Classic Kaposi Sarcoma in the United States over the last two decades: A clinicopathologic and molecular study of 438 non-HIV-related ... View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2008-05

AUTHORS

Kim M Hiatt, Ann M Nelson, Jack H Lichy, Julie C Fanburg-Smith

ABSTRACT

Classic Kaposi sarcoma is rare and occurs predominantly in Mediterranean and Middle Eastern men. Since the emergence of acquired immune deficiency syndrome (AIDS)-related Kaposi sarcoma, the incidence, clinicopathologic features, and molecular human herpesvirus 8 (HHV-8) association of American Classic Kaposi Sarcoma has not been fully explored. This study compares Classic Kaposi Sarcoma to AIDS-related Kaposi Sarcoma over the same two decade time period. There were 438 histologically and clinically confirmed Classic Kaposi Sarcoma patients. The ethnic/racial distribution included Caucasian/American (56%), Mediterranean (22%), South American Hispanic (18%), Black (10%), western European (4%), Middle East (4%), Scandinavian (2%), and other (2%). Classic Kaposi Sarcoma was more common in men, 7:1, with a mean age of 74 years. The lesions presented in the lower extremity (69%), in the nodular stage (83%), and HHV-8 was detected by PCR in 40/41 randomly selected cases. A second, non-Classic Kaposi Sarcoma, malignancy was present in 42% (n=45) of the 108 Classic Kaposi Sarcoma patients with complete clinical information, 73% (33 patients) with a higher incidence over the general population. Follow-up of <1–19 years (mean=4.8 years) revealed that 24% of patients died of second malignancy, 22% died of other medical conditions, 2% died of treatment-related complications, and 2% patients died of widespread disease. Thirty-five percent are alive with no evidence of disease and 15% with persistent disease. Human immunodeficiency virus-related Kaposi Sarcoma was observed in 354 cases. There was a male predominance and more aggressive behavior, with higher rates of visceral and disseminated disease. While Classic Kaposi Sarcoma in the United States is an indolent disease and rarely accounts for patient demise, predominantly affecting Caucasian/American males on the lower extremity in the nodular phase, it more importantly may denote an underlying other malignancy. Current PCR probes detect HHV-8 in 98% of Classic Kaposi Sarcoma cases. In comparison, AIDS-related Kaposi Sarcoma is predominately multicentric, visceral, and disseminated, with more aggressive behavior. More... »

