Ontology type: schema:ScholarlyArticle Open Access: True
2016-11
AUTHORSV S Pelly, Y Kannan, S M Coomes, L J Entwistle, D Rückerl, B Seddon, A S MacDonald, A McKenzie, M S Wilson
ABSTRACTImmunity to many human and murine gastrointestinal helminth parasites requires interleukin-4 (IL-4)-directed type 2 helper (TH2) differentiation of CD4+ T cells to elicit type-2 immunity. Despite a good understanding of the inflammatory cascade elicited following helminth infection, the initial source of IL-4 is unclear. Previous studies using the rat helminth parasite Nippostronglyus brasiliensis, identified an important role for basophil-derived IL-4 for TH2 differentiation. However, basophils are redundant for TH2 differentiation following infection with the natural helminth parasite of mice Heligmosomoides polygyrus, indicating that other sources of IL-4 are required. In this study using H. polygyrus, which is controlled by IL-4-dependent immunity, we identified that group-2 innate lymphoid cells (ILC2s) produced significant amounts of IL-4 and IL-2 following H. polygyrus infection. Leukotriene D4 was sufficient to stimulate IL-4 secretion by ILC2s, and the supernatant from activated ILC2s could potently drive TH2 differentiation in vitro in an IL-4-dependent manner. Furthermore, specific deletion of IL-4 from ILC2s compromised TH2 differentiation in vivo. Overall, this study highlights a previously unrecognized and important role for ILC2-derived IL-4 for TH2 differentiation in a natural TH2-dependent model of human helminthiasis. More... »
PAGES1407
http://scigraph.springernature.com/pub.10.1038/mi.2016.4
DOIhttp://dx.doi.org/10.1038/mi.2016.4
DIMENSIONShttps://app.dimensions.ai/details/publication/pub.1031737667
PUBMEDhttps://www.ncbi.nlm.nih.gov/pubmed/26883724
JSON-LD is the canonical representation for SciGraph data.
TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT
[
{
"@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json",
"about": [
{
"id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1107",
"inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/",
"name": "Immunology",
"type": "DefinedTerm"
},
{
"id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11",
"inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/",
"name": "Medical and Health Sciences",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Animals",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Cell Differentiation",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Cytokines",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Disease Models, Animal",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Host-Parasite Interactions",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Immunity, Innate",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Interleukin-4",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Lymph Nodes",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Lymphocyte Subsets",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Mice",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Mice, Knockout",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Mice, Transgenic",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Nematospiroides dubius",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Strongylida Infections",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Th2 Cells",
"type": "DefinedTerm"
}
],
"author": [
{
"affiliation": {
"alternateName": "The Francis Crick Institute",
"id": "https://www.grid.ac/institutes/grid.451388.3",
"name": [
"Mill Hill Laboratory, The Francis Crick Institute, London, UK"
],
"type": "Organization"
},
"familyName": "Pelly",
"givenName": "V S",
"id": "sg:person.0703565022.69",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0703565022.69"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "The Francis Crick Institute",
"id": "https://www.grid.ac/institutes/grid.451388.3",
"name": [
"Mill Hill Laboratory, The Francis Crick Institute, London, UK"
],
"type": "Organization"
},
"familyName": "Kannan",
"givenName": "Y",
"id": "sg:person.01215064754.93",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01215064754.93"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "The Francis Crick Institute",
"id": "https://www.grid.ac/institutes/grid.451388.3",
"name": [
"Mill Hill Laboratory, The Francis Crick Institute, London, UK"
],
"type": "Organization"
},
"familyName": "Coomes",
"givenName": "S M",
"id": "sg:person.0635451622.82",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0635451622.82"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "The Francis Crick Institute",
"id": "https://www.grid.ac/institutes/grid.451388.3",
"name": [
"Mill Hill Laboratory, The Francis Crick Institute, London, UK"
],
"type": "Organization"
},
"familyName": "Entwistle",
"givenName": "L J",
"id": "sg:person.01021733065.65",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01021733065.65"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "University of Edinburgh",
"id": "https://www.grid.ac/institutes/grid.4305.2",
"name": [
"Institute of Immunology and Infection Research (3IR), University of Edinburgh, Edinburgh, UK"
],
"type": "Organization"
},
"familyName": "R\u00fcckerl",
"givenName": "D",
"id": "sg:person.0676215456.80",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0676215456.80"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "University College London",
"id": "https://www.grid.ac/institutes/grid.83440.3b",
"name": [
"Institute of Immunity and Transplantation, UCL, London, UK"
],
"type": "Organization"
},
"familyName": "Seddon",
"givenName": "B",
"id": "sg:person.012441212237.11",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012441212237.11"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "University of Manchester",
"id": "https://www.grid.ac/institutes/grid.5379.8",
"name": [
"Faculty of Life Sciences, University of Manchester, Manchester, UK"
],
"type": "Organization"
},
"familyName": "MacDonald",
"givenName": "A S",
