An in vitro model of innate lymphoid cell function and differentiation View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2015-03

AUTHORS

D S J Allan, C L Kirkham, O A Aguilar, L C Qu, P Chen, J H Fine, P Serra, G Awong, J L Gommerman, J C Zúñiga-Pflücker, J R Carlyle

ABSTRACT

Innate lymphoid cells (ILC) are RAG-independent lymphocytes with important roles in innate immunity, and include group-1 (natural killer (NK) cell, ILC1), group-2 (ILC2), and group-3 (lymphoid tissue inducer (LTi), NCR(+) ILC3) subsets. Group-3 ILC express Rorγt, produce interleukin (IL)-22, and are critically important in the normal function of mucosal tissues. Here, we describe a novel model cell line for the study of ILC function and differentiation. The parental MNK cell line, derived from NKR-P1B(+) fetal thymocytes, shows a capacity to differentiate in γc cytokines. One IL-7-responsive subline, designated MNK-3, expresses Rorγt and produces high levels of IL-22 in response to IL-23 and IL-1β stimulation. MNK-3 cells display surface markers and transcript expression characteristic of group-3 ILC, including IL-7Rα (CD127), c-kit (CD117), CCR6, Thy1 (CD90), RANK, RANKL, and lymphotoxin (LTα1β2). Using an in vitro assay of LTi cell activity, MNK-3 cells induce ICAM-1 and VCAM-1 expression on stromal cells in a manner dependent upon LTα1β2 expression. A second IL-2-responsive subline, MNK-1, expresses several NK cell receptors, perforin and granzymes, and shows some cytotoxic activity. Thus, MNK-1 cells serve as a model of ILC1/NK development and differentiation, whereas MNK-3 cells provide an attractive in vitro system to study the function of ILC3/LTi cells. More... »

PAGES

340

References to SciGraph publications

  • 2003-08. Genetically linked C-type lectin-related ligands for the NKRP1 family of natural killer cell receptors in NATURE IMMUNOLOGY
  • 2009-02-05. A human natural killer cell subset provides an innate source of IL-22 for mucosal immunity in NATURE
  • 2013-02. Innate lymphoid cells — a proposal for uniform nomenclature in NATURE REVIEWS IMMUNOLOGY
  • 2013-04. The transcription factor T-bet is essential for the development of NKp46+ innate lymphocytes via the Notch pathway in NATURE IMMUNOLOGY
  • 2012-02. AHR drives the development of gut ILC22 cells and postnatal lymphoid tissues via pathways dependent on and independent of Notch in NATURE IMMUNOLOGY
  • 2013-01-16. A T-bet gradient controls the fate and function of CCR6−RORγt+ innate lymphoid cells in NATURE
  • 2012-10. Molecular definition of the identity and activation of natural killer cells in NATURE IMMUNOLOGY
  • 2011-04. RORγt+ innate lymphoid cells regulate intestinal homeostasis by integrating negative signals from the symbiotic microbiota in NATURE IMMUNOLOGY
  • 2013-06. Innate lymphoid cells regulate CD4+ T-cell responses to intestinal commensal bacteria in NATURE
  • 2013-03. Human type 1 innate lymphoid cells accumulate in inflamed mucosal tissues in NATURE IMMUNOLOGY
  • 2008-10. The Immunological Genome Project: networks of gene expression in immune cells in NATURE IMMUNOLOGY
  • 2009-01. Influence of the transcription factor RORγt on the development of NKp46+ cell populations in gut and skin in NATURE IMMUNOLOGY
  • 2011-10. Notch signaling is necessary for adult, but not fetal, development of RORγt+ innate lymphoid cells in NATURE IMMUNOLOGY
  • 2014-04. A committed precursor to innate lymphoid cells in NATURE
  • 2010-04. Innate lymphoid cells drive interleukin-23-dependent innate intestinal pathology in NATURE
  • 2009-01. RORγt and commensal microflora are required for the differentiation of mucosal interleukin 22–producing NKp46+ cells in NATURE IMMUNOLOGY
  • 2009-01. Human fetal lymphoid tissue–inducer cells are interleukin 17–producing precursors to RORC+ CD127+ natural killer–like cells in NATURE IMMUNOLOGY
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/mi.2014.71

    DOI

    http://dx.doi.org/10.1038/mi.2014.71

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1010220614

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/25138665


    Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
    Incoming Citations Browse incoming citations for this publication using opencitations.net

    JSON-LD is the canonical representation for SciGraph data.

    TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

    [
      {
        "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
        "about": [
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1107", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Immunology", 
            "type": "DefinedTerm"
          }, 
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Medical and Health Sciences", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Animals", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Antigens, Surface", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Cell Differentiation", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Cell Lineage", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Cluster Analysis", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Cytokines", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Gene Expression Profiling", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Gene Expression Regulation", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Immunity, Innate", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Immunophenotyping", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Lymphocyte Subsets", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Lymphocytes", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Mice", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Nuclear Receptor Subfamily 1, Group F, Member 3", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Phenotype", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Receptors, Natural Killer Cell", 
            "type": "DefinedTerm"
          }
        ], 
        "author": [
          {
            "affiliation": {
              "alternateName": "University of Toronto", 
              "id": "https://www.grid.ac/institutes/grid.17063.33", 
              "name": [
                "1] Department of Immunology, University of Toronto, Toronto, Ontario, Canada [2] Sunnybrook Research Institute, Toronto, Ontario, Canada."
              ], 
              "type": "Organization"
            }, 
            "familyName": "Allan", 
            "givenName": "D S J", 
            "id": "sg:person.010471603052.51", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.010471603052.51"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "University of Toronto", 
              "id": "https://www.grid.ac/institutes/grid.17063.33", 
              "name": [
                "1] Department of Immunology, University of Toronto, Toronto, Ontario, Canada [2] Sunnybrook Research Institute, Toronto, Ontario, Canada."
              ], 
              "type": "Organization"
            }, 
            "familyName": "Kirkham", 
            "givenName": "C L", 
            "id": "sg:person.0775323322.62", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0775323322.62"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "University of Toronto", 
              "id": "https://www.grid.ac/institutes/grid.17063.33", 
              "name": [
                "1] Department of Immunology, University of Toronto, Toronto, Ontario, Canada [2] Sunnybrook Research Institute, Toronto, Ontario, Canada."
              ], 
              "type": "Organization"
            }, 
            "familyName": "Aguilar", 
            "givenName": "O A", 
            "id": "sg:person.01050466517.28", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01050466517.28"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "University of Toronto", 
              "id": "https://www.grid.ac/institutes/grid.17063.33", 
              "name": [
                "1] Department of Immunology, University of Toronto, Toronto, Ontario, Canada [2] Sunnybrook Research Institute, Toronto, Ontario, Canada."
              ], 
              "type": "Organization"
            }, 
            "familyName": "Qu", 
            "givenName": "L C", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "University of Toronto", 
              "id": "https://www.grid.ac/institutes/grid.17063.33", 
              "name": [
                "1] Department of Immunology, University of Toronto, Toronto, Ontario, Canada [2] Sunnybrook Research Institute, Toronto, Ontario, Canada."
              ], 
              "type": "Organization"
            }, 
            "familyName": "Chen", 
            "givenName": "P", 
            "id": "sg:person.01273510265.21", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01273510265.21"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "University of Toronto", 
              "id": "https://www.grid.ac/institutes/grid.17063.33", 
              "name": [
                "1] Department of Immunology, University of Toronto, Toronto, Ontario, Canada [2] Sunnybrook Research Institute, Toronto, Ontario, Canada."
              ], 
              "type": "Organization"
            }, 
            "familyName": "Fine", 
            "givenName": "J H", 
            "id": "sg:person.01121241657.40", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01121241657.40"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "University of Toronto", 
              "id": "https://www.grid.ac/institutes/grid.17063.33", 
              "name": [
                "1] Department of Immunology, University of Toronto, Toronto, Ontario, Canada [2] Sunnybrook Research Institute, Toronto, Ontario, Canada."
              ], 
              "type": "Organization"
            }, 
            "familyName": "Serra", 
            "givenName": "P", 
            "id": "sg:person.01336147260.15", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01336147260.15"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "University of Toronto", 
              "id": "https://www.grid.ac/institutes/grid.17063.33", 
              "name": [
                "1] Department of Immunology, University of Toronto, Toronto, Ontario, Canada [2] Sunnybrook Research Institute, Toronto, Ontario, Canada."
              ], 
              "type": "Organization"
            }, 
            "familyName": "Awong", 
            "givenName": "G", 
            "id": "sg:person.0703454725.02", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0703454725.02"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "University of Toronto", 
              "id": "https://www.grid.ac/institutes/grid.17063.33", 
              "name": [
                "Department of Immunology, University of Toronto, Toronto, Ontario, Canada."
              ], 
              "type": "Organization"
            }, 
            "familyName": "Gommerman", 
            "givenName": "J L", 
            "id": "sg:person.01130567300.79", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01130567300.79"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "University of Toronto", 
              "id": "https://www.grid.ac/institutes/grid.17063.33", 
              "name": [
                "1] Department of Immunology, University of Toronto, Toronto, Ontario, Canada [2] Sunnybrook Research Institute, Toronto, Ontario, Canada."
              ], 
              "type": "Organization"
            }, 
            "familyName": "Z\u00fa\u00f1iga-Pfl\u00fccker", 
            "givenName": "J C", 
            "id": "sg:person.01017703325.35", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01017703325.35"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "University of Toronto", 
              "id": "https://www.grid.ac/institutes/grid.17063.33", 
              "name": [
                "1] Department of Immunology, University of Toronto, Toronto, Ontario, Canada [2] Sunnybrook Research Institute, Toronto, Ontario, Canada."
              ], 
              "type": "Organization"
            }, 
            "familyName": "Carlyle", 
            "givenName": "J R", 
            "id": "sg:person.01201541270.79", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01201541270.79"
            ], 
            "type": "Person"
          }
        ], 
        "citation": [
          {
            "id": "https://doi.org/10.1073/pnas.1005641107", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1001994808"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1084/jem.20070991", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1003052883"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature12240", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1003249903", 
              "https://doi.org/10.1038/nature12240"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.immuni.2013.05.013", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1005013952"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.immuni.2011.11.011", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1005043085"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1126/science.1194597", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1006891321"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1084/jem.186.2.173", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1010307365"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1126/science.1222551", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1011112407"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ni.2395", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1012307741", 
              "https://doi.org/10.1038/ni.2395"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1084/jem.20071451", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1012642710"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ni.2105", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1012988142", 
              "https://doi.org/10.1038/ni.2105"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.4049/jimmunol.176.12.7511", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1013737144"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ni.1684", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1013769615", 
              "https://doi.org/10.1038/ni.1684"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1111/j.1365-2567.2007.02750.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1013947886"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.coi.2013.02.010", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1014688955"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ni.2187", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1014806810", 
