Gene-centric association mapping of chromosome 3p implicates MST1 in IBD pathogenesis View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2008-03

AUTHORS

P Goyette, C Lefebvre, A Ng, S R Brant, J H Cho, R H Duerr, M S Silverberg, K D Taylor, A Latiano, G Aumais, C Deslandres, G Jobin, V Annese, M J Daly, R J Xavier, J D Rioux

ABSTRACT

Association mapping and candidate gene studies within inflammatory bowel diseases (IBD) linkage regions, as well as genome-wide association studies in Crohn's disease (CD) have led to the discovery of multiple risk genes, but these explain only a fraction of the genetic susceptibility observed in IBD. We have thus been pursuing a region on chromosome 3p21-22 showing linkage to CD and ulcerative colitis (UC) using a gene-centric association mapping approach. We identified 12 functional candidate genes by searching for literature cocitations with relevant keywords and for gene expression patterns consistent with immune/intestinal function. We then performed an association study composed of a screening phase, where tagging single nucleotide polymorphisms (SNPs) were evaluated in 1,020 IBD patients, and an independent replication phase in 745 IBD patients. These analyses identified and replicated significant association with IBD for four SNPs within a 1.2 Mb linkage disequilibrium region. We then identified a non-synonymous coding variant (rs3197999, R689C) in the macrophage-stimulating 1 (MST1) gene (P-value 3.62 x 10(-6)) that accounts for the association signal, and shows association with both CD and UC. MST1 encodes macrophage-stimulating protein (MSP), a protein regulating the innate immune responses to bacterial ligands. R689C is predicted to interfere with MSP binding to its receptor, suggesting a role for this gene in the pathogenesis of IBD. More... »

