An innate defense peptide BPIFA1/SPLUNC1 restricts influenza A virus infection View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2018-01

AUTHORS

K M Akram, N A Moyo, G H Leeming, L Bingle, S Jasim, S Hussain, A Schorlemmer, A Kipar, P Digard, R A Tripp, R V Shohet, C D Bingle, J P Stewart

ABSTRACT

The airway epithelium secretes proteins that function in innate defense against infection. Bactericidal/permeability-increasing fold-containing family member A1 (BPIFA1) is secreted into airways and has a protective role during bacterial infections, but it is not known whether it also has an antiviral role. To determine a role in host defense against influenza A virus (IAV) infection and to find the underlying defense mechanism, we developed transgenic mouse models that are deficient in BPIFA1 and used these, in combination with in vitro three-dimensional mouse tracheal epithelial cell (mTEC) cultures, to investigate its antiviral properties. We show that BPIFA1 has a significant role in mucosal defense against IAV infection. BPIFA1 secretion was highly modulated after IAV infection. Mice deficient in BPIFA1 lost more weight after infection, supported a higher viral load and virus reached the peripheral lung earlier, indicative of a defect in the control of infection. Further analysis using mTEC cultures showed that BPIFA1-deficient cells bound more virus particles, displayed increased nuclear import of IAV ribonucleoprotein complexes, and supported higher levels of viral replication. Our results identify a critical role of BPIFA1 in the initial phase of infection by inhibiting the binding and entry of IAV into airway epithelial cells. More... »