PAGES

modpathol200815

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/modpathol.2008.15

DOI

http://dx.doi.org/10.1038/modpathol.2008.15

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1040264819


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1103", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Clinical Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "University of Arkansas for Medical Sciences", 
          "id": "https://www.grid.ac/institutes/grid.241054.6", 
          "name": [
            "Dermatopathology, University of Arkansas for Medical Sciences, Little Rock, AR, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Hiatt", 
        "givenName": "Kim M", 
        "id": "sg:person.012677707243.20", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012677707243.20"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Walter Reed National Military Medical Center", 
          "id": "https://www.grid.ac/institutes/grid.414467.4", 
          "name": [
            "Departments of Infectious Disease, Molecular, and Soft Tissue/Orthopaedic Pathology, Armed Forces Institute of Pathology, Washington, DC, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Nelson", 
        "givenName": "Ann M", 
        "id": "sg:person.0717753402.35", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0717753402.35"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Walter Reed National Military Medical Center", 
          "id": "https://www.grid.ac/institutes/grid.414467.4", 
          "name": [
            "Departments of Infectious Disease, Molecular, and Soft Tissue/Orthopaedic Pathology, Armed Forces Institute of Pathology, Washington, DC, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Lichy", 
        "givenName": "Jack H", 
        "id": "sg:person.01353627553.02", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01353627553.02"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Walter Reed National Military Medical Center", 
          "id": "https://www.grid.ac/institutes/grid.414467.4", 
          "name": [
            "Departments of Infectious Disease, Molecular, and Soft Tissue/Orthopaedic Pathology, Armed Forces Institute of Pathology, Washington, DC, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Fanburg-Smith", 
        "givenName": "Julie C", 
        "id": "sg:person.01325331750.50", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01325331750.50"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "sg:pub.10.1054/bjoc.2001.1912", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1002283476", 
          "https://doi.org/10.1054/bjoc.2001.1912"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1159/000247978", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1004615337"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/bjc.1998.509", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1006612904", 
          "https://doi.org/10.1038/bjc.1998.509"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/bjc.1998.509", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1006612904", 
          "https://doi.org/10.1038/bjc.1998.509"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/(sici)1097-0142(19990401)85:7<1611::aid-cncr25>3.0.co;2-m", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1007093852"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/1097-0142(19800315)45:6<1472::aid-cncr2820450629>3.0.co;2-a", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1008847840"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0889-8588(05)70118-0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1010359557"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1399-0039.1995.tb02427.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1010505257"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/(sici)1097-0215(19971210)73:6<840::aid-ijc13>3.0.co;2-8", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1012905770"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/1097-0142(195903/04)12:2<289::aid-cncr2820120213>3.0.co;2-z", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1014166007"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1086/507648", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1014922493"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/345084a0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1014935163", 
          "https://doi.org/10.1038/345084a0"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00000372-199006000-00006", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1015134096"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00000372-199006000-00006", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1015134096"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1056/nejmcibr063911", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1016065365"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf01830024", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1017280345", 
          "https://doi.org/10.1007/bf01830024"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/(sici)1097-0215(19990118)80:2<178::aid-ijc3>3.0.co;2-l", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1019819476"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/(sici)1097-0215(19990118)80:2<173::aid-ijc2>3.0.co;2-2", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1022098175"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00002030-199602000-00007", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1022848421"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00002030-199602000-00007", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1022848421"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1056/nejm199605023341805", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1024322145"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1046/j.1365-4362.1997.00284.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1031559465"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1056/nejm199505043321810", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1033460763"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0002-9440(10)65568-x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1034981327"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0140-6736(95)91611-3", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1042703876"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0140-6736(95)91611-3", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1042703876"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/jmv.1890470212", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1043038708"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1056/nejm199505043321802", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1044023622"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.93.25.14862", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1047474450"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/bjc.1996.635", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1048498634", 