PAGES

131

References to SciGraph publications

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/mi.2007.15

DOI

http://dx.doi.org/10.1038/mi.2007.15

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1024892825

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/19079170


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/0604", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Genetics", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/06", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Biological Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Chromosome Mapping", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Chromosomes, Human, Pair 3", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Colitis, Ulcerative", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Crohn Disease", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Female", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Genetic Predisposition to Disease", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Genome, Human", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Hepatocyte Growth Factor", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Linkage Disequilibrium", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Male", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Polymorphism, Single Nucleotide", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Protein Binding", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Proto-Oncogene Proteins", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Receptor Protein-Tyrosine Kinases", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "McGill University Health Centre", 
          "id": "https://www.grid.ac/institutes/grid.63984.30", 
          "name": [
            "Department of Medicine, Universit\u00e9 de Montr\u00e9al and the Montreal Heart Institute, Research Center, Montreal, Qu\u00e9bec, Canada"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Goyette", 
        "givenName": "P", 
        "id": "sg:person.01263200673.64", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01263200673.64"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "McGill University Health Centre", 
          "id": "https://www.grid.ac/institutes/grid.63984.30", 
          "name": [
            "Department of Medicine, Universit\u00e9 de Montr\u00e9al and the Montreal Heart Institute, Research Center, Montreal, Qu\u00e9bec, Canada"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Lefebvre", 
        "givenName": "C", 
        "id": "sg:person.01241436477.05", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01241436477.05"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Gastrointestinal Unit and Center for Computational and Integrative Biology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Ng", 
        "givenName": "A", 
        "id": "sg:person.0645153566.99", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0645153566.99"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Johns Hopkins University", 
          "id": "https://www.grid.ac/institutes/grid.21107.35", 
          "name": [
            "Department of Medicine, Johns Hopkins University, Harvey M and Lyn P Meyerhoff Inflammatory Bowel Disease Center, Baltimore, Maryland, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Brant", 
        "givenName": "S R", 
        "id": "sg:person.014711463364.57", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.014711463364.57"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Yale University", 
          "id": "https://www.grid.ac/institutes/grid.47100.32", 
          "name": [
            "Division of Gastroenterology, Department of Medicine, Yale University, New Haven, Connecticut, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Cho", 
        "givenName": "J H", 
        "id": "sg:person.011054712507.07", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011054712507.07"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Pittsburgh", 
          "id": "https://www.grid.ac/institutes/grid.21925.3d", 
          "name": [
            "Division of Gastroenterology, Department of Medicine, Hepatology and Nutrition, School of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Duerr", 
        "givenName": "R H", 
        "id": "sg:person.010100255137.24", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.010100255137.24"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Toronto", 
          "id": "https://www.grid.ac/institutes/grid.17063.33", 
          "name": [
            "Mount Sinai Hospital IBD Centre, University of Toronto, Toronto, Ontario, Canada"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Silverberg", 
        "givenName": "M S", 
        "id": "sg:person.01262212013.68", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01262212013.68"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Cedars-Sinai Medical Center", 
          "id": "https://www.grid.ac/institutes/grid.50956.3f", 
          "name": [
            "Medical Genetics Institute and IBD Center, Cedars-Sinai Medical Center, Los Angeles, California, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Taylor", 
        "givenName": "K D", 
        "id": "sg:person.010452447462.48", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.010452447462.48"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Gastrointestinal & Endoscopy Units, CSS-RCCS Hospital, Viale Cappuccini, San Giovanni Rotondo, Italy"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Latiano", 
        "givenName": "A", 
        "id": "sg:person.0602015303.44", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0602015303.44"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "H\u00f4pital Maisonneuve-Rosemont", 
          "id": "https://www.grid.ac/institutes/grid.414216.4", 
          "name": [
            "Department of Gastroenterology, H\u00f4pital Maisonneuve-Rosemont, Montr\u00e9al, Qu\u00e9bec, Canada"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Aumais", 
        "givenName": "G", 
        "id": "sg:person.01120653610.55", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01120653610.55"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Centre Hospitalier Universitaire Sainte-Justine", 
          "id": "https://www.grid.ac/institutes/grid.411418.9", 
          "name": [
            "Department of Gastroenterology, H\u00f4pital Sainte-Justine, Montreal, Qu\u00e9bec, Canada"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Deslandres", 
        "givenName": "C", 
        "id": "sg:person.01165201714.56", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01165201714.56"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "H\u00f4pital Maisonneuve-Rosemont", 
          "id": "https://www.grid.ac/institutes/grid.414216.4", 
          "name": [
            "Department of Gastroenterology, H\u00f4pital Maisonneuve-Rosemont, Montr\u00e9al, Qu\u00e9bec, Canada"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Jobin", 
        "givenName": "G", 
        "id": "sg:person.0700143712.08", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0700143712.08"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Gastrointestinal & Endoscopy Units, CSS-RCCS Hospital, Viale Cappuccini, San Giovanni Rotondo, Italy"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Annese", 
        "givenName": "V", 
        "id": "sg:person.0655214656.73", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0655214656.73"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Broad Institute", 
          "id": "https://www.grid.ac/institutes/grid.66859.34", 
          "name": [
            "The Broad Institute of MIT and Harvard, Cambridge, Massachusetts, USA", 
            "Center for Human Genetic Research, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Daly", 
