (>or=50% of cells) p16 staining (P<0.001). 23% of gynecologic leiomyosarcomas showed p53 immunopositivity (>or=50% of cells) whereas none of the leiomyomas were positive for p53 (P<0.001). 65% of the gynecologic leiomyosarcomas and 0% of the leiomyomas exhibited >10% Ki-67 proliferation index (P<0.001). Diffuse p16 and p53 immunopositivity and high Ki-67 proliferation index, singly or in combination, yielded an overall sensitivity of 92% and specificity of 98% for distinguishing between gynecologic leiomyosarcomas and leiomyomas and can be used as indicators of malignancy for gynecologic smooth muscle tumors. Although ER positivity can be used to support the gynecologic origin of a leiomyosarcomas, nuclear WT1 immunostaining is of little use.
75 schema:genre research_article
76 schema:inLanguage en
77 schema:isAccessibleForFree true
78 schema:isPartOf N4d5354ed32b34983acfe6827e8b51fc6
79 N9483072afb7341538416328928d26961
80 sg:journal.1098208
81 schema:name A panel of antibodies to determine site of origin and malignancy in smooth muscle tumors
82 schema:pagination 1519
83 schema:productId N1052db7e8b0b404eaf27140bf6c1e38e
84 Nb3ddf79e901f42a7ac7f677336031d72
85 Nd2cdc06f60df46bfbc7b6a37fa95774b
86 Ne33741f853fc439a923ed86cc9208185
87 Nf3a10d5cdd194185a1e86ef22d3488af
88 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002470538
89 https://doi.org/10.1038/modpathol.2009.122
90 schema:sdDatePublished 2019-04-11T09:32
91 schema:sdLicense https://scigraph.springernature.com/explorer/license/
92 schema:sdPublisher Nfdca83366d8d4103af2f57409ba3099e
93 schema:url https://www.nature.com/articles/modpathol2009122
94 sgo:license sg:explorer/license/
95 sgo:sdDataset articles
96 rdf:type schema:ScholarlyArticle
97 N00a931acb5be424b97c77255890fb5b2 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
98 schema:name Tissue Array Analysis
99 rdf:type schema:DefinedTerm
100 N1052db7e8b0b404eaf27140bf6c1e38e schema:name readcube_id
101 schema:value 0bc3186eadc791487e82975e5288ac4f58f6379c369a612c8bde8ec83f37a236
102 rdf:type schema:PropertyValue
103 N116dd99f5cd14e3181fa160f10801838 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
104 schema:name Muscle, Smooth
105 rdf:type schema:DefinedTerm
106 N26c5b107db1b4196bf833d75b042b1a3 rdf:first sg:person.0673466335.52
107 rdf:rest N546dcd6473824536bf6ac2ebeb81f9a5
108 N2af29bb471c5442a9538e283608c628b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
109 schema:name Kaplan-Meier Estimate
110 rdf:type schema:DefinedTerm
111 N394bb5ceff5847339fecc7c303366f58 schema:affiliation https://www.grid.ac/institutes/grid.17091.3e
112 schema:familyName Sung
113 schema:givenName Y-C Vanessa
114 rdf:type schema:Person
115 N45468fc1ed554f0098cc627815f49436 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
116 schema:name United States
117 rdf:type schema:DefinedTerm
118 N4d5354ed32b34983acfe6827e8b51fc6 schema:volumeNumber 22
119 rdf:type schema:PublicationVolume
120 N4f8ab2a29a964ab0a69f2c6bef0ea2c0 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
121 schema:name Europe
122 rdf:type schema:DefinedTerm
123 N506519789db04253b77f7c4c7f0b135d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
124 schema:name Leiomyoma
125 rdf:type schema:DefinedTerm
126 N546dcd6473824536bf6ac2ebeb81f9a5 rdf:first sg:person.0737427052.58
127 rdf:rest N7c398b2349d64bc8aa4bd389fb70d59d
128 N5a69ca2333ea4cdfbded30a274c472d1 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
129 schema:name Tumor Suppressor Protein p53
130 rdf:type schema:DefinedTerm
131 N5ab49ceedcdc419da865b41ce0eb1d5c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
132 schema:name Cell Nucleus
133 rdf:type schema:DefinedTerm
134 N5b86f678c80c437d832afc5706c2a46b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
135 schema:name Adult
136 rdf:type schema:DefinedTerm
137 N696adb0800234846901a34be2f027f62 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
138 schema:name Leiomyosarcoma
139 rdf:type schema:DefinedTerm
140 N6a0be2739c8c4f989efecb9e5d053601 rdf:first sg:person.01134051654.56
141 rdf:rest N7b70756374f74e5695175a965312a177