              "https://doi.org/10.1038/ni.2187"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.immuni.2010.10.017", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1016292624"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.immuni.2008.11.001", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1016376003"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nri3365", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1016630001", 
              "https://doi.org/10.1038/nri3365"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature11813", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1016917426", 
              "https://doi.org/10.1038/nature11813"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.immuni.2012.06.020", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1018532766"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.coi.2013.02.002", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1018918875"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ni.1668", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1019859816", 
              "https://doi.org/10.1038/ni.1668"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.immuni.2013.02.010", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1020446447"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ni.1681", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1020550984", 
              "https://doi.org/10.1038/ni.1681"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1084/jem.20072713", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1021611842"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s1074-7613(00)80371-4", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1022179174"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature13047", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1022835072", 
              "https://doi.org/10.1038/nature13047"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1038/sj.mt.6300184", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1023958946"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ni1008-1091", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1024946259", 
              "https://doi.org/10.1038/ni1008-1091"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ni.2534", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1028166729", 
              "https://doi.org/10.1038/ni.2534"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ni.2545", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1030003509", 
              "https://doi.org/10.1038/ni.2545"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ni.2002", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1032260623", 
              "https://doi.org/10.1038/ni.2002"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.0308304101", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1032868319"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.chom.2011.06.002", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1033666484"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature08949", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1034349190", 
              "https://doi.org/10.1038/nature08949"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature08949", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1034349190", 
              "https://doi.org/10.1038/nature08949"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1126/science.1249288", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1035250984"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1084/jem.20062497", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1035266957"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.immuni.2008.11.003", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1035408437"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1146/annurev.immunol.26.021607.090257", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1035986763"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1084/jem.20131038", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1036539999"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1126/science.1214914", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1038071037"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.immuni.2012.05.028", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1040417808"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1126/science.1218004", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1044125042"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1126/science.1218004", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1044125042"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.immuni.2010.12.009", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1044765875"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature07537", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1044944247", 
              "https://doi.org/10.1038/nature07537"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s1673-8527(09)60067-9", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1047562910"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/intimm/dxt063", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1048776058"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1084/jem.20111594", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1049171101"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.coi.2005.01.006", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1050696160"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.4049/jimmunol.1202924", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1050872915"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1146/annurev-immunol-020711-075053", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1050933093"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.cell.2012.09.016", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1051015260"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ni954", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1051530121", 
              "https://doi.org/10.1038/ni954"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ni954", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1051530121", 
              "https://doi.org/10.1038/ni954"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1126/science.1243364", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1062468970"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1074368132", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.4049/jimmunol.1301228", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1078786996"
            ], 
            "type": "CreativeWork"
          }
        ], 
        "datePublished": "2015-03", 
        "datePublishedReg": "2015-03-01", 
        "description": "Innate lymphoid cells (ILC) are RAG-independent lymphocytes with important roles in innate immunity, and include group-1 (natural killer (NK) cell, ILC1), group-2 (ILC2), and group-3 (lymphoid tissue inducer (LTi), NCR(+) ILC3) subsets. Group-3 ILC express Ror\u03b3t, produce interleukin (IL)-22, and are critically important in the normal function of mucosal tissues. Here, we describe a novel model cell line for the study of ILC function and differentiation. The parental MNK cell line, derived from NKR-P1B(+) fetal thymocytes, shows a capacity to differentiate in \u03b3c cytokines. One IL-7-responsive subline, designated MNK-3, expresses Ror\u03b3t and produces high levels of IL-22 in response to IL-23 and IL-1\u03b2 stimulation. MNK-3 cells display surface markers and transcript expression characteristic of group-3 ILC, including IL-7R\u03b1 (CD127), c-kit (CD117), CCR6, Thy1 (CD90), RANK, RANKL, and lymphotoxin (LT\u03b11\u03b22). Using an in vitro assay of LTi cell activity, MNK-3 cells induce ICAM-1 and VCAM-1 expression on stromal cells in a manner dependent upon LT\u03b11\u03b22 expression. A second IL-2-responsive subline, MNK-1, expresses several NK cell receptors, perforin and granzymes, and shows some cytotoxic activity. Thus, MNK-1 cells serve as a model of ILC1/NK development and differentiation, whereas MNK-3 cells provide an attractive in vitro system to study the function of ILC3/LTi cells. ", 
        "genre": "research_article", 
        "id": "sg:pub.10.1038/mi.2014.71", 
        "inLanguage": [
          "en"
        ], 
        "isAccessibleForFree": true, 
        "isPartOf": [
          {
            "id": "sg:journal.1038363", 
            "issn": [
              "1933-0219", 
              "1935-3456"
            ], 
            "name": "Mucosal Immunology", 
            "type": "Periodical"
          }, 
          {
            "issueNumber": "2", 
            "type": "PublicationIssue"
          }, 
          {
            "type": "PublicationVolume", 
            "volumeNumber": "8"
          }
        ], 
        "name": "An in vitro model of innate lymphoid cell function and differentiation", 
        "pagination": "340", 
        "productId": [
          {
            "name": "readcube_id", 
            "type": "PropertyValue", 
            "value": [
              "30b12f6228144410267b5250b7fa064f4dbb2be78fb8d6520cd27cd733709b61"
            ]
          }, 
          {
            "name": "pubmed_id", 
            "type": "PropertyValue", 
            "value": [
              "25138665"
            ]
          }, 
          {
            "name": "nlm_unique_id", 
            "type": "PropertyValue", 
            "value": [
              "101299742"
            ]
          }, 
          {
            "name": "doi", 
            "type": "PropertyValue", 
            "value": [
              "10.1038/mi.2014.71"
            ]
          }, 
          {
            "name": "dimensions_id", 
            "type": "PropertyValue", 
            "value": [
              "pub.1010220614"
            ]
          }
        ], 
        "sameAs": [
          "https://doi.org/10.1038/mi.2014.71", 
          "https://app.dimensions.ai/details/publication/pub.1010220614"
        ], 
        "sdDataset": "articles", 
        "sdDatePublished": "2019-04-10T13:57", 
        "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
        "sdPublisher": {
          "name": "Springer Nature - SN SciGraph project", 
          "type": "Organization"
        }, 
        "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8660_00000434.jsonl", 
        "type": "ScholarlyArticle", 
        "url": "https://www.nature.com/articles/mi201471"
      }
    ]
     