        "givenName": "M J", 
        "id": "sg:person.011517303117.07", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011517303117.07"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Gastrointestinal Unit and Center for Computational and Integrative Biology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA", 
            "Center for Human Genetic Research, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Xavier", 
        "givenName": "R J", 
        "id": "sg:person.0717130066.82", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0717130066.82"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Broad Institute", 
          "id": "https://www.grid.ac/institutes/grid.66859.34", 
          "name": [
            "Department of Medicine, Universit\u00e9 de Montr\u00e9al and the Montreal Heart Institute, Research Center, Montreal, Qu\u00e9bec, Canada", 
            "The Broad Institute of MIT and Harvard, Cambridge, Massachusetts, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Rioux", 
        "givenName": "J D", 
        "id": "sg:person.01266053113.52", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01266053113.52"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "sg:pub.10.1038/ng2032", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1003006579", 
          "https://doi.org/10.1038/ng2032"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ng2032", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1003006579", 
          "https://doi.org/10.1038/ng2032"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1086/302913", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1003295861"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/hmg/11.21.2599", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1003887797"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ng1001-223", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1004202019", 
          "https://doi.org/10.1038/ng1001-223"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ng1001-223", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1004202019", 
          "https://doi.org/10.1038/ng1001-223"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature05911", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1004556449", 
          "https://doi.org/10.1038/nature05911"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/bioinformatics/bth457", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1008081196"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1136/gut.34.11.1547", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1010867864"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1046/j.1365-4624.1997.00009.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1012912203"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1046/j.1365-4624.1997.00009.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1012912203"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00054725-199911000-00005", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1013907489"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00054725-199911000-00005", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1013907489"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00054725-199911000-00005", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1013907489"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1074/jbc.m404795200", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1015852652"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1172/jci118470", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1016371173"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00054725-200108000-00006", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1017367725"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00054725-200108000-00006", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1017367725"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00054725-200108000-00006", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1017367725"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1084/jem.20061082", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1018472097"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0014-4827(76)90065-3", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1019302724"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ng1954", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1020669934", 
          "https://doi.org/10.1038/ng1954"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ng1954", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1020669934", 
          "https://doi.org/10.1038/ng1954"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1053/j.gastro.2006.09.011", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1020820452"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/379821a0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1021473922", 
          "https://doi.org/10.1038/379821a0"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.ejhg.5200626", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1023875099", 
          "https://doi.org/10.1038/sj.ejhg.5200626"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.ejhg.5200626", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1023875099", 
          "https://doi.org/10.1038/sj.ejhg.5200626"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1023/a:1018849405922", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1024775392", 
          "https://doi.org/10.1023/a:1018849405922"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/01.mib.0000194183.92671.b6", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1028502321"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/01.mib.0000194183.92671.b6", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1028502321"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1056/nejm199109263251306", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1029031473"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1074/jbc.274.42.29937", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1029780285"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/35079114", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030806509", 
          "https://doi.org/10.1038/35079114"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/35079114", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030806509", 
          "https://doi.org/10.1038/35079114"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/35079107", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1031360950", 
          "https://doi.org/10.1038/35079107"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/35079107", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1031360950", 
          "https://doi.org/10.1038/35079107"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1172/jci19229", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1032205831"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.95.13.7502", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1032264404"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ng2061", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1032812994", 