PAGES

71

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/mi.2017.45

DOI

http://dx.doi.org/10.1038/mi.2017.45

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1085424257

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/28513596


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1108", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical Microbiology", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Animals", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cells, Cultured", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Gene Expression Regulation", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Glycoproteins", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Host-Pathogen Interactions", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Immunity, Innate", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Influenza A virus", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Influenza, Human", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Mice", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Mice, Inbred C57BL", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Mice, Knockout", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Orthomyxoviridae Infections", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Phosphoproteins", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Respiratory Mucosa", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Virus Replication", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "University of Sheffield", 
          "id": "https://www.grid.ac/institutes/grid.11835.3e", 
          "name": [
            "Academic Unit of Respiratory Medicine, Department of Infection, Immunity and Cardiovascular Disease, University of Sheffield, Sheffield, UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Akram", 
        "givenName": "K M", 
        "id": "sg:person.01036656151.10", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01036656151.10"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Liverpool", 
          "id": "https://www.grid.ac/institutes/grid.10025.36", 
          "name": [
            "Department of Infection Biology, University of Liverpool, Liverpool, UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Moyo", 
        "givenName": "N A", 
        "id": "sg:person.01071757320.32", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01071757320.32"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Liverpool", 
          "id": "https://www.grid.ac/institutes/grid.10025.36", 
          "name": [
            "Department of Infection Biology, University of Liverpool, Liverpool, UK", 
            "Department of Veterinary Pathology, University of Liverpool, Liverpool, UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Leeming", 
        "givenName": "G H", 
        "id": "sg:person.01346554573.34", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01346554573.34"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Sheffield", 
          "id": "https://www.grid.ac/institutes/grid.11835.3e", 
          "name": [
            "Academic Unit of Oral and Maxillofacial Pathology, School of Clinical Dentistry, University of Sheffield, Sheffield, UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Bingle", 
        "givenName": "L", 
        "id": "sg:person.01145737302.37", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01145737302.37"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Edinburgh", 
          "id": "https://www.grid.ac/institutes/grid.4305.2", 
          "name": [
            "The Roslin Institute, University of Edinburgh, Edinburgh, UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Jasim", 
        "givenName": "S", 
        "id": "sg:person.01200702415.14", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01200702415.14"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Edinburgh", 
          "id": "https://www.grid.ac/institutes/grid.4305.2", 
          "name": [
            "The Roslin Institute, University of Edinburgh, Edinburgh, UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Hussain", 
        "givenName": "S", 
        "id": "sg:person.013342424677.47", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013342424677.47"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Hawaii at Manoa", 
          "id": "https://www.grid.ac/institutes/grid.410445.0", 
          "name": [
            "Center for Cardiovascular Research, John A. Burns School of Medicine, University of Hawaii, Honolulu, Hawaii, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Schorlemmer", 
        "givenName": "A", 
        "id": "sg:person.01320726553.38", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01320726553.38"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Zurich", 
          "id": "https://www.grid.ac/institutes/grid.7400.3", 
          "name": [
            "Department of Infection Biology, University of Liverpool, Liverpool, UK", 
            "Department of Veterinary Pathology, University of Liverpool, Liverpool, UK", 
            "Institute of Veterinary Pathology, Vetsuisse Faculty, University of Zurich, Zurich, Switzerland"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Kipar", 
        "givenName": "A", 
        "id": "sg:person.01261356740.22", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01261356740.22"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Edinburgh", 
          "id": "https://www.grid.ac/institutes/grid.4305.2", 
          "name": [
            "The Roslin Institute, University of Edinburgh, Edinburgh, UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Digard", 
        "givenName": "P", 
        "id": "sg:person.0611726352.14", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0611726352.14"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Georgia", 
          "id": "https://www.grid.ac/institutes/grid.213876.9", 
          "name": [
            "Department of Infectious Diseases, University of Georgia, Athens, Georgia, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Tripp", 
        "givenName": "R A", 
        "id": "sg:person.0614371336.13", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0614371336.13"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Hawaii at Manoa", 
          "id": "https://www.grid.ac/institutes/grid.410445.0", 
          "name": [
            "Center for Cardiovascular Research, John A. Burns School of Medicine, University of Hawaii, Honolulu, Hawaii, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Shohet", 
        "givenName": "R V", 
        "id": "sg:person.0616034223.62", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0616034223.62"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Sheffield", 
          "id": "https://www.grid.ac/institutes/grid.11835.3e", 
          "name": [
            "Academic Unit of Respiratory Medicine, Department of Infection, Immunity and Cardiovascular Disease, University of Sheffield, Sheffield, UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Bingle", 
        "givenName": "C D", 
        "id": "sg:person.0667373666.74", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0667373666.74"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Liverpool", 
          "id": "https://www.grid.ac/institutes/grid.10025.36", 
          "name": [
            "Department of Infection Biology, University of Liverpool, Liverpool, UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Stewart", 
        "givenName": "J P", 
        "id": "sg:person.01061637047.51", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01061637047.51"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "sg:pub.10.1038/mi.2012.81", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1000906222", 
          "https://doi.org/10.1038/mi.2012.81"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/1743-422x-3-63", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1000911842", 
          "https://doi.org/10.1186/1743-422x-3-63"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1096/fj.14-259291", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1002947100"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.biocel.2004.05.002", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1003694650"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1146/annurev.biochem.69.1.531", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1003838837"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/labinvest.2014.162", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1004149266", 