    Download the RDF metadata as:  json-ld nt turtle xml License info

    HOW TO GET THIS DATA PROGRAMMATICALLY:

    JSON-LD is a popular format for linked data which is fully compatible with JSON.

    curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/mi.2014.71'

    N-Triples is a line-based linked data format ideal for batch operations.

    curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/mi.2014.71'

    Turtle is a human-readable linked data format.

    curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/mi.2014.71'

    RDF/XML is a standard XML format for linked data.

    curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/mi.2014.71'


     

    This table displays all metadata directly associated to this object as RDF triples.

    390 TRIPLES      21 PREDICATES      102 URIs      37 LITERALS      25 BLANK NODES

    Subject Predicate Object
    1 sg:pub.10.1038/mi.2014.71 schema:about N0a558264917d4561a2f609381236f752
    2 N0fdfaf968e1b4583bb190d9c1bb1e76f
    3 N1e46c31b1a3746b789ae0e4595a9f257
    4 N24ec26c09ca84e958dbdd848f78c6af7
    5 N28f37602e13d4c7eaf48e33e3bdc51d1
    6 N29abc6a480754d229b354ecb854e0415
    7 N2b4e819a31c44798a6b8dd9a69206c85
    8 N4535ef0e2fde4b23b21333dfd955c95e
    9 N53314894311c4dc99977a1f30a277091
    10 N541ea81155b345c6a322e2d21232a5b7
    11 N651ebe65668a4a20924f0ab8950738e2
    12 N9592f4c7729a4e3d8d1ad3fbe0b09e6a
    13 Na77c540a8e6f4bbb9d6362950b112e40
    14 Nc1ed5d1c33a14af7abbae07f77b6d821
    15 Nc5bb27da3f984306892d43ef4b2f870e
    16 Ne6da063896bc481f9912b790dbe33a37
    17 anzsrc-for:11
    18 anzsrc-for:1107
    19 schema:author N5e94c768a15444238ff9ff3f20346e9c
    20 schema:citation sg:pub.10.1038/nature07537
    21 sg:pub.10.1038/nature08949
    22 sg:pub.10.1038/nature11813
    23 sg:pub.10.1038/nature12240
    24 sg:pub.10.1038/nature13047
    25 sg:pub.10.1038/ni.1668
    26 sg:pub.10.1038/ni.1681
    27 sg:pub.10.1038/ni.1684
    28 sg:pub.10.1038/ni.2002
    29 sg:pub.10.1038/ni.2105
    30 sg:pub.10.1038/ni.2187
    31 sg:pub.10.1038/ni.2395
    32 sg:pub.10.1038/ni.2534
    33 sg:pub.10.1038/ni.2545
    34 sg:pub.10.1038/ni1008-1091
    35 sg:pub.10.1038/ni954
    36 sg:pub.10.1038/nri3365
    37 https://app.dimensions.ai/details/publication/pub.1074368132
    38 https://doi.org/10.1016/j.cell.2012.09.016
    39 https://doi.org/10.1016/j.chom.2011.06.002
    40 https://doi.org/10.1016/j.coi.2005.01.006
    41 https://doi.org/10.1016/j.coi.2013.02.002
    42 https://doi.org/10.1016/j.coi.2013.02.010
    43 https://doi.org/10.1016/j.immuni.2008.11.001
    44 https://doi.org/10.1016/j.immuni.2008.11.003
    45 https://doi.org/10.1016/j.immuni.2010.10.017
    46 https://doi.org/10.1016/j.immuni.2010.12.009
    47 https://doi.org/10.1016/j.immuni.2011.11.011
    48 https://doi.org/10.1016/j.immuni.2012.05.028
    49 https://doi.org/10.1016/j.immuni.2012.06.020
    50 https://doi.org/10.1016/j.immuni.2013.02.010
    51 https://doi.org/10.1016/j.immuni.2013.05.013
    52 https://doi.org/10.1016/s1074-7613(00)80371-4
    53 https://doi.org/10.1016/s1673-8527(09)60067-9
    54 https://doi.org/10.1038/sj.mt.6300184
    55 https://doi.org/10.1073/pnas.0308304101
    56 https://doi.org/10.1073/pnas.1005641107
    57 https://doi.org/10.1084/jem.186.2.173
    58 https://doi.org/10.1084/jem.20062497
    59 https://doi.org/10.1084/jem.20070991
    60 https://doi.org/10.1084/jem.20071451
    61 https://doi.org/10.1084/jem.20072713
    62 https://doi.org/10.1084/jem.20111594
    63 https://doi.org/10.1084/jem.20131038
    64 https://doi.org/10.1093/intimm/dxt063
    65 https://doi.org/10.1111/j.1365-2567.2007.02750.x
    66 https://doi.org/10.1126/science.1194597
    67 https://doi.org/10.1126/science.1214914
    68 https://doi.org/10.1126/science.1218004
    69 https://doi.org/10.1126/science.1222551
    70 https://doi.org/10.1126/science.1243364
    71 https://doi.org/10.1126/science.1249288
    72 https://doi.org/10.1146/annurev-immunol-020711-075053
    73 https://doi.org/10.1146/annurev.immunol.26.021607.090257
    74 https://doi.org/10.4049/jimmunol.1202924
    75 https://doi.org/10.4049/jimmunol.1301228
    76 https://doi.org/10.4049/jimmunol.176.12.7511
    77 schema:datePublished 2015-03
    78 schema:datePublishedReg 2015-03-01