          "https://doi.org/10.1038/ng2061"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1371/journal.pgen.0030058", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1034397645"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1136/gut.48.2.191", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1034484313"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1084/jem.20061099", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1034826951"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1159/000016891", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037421894"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s1074-7613(00)80005-9", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037464381"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1056/nejm199101103240203", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037723482"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1086/302294", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037792018"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1136/gut.42.4.477", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037865120"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.ejhg.5201612", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1040512666", 
          "https://doi.org/10.1038/sj.ejhg.5201612"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.ejhg.5201612", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1040512666", 
          "https://doi.org/10.1038/sj.ejhg.5201612"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/science.1135245", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1040685270"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.gene.6364398", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1041412826", 
          "https://doi.org/10.1038/sj.gene.6364398"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ng1669", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1042975627", 
          "https://doi.org/10.1038/ng1669"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ng1669", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1042975627", 
          "https://doi.org/10.1038/ng1669"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ng1669", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1042975627", 
          "https://doi.org/10.1038/ng1669"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.0706645104", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1043827816"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3109/00365528909091339", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1045122809"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0014-4827(78)90043-5", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1045267112"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1172/jci11881", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1045731226"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1074/jbc.m206167200", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1049008207"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ng1096-199", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1050602394", 
          "https://doi.org/10.1038/ng1096-199"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1742-4658.2005.04968.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1052128420"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1742-4658.2005.04968.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1052128420"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1038/sj.emboj.7600243", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1052262305"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.0105-2896.2005.00288.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1053074135"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1021/bi00104a029", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1055161047"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1086/302947", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1058610494"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1172/jci17464", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1063416270"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1074558470", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.4049/jimmunol.172.3.1825", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1076628023"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1082422062", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1082693168", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1082788087", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1083338661", 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2008-03", 
    "datePublishedReg": "2008-03-01", 
    "description": "Association mapping and candidate gene studies within inflammatory bowel diseases (IBD) linkage regions, as well as genome-wide association studies in Crohn's disease (CD) have led to the discovery of multiple risk genes, but these explain only a fraction of the genetic susceptibility observed in IBD. We have thus been pursuing a region on chromosome 3p21-22 showing linkage to CD and ulcerative colitis (UC) using a gene-centric association mapping approach. We identified 12 functional candidate genes by searching for literature cocitations with relevant keywords and for gene expression patterns consistent with immune/intestinal function. We then performed an association study composed of a screening phase, where tagging single nucleotide polymorphisms (SNPs) were evaluated in 1,020 IBD patients, and an independent replication phase in 745 IBD patients. These analyses identified and replicated significant association with IBD for four SNPs within a 1.2 Mb linkage disequilibrium region. We then identified a non-synonymous coding variant (rs3197999, R689C) in the macrophage-stimulating 1 (MST1) gene (P-value 3.62 x 10(-6)) that accounts for the association signal, and shows association with both CD and UC. MST1 encodes macrophage-stimulating protein (MSP), a protein regulating the innate immune responses to bacterial ligands. R689C is predicted to interfere with MSP binding to its receptor, suggesting a role for this gene in the pathogenesis of IBD.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1038/mi.2007.15", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": true, 
    "isFundedItemOf": [
      {
        "id": "sg:grant.2690022", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.2690019", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.2690023", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.2690017", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.2438997", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.2690020", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.2690021", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.2456929", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.2498015", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.2690024", 
        "type": "MonetaryGrant"
      }
    ], 
    "isPartOf": [
      {
        "id": "sg:journal.1038363", 
        "issn": [
          "1933-0219", 
          "1935-3456"
        ], 
        "name": "Mucosal Immunology", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "2", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "1"
      }
    ], 
    "name": "Gene-centric association mapping of chromosome 3p implicates MST1 in IBD pathogenesis", 
    "pagination": "131", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "769745c18585d614fcea4a2961a152e76dfbcf262488f70e2f38895039deabed"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "19079170"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "101299742"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1038/mi.2007.15"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1024892825"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1038/mi.2007.15", 
      "https://app.dimensions.ai/details/publication/pub.1024892825"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-11T00:17", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8695_00000518.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://www.nature.com/articles/mi200715"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/mi.2007.15'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/mi.2007.15'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/mi.2007.15'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/mi.2007.15'