142 N6d6d8a6412c34b12a7da4b2811410215 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
143 schema:name Female
144 rdf:type schema:DefinedTerm
145 N7ab5ac2330ae44f488e35bf73a0cf4bf schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
146 schema:name Sensitivity and Specificity
147 rdf:type schema:DefinedTerm
148 N7b70756374f74e5695175a965312a177 rdf:first N394bb5ceff5847339fecc7c303366f58
149 rdf:rest Nee5b8af2f6d1443f91135a2846b5be3c
150 N7c398b2349d64bc8aa4bd389fb70d59d rdf:first sg:person.01120560217.98
151 rdf:rest rdf:nil
152 N8b0d14ac1c964614a71831509dae776a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
153 schema:name Ki-67 Antigen
154 rdf:type schema:DefinedTerm
155 N92955933f7914d1bbbfa62af3ff30ca3 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
156 schema:name Humans
157 rdf:type schema:DefinedTerm
158 N9483072afb7341538416328928d26961 schema:issueNumber 12
159 rdf:type schema:PublicationIssue
160 Na46ea91bb87e438ab2f2da41034a8f6f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
161 schema:name Cyclin-Dependent Kinase Inhibitor p16
162 rdf:type schema:DefinedTerm
163 Na53236ae5a144f77be9de60439520172 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
164 schema:name Canada
165 rdf:type schema:DefinedTerm
166 Naea9036376ad437e9b53cfaa518dc6cb schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
167 schema:name Receptors, Estrogen
168 rdf:type schema:DefinedTerm
169 Nb3ddf79e901f42a7ac7f677336031d72 schema:name nlm_unique_id
170 schema:value 8806605
171 rdf:type schema:PropertyValue
172 Nbd87c37f34c442708211e6be9a7d88b4 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
173 schema:name WT1 Proteins
174 rdf:type schema:DefinedTerm
175 Nc2d8318f05aa4ef4b1e5ea10f6b75809 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
176 schema:name Muscle Neoplasms
177 rdf:type schema:DefinedTerm
178 Nc503042a24864abb88cce7d36be389a8 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
179 schema:name Diagnosis, Differential
180 rdf:type schema:DefinedTerm
181 Nd1c17777371046bbb7e4154dd711403b rdf:first sg:person.0777615543.62
182 rdf:rest N6a0be2739c8c4f989efecb9e5d053601
183 Nd2cdc06f60df46bfbc7b6a37fa95774b schema:name dimensions_id
184 schema:value pub.1002470538
185 rdf:type schema:PropertyValue
186 Nd73c1b99ec144ed39196de91a25993c4 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
187 schema:name Predictive Value of Tests
188 rdf:type schema:DefinedTerm
189 Ne33741f853fc439a923ed86cc9208185 schema:name pubmed_id
190 schema:value 19734847
191 rdf:type schema:PropertyValue
192 Ne94a7b2820214912a9cc0c31c205c55f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
193 schema:name Uterine Neoplasms
194 rdf:type schema:DefinedTerm
195 Nee5b8af2f6d1443f91135a2846b5be3c rdf:first sg:person.01264471130.83
196 rdf:rest N26c5b107db1b4196bf833d75b042b1a3
197 Nef14837c2d8344039ba73db969ea3916 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
198 schema:name Middle Aged
199 rdf:type schema:DefinedTerm
200 Nf05beceb826549679baef1510f250ea3 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
201 schema:name Male
202 rdf:type schema:DefinedTerm
203 Nf3a10d5cdd194185a1e86ef22d3488af schema:name doi
204 schema:value 10.1038/modpathol.2009.122
205 rdf:type schema:PropertyValue
206 Nf521665b6d8d49e49cc59cefd0c637c4 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
207 schema:name Immunohistochemistry
208 rdf:type schema:DefinedTerm
209 Nf9ae3f2dd63d44609e3eeccc2903b5b1 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
210 schema:name Biomarkers, Tumor
211 rdf:type schema:DefinedTerm
212 Nfd3eaafd9ffc4719a0d45160cb524922 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
213 schema:name Antibodies
214 rdf:type schema:DefinedTerm
215 Nfdca83366d8d4103af2f57409ba3099e schema:name Springer Nature - SN SciGraph project
216 rdf:type schema:Organization
217 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
218 schema:name Medical and Health Sciences
219 rdf:type schema:DefinedTerm
220 anzsrc-for:1116 schema:inDefinedTermSet anzsrc-for:
221 schema:name Medical Physiology