    79 schema:description Innate lymphoid cells (ILC) are RAG-independent lymphocytes with important roles in innate immunity, and include group-1 (natural killer (NK) cell, ILC1), group-2 (ILC2), and group-3 (lymphoid tissue inducer (LTi), NCR(+) ILC3) subsets. Group-3 ILC express Rorγt, produce interleukin (IL)-22, and are critically important in the normal function of mucosal tissues. Here, we describe a novel model cell line for the study of ILC function and differentiation. The parental MNK cell line, derived from NKR-P1B(+) fetal thymocytes, shows a capacity to differentiate in γc cytokines. One IL-7-responsive subline, designated MNK-3, expresses Rorγt and produces high levels of IL-22 in response to IL-23 and IL-1β stimulation. MNK-3 cells display surface markers and transcript expression characteristic of group-3 ILC, including IL-7Rα (CD127), c-kit (CD117), CCR6, Thy1 (CD90), RANK, RANKL, and lymphotoxin (LTα1β2). Using an in vitro assay of LTi cell activity, MNK-3 cells induce ICAM-1 and VCAM-1 expression on stromal cells in a manner dependent upon LTα1β2 expression. A second IL-2-responsive subline, MNK-1, expresses several NK cell receptors, perforin and granzymes, and shows some cytotoxic activity. Thus, MNK-1 cells serve as a model of ILC1/NK development and differentiation, whereas MNK-3 cells provide an attractive in vitro system to study the function of ILC3/LTi cells.
    80 schema:genre research_article
    81 schema:inLanguage en
    82 schema:isAccessibleForFree true
    83 schema:isPartOf N89ad28d79d2a4604928893d79b82b00f
    84 Nde460bafbc2e4de1b0fb62049bc78656
    85 sg:journal.1038363
    86 schema:name An in vitro model of innate lymphoid cell function and differentiation
    87 schema:pagination 340
    88 schema:productId N308a8266d5d54c9c95f5898b35925da4
    89 N3ebca133e64c430f86e889dac40cbbb9
    90 N4f2b2e35473a411a8ad5cf4aef4bd9c9
    91 Nb146da6280f74c018454272bcdd1c398
    92 Ne155bb6a29c5408f81beb6610b0d4295
    93 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010220614
    94 https://doi.org/10.1038/mi.2014.71
    95 schema:sdDatePublished 2019-04-10T13:57
    96 schema:sdLicense https://scigraph.springernature.com/explorer/license/
    97 schema:sdPublisher Nc420c022749848a7aca16e3a087036d0
    98 schema:url https://www.nature.com/articles/mi201471
    99 sgo:license sg:explorer/license/
    100 sgo:sdDataset articles
    101 rdf:type schema:ScholarlyArticle
    102 N0a558264917d4561a2f609381236f752 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    103 schema:name Gene Expression Regulation
    104 rdf:type schema:DefinedTerm
    105 N0fdfaf968e1b4583bb190d9c1bb1e76f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    106 schema:name Gene Expression Profiling
    107 rdf:type schema:DefinedTerm
    108 N1bb0f073b3be470fb00ba769d662e76e rdf:first sg:person.01017703325.35
    109 rdf:rest N613b7588b84940a3ac61c1a258c84a21
    110 N1e46c31b1a3746b789ae0e4595a9f257 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    111 schema:name Immunity, Innate
    112 rdf:type schema:DefinedTerm
    113 N22d9028b036644f98437553bb064055a rdf:first sg:person.0703454725.02
    114 rdf:rest N69b91043407544c6a8bcfe4d8fbf7f60
    115 N24ec26c09ca84e958dbdd848f78c6af7 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    116 schema:name Cell Differentiation
    117 rdf:type schema:DefinedTerm
    118 N28f37602e13d4c7eaf48e33e3bdc51d1 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    119 schema:name Lymphocytes
    120 rdf:type schema:DefinedTerm
    121 N29abc6a480754d229b354ecb854e0415 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    122 schema:name Cluster Analysis
    123 rdf:type schema:DefinedTerm
    124 N2b4e819a31c44798a6b8dd9a69206c85 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    125 schema:name Nuclear Receptor Subfamily 1, Group F, Member 3
    126 rdf:type schema:DefinedTerm
    127 N308a8266d5d54c9c95f5898b35925da4 schema:name readcube_id
    128 schema:value 30b12f6228144410267b5250b7fa064f4dbb2be78fb8d6520cd27cd733709b61
    129 rdf:type schema:PropertyValue
    130 N31c48cf2be404b78af312bb695351b4f rdf:first sg:person.01050466517.28
    131 rdf:rest N3721cd456ff04f2897a6b71ff6235339
    132 N3721cd456ff04f2897a6b71ff6235339 rdf:first Nf2bc6cc7fecf4dc4b5ad51bc64af50b5
    133 rdf:rest N735a652f9c1e4c1c986e74a26ea6bd9a
    134 N3ebca133e64c430f86e889dac40cbbb9 schema:name doi
    135 schema:value 10.1038/mi.2014.71
    136 rdf:type schema:PropertyValue
    137 N4535ef0e2fde4b23b21333dfd955c95e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    138 schema:name Lymphocyte Subsets
    139 rdf:type schema:DefinedTerm
    140 N4f2b2e35473a411a8ad5cf4aef4bd9c9 schema:name pubmed_id
    141 schema:value 25138665
    142 rdf:type schema:PropertyValue
    143 N53314894311c4dc99977a1f30a277091 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    144 schema:name Animals
    145 rdf:type schema:DefinedTerm
    146 N541ea81155b345c6a322e2d21232a5b7 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    147 schema:name Antigens, Surface
    148 rdf:type schema:DefinedTerm
    149 N5e94c768a15444238ff9ff3f20346e9c rdf:first sg:person.010471603052.51
    150 rdf:rest Ndb1d41585ba34b4baa0f3d2f8f665016
    151 N613b7588b84940a3ac61c1a258c84a21 rdf:first sg:person.01201541270.79
    152 rdf:rest rdf:nil
    153 N634eb93b057b4c0a882fb1759f240460 rdf:first sg:person.01121241657.40
    154 rdf:rest N6cee3ea4e88344db8641248a2df19ec7