 

This table displays all metadata directly associated to this object as RDF triples.

469 TRIPLES      21 PREDICATES      101 URIs      36 LITERALS      24 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1038/mi.2007.15 schema:about N001332c1b9ac441ba622d09c6a68c480
2 N041c3678c0e84cdf91358dc95528edc9
3 N10ec4457386349189bc1b1d654e3657c
4 N376bce21500e41ab942206a8501abeb5
5 N44ac563494cd4bcfb0aa4579cddfb07e
6 N4bd7943f7be043c8846abc24369d1e50
7 N5cdbbd219f154b0db30dddba01ec1034
8 N5ff5bebe59404e25901db39078b0cff5
9 N60ed0694995549be92548648145da182
10 N7269e61eded94316a10afe19c137fe21
11 N80963266d45d4a17b6a92f83629491e0
12 N89473fc046554d63b14f711c6c541ab0
13 Nabf7e6b1c8014076969da41fc4241e9f
14 Nae733832acf74f2d9ba15bb35a07c0ab
15 Nbaae0acfd78b4ddcb6f7dc55de4e321b
16 anzsrc-for:06
17 anzsrc-for:0604
18 schema:author N944db494de38415f90058a1383e9b43e
19 schema:citation sg:pub.10.1023/a:1018849405922
20 sg:pub.10.1038/35079107
21 sg:pub.10.1038/35079114
22 sg:pub.10.1038/379821a0
23 sg:pub.10.1038/nature05911
24 sg:pub.10.1038/ng1001-223
25 sg:pub.10.1038/ng1096-199
26 sg:pub.10.1038/ng1669
27 sg:pub.10.1038/ng1954
28 sg:pub.10.1038/ng2032
29 sg:pub.10.1038/ng2061
30 sg:pub.10.1038/sj.ejhg.5200626
31 sg:pub.10.1038/sj.ejhg.5201612
32 sg:pub.10.1038/sj.gene.6364398
33 https://app.dimensions.ai/details/publication/pub.1074558470
34 https://app.dimensions.ai/details/publication/pub.1082422062
35 https://app.dimensions.ai/details/publication/pub.1082693168
36 https://app.dimensions.ai/details/publication/pub.1082788087
37 https://app.dimensions.ai/details/publication/pub.1083338661
38 https://doi.org/10.1016/0014-4827(76)90065-3
39 https://doi.org/10.1016/0014-4827(78)90043-5
40 https://doi.org/10.1016/s1074-7613(00)80005-9
41 https://doi.org/10.1021/bi00104a029
42 https://doi.org/10.1038/sj.emboj.7600243
43 https://doi.org/10.1046/j.1365-4624.1997.00009.x
44 https://doi.org/10.1053/j.gastro.2006.09.011
45 https://doi.org/10.1056/nejm199101103240203
46 https://doi.org/10.1056/nejm199109263251306
47 https://doi.org/10.1073/pnas.0706645104
48 https://doi.org/10.1073/pnas.95.13.7502
49 https://doi.org/10.1074/jbc.274.42.29937
50 https://doi.org/10.1074/jbc.m206167200
51 https://doi.org/10.1074/jbc.m404795200
52 https://doi.org/10.1084/jem.20061082
53 https://doi.org/10.1084/jem.20061099
54 https://doi.org/10.1086/302294
55 https://doi.org/10.1086/302913
56 https://doi.org/10.1086/302947
57 https://doi.org/10.1093/bioinformatics/bth457
58 https://doi.org/10.1093/hmg/11.21.2599
59 https://doi.org/10.1097/00054725-199911000-00005
60 https://doi.org/10.1097/00054725-200108000-00006
61 https://doi.org/10.1097/01.mib.0000194183.92671.b6
62 https://doi.org/10.1111/j.0105-2896.2005.00288.x
63 https://doi.org/10.1111/j.1742-4658.2005.04968.x
64 https://doi.org/10.1126/science.1135245
65 https://doi.org/10.1136/gut.34.11.1547
66 https://doi.org/10.1136/gut.42.4.477
67 https://doi.org/10.1136/gut.48.2.191
68 https://doi.org/10.1159/000016891
69 https://doi.org/10.1172/jci118470
70 https://doi.org/10.1172/jci11881
71 https://doi.org/10.1172/jci17464
72 https://doi.org/10.1172/jci19229
73 https://doi.org/10.1371/journal.pgen.0030058
74 https://doi.org/10.3109/00365528909091339
75 https://doi.org/10.4049/jimmunol.172.3.1825
76 schema:datePublished 2008-03
77 schema:datePublishedReg 2008-03-01
78 schema:description Association mapping and candidate gene studies within inflammatory bowel diseases (IBD) linkage regions, as well as genome-wide association studies in Crohn's disease (CD) have led to the discovery of multiple risk genes, but these explain only a fraction of the genetic susceptibility observed in IBD. We have thus been pursuing a region on chromosome 3p21-22 showing linkage to CD and ulcerative colitis (UC) using a gene-centric association mapping approach. We identified 12 functional candidate genes by searching for literature cocitations with relevant keywords and for gene expression patterns consistent with