"id": "sg:person.01215400703.60",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01215400703.60"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "University of Cambridge",
"id": "https://www.grid.ac/institutes/grid.5335.0",
"name": [
"MRC Laboratory of Molecular Biology, University of Cambridge, Cambridge, UK"
],
"type": "Organization"
},
"familyName": "McKenzie",
"givenName": "A",
"id": "sg:person.0603056221.77",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0603056221.77"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "The Francis Crick Institute",
"id": "https://www.grid.ac/institutes/grid.451388.3",
"name": [
"Mill Hill Laboratory, The Francis Crick Institute, London, UK"
],
"type": "Organization"
},
"familyName": "Wilson",
"givenName": "M S",
"id": "sg:person.012276151467.88",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012276151467.88"
],
"type": "Person"
}
],
"citation": [
{
"id": "https://doi.org/10.1182/blood-2006-04-016857",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1001830232"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.4049/jimmunol.1401307",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1004695364"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.4049/jimmunol.1003383",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1004875721"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/ni.2208",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1005144013",
"https://doi.org/10.1038/ni.2208"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1073/pnas.1112268109",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1005542851"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/362245a0",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1007962456",
"https://doi.org/10.1038/362245a0"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/j.jaci.2013.03.048",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1008451887"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.4049/jimmunol.0902408",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1009121884"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1084/jem.20040590",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1011179981"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/ni.2131",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1015182063",
"https://doi.org/10.1038/ni.2131"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1084/jem.20091268",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1015861098"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1073/pnas.88.13.5513",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1015967905"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1084/jem.20121964",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1017309709"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/nature12526",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1017384485",
"https://doi.org/10.1038/nature12526"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/nm1451",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1017633261",
"https://doi.org/10.1038/nm1451"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/nm1451",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1017633261",
"https://doi.org/10.1038/nm1451"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1186/1756-3305-7-37",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1017909505",
"https://doi.org/10.1186/1756-3305-7-37"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/j.immuni.2012.06.020",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1018532766"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1371/journal.ppat.1004607",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1019565303"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/s1074-7613(00)80477-x",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1022160457"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1031/ni.2131",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1022898993"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1073/pnas.1121231109",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1023445946"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1073/pnas.0400339101",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1024128607"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.4049/jimmunol.1301176",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1026107525"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1084/jem.20051615",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1027619975"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.4049/jimmunol.1300974",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1027842215"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/nature08636",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1027865662",
"https://doi.org/10.1038/nature08636"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/nature08636",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1027865662",
"https://doi.org/10.1038/nature08636"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1371/journal.pntd.0003627",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1029664178"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/j.immuni.2014.01.011",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1031181072"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/ncomms6862",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1031334338",
"https://doi.org/10.1038/ncomms6862"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1084/jem.20051304",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1031524388"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/j.immuni.2012.08.015",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1031794777"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1128/iai.00436-12",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1035205743"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1182/blood-2014-07-587493",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1036726269"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/icb.2013.109",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1036781882",