    155 N651ebe65668a4a20924f0ab8950738e2 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    156 schema:name Cell Lineage
    157 rdf:type schema:DefinedTerm
    158 N69b91043407544c6a8bcfe4d8fbf7f60 rdf:first sg:person.01130567300.79
    159 rdf:rest N1bb0f073b3be470fb00ba769d662e76e
    160 N6cee3ea4e88344db8641248a2df19ec7 rdf:first sg:person.01336147260.15
    161 rdf:rest N22d9028b036644f98437553bb064055a
    162 N735a652f9c1e4c1c986e74a26ea6bd9a rdf:first sg:person.01273510265.21
    163 rdf:rest N634eb93b057b4c0a882fb1759f240460
    164 N89ad28d79d2a4604928893d79b82b00f schema:volumeNumber 8
    165 rdf:type schema:PublicationVolume
    166 N9592f4c7729a4e3d8d1ad3fbe0b09e6a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    167 schema:name Immunophenotyping
    168 rdf:type schema:DefinedTerm
    169 Na77c540a8e6f4bbb9d6362950b112e40 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    170 schema:name Mice
    171 rdf:type schema:DefinedTerm
    172 Nb146da6280f74c018454272bcdd1c398 schema:name dimensions_id
    173 schema:value pub.1010220614
    174 rdf:type schema:PropertyValue
    175 Nc1ed5d1c33a14af7abbae07f77b6d821 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    176 schema:name Receptors, Natural Killer Cell
    177 rdf:type schema:DefinedTerm
    178 Nc420c022749848a7aca16e3a087036d0 schema:name Springer Nature - SN SciGraph project
    179 rdf:type schema:Organization
    180 Nc5bb27da3f984306892d43ef4b2f870e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    181 schema:name Phenotype
    182 rdf:type schema:DefinedTerm
    183 Ndb1d41585ba34b4baa0f3d2f8f665016 rdf:first sg:person.0775323322.62
    184 rdf:rest N31c48cf2be404b78af312bb695351b4f
    185 Nde460bafbc2e4de1b0fb62049bc78656 schema:issueNumber 2
    186 rdf:type schema:PublicationIssue
    187 Ne155bb6a29c5408f81beb6610b0d4295 schema:name nlm_unique_id
    188 schema:value 101299742
    189 rdf:type schema:PropertyValue
    190 Ne6da063896bc481f9912b790dbe33a37 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    191 schema:name Cytokines
    192 rdf:type schema:DefinedTerm
    193 Nf2bc6cc7fecf4dc4b5ad51bc64af50b5 schema:affiliation https://www.grid.ac/institutes/grid.17063.33
    194 schema:familyName Qu
    195 schema:givenName L C
    196 rdf:type schema:Person
    197 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
    198 schema:name Medical and Health Sciences
    199 rdf:type schema:DefinedTerm
    200 anzsrc-for:1107 schema:inDefinedTermSet anzsrc-for:
    201 schema:name Immunology
    202 rdf:type schema:DefinedTerm
    203 sg:journal.1038363 schema:issn 1933-0219
    204 1935-3456
    205 schema:name Mucosal Immunology
    206 rdf:type schema:Periodical
    207 sg:person.01017703325.35 schema:affiliation https://www.grid.ac/institutes/grid.17063.33
    208 schema:familyName Zúñiga-Pflücker
    209 schema:givenName J C
    210 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01017703325.35
    211 rdf:type schema:Person
    212 sg:person.010471603052.51 schema:affiliation https://www.grid.ac/institutes/grid.17063.33
    213 schema:familyName Allan
    214 schema:givenName D S J
    215 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.010471603052.51
    216 rdf:type schema:Person
    217 sg:person.01050466517.28 schema:affiliation https://www.grid.ac/institutes/grid.17063.33
    218 schema:familyName Aguilar
    219 schema:givenName O A
    220 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01050466517.28
    221 rdf:type schema:Person
    222 sg:person.01121241657.40 schema:affiliation https://www.grid.ac/institutes/grid.17063.33
    223 schema:familyName Fine
    224 schema:givenName J H
    225 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01121241657.40
    226 rdf:type schema:Person
    227 sg:person.01130567300.79 schema:affiliation https://www.grid.ac/institutes/grid.17063.33
    228 schema:familyName Gommerman
    229 schema:givenName J L
    230 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01130567300.79
    231 rdf:type schema:Person
    232 sg:person.01201541270.79 schema:affiliation https://www.grid.ac/institutes/grid.17063.33
    233 schema:familyName Carlyle
    234 schema:givenName J R
    235 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01201541270.79
    236 rdf:type schema:Person
    237 sg:person.01273510265.21 schema:affiliation https://www.grid.ac/institutes/grid.17063.33
    238 schema:familyName Chen
    239 schema:givenName P
    240 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01273510265.21
    241 rdf:type schema:Person
    242 sg:person.01336147260.15 schema:affiliation https://www.grid.ac/institutes/grid.17063.33
    243 schema:familyName Serra
    244 schema:givenName P
    245 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01336147260.15
    246 rdf:type schema:Person
    247 sg:person.0703454725.02 schema:affiliation https://www.grid.ac/institutes/grid.17063.33