          "https://doi.org/10.1038/bjc.1996.635"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/bjc.1996.635", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1048498634", 
          "https://doi.org/10.1038/bjc.1996.635"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1001/archderm.133.1.25", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1054100024"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1086/515340", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1058789730"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00000421-199810000-00016", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1060113786"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00000421-199810000-00016", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1060113786"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00000421-199810000-00016", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1060113786"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00042560-200007010-00013", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1060297180"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/science.276.5320.1851", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1062557080"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/science.7997879", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1062650916"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1177/120347549900300305", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1074266321"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1177/120347549900300305", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1074266321"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1074687113", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1074687115", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1074687116", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1074687117", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1074696653", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1082442937", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/oxfordjournals.aje.a117008", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1082655253"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1082843572", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1083089659", 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2008-05", 
    "datePublishedReg": "2008-05-01", 
    "description": "Classic Kaposi sarcoma is rare and occurs predominantly in Mediterranean and Middle Eastern men. Since the emergence of acquired immune deficiency syndrome (AIDS)-related Kaposi sarcoma, the incidence, clinicopathologic features, and molecular human herpesvirus 8 (HHV-8) association of American Classic Kaposi Sarcoma has not been fully explored. This study compares Classic Kaposi Sarcoma to AIDS-related Kaposi Sarcoma over the same two decade time period. There were 438 histologically and clinically confirmed Classic Kaposi Sarcoma patients. The ethnic/racial distribution included Caucasian/American (56%), Mediterranean (22%), South American Hispanic (18%), Black (10%), western European (4%), Middle East (4%), Scandinavian (2%), and other (2%). Classic Kaposi Sarcoma was more common in men, 7:1, with a mean age of 74 years. The lesions presented in the lower extremity (69%), in the nodular stage (83%), and HHV-8 was detected by PCR in 40/41 randomly selected cases. A second, non-Classic Kaposi Sarcoma, malignancy was present in 42% (n=45) of the 108 Classic Kaposi Sarcoma patients with complete clinical information, 73% (33 patients) with a higher incidence over the general population. Follow-up of <1\u201319 years (mean=4.8 years) revealed that 24% of patients died of second malignancy, 22% died of other medical conditions, 2% died of treatment-related complications, and 2% patients died of widespread disease. Thirty-five percent are alive with no evidence of disease and 15% with persistent disease. Human immunodeficiency virus-related Kaposi Sarcoma was observed in 354 cases. There was a male predominance and more aggressive behavior, with higher rates of visceral and disseminated disease. While Classic Kaposi Sarcoma in the United States is an indolent disease and rarely accounts for patient demise, predominantly affecting Caucasian/American males on the lower extremity in the nodular phase, it more importantly may denote an underlying other malignancy. Current PCR probes detect HHV-8 in 98% of Classic Kaposi Sarcoma cases. In comparison, AIDS-related Kaposi Sarcoma is predominately multicentric, visceral, and disseminated, with more aggressive behavior.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1038/modpathol.2008.15", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": true, 
    "isPartOf": [
      {
        "id": "sg:journal.1098208", 
        "issn": [
          "0893-3952", 
          "1530-0285"
        ], 
        "name": "Modern Pathology", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "5", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "21"
      }
    ], 
    "name": "Classic Kaposi Sarcoma in the United States over the last two decades: A clinicopathologic and molecular study of 438 non-HIV-related Kaposi Sarcoma patients with comparison to HIV-related Kaposi Sarcoma", 
    "pagination": "modpathol200815", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "bfce36f381bb5caddb6eb16df093b7b35406532f429cd69bf0e618d1703e6f89"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1038/modpathol.2008.15"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1040264819"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1038/modpathol.2008.15", 
      "https://app.dimensions.ai/details/publication/pub.1040264819"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-10T20:34", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8684_00000425.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "http://www.nature.com/articles/modpathol200815"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/modpathol.2008.15'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/modpathol.2008.15'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/modpathol.2008.15'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/modpathol.2008.15'