          "https://doi.org/10.1038/labinvest.2014.162"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1165/rcmb.2012-0064oc", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1004693959"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1371/journal.pone.0066546", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1004790605"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0167-4781(00)00196-2", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1004979905"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1371/journal.pone.0013224", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1005157298"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.1206552109", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1005775334"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.0903609106", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1006151482"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.bbalip.2016.01.016", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1008981899"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1110/ps.03332704", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1010308863"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/978-1-62703-125-7_9", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1011565468", 
          "https://doi.org/10.1007/978-1-62703-125-7_9"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00441-012-1490-9", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1011808904", 
          "https://doi.org/10.1007/s00441-012-1490-9"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00441-012-1490-9", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1011808904", 
          "https://doi.org/10.1007/s00441-012-1490-9"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/mi.2016.27", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1011917276", 
          "https://doi.org/10.1038/mi.2016.27"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1165/rcmb.2012-0072oc", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1012218923"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1152/ajplung.00169.2002", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1012306464"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1053/jcpa.2001.0501", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1014909475"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.arcmed.2012.08.008", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1016849786"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s11010-007-9659-3", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1017792695", 
          "https://doi.org/10.1007/s11010-007-9659-3"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1371/journal.pone.0001673", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1017825184"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1006/bbrc.2001.5024", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1020888229"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1074/jbc.274.19.13698", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1032037625"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/1465-9921-11-155", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1033254428", 
          "https://doi.org/10.1186/1465-9921-11-155"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/path.1726", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1034290222"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3390/v20801530", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1034911757"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1042/bst0310801", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1034987849"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1042/bst0310801", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1034987849"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.virusres.2006.09.013", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035120754"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.ajpath.2013.01.050", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035992502"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.ygeno.2003.09.015", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1039027098"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/hmg/11.8.937", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1040534180"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ni.3045", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1040803973", 
          "https://doi.org/10.1038/ni.3045"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1074/jbc.m210523200", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1041490793"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1128/jcm.01532-09", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1042062675"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1371/journal.pone.0009098", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1046506397"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/gcc.10247", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1046929895"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1042/bst0390961", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1047827734"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1042/bst0390961", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1047827734"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1136/jmg.2004.022616", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1048700157"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1750-2659.2010.00130.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1048819938"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1750-2659.2010.00130.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1048819938"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nrd4529", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1051459749", 
          "https://doi.org/10.1038/nrd4529"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1021/pr050341h", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1056290850"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1099/0022-1317-75-4-945", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1060359190"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1099/0022-1317-83-4-723", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1060362250"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.4049/jimmunol.179.6.3995", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1077475243"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2018-01", 
    "datePublishedReg": "2018-01-01", 
    "description": "The airway epithelium secretes proteins that function in innate defense against infection. Bactericidal/permeability-increasing fold-containing family member A1 (BPIFA1) is secreted into airways and has a protective role during bacterial infections, but it is not known whether it also has an antiviral role. To determine a role in host defense against influenza A virus (IAV) infection and to find the underlying defense mechanism, we developed transgenic mouse models that are deficient in BPIFA1 and used these, in combination with in vitro three-dimensional mouse tracheal epithelial cell (mTEC) cultures, to investigate its antiviral properties. We show that BPIFA1 has a significant role in mucosal defense against IAV infection. BPIFA1 secretion was highly modulated after IAV infection. Mice deficient in BPIFA1 lost more weight after infection, supported a higher viral load and virus reached the peripheral lung earlier, indicative of a defect in the control of infection. Further analysis using mTEC cultures showed that BPIFA1-deficient cells bound more virus particles, displayed increased nuclear import of IAV ribonucleoprotein complexes, and supported higher levels of viral replication. Our results identify a critical role of BPIFA1 in the initial phase of infection by inhibiting the binding and entry of IAV into airway epithelial cells.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1038/mi.2017.45", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": true, 
    "isFundedItemOf": [
      {
        "id": "sg:grant.2758487", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.2752302", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.2754047", 
        "type": "MonetaryGrant"
      }
    ], 
    "isPartOf": [
      {
        "id": "sg:journal.1038363", 
        "issn": [
          "1933-0219", 
          "1935-3456"
        ], 
        "name": "Mucosal Immunology", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "1", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "11"
      }
    ], 
    "name": "An innate defense peptide BPIFA1/SPLUNC1 restricts influenza A virus infection", 
    "pagination": "71", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "7392d680d5e88b848f96c8f135f9388e43573e4da73f0e387579f064b55c2f1a"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "28513596"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "101299742"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1038/mi.2017.45"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1085424257"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1038/mi.2017.45", 
      "https://app.dimensions.ai/details/publication/pub.1085424257"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-10T14:08", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8660_00000508.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://www.nature.com/articles/mi201745"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/mi.2017.45'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/mi.2017.45'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/mi.2017.45'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/mi.2017.45'


