Intraepithelial T cells and prognosis in ovarian carcinoma: novel associations with stage, tumor type, and BRCA1 loss View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2009-03

AUTHORS

Blaise Clarke, Anna V Tinker, Cheng-Han Lee, Subbaya Subramanian, Matt van de Rijn, Dmitry Turbin, Steve Kalloger, Guangming Han, Kathy Ceballos, Mark G Cadungog, David G Huntsman, George Coukos, C Blake Gilks

ABSTRACT

Intraepithelial tumor-infiltrating T cells have been correlated with improved outcomes in ovarian carcinoma, however, it is not known whether there is an association with disease stage, histological subtype, or BRCA mutation/expression. Two case series of ovarian carcinomas were included in the study; a retrospective series of 500 patients, and 40 prospectively collected cases fully characterized for BRCA1 mutation status and expression. Intraepithelial immune cells were assessed as present or absent by immunohistochemical staining of tissue microarrays. In the retrospective case series, the presence of intraepithelial CD8(+) T-cells correlated with improved disease-specific survival (P=0.027), whereas intraepithelial CD3(+) T cells did not (P=0.49). For serous ovarian carcinomas, the presence of intraepithelial CD3(+) and CD8(+) T-cells correlated with improved disease-specific survival (P=0.0016 and P More... »

PAGES

modpathol2008191

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/modpathol.2008.191

DOI

http://dx.doi.org/10.1038/modpathol.2008.191

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1021329795

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/19060844


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