 

This table displays all metadata directly associated to this object as RDF triples.

208 TRIPLES      21 PREDICATES      69 URIs      19 LITERALS      7 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1038/modpathol.2008.15 schema:about anzsrc-for:11
2 anzsrc-for:1103
3 schema:author N11114f6d44b04554ae50f38b8036f672
4 schema:citation sg:pub.10.1007/bf01830024
5 sg:pub.10.1038/345084a0
6 sg:pub.10.1038/bjc.1996.635
7 sg:pub.10.1038/bjc.1998.509
8 sg:pub.10.1054/bjoc.2001.1912
9 https://app.dimensions.ai/details/publication/pub.1074687113
10 https://app.dimensions.ai/details/publication/pub.1074687115
11 https://app.dimensions.ai/details/publication/pub.1074687116
12 https://app.dimensions.ai/details/publication/pub.1074687117
13 https://app.dimensions.ai/details/publication/pub.1074696653
14 https://app.dimensions.ai/details/publication/pub.1082442937
15 https://app.dimensions.ai/details/publication/pub.1082843572
16 https://app.dimensions.ai/details/publication/pub.1083089659
17 https://doi.org/10.1001/archderm.133.1.25
18 https://doi.org/10.1002/(sici)1097-0142(19990401)85:7<1611::aid-cncr25>3.0.co;2-m
19 https://doi.org/10.1002/(sici)1097-0215(19971210)73:6<840::aid-ijc13>3.0.co;2-8
20 https://doi.org/10.1002/(sici)1097-0215(19990118)80:2<173::aid-ijc2>3.0.co;2-2
21 https://doi.org/10.1002/(sici)1097-0215(19990118)80:2<178::aid-ijc3>3.0.co;2-l
22 https://doi.org/10.1002/1097-0142(195903/04)12:2<289::aid-cncr2820120213>3.0.co;2-z
23 https://doi.org/10.1002/1097-0142(19800315)45:6<1472::aid-cncr2820450629>3.0.co;2-a
24 https://doi.org/10.1002/jmv.1890470212
25 https://doi.org/10.1016/s0002-9440(10)65568-x
26 https://doi.org/10.1016/s0140-6736(95)91611-3
27 https://doi.org/10.1016/s0889-8588(05)70118-0
28 https://doi.org/10.1046/j.1365-4362.1997.00284.x
29 https://doi.org/10.1056/nejm199505043321802
30 https://doi.org/10.1056/nejm199505043321810
31 https://doi.org/10.1056/nejm199605023341805
32 https://doi.org/10.1056/nejmcibr063911
33 https://doi.org/10.1073/pnas.93.25.14862
34 https://doi.org/10.1086/507648
35 https://doi.org/10.1086/515340
36 https://doi.org/10.1093/oxfordjournals.aje.a117008
37 https://doi.org/10.1097/00000372-199006000-00006
38 https://doi.org/10.1097/00000421-199810000-00016
39 https://doi.org/10.1097/00002030-199602000-00007
40 https://doi.org/10.1097/00042560-200007010-00013
41 https://doi.org/10.1111/j.1399-0039.1995.tb02427.x
42 https://doi.org/10.1126/science.276.5320.1851
43 https://doi.org/10.1126/science.7997879
44 https://doi.org/10.1159/000247978
45 https://doi.org/10.1177/120347549900300305
46 schema:datePublished 2008-05
47 schema:datePublishedReg 2008-05-01
48 schema:description Classic Kaposi sarcoma is rare and occurs predominantly in Mediterranean and Middle Eastern men. Since the emergence of acquired immune deficiency syndrome (AIDS)-related Kaposi sarcoma, the incidence, clinicopathologic features, and molecular human herpesvirus 8 (HHV-8) association of American Classic Kaposi Sarcoma has not been fully explored. This study compares Classic Kaposi Sarcoma to AIDS-related Kaposi Sarcoma over the same two decade time period. There were 438 histologically and clinically confirmed Classic Kaposi Sarcoma patients. The ethnic/racial distribution included Caucasian/American (56%), Mediterranean (22%), South American Hispanic (18%), Black (10%), western European (4%), Middle East (4%), Scandinavian (2%), and other (2%). Classic Kaposi Sarcoma was more common in men, 7:1, with a mean age of 74 years. The lesions presented in the lower extremity (69%), in the nodular stage (83%), and HHV-8 was detected by PCR in 40/41 randomly selected cases. A second, non-Classic Kaposi Sarcoma, malignancy was present in 42% (n=45) of the 108 Classic Kaposi Sarcoma patients with complete clinical information, 73% (33 patients) with a higher incidence over the general population. Follow-up of <1–19 years (mean=4.8 years) revealed that 24% of patients died of second malignancy, 22% died of other medical conditions, 2% died of treatment-related complications, and 2% patients died of widespread disease. Thirty-five percent are alive with no evidence of disease and 15% with persistent disease. Human immunodeficiency virus-related Kaposi Sarcoma was observed in 354 cases. There was a male predominance and more aggressive behavior, with higher rates of visceral and disseminated disease. While Classic Kaposi Sarcoma in the United States is an indolent disease and rarely accounts for patient demise, predominantly affecting Caucasian/American males on the lower extremity in the nodular phase, it more importantly may denote an underlying other malignancy. Current PCR probes detect HHV-8 in 98% of Classic Kaposi Sarcoma cases. In comparison, AIDS-related Kaposi Sarcoma is predominately multicentric, visceral, and disseminated, with more aggressive behavior.
49 schema:genre research_article
50 schema:inLanguage en
51 schema:isAccessibleForFree true
52 schema:isPartOf Na6e853f447f84497b9fc9a4553997a9d