 

This table displays all metadata directly associated to this object as RDF triples.

390 TRIPLES      21 PREDICATES      91 URIs      37 LITERALS      25 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1038/mi.2017.45 schema:about N0790990790a5419098e30e8ba1a77798
2 N0d3915c3add94e5797a0470b38ef49de
3 N13b3960c317741879484b9e3d991f8ee
4 N40766433d90c4e88af8a0731f062a148
5 N5032293e08f84894940b3312fb8d38be
6 N52edbd44c2a248689a359842083c1595
7 N5370ba87ccb343c1a522fe9ab9e8821b
8 N561111d804354881a953d0fed88185aa
9 N5ec6c3f0fee8461ab014ec95bf547e0e
10 N5f07988d23fb4810be1f84bc64b16986
11 N80236159c33f4b7a8f1f4b18ff217cf2
12 Na55c52b7113646c4b7bfcf8662624120
13 Nd93bff6d054d44839253b12b2356a985
14 Ne5ccb5c609364e7bb35107e5d355d448
15 Necd06508d30540949141cb2c7cf72e47
16 Nf5854a150dba45df9929f3b4e1b6386c
17 anzsrc-for:11
18 anzsrc-for:1108
19 schema:author Nc14af90f90784b37a0f86fd10c4ad5ea
20 schema:citation sg:pub.10.1007/978-1-62703-125-7_9
21 sg:pub.10.1007/s00441-012-1490-9
22 sg:pub.10.1007/s11010-007-9659-3
23 sg:pub.10.1038/labinvest.2014.162
24 sg:pub.10.1038/mi.2012.81
25 sg:pub.10.1038/mi.2016.27
26 sg:pub.10.1038/ni.3045
27 sg:pub.10.1038/nrd4529
28 sg:pub.10.1186/1465-9921-11-155
29 sg:pub.10.1186/1743-422x-3-63
30 https://doi.org/10.1002/gcc.10247
31 https://doi.org/10.1002/path.1726
32 https://doi.org/10.1006/bbrc.2001.5024
33 https://doi.org/10.1016/j.ajpath.2013.01.050
34 https://doi.org/10.1016/j.arcmed.2012.08.008
35 https://doi.org/10.1016/j.bbalip.2016.01.016
36 https://doi.org/10.1016/j.biocel.2004.05.002
37 https://doi.org/10.1016/j.virusres.2006.09.013
38 https://doi.org/10.1016/j.ygeno.2003.09.015
39 https://doi.org/10.1016/s0167-4781(00)00196-2
40 https://doi.org/10.1021/pr050341h
41 https://doi.org/10.1042/bst0310801
42 https://doi.org/10.1042/bst0390961
43 https://doi.org/10.1053/jcpa.2001.0501
44 https://doi.org/10.1073/pnas.0903609106
45 https://doi.org/10.1073/pnas.1206552109
46 https://doi.org/10.1074/jbc.274.19.13698
47 https://doi.org/10.1074/jbc.m210523200
48 https://doi.org/10.1093/hmg/11.8.937
49 https://doi.org/10.1096/fj.14-259291
50 https://doi.org/10.1099/0022-1317-75-4-945
51 https://doi.org/10.1099/0022-1317-83-4-723
52 https://doi.org/10.1110/ps.03332704
53 https://doi.org/10.1111/j.1750-2659.2010.00130.x
54 https://doi.org/10.1128/jcm.01532-09
55 https://doi.org/10.1136/jmg.2004.022616
56 https://doi.org/10.1146/annurev.biochem.69.1.531
57 https://doi.org/10.1152/ajplung.00169.2002
58 https://doi.org/10.1165/rcmb.2012-0064oc
59 https://doi.org/10.1165/rcmb.2012-0072oc
60 https://doi.org/10.1371/journal.pone.0001673
61 https://doi.org/10.1371/journal.pone.0009098
62 https://doi.org/10.1371/journal.pone.0013224
63 https://doi.org/10.1371/journal.pone.0066546
64 https://doi.org/10.3390/v20801530
65 https://doi.org/10.4049/jimmunol.179.6.3995
66 schema:datePublished 2018-01
67 schema:datePublishedReg 2018-01-01
68 schema:description The airway epithelium secretes proteins that function in innate defense against infection. Bactericidal/permeability-increasing fold-containing family member A1 (BPIFA1) is secreted into airways and has a protective role during bacterial infections, but it is not known whether it also has an antiviral role. To determine a role in host defense against influenza A virus (IAV) infection and to find the underlying defense mechanism, we developed transgenic mouse models that are deficient in BPIFA1 and used these, in combination with in vitro three-dimensional mouse tracheal epithelial cell (mTEC) cultures, to investigate its antiviral properties. We show that BPIFA1 has a significant role in mucosal defense against IAV infection. BPIFA1 secretion was highly modulated after IAV infection. Mice deficient in BPIFA1 lost more weight after infection, supported a higher viral load and virus reached the peripheral lung earlier, indicative of a defect in the control of infection. Further analysis using mTEC cultures showed that BPIFA1-deficient cells bound more virus particles, displayed increased nuclear import of IAV ribonucleoprotein complexes, and supported higher levels of viral replication. Our results identify a critical role of BPIFA1 in the initial phase of infection by inhibiting the binding and entry of IAV into airway epithelial cells.
69 schema:genre research_article
70 schema:inLanguage en
71 schema:isAccessibleForFree true
72 schema:isPartOf N45ac1fdd4eb4409395d7737e20573873
73 Nf6eff372902b40778aed67d54b22b8ab
74 sg:journal.1038363
75 schema:name An innate defense peptide BPIFA1/SPLUNC1 restricts influenza A virus infection