222 rdf:type schema:DefinedTerm
223 sg:grant.2477881 http://pending.schema.org/fundedItem sg:pub.10.1038/modpathol.2009.122
224 rdf:type schema:MonetaryGrant
225 sg:journal.1098208 schema:issn 0893-3952
226 1530-0285
227 schema:name Modern Pathology
228 rdf:type schema:Periodical
229 sg:person.01120560217.98 schema:affiliation https://www.grid.ac/institutes/grid.17091.3e
230 schema:familyName Gilks
231 schema:givenName C Blake
232 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01120560217.98
233 rdf:type schema:Person
234 sg:person.01134051654.56 schema:affiliation https://www.grid.ac/institutes/grid.17091.3e
235 schema:familyName Turbin
236 schema:givenName Dmitry A
237 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01134051654.56
238 rdf:type schema:Person
239 sg:person.01264471130.83 schema:affiliation https://www.grid.ac/institutes/grid.413396.a
240 schema:familyName Espinosa
241 schema:givenName Inigo
242 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01264471130.83
243 rdf:type schema:Person
244 sg:person.0673466335.52 schema:affiliation https://www.grid.ac/institutes/grid.240952.8
245 schema:familyName Montgomery
246 schema:givenName Kelli
247 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0673466335.52
248 rdf:type schema:Person
249 sg:person.0737427052.58 schema:affiliation https://www.grid.ac/institutes/grid.240952.8
250 schema:familyName van de Rijn
251 schema:givenName Matt
252 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0737427052.58
253 rdf:type schema:Person
254 sg:person.0777615543.62 schema:affiliation https://www.grid.ac/institutes/grid.17091.3e
255 schema:familyName Lee
256 schema:givenName Cheng-Han
257 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0777615543.62
258 rdf:type schema:Person
259 https://app.dimensions.ai/details/publication/pub.1074554941 schema:CreativeWork
260 https://app.dimensions.ai/details/publication/pub.1074584391 schema:CreativeWork
261 https://app.dimensions.ai/details/publication/pub.1075265123 schema:CreativeWork
262 https://app.dimensions.ai/details/publication/pub.1077583720 schema:CreativeWork
263 https://app.dimensions.ai/details/publication/pub.1083080422 schema:CreativeWork
264 https://doi.org/10.1002/cncr.20521 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029319376
265 rdf:type schema:CreativeWork
266 https://doi.org/10.1006/gyno.1994.1194 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036529698
267 rdf:type schema:CreativeWork
268 https://doi.org/10.1006/gyno.1997.4634 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026367828
269 rdf:type schema:CreativeWork
270 https://doi.org/10.1006/gyno.1997.4653 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010681420
271 rdf:type schema:CreativeWork
272 https://doi.org/10.1006/gyno.1997.4889 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028056874
273 rdf:type schema:CreativeWork
274 https://doi.org/10.1016/0046-8177(95)90136-1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001721310
275 rdf:type schema:CreativeWork
276 https://doi.org/10.1016/j.ejca.2007.04.008 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008531325
277 rdf:type schema:CreativeWork
278 https://doi.org/10.1016/j.fertnstert.2003.08.043 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025308626
279 rdf:type schema:CreativeWork
280 https://doi.org/10.1016/j.fertnstert.2004.02.130 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009507818
281 rdf:type schema:CreativeWork
282 https://doi.org/10.1016/j.ygyno.2003.10.028 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007898506
283 rdf:type schema:CreativeWork
284 https://doi.org/10.1016/j.ygyno.2004.09.026 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046120823
285 rdf:type schema:CreativeWork
286 https://doi.org/10.1016/j.ygyno.2005.05.019 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036631690
287 rdf:type schema:CreativeWork
288 https://doi.org/10.1016/s0046-8177(98)90393-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007381179
289 rdf:type schema:CreativeWork