53 Nb181af997eef4cd696e83e63cfc0d1d0
54 sg:journal.1098208
55 schema:name Classic Kaposi Sarcoma in the United States over the last two decades: A clinicopathologic and molecular study of 438 non-HIV-related Kaposi Sarcoma patients with comparison to HIV-related Kaposi Sarcoma
56 schema:pagination modpathol200815
57 schema:productId N1b55f70027674dfa8adcb145d90c90b3
58 N4830e5a2eca541afb659e5e01edc0a90
59 Ne5219acaa70248cda29db69f0c713bc0
60 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040264819
61 https://doi.org/10.1038/modpathol.2008.15
62 schema:sdDatePublished 2019-04-10T20:34
63 schema:sdLicense https://scigraph.springernature.com/explorer/license/
64 schema:sdPublisher Nd415c1a192ee48eb9cb605fabe6f1d2f
65 schema:url http://www.nature.com/articles/modpathol200815
66 sgo:license sg:explorer/license/
67 sgo:sdDataset articles
68 rdf:type schema:ScholarlyArticle
69 N11114f6d44b04554ae50f38b8036f672 rdf:first sg:person.012677707243.20
70 rdf:rest N66e17f85a0bc48aba67312f51fee1801
71 N1b55f70027674dfa8adcb145d90c90b3 schema:name doi
72 schema:value 10.1038/modpathol.2008.15
73 rdf:type schema:PropertyValue
74 N2e44d84c83234042a7f85a3c21f2cb6b rdf:first sg:person.01325331750.50
75 rdf:rest rdf:nil
76 N4830e5a2eca541afb659e5e01edc0a90 schema:name dimensions_id
77 schema:value pub.1040264819
78 rdf:type schema:PropertyValue
79 N64c99fdf76fc4c4bbc7190310c35bbca rdf:first sg:person.01353627553.02
80 rdf:rest N2e44d84c83234042a7f85a3c21f2cb6b
81 N66e17f85a0bc48aba67312f51fee1801 rdf:first sg:person.0717753402.35
82 rdf:rest N64c99fdf76fc4c4bbc7190310c35bbca
83 Na6e853f447f84497b9fc9a4553997a9d schema:issueNumber 5
84 rdf:type schema:PublicationIssue
85 Nb181af997eef4cd696e83e63cfc0d1d0 schema:volumeNumber 21
86 rdf:type schema:PublicationVolume
87 Nd415c1a192ee48eb9cb605fabe6f1d2f schema:name Springer Nature - SN SciGraph project
88 rdf:type schema:Organization
89 Ne5219acaa70248cda29db69f0c713bc0 schema:name readcube_id
90 schema:value bfce36f381bb5caddb6eb16df093b7b35406532f429cd69bf0e618d1703e6f89
91 rdf:type schema:PropertyValue
92 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
93 schema:name Medical and Health Sciences
94 rdf:type schema:DefinedTerm
95 anzsrc-for:1103 schema:inDefinedTermSet anzsrc-for:
96 schema:name Clinical Sciences
97 rdf:type schema:DefinedTerm
98 sg:journal.1098208 schema:issn 0893-3952
99 1530-0285
100 schema:name Modern Pathology
101 rdf:type schema:Periodical
102 sg:person.012677707243.20 schema:affiliation https://www.grid.ac/institutes/grid.241054.6
103 schema:familyName Hiatt
104 schema:givenName Kim M
105 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012677707243.20
106 rdf:type schema:Person
107 sg:person.01325331750.50 schema:affiliation https://www.grid.ac/institutes/grid.414467.4
108 schema:familyName Fanburg-Smith
109 schema:givenName Julie C
110 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01325331750.50
111 rdf:type schema:Person
112 sg:person.01353627553.02 schema:affiliation https://www.grid.ac/institutes/grid.414467.4
113 schema:familyName Lichy
114 schema:givenName Jack H
115 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01353627553.02
116 rdf:type schema:Person
117 sg:person.0717753402.35 schema:affiliation https://www.grid.ac/institutes/grid.414467.4
118 schema:familyName Nelson
119 schema:givenName Ann M
120 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0717753402.35
121 rdf:type schema:Person
122 sg:pub.10.1007/bf01830024 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017280345
123 https://doi.org/10.1007/bf01830024
124 rdf:type schema:CreativeWork
125 sg:pub.10.1038/345084a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014935163
126 https://doi.org/10.1038/345084a0
127 rdf:type schema:CreativeWork
128 sg:pub.10.1038/bjc.1996.635 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048498634
129 https://doi.org/10.1038/bjc.1996.635
130 rdf:type schema:CreativeWork
131 sg:pub.10.1038/bjc.1998.509 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006612904
132 https://doi.org/10.1038/bjc.1998.509
133 rdf:type schema:CreativeWork
134 sg:pub.10.1054/bjoc.2001.1912 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002283476
135 https://doi.org/10.1054/bjoc.2001.1912
136 rdf:type schema:CreativeWork
137 https://app.dimensions.ai/details/publication/pub.1074687113 schema:CreativeWork
138 https://app.dimensions.ai/details/publication/pub.1074687115 schema:CreativeWork
139 https://app.dimensions.ai/details/publication/pub.1074687116 schema:CreativeWork
140 https://app.dimensions.ai/details/publication/pub.1074687117 schema:CreativeWork
141 https://app.dimensions.ai/details/publication/pub.1074696653 schema:CreativeWork
142 https://app.dimensions.ai/details/publication/pub.1082442937 schema:CreativeWork
143 https://app.dimensions.ai/details/publication/pub.1082843572 schema:CreativeWork
144 https://app.dimensions.ai/details/publication/pub.1083089659 schema:CreativeWork
145 https://doi.org/10.1001/archderm.133.1.25 schema:sameAs https://app.dimensions.ai/details/publication/pub.1054100024