76 schema:pagination 71
77 schema:productId N2629ba31274842f097011fef6939033c
78 N770fdaa5cf52403096dc55252010a68a
79 N9f4eabe76dd3447fb4adc1ab9be2f91d
80 Nbba24df9a9a6413595340dac4f35d7e4
81 Nc61c04d0990743a1b9ae4e538822334d
82 schema:sameAs https://app.dimensions.ai/details/publication/pub.1085424257
83 https://doi.org/10.1038/mi.2017.45
84 schema:sdDatePublished 2019-04-10T14:08
85 schema:sdLicense https://scigraph.springernature.com/explorer/license/
86 schema:sdPublisher Nba7729d8f17a4c2d838335b3b1a36ada
87 schema:url https://www.nature.com/articles/mi201745
88 sgo:license sg:explorer/license/
89 sgo:sdDataset articles
90 rdf:type schema:ScholarlyArticle
91 N018180fd45f94717b384ad97a94f57c1 rdf:first sg:person.013342424677.47
92 rdf:rest N300fe8c3cf094f5895f3c18cd3309f9f
93 N018bd650fa34471abbe117fecbc4b4e5 rdf:first sg:person.01061637047.51
94 rdf:rest rdf:nil
95 N0790990790a5419098e30e8ba1a77798 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
96 schema:name Humans
97 rdf:type schema:DefinedTerm
98 N0d3915c3add94e5797a0470b38ef49de schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
99 schema:name Mice, Inbred C57BL
100 rdf:type schema:DefinedTerm
101 N13b3960c317741879484b9e3d991f8ee schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
102 schema:name Influenza, Human
103 rdf:type schema:DefinedTerm
104 N2629ba31274842f097011fef6939033c schema:name doi
105 schema:value 10.1038/mi.2017.45
106 rdf:type schema:PropertyValue
107 N28f204be31db47b7a0d9b7a3b7457e0b rdf:first sg:person.0616034223.62
108 rdf:rest N9df4f32c81b74d138114b5316c7cf7c4
109 N2ce5e28ab4f34272b5002da45d3c278d rdf:first sg:person.01145737302.37
110 rdf:rest Na8a9527bcd7e42548ce62b81fbf12cbb
111 N300fe8c3cf094f5895f3c18cd3309f9f rdf:first sg:person.01320726553.38
112 rdf:rest Nec23def90d9243b4ad1ccb356cdfc89d
113 N40766433d90c4e88af8a0731f062a148 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
114 schema:name Glycoproteins
115 rdf:type schema:DefinedTerm
116 N4095e81e532e4ab584214f6ce8798cac rdf:first sg:person.01346554573.34
117 rdf:rest N2ce5e28ab4f34272b5002da45d3c278d
118 N45ac1fdd4eb4409395d7737e20573873 schema:volumeNumber 11
119 rdf:type schema:PublicationVolume
120 N5032293e08f84894940b3312fb8d38be schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
121 schema:name Gene Expression Regulation
122 rdf:type schema:DefinedTerm
123 N52edbd44c2a248689a359842083c1595 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
124 schema:name Immunity, Innate
125 rdf:type schema:DefinedTerm
126 N5370ba87ccb343c1a522fe9ab9e8821b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
127 schema:name Host-Pathogen Interactions
128 rdf:type schema:DefinedTerm
129 N561111d804354881a953d0fed88185aa schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
130 schema:name Mice, Knockout
131 rdf:type schema:DefinedTerm
132 N5ec6c3f0fee8461ab014ec95bf547e0e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
133 schema:name Cells, Cultured
134 rdf:type schema:DefinedTerm
135 N5f07988d23fb4810be1f84bc64b16986 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
136 schema:name Influenza A virus
137 rdf:type schema:DefinedTerm
138 N770fdaa5cf52403096dc55252010a68a schema:name pubmed_id
139 schema:value 28513596
140 rdf:type schema:PropertyValue
141 N80236159c33f4b7a8f1f4b18ff217cf2 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
142 schema:name Mice
143 rdf:type schema:DefinedTerm
144 N811c3850746f47e29c765c412cff5d36 rdf:first sg:person.0611726352.14
145 rdf:rest Na517b186516f4962b84b0f7fa513bed9
146 N9df4f32c81b74d138114b5316c7cf7c4 rdf:first sg:person.0667373666.74
147 rdf:rest N018bd650fa34471abbe117fecbc4b4e5
148 N9f4eabe76dd3447fb4adc1ab9be2f91d schema:name readcube_id
149 schema:value 7392d680d5e88b848f96c8f135f9388e43573e4da73f0e387579f064b55c2f1a
150 rdf:type schema:PropertyValue
151 Na517b186516f4962b84b0f7fa513bed9 rdf:first sg:person.0614371336.13
152 rdf:rest N28f204be31db47b7a0d9b7a3b7457e0b
153 Na55c52b7113646c4b7bfcf8662624120 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
154 schema:name Virus Replication
155 rdf:type schema:DefinedTerm
156 Na8a9527bcd7e42548ce62b81fbf12cbb rdf:first sg:person.01200702415.14
157 rdf:rest N018180fd45f94717b384ad97a94f57c1
158 Nba7729d8f17a4c2d838335b3b1a36ada schema:name Springer Nature - SN SciGraph project
159 rdf:type schema:Organization
160 Nbba24df9a9a6413595340dac4f35d7e4 schema:name nlm_unique_id
161 schema:value 101299742
162 rdf:type schema:PropertyValue
163 Nc14af90f90784b37a0f86fd10c4ad5ea rdf:first sg:person.01036656151.10