"https://doi.org/10.1038/icb.2013.109"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.4110/in.2013.13.6.249",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1038337159"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/ni.2584",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1039602941",
"https://doi.org/10.1038/ni.2584"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/s0022-3476(83)80341-2",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1042369455"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/j.immuni.2014.06.016",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1043606115"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.4049/jimmunol.1500068",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1043964593"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1371/journal.ppat.1003531",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1045573178"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/j.immuni.2005.09.006",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1045620935"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1073/pnas.0501701102",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1046921863"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/ni.2133",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1048164096",
"https://doi.org/10.1038/ni.2133"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/nature08900",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1048663015",
"https://doi.org/10.1038/nature08900"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/nature08900",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1048663015",
"https://doi.org/10.1038/nature08900"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/j.immuni.2014.04.013",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1050210498"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.4049/jimmunol.167.4.2234",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1074859901"
],
"type": "CreativeWork"
},
{
"id": "https://app.dimensions.ai/details/publication/pub.1078378468",
"type": "CreativeWork"
},
{
"id": "https://app.dimensions.ai/details/publication/pub.1082479633",
"type": "CreativeWork"
}
],
"datePublished": "2016-11",
"datePublishedReg": "2016-11-01",
"description": "Immunity to many human and murine gastrointestinal helminth parasites requires interleukin-4 (IL-4)-directed type 2 helper (TH2) differentiation of CD4+ T cells to elicit type-2 immunity. Despite a good understanding of the inflammatory cascade elicited following helminth infection, the initial source of IL-4 is unclear. Previous studies using the rat helminth parasite Nippostronglyus brasiliensis, identified an important role for basophil-derived IL-4 for TH2 differentiation. However, basophils are redundant for TH2 differentiation following infection with the natural helminth parasite of mice Heligmosomoides polygyrus, indicating that other sources of IL-4 are required. In this study using H. polygyrus, which is controlled by IL-4-dependent immunity, we identified that group-2 innate lymphoid cells (ILC2s) produced significant amounts of IL-4 and IL-2 following H. polygyrus infection. Leukotriene D4 was sufficient to stimulate IL-4 secretion by ILC2s, and the supernatant from activated ILC2s could potently drive TH2 differentiation in vitro in an IL-4-dependent manner. Furthermore, specific deletion of IL-4 from ILC2s compromised TH2 differentiation in vivo. Overall, this study highlights a previously unrecognized and important role for ILC2-derived IL-4 for TH2 differentiation in a natural TH2-dependent model of human helminthiasis.",
"genre": "research_article",
"id": "sg:pub.10.1038/mi.2016.4",
"inLanguage": [
"en"
],
"isAccessibleForFree": true,
"isFundedItemOf": [
{
"id": "sg:grant.2779972",
"type": "MonetaryGrant"
},
{
"id": "sg:grant.2753023",
"type": "MonetaryGrant"
},
{
"id": "sg:grant.3640455",
"type": "MonetaryGrant"
}
],
"isPartOf": [
{
"id": "sg:journal.1038363",
"issn": [
"1933-0219",
"1935-3456"
],
"name": "Mucosal Immunology",
"type": "Periodical"
},
{
"issueNumber": "6",
"type": "PublicationIssue"
},
{
"type": "PublicationVolume",
"volumeNumber": "9"
}
],
"name": "IL-4-producing ILC2s are required for the differentiation of TH2 cells following Heligmosomoides polygyrus infection",
"pagination": "1407",
"productId": [
{
"name": "readcube_id",
"type": "PropertyValue",
"value": [
"9730fef213b3cf06eaee475d820152a627fa12d76360f042d0b08722235fd878"
]
},
{
"name": "pubmed_id",
"type": "PropertyValue",
"value": [
"26883724"
]
},
{
"name": "nlm_unique_id",
"type": "PropertyValue",
"value": [
"101299742"
]
},
{
"name": "doi",
"type": "PropertyValue",
"value": [
"10.1038/mi.2016.4"
]
},
{
"name": "dimensions_id",
"type": "PropertyValue",
"value": [
"pub.1031737667"
]
}
],
"sameAs": [
"https://doi.org/10.1038/mi.2016.4",
"https://app.dimensions.ai/details/publication/pub.1031737667"
],
"sdDataset": "articles",
"sdDatePublished": "2019-04-11T02:19",
"sdLicense": "https://scigraph.springernature.com/explorer/license/",
"sdPublisher": {
"name": "Springer Nature - SN SciGraph project",
"type": "Organization"
},
"sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8700_00000550.jsonl",
"type": "ScholarlyArticle",
"url": "https://www.nature.com/articles/mi20164"
}
]
Download the RDF metadata as: json-ld nt turtle xml License info
JSON-LD is a popular format for linked data which is fully compatible with JSON.
curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/mi.2016.4'
N-Triples is a line-based linked data format ideal for batch operations.
curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/mi.2016.4'
Turtle is a human-readable linked data format.
curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/mi.2016.4'
RDF/XML is a standard XML format for linked data.
curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/mi.2016.4'
This table displays all metadata directly associated to this object as RDF triples.
357 TRIPLES
21 PREDICATES
92 URIs
36 LITERALS
24 BLANK NODES