immune/intestinal function. We then performed an association study composed of a screening phase, where tagging single nucleotide polymorphisms (SNPs) were evaluated in 1,020 IBD patients, and an independent replication phase in 745 IBD patients. These analyses identified and replicated significant association with IBD for four SNPs within a 1.2 Mb linkage disequilibrium region. We then identified a non-synonymous coding variant (rs3197999, R689C) in the macrophage-stimulating 1 (MST1) gene (P-value 3.62 x 10(-6)) that accounts for the association signal, and shows association with both CD and UC. MST1 encodes macrophage-stimulating protein (MSP), a protein regulating the innate immune responses to bacterial ligands. R689C is predicted to interfere with MSP binding to its receptor, suggesting a role for this gene in the pathogenesis of IBD.
79 schema:genre research_article
80 schema:inLanguage en
81 schema:isAccessibleForFree true
82 schema:isPartOf N1ce6b97a371c445294b4a1de258f5276
83 N8eaaa661cfa749cbabcc61c5454dd8af
84 sg:journal.1038363
85 schema:name Gene-centric association mapping of chromosome 3p implicates MST1 in IBD pathogenesis
86 schema:pagination 131
87 schema:productId N10b73b92f6704ad1b9320aead9d566f8
88 N3a6f467027cc4a7f9287cab87dc22326
89 N3e71a5e0208d4d009b19c59c597d6a4c
90 N8bc2bccd94d34c50b2553e1bc7e72f90
91 Nee67adfa37514a179d365af7e4354166
92 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024892825
93 https://doi.org/10.1038/mi.2007.15
94 schema:sdDatePublished 2019-04-11T00:17
95 schema:sdLicense https://scigraph.springernature.com/explorer/license/
96 schema:sdPublisher N1e4036d004df4d819ad9a3a77bacfff2
97 schema:url https://www.nature.com/articles/mi200715
98 sgo:license sg:explorer/license/
99 sgo:sdDataset articles
100 rdf:type schema:ScholarlyArticle
101 N001332c1b9ac441ba622d09c6a68c480 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
102 schema:name Female
103 rdf:type schema:DefinedTerm
104 N041c3678c0e84cdf91358dc95528edc9 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
105 schema:name Crohn Disease
106 rdf:type schema:DefinedTerm
107 N051a3e40273048edb7076f1228d266bc rdf:first sg:person.01262212013.68
108 rdf:rest Nd85620eab1e34a5e996b600dea49953c
109 N0f202aef3a634702b6a7435b99a50ee7 rdf:first sg:person.011517303117.07
110 rdf:rest N965db257552a4b3bb6afe679eb72f5d3
111 N10b73b92f6704ad1b9320aead9d566f8 schema:name pubmed_id
112 schema:value 19079170
113 rdf:type schema:PropertyValue
114 N10ec4457386349189bc1b1d654e3657c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
115 schema:name Male
116 rdf:type schema:DefinedTerm
117 N18ff9ce9560c483ca7c274d2a849932c schema:name Gastrointestinal Unit and Center for Computational and Integrative Biology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA
118 rdf:type schema:Organization
119 N1ce6b97a371c445294b4a1de258f5276 schema:volumeNumber 1
120 rdf:type schema:PublicationVolume
121 N1e4036d004df4d819ad9a3a77bacfff2 schema:name Springer Nature - SN SciGraph project
122 rdf:type schema:Organization
123 N251644753b1f43ab80183fec4ff6213f schema:name Center for Human Genetic Research, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA
124 Gastrointestinal Unit and Center for Computational and Integrative Biology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA
125 rdf:type schema:Organization
126 N32ca59f35b3a4a3682822374c8880fd5 rdf:first sg:person.01120653610.55
127 rdf:rest N9f21bab7f7e14c18924727f94ebc5faa
128 N376bce21500e41ab942206a8501abeb5 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
129 schema:name Receptor Protein-Tyrosine Kinases
130 rdf:type schema:DefinedTerm
131 N3a6f467027cc4a7f9287cab87dc22326 schema:name nlm_unique_id
132 schema:value 101299742
133 rdf:type schema:PropertyValue
134 N3e71a5e0208d4d009b19c59c597d6a4c schema:name dimensions_id
135 schema:value pub.1024892825
136 rdf:type schema:PropertyValue
137 N44ac563494cd4bcfb0aa4579cddfb07e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