164 rdf:rest Nd960582a8d8f44fea2c041313ac07763
165 Nc61c04d0990743a1b9ae4e538822334d schema:name dimensions_id
166 schema:value pub.1085424257
167 rdf:type schema:PropertyValue
168 Nd93bff6d054d44839253b12b2356a985 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
169 schema:name Animals
170 rdf:type schema:DefinedTerm
171 Nd960582a8d8f44fea2c041313ac07763 rdf:first sg:person.01071757320.32
172 rdf:rest N4095e81e532e4ab584214f6ce8798cac
173 Ne5ccb5c609364e7bb35107e5d355d448 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
174 schema:name Respiratory Mucosa
175 rdf:type schema:DefinedTerm
176 Nec23def90d9243b4ad1ccb356cdfc89d rdf:first sg:person.01261356740.22
177 rdf:rest N811c3850746f47e29c765c412cff5d36
178 Necd06508d30540949141cb2c7cf72e47 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
179 schema:name Orthomyxoviridae Infections
180 rdf:type schema:DefinedTerm
181 Nf5854a150dba45df9929f3b4e1b6386c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
182 schema:name Phosphoproteins
183 rdf:type schema:DefinedTerm
184 Nf6eff372902b40778aed67d54b22b8ab schema:issueNumber 1
185 rdf:type schema:PublicationIssue
186 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
187 schema:name Medical and Health Sciences
188 rdf:type schema:DefinedTerm
189 anzsrc-for:1108 schema:inDefinedTermSet anzsrc-for:
190 schema:name Medical Microbiology
191 rdf:type schema:DefinedTerm
192 sg:grant.2752302 http://pending.schema.org/fundedItem sg:pub.10.1038/mi.2017.45
193 rdf:type schema:MonetaryGrant
194 sg:grant.2754047 http://pending.schema.org/fundedItem sg:pub.10.1038/mi.2017.45
195 rdf:type schema:MonetaryGrant
196 sg:grant.2758487 http://pending.schema.org/fundedItem sg:pub.10.1038/mi.2017.45
197 rdf:type schema:MonetaryGrant
198 sg:journal.1038363 schema:issn 1933-0219
199 1935-3456
200 schema:name Mucosal Immunology
201 rdf:type schema:Periodical
202 sg:person.01036656151.10 schema:affiliation https://www.grid.ac/institutes/grid.11835.3e
203 schema:familyName Akram
204 schema:givenName K M
205 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01036656151.10
206 rdf:type schema:Person
207 sg:person.01061637047.51 schema:affiliation https://www.grid.ac/institutes/grid.10025.36
208 schema:familyName Stewart
209 schema:givenName J P
210 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01061637047.51
211 rdf:type schema:Person
212 sg:person.01071757320.32 schema:affiliation https://www.grid.ac/institutes/grid.10025.36
213 schema:familyName Moyo
214 schema:givenName N A
215 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01071757320.32
216 rdf:type schema:Person
217 sg:person.01145737302.37 schema:affiliation https://www.grid.ac/institutes/grid.11835.3e
218 schema:familyName Bingle
219 schema:givenName L
220 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01145737302.37
221 rdf:type schema:Person
222 sg:person.01200702415.14 schema:affiliation https://www.grid.ac/institutes/grid.4305.2
223 schema:familyName Jasim
224 schema:givenName S
225 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01200702415.14
226 rdf:type schema:Person
227 sg:person.01261356740.22 schema:affiliation https://www.grid.ac/institutes/grid.7400.3
228 schema:familyName Kipar
229 schema:givenName A
230 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01261356740.22
231 rdf:type schema:Person
232 sg:person.01320726553.38 schema:affiliation https://www.grid.ac/institutes/grid.410445.0
233 schema:familyName Schorlemmer
234 schema:givenName A
235 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01320726553.38
236 rdf:type schema:Person
237 sg:person.013342424677.47 schema:affiliation https://www.grid.ac/institutes/grid.4305.2
238 schema:familyName Hussain
239 schema:givenName S
240 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013342424677.47
241 rdf:type schema:Person
242 sg:person.01346554573.34 schema:affiliation https://www.grid.ac/institutes/grid.10025.36
243 schema:familyName Leeming
244 schema:givenName G H
245 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01346554573.34
246 rdf:type schema:Person
247 sg:person.0611726352.14 schema:affiliation https://www.grid.ac/institutes/grid.4305.2
248 schema:familyName Digard
249 schema:givenName P
250 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0611726352.14
251 rdf:type schema:Person
252 sg:person.0614371336.13 schema:affiliation https://www.grid.ac/institutes/grid.213876.9
253 schema:familyName Tripp
254 schema:givenName R A
255 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0614371336.13
256 rdf:type schema:Person