290 https://doi.org/10.1043/1543-2165(2008)132[175:iigp]2.0.co;2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1077603614
291 rdf:type schema:CreativeWork
292 https://doi.org/10.1053/hupa.2001.27113 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052754799
293 rdf:type schema:CreativeWork
294 https://doi.org/10.1097/00004347-199504000-00007 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012157117
295 rdf:type schema:CreativeWork
296 https://doi.org/10.1097/00004347-199901000-00004 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043696805
297 rdf:type schema:CreativeWork
298 https://doi.org/10.1097/00022744-200106000-00009 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035778966
299 rdf:type schema:CreativeWork
300 https://doi.org/10.1097/00129039-200106000-00009 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027482177
301 rdf:type schema:CreativeWork
302 https://doi.org/10.1097/00129039-200412000-00008 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015661960
303 rdf:type schema:CreativeWork
304 https://doi.org/10.1097/01.cco.0000127721.55676.f6 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046439205
305 rdf:type schema:CreativeWork
306 https://doi.org/10.1097/pai.0b013e31815c2e02 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033013464
307 rdf:type schema:CreativeWork
308 https://doi.org/10.1097/pas.0b013e3181574d1e schema:sameAs https://app.dimensions.ai/details/publication/pub.1022322284
309 rdf:type schema:CreativeWork
310 https://doi.org/10.1097/pas.0b013e3181a02d1c schema:sameAs https://app.dimensions.ai/details/publication/pub.1026660231
311 rdf:type schema:CreativeWork
312 https://doi.org/10.1097/pgp.0b013e3180ca954f schema:sameAs https://app.dimensions.ai/details/publication/pub.1053308295
313 rdf:type schema:CreativeWork
314 https://doi.org/10.1097/pgp.0b013e31815ea7f5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005549403
315 rdf:type schema:CreativeWork
316 https://doi.org/10.1111/j.0001-6349.2004.00502.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1035636778
317 rdf:type schema:CreativeWork
318 https://doi.org/10.1111/j.1365-2559.1996.tb01394.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1042295721
319 rdf:type schema:CreativeWork
320 https://doi.org/10.1111/j.1365-2559.2005.02292.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1006026850
321 rdf:type schema:CreativeWork
322 https://doi.org/10.1111/j.1365-2559.2007.02699.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1009400753
323 rdf:type schema:CreativeWork
324 https://doi.org/10.1111/j.1525-1438.2006.00542.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1043808912
325 rdf:type schema:CreativeWork
326 https://doi.org/10.1158/1078-0432.ccr-07-1712 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045614116
327 rdf:type schema:CreativeWork
328 https://doi.org/10.1159/000080933 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024798060
329 rdf:type schema:CreativeWork
330 https://doi.org/10.1177/107327480501200102 schema:sameAs https://app.dimensions.ai/details/publication/pub.1076997996
331 rdf:type schema:CreativeWork
332 https://doi.org/10.1369/jhc.7a7333.2007 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002926949
333 rdf:type schema:CreativeWork
334 https://doi.org/10.2353/ajpath.2009.081037 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038843671
335 rdf:type schema:CreativeWork
336 https://www.grid.ac/institutes/grid.17091.3e schema:alternateName University of British Columbia
337 schema:name Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver General Hospital, Vancouver, BC, Canada
338 rdf:type schema:Organization
339 https://www.grid.ac/institutes/grid.240952.8 schema:alternateName Stanford Medicine
340 schema:name Department of Pathology, Stanford University Medical Center, Stanford, CA, USA
341 rdf:type schema:Organization
342 https://www.grid.ac/institutes/grid.413396.a schema:alternateName Hospital de Sant Pau
343 schema:name Department of Pathology, Hospital de la Santa Creu i Sant Pau, Barcelona, Spain
344 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...