146 rdf:type schema:CreativeWork
147 https://doi.org/10.1002/(sici)1097-0142(19990401)85:7<1611::aid-cncr25>3.0.co;2-m schema:sameAs https://app.dimensions.ai/details/publication/pub.1007093852
148 rdf:type schema:CreativeWork
149 https://doi.org/10.1002/(sici)1097-0215(19971210)73:6<840::aid-ijc13>3.0.co;2-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012905770
150 rdf:type schema:CreativeWork
151 https://doi.org/10.1002/(sici)1097-0215(19990118)80:2<173::aid-ijc2>3.0.co;2-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022098175
152 rdf:type schema:CreativeWork
153 https://doi.org/10.1002/(sici)1097-0215(19990118)80:2<178::aid-ijc3>3.0.co;2-l schema:sameAs https://app.dimensions.ai/details/publication/pub.1019819476
154 rdf:type schema:CreativeWork
155 https://doi.org/10.1002/1097-0142(195903/04)12:2<289::aid-cncr2820120213>3.0.co;2-z schema:sameAs https://app.dimensions.ai/details/publication/pub.1014166007
156 rdf:type schema:CreativeWork
157 https://doi.org/10.1002/1097-0142(19800315)45:6<1472::aid-cncr2820450629>3.0.co;2-a schema:sameAs https://app.dimensions.ai/details/publication/pub.1008847840
158 rdf:type schema:CreativeWork
159 https://doi.org/10.1002/jmv.1890470212 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043038708
160 rdf:type schema:CreativeWork
161 https://doi.org/10.1016/s0002-9440(10)65568-x schema:sameAs https://app.dimensions.ai/details/publication/pub.1034981327
162 rdf:type schema:CreativeWork
163 https://doi.org/10.1016/s0140-6736(95)91611-3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042703876
164 rdf:type schema:CreativeWork
165 https://doi.org/10.1016/s0889-8588(05)70118-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010359557
166 rdf:type schema:CreativeWork
167 https://doi.org/10.1046/j.1365-4362.1997.00284.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1031559465
168 rdf:type schema:CreativeWork
169 https://doi.org/10.1056/nejm199505043321802 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044023622
170 rdf:type schema:CreativeWork
171 https://doi.org/10.1056/nejm199505043321810 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033460763
172 rdf:type schema:CreativeWork
173 https://doi.org/10.1056/nejm199605023341805 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024322145
174 rdf:type schema:CreativeWork
175 https://doi.org/10.1056/nejmcibr063911 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016065365
176 rdf:type schema:CreativeWork
177 https://doi.org/10.1073/pnas.93.25.14862 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047474450
178 rdf:type schema:CreativeWork
179 https://doi.org/10.1086/507648 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014922493
180 rdf:type schema:CreativeWork
181 https://doi.org/10.1086/515340 schema:sameAs https://app.dimensions.ai/details/publication/pub.1058789730
182 rdf:type schema:CreativeWork
183 https://doi.org/10.1093/oxfordjournals.aje.a117008 schema:sameAs https://app.dimensions.ai/details/publication/pub.1082655253
184 rdf:type schema:CreativeWork
185 https://doi.org/10.1097/00000372-199006000-00006 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015134096
186 rdf:type schema:CreativeWork
187 https://doi.org/10.1097/00000421-199810000-00016 schema:sameAs https://app.dimensions.ai/details/publication/pub.1060113786
188 rdf:type schema:CreativeWork
189 https://doi.org/10.1097/00002030-199602000-00007 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022848421
190 rdf:type schema:CreativeWork
191 https://doi.org/10.1097/00042560-200007010-00013 schema:sameAs https://app.dimensions.ai/details/publication/pub.1060297180
192 rdf:type schema:CreativeWork
193 https://doi.org/10.1111/j.1399-0039.1995.tb02427.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1010505257
194 rdf:type schema:CreativeWork
195 https://doi.org/10.1126/science.276.5320.1851 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062557080
196 rdf:type schema:CreativeWork
197 https://doi.org/10.1126/science.7997879 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062650916
198 rdf:type schema:CreativeWork
199 https://doi.org/10.1159/000247978 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004615337
200 rdf:type schema:CreativeWork
201 https://doi.org/10.1177/120347549900300305 schema:sameAs https://app.dimensions.ai/details/publication/pub.1074266321
202 rdf:type schema:CreativeWork
203 https://www.grid.ac/institutes/grid.241054.6 schema:alternateName University of Arkansas for Medical Sciences
204 schema:name Dermatopathology, University of Arkansas for Medical Sciences, Little Rock, AR, USA
205 rdf:type schema:Organization
206 https://www.grid.ac/institutes/grid.414467.4 schema:alternateName Walter Reed National Military Medical Center
207 schema:name Departments of Infectious Disease, Molecular, and Soft Tissue/Orthopaedic Pathology, Armed Forces Institute of Pathology, Washington, DC, USA
208 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...