138 schema:name Proto-Oncogene Proteins
139 rdf:type schema:DefinedTerm
140 N4bd7943f7be043c8846abc24369d1e50 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
141 schema:name Hepatocyte Growth Factor
142 rdf:type schema:DefinedTerm
143 N59224ae26cd2415884040ae02830dfe8 rdf:first sg:person.0645153566.99
144 rdf:rest Ncdd8723762f64bb8a5c95b9982244d37
145 N5cdbbd219f154b0db30dddba01ec1034 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
146 schema:name Chromosomes, Human, Pair 3
147 rdf:type schema:DefinedTerm
148 N5ff5bebe59404e25901db39078b0cff5 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
149 schema:name Protein Binding
150 rdf:type schema:DefinedTerm
151 N60ed0694995549be92548648145da182 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
152 schema:name Chromosome Mapping
153 rdf:type schema:DefinedTerm
154 N631526c8b6c2428cb9a693e030f969a3 rdf:first sg:person.0700143712.08
155 rdf:rest N678f1d974a284d6696b1697770885b15
156 N678f1d974a284d6696b1697770885b15 rdf:first sg:person.0655214656.73
157 rdf:rest N0f202aef3a634702b6a7435b99a50ee7
158 N725606de14144684b0782a41dddfe6c1 rdf:first sg:person.0602015303.44
159 rdf:rest N32ca59f35b3a4a3682822374c8880fd5
160 N7269e61eded94316a10afe19c137fe21 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
161 schema:name Genetic Predisposition to Disease
162 rdf:type schema:DefinedTerm
163 N78ea0fab456a442e897e8435834d1663 schema:name Gastrointestinal & Endoscopy Units, CSS-RCCS Hospital, Viale Cappuccini, San Giovanni Rotondo, Italy
164 rdf:type schema:Organization
165 N80963266d45d4a17b6a92f83629491e0 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
166 schema:name Humans
167 rdf:type schema:DefinedTerm
168 N89473fc046554d63b14f711c6c541ab0 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
169 schema:name Genome, Human
170 rdf:type schema:DefinedTerm
171 N8bc2bccd94d34c50b2553e1bc7e72f90 schema:name readcube_id
172 schema:value 769745c18585d614fcea4a2961a152e76dfbcf262488f70e2f38895039deabed
173 rdf:type schema:PropertyValue
174 N8eaaa661cfa749cbabcc61c5454dd8af schema:issueNumber 2
175 rdf:type schema:PublicationIssue
176 N944db494de38415f90058a1383e9b43e rdf:first sg:person.01263200673.64
177 rdf:rest Nfa04cb8b931b487b87d7fc60814df2dd
178 N965db257552a4b3bb6afe679eb72f5d3 rdf:first sg:person.0717130066.82
179 rdf:rest Nc3da90bde55f4ca49036cd080957ee26
180 N9f21bab7f7e14c18924727f94ebc5faa rdf:first sg:person.01165201714.56
181 rdf:rest N631526c8b6c2428cb9a693e030f969a3
182 Nabf7e6b1c8014076969da41fc4241e9f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
183 schema:name Polymorphism, Single Nucleotide
184 rdf:type schema:DefinedTerm
185 Nae733832acf74f2d9ba15bb35a07c0ab schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
186 schema:name Colitis, Ulcerative
187 rdf:type schema:DefinedTerm
188 Nb6ec465f4a8145f8a3dd0be32692bfae rdf:first sg:person.010100255137.24
189 rdf:rest N051a3e40273048edb7076f1228d266bc
190 Nbaae0acfd78b4ddcb6f7dc55de4e321b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
191 schema:name Linkage Disequilibrium
192 rdf:type schema:DefinedTerm
193 Nc3da90bde55f4ca49036cd080957ee26 rdf:first sg:person.01266053113.52
194 rdf:rest rdf:nil
195 Ncdd8723762f64bb8a5c95b9982244d37 rdf:first sg:person.014711463364.57
196 rdf:rest Ne135876752e34c7eb6157036307414a6
197 Nd85620eab1e34a5e996b600dea49953c rdf:first sg:person.010452447462.48
198 rdf:rest N725606de14144684b0782a41dddfe6c1
199 Ne135876752e34c7eb6157036307414a6 rdf:first sg:person.011054712507.07
200 rdf:rest Nb6ec465f4a8145f8a3dd0be32692bfae
201 Nee67adfa37514a179d365af7e4354166 schema:name doi
202 schema:value 10.1038/mi.2007.15
203 rdf:type schema:PropertyValue
204 Nf2b056473d0e4f19aa855b1eb82810fa schema:name Gastrointestinal & Endoscopy Units, CSS-RCCS Hospital, Viale Cappuccini, San Giovanni Rotondo, Italy
205 rdf:type schema:Organization
206 Nfa04cb8b931b487b87d7fc60814df2dd rdf:first sg:person.01241436477.05
207 rdf:rest N59224ae26cd2415884040ae