257 sg:person.0616034223.62 schema:affiliation https://www.grid.ac/institutes/grid.410445.0
258 schema:familyName Shohet
259 schema:givenName R V
260 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0616034223.62
261 rdf:type schema:Person
262 sg:person.0667373666.74 schema:affiliation https://www.grid.ac/institutes/grid.11835.3e
263 schema:familyName Bingle
264 schema:givenName C D
265 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0667373666.74
266 rdf:type schema:Person
267 sg:pub.10.1007/978-1-62703-125-7_9 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011565468
268 https://doi.org/10.1007/978-1-62703-125-7_9
269 rdf:type schema:CreativeWork
270 sg:pub.10.1007/s00441-012-1490-9 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011808904
271 https://doi.org/10.1007/s00441-012-1490-9
272 rdf:type schema:CreativeWork
273 sg:pub.10.1007/s11010-007-9659-3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017792695
274 https://doi.org/10.1007/s11010-007-9659-3
275 rdf:type schema:CreativeWork
276 sg:pub.10.1038/labinvest.2014.162 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004149266
277 https://doi.org/10.1038/labinvest.2014.162
278 rdf:type schema:CreativeWork
279 sg:pub.10.1038/mi.2012.81 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000906222
280 https://doi.org/10.1038/mi.2012.81
281 rdf:type schema:CreativeWork
282 sg:pub.10.1038/mi.2016.27 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011917276
283 https://doi.org/10.1038/mi.2016.27
284 rdf:type schema:CreativeWork
285 sg:pub.10.1038/ni.3045 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040803973
286 https://doi.org/10.1038/ni.3045
287 rdf:type schema:CreativeWork
288 sg:pub.10.1038/nrd4529 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051459749
289 https://doi.org/10.1038/nrd4529
290 rdf:type schema:CreativeWork
291 sg:pub.10.1186/1465-9921-11-155 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033254428
292 https://doi.org/10.1186/1465-9921-11-155
293 rdf:type schema:CreativeWork
294 sg:pub.10.1186/1743-422x-3-63 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000911842
295 https://doi.org/10.1186/1743-422x-3-63
296 rdf:type schema:CreativeWork
297 https://doi.org/10.1002/gcc.10247 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046929895
298 rdf:type schema:CreativeWork
299 https://doi.org/10.1002/path.1726 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034290222
300 rdf:type schema:CreativeWork
301 https://doi.org/10.1006/bbrc.2001.5024 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020888229
302 rdf:type schema:CreativeWork
303 https://doi.org/10.1016/j.ajpath.2013.01.050 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035992502
304 rdf:type schema:CreativeWork
305 https://doi.org/10.1016/j.arcmed.2012.08.008 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016849786
306 rdf:type schema:CreativeWork
307 https://doi.org/10.1016/j.bbalip.2016.01.016 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008981899
308 rdf:type schema:CreativeWork
309 https://doi.org/10.1016/j.biocel.2004.05.002 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003694650
310 rdf:type schema:CreativeWork
311 https://doi.org/10.1016/j.virusres.2006.09.013 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035120754
312 rdf:type schema:CreativeWork
313 https://doi.org/10.1016/j.ygeno.2003.09.015 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039027098
314 rdf:type schema:CreativeWork
315 https://doi.org/10.1016/s0167-4781(00)00196-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004979905
316 rdf:type schema:CreativeWork
317 https://doi.org/10.1021/pr050341h schema:sameAs https://app.dimensions.ai/details/publication/pub.1056290850
318 rdf:type schema:CreativeWork
319 https://doi.org/10.1042/bst0310801 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034987849
320 rdf:type schema:CreativeWork
321 https://doi.org/10.1042/bst0390961 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047827734
322 rdf:type schema:CreativeWork
323 https://doi.org/10.1053/jcpa.2001.0501 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014909475
324 rdf:type schema:CreativeWork
325 https://doi.org/10.1073/pnas.0903609106 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006151482
326 rdf:type schema:CreativeWork
327 https://doi.org/10.1073/pnas.1206552109 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005775334
328 rdf:type schema:CreativeWork
329 https://doi.org/10.1074/jbc.274.19.13698 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032037625