    248 schema:familyName Awong
    249 schema:givenName G
    250 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0703454725.02
    251 rdf:type schema:Person
    252 sg:person.0775323322.62 schema:affiliation https://www.grid.ac/institutes/grid.17063.33
    253 schema:familyName Kirkham
    254 schema:givenName C L
    255 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0775323322.62
    256 rdf:type schema:Person
    257 sg:pub.10.1038/nature07537 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044944247
    258 https://doi.org/10.1038/nature07537
    259 rdf:type schema:CreativeWork
    260 sg:pub.10.1038/nature08949 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034349190
    261 https://doi.org/10.1038/nature08949
    262 rdf:type schema:CreativeWork
    263 sg:pub.10.1038/nature11813 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016917426
    264 https://doi.org/10.1038/nature11813
    265 rdf:type schema:CreativeWork
    266 sg:pub.10.1038/nature12240 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003249903
    267 https://doi.org/10.1038/nature12240
    268 rdf:type schema:CreativeWork
    269 sg:pub.10.1038/nature13047 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022835072
    270 https://doi.org/10.1038/nature13047
    271 rdf:type schema:CreativeWork
    272 sg:pub.10.1038/ni.1668 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019859816
    273 https://doi.org/10.1038/ni.1668
    274 rdf:type schema:CreativeWork
    275 sg:pub.10.1038/ni.1681 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020550984
    276 https://doi.org/10.1038/ni.1681
    277 rdf:type schema:CreativeWork
    278 sg:pub.10.1038/ni.1684 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013769615
    279 https://doi.org/10.1038/ni.1684
    280 rdf:type schema:CreativeWork
    281 sg:pub.10.1038/ni.2002 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032260623
    282 https://doi.org/10.1038/ni.2002
    283 rdf:type schema:CreativeWork
    284 sg:pub.10.1038/ni.2105 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012988142
    285 https://doi.org/10.1038/ni.2105
    286 rdf:type schema:CreativeWork
    287 sg:pub.10.1038/ni.2187 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014806810
    288 https://doi.org/10.1038/ni.2187
    289 rdf:type schema:CreativeWork
    290 sg:pub.10.1038/ni.2395 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012307741
    291 https://doi.org/10.1038/ni.2395
    292 rdf:type schema:CreativeWork
    293 sg:pub.10.1038/ni.2534 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028166729
    294 https://doi.org/10.1038/ni.2534
    295 rdf:type schema:CreativeWork
    296 sg:pub.10.1038/ni.2545 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030003509
    297 https://doi.org/10.1038/ni.2545
    298 rdf:type schema:CreativeWork
    299 sg:pub.10.1038/ni1008-1091 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024946259
    300 https://doi.org/10.1038/ni1008-1091
    301 rdf:type schema:CreativeWork
    302 sg:pub.10.1038/ni954 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051530121
    303 https://doi.org/10.1038/ni954
    304 rdf:type schema:CreativeWork
    305 sg:pub.10.1038/nri3365 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016630001
    306 https://doi.org/10.1038/nri3365
    307 rdf:type schema:CreativeWork
    308 https://app.dimensions.ai/details/publication/pub.1074368132 schema:CreativeWork
    309 https://doi.org/10.1016/j.cell.2012.09.016 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051015260
    310 rdf:type schema:CreativeWork
    311 https://doi.org/10.1016/j.chom.2011.06.002 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033666484
    312 rdf:type schema:CreativeWork
    313 https://doi.org/10.1016/j.coi.2005.01.006 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050696160
    314 rdf:type schema:CreativeWork
    315 https://doi.org/10.1016/j.coi.2013.02.002 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018918875
    316 rdf:type schema:CreativeWork
    317 https://doi.org/10.1016/j.coi.2013.02.010 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014688955
    318 rdf:type schema:CreativeWork
    319 https://doi.org/10.1016/j.immuni.2008.11.001 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016376003
    320 rdf:type schema:CreativeWork
    321 https://doi.org/10.1016/j.immuni.2008.11.003 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035408437
    322 rdf:type schema:CreativeWork
    323 https://doi.org/10.1016/j.immuni.2010.10.017 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016292624
    324 rdf:type schema:CreativeWork
    325 https://doi.org/10.1016/j.immuni.2010.12.009 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044765875
    326 rdf:type schema:CreativeWork