330 rdf:type schema:CreativeWork
331 https://doi.org/10.1074/jbc.m210523200 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041490793
332 rdf:type schema:CreativeWork
333 https://doi.org/10.1093/hmg/11.8.937 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040534180
334 rdf:type schema:CreativeWork
335 https://doi.org/10.1096/fj.14-259291 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002947100
336 rdf:type schema:CreativeWork
337 https://doi.org/10.1099/0022-1317-75-4-945 schema:sameAs https://app.dimensions.ai/details/publication/pub.1060359190
338 rdf:type schema:CreativeWork
339 https://doi.org/10.1099/0022-1317-83-4-723 schema:sameAs https://app.dimensions.ai/details/publication/pub.1060362250
340 rdf:type schema:CreativeWork
341 https://doi.org/10.1110/ps.03332704 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010308863
342 rdf:type schema:CreativeWork
343 https://doi.org/10.1111/j.1750-2659.2010.00130.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1048819938
344 rdf:type schema:CreativeWork
345 https://doi.org/10.1128/jcm.01532-09 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042062675
346 rdf:type schema:CreativeWork
347 https://doi.org/10.1136/jmg.2004.022616 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048700157
348 rdf:type schema:CreativeWork
349 https://doi.org/10.1146/annurev.biochem.69.1.531 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003838837
350 rdf:type schema:CreativeWork
351 https://doi.org/10.1152/ajplung.00169.2002 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012306464
352 rdf:type schema:CreativeWork
353 https://doi.org/10.1165/rcmb.2012-0064oc schema:sameAs https://app.dimensions.ai/details/publication/pub.1004693959
354 rdf:type schema:CreativeWork
355 https://doi.org/10.1165/rcmb.2012-0072oc schema:sameAs https://app.dimensions.ai/details/publication/pub.1012218923
356 rdf:type schema:CreativeWork
357 https://doi.org/10.1371/journal.pone.0001673 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017825184
358 rdf:type schema:CreativeWork
359 https://doi.org/10.1371/journal.pone.0009098 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046506397
360 rdf:type schema:CreativeWork
361 https://doi.org/10.1371/journal.pone.0013224 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005157298
362 rdf:type schema:CreativeWork
363 https://doi.org/10.1371/journal.pone.0066546 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004790605
364 rdf:type schema:CreativeWork
365 https://doi.org/10.3390/v20801530 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034911757
366 rdf:type schema:CreativeWork
367 https://doi.org/10.4049/jimmunol.179.6.3995 schema:sameAs https://app.dimensions.ai/details/publication/pub.1077475243
368 rdf:type schema:CreativeWork
369 https://www.grid.ac/institutes/grid.10025.36 schema:alternateName University of Liverpool
370 schema:name Department of Infection Biology, University of Liverpool, Liverpool, UK
371 Department of Veterinary Pathology, University of Liverpool, Liverpool, UK
372 rdf:type schema:Organization
373 https://www.grid.ac/institutes/grid.11835.3e schema:alternateName University of Sheffield
374 schema:name Academic Unit of Oral and Maxillofacial Pathology, School of Clinical Dentistry, University of Sheffield, Sheffield, UK
375 Academic Unit of Respiratory Medicine, Department of Infection, Immunity and Cardiovascular Disease, University of Sheffield, Sheffield, UK
376 rdf:type schema:Organization
377 https://www.grid.ac/institutes/grid.213876.9 schema:alternateName University of Georgia
378 schema:name Department of Infectious Diseases, University of Georgia, Athens, Georgia, USA
379 rdf:type schema:Organization
380 https://www.grid.ac/institutes/grid.410445.0 schema:alternateName University of Hawaii at Manoa
381 schema:name Center for Cardiovascular Research, John A. Burns School of Medicine, University of Hawaii, Honolulu, Hawaii, USA
382 rdf:type schema:Organization
383 https://www.grid.ac/institutes/grid.4305.2 schema:alternateName University of Edinburgh
384 schema:name The Roslin Institute, University of Edinburgh, Edinburgh, UK
385 rdf:type schema:Organization
386 https://www.grid.ac/institutes/grid.7400.3 schema:alternateName University of Zurich
387 schema:name Department of Infection Biology, University of Liverpool, Liverpool, UK
388 Department of Veterinary Pathology, University of Liverpool, Liverpool, UK
389 Institute of Veterinary Pathology, Vetsuisse Faculty, University of Zurich, Zurich, Switzerland
390 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...