    327 https://doi.org/10.1016/j.immuni.2011.11.011 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005043085
    328 rdf:type schema:CreativeWork
    329 https://doi.org/10.1016/j.immuni.2012.05.028 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040417808
    330 rdf:type schema:CreativeWork
    331 https://doi.org/10.1016/j.immuni.2012.06.020 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018532766
    332 rdf:type schema:CreativeWork
    333 https://doi.org/10.1016/j.immuni.2013.02.010 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020446447
    334 rdf:type schema:CreativeWork
    335 https://doi.org/10.1016/j.immuni.2013.05.013 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005013952
    336 rdf:type schema:CreativeWork
    337 https://doi.org/10.1016/s1074-7613(00)80371-4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022179174
    338 rdf:type schema:CreativeWork
    339 https://doi.org/10.1016/s1673-8527(09)60067-9 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047562910
    340 rdf:type schema:CreativeWork
    341 https://doi.org/10.1038/sj.mt.6300184 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023958946
    342 rdf:type schema:CreativeWork
    343 https://doi.org/10.1073/pnas.0308304101 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032868319
    344 rdf:type schema:CreativeWork
    345 https://doi.org/10.1073/pnas.1005641107 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001994808
    346 rdf:type schema:CreativeWork
    347 https://doi.org/10.1084/jem.186.2.173 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010307365
    348 rdf:type schema:CreativeWork
    349 https://doi.org/10.1084/jem.20062497 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035266957
    350 rdf:type schema:CreativeWork
    351 https://doi.org/10.1084/jem.20070991 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003052883
    352 rdf:type schema:CreativeWork
    353 https://doi.org/10.1084/jem.20071451 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012642710
    354 rdf:type schema:CreativeWork
    355 https://doi.org/10.1084/jem.20072713 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021611842
    356 rdf:type schema:CreativeWork
    357 https://doi.org/10.1084/jem.20111594 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049171101
    358 rdf:type schema:CreativeWork
    359 https://doi.org/10.1084/jem.20131038 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036539999
    360 rdf:type schema:CreativeWork
    361 https://doi.org/10.1093/intimm/dxt063 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048776058
    362 rdf:type schema:CreativeWork
    363 https://doi.org/10.1111/j.1365-2567.2007.02750.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1013947886
    364 rdf:type schema:CreativeWork
    365 https://doi.org/10.1126/science.1194597 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006891321
    366 rdf:type schema:CreativeWork
    367 https://doi.org/10.1126/science.1214914 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038071037
    368 rdf:type schema:CreativeWork
    369 https://doi.org/10.1126/science.1218004 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044125042
    370 rdf:type schema:CreativeWork
    371 https://doi.org/10.1126/science.1222551 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011112407
    372 rdf:type schema:CreativeWork
    373 https://doi.org/10.1126/science.1243364 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062468970
    374 rdf:type schema:CreativeWork
    375 https://doi.org/10.1126/science.1249288 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035250984
    376 rdf:type schema:CreativeWork
    377 https://doi.org/10.1146/annurev-immunol-020711-075053 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050933093
    378 rdf:type schema:CreativeWork
    379 https://doi.org/10.1146/annurev.immunol.26.021607.090257 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035986763
    380 rdf:type schema:CreativeWork
    381 https://doi.org/10.4049/jimmunol.1202924 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050872915
    382 rdf:type schema:CreativeWork
    383 https://doi.org/10.4049/jimmunol.1301228 schema:sameAs https://app.dimensions.ai/details/publication/pub.1078786996
    384 rdf:type schema:CreativeWork
    385 https://doi.org/10.4049/jimmunol.176.12.7511 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013737144
    386 rdf:type schema:CreativeWork
    387 https://www.grid.ac/institutes/grid.17063.33 schema:alternateName University of Toronto
    388 schema:name 1] Department of Immunology, University of Toronto, Toronto, Ontario, Canada [2] Sunnybrook Research Institute, Toronto, Ontario, Canada.
    389 Department of Immunology, University of Toronto, Toronto, Ontario, Canada.
    390 rdf:type schema:Organization
     




    Preview window. Press ESC to close (or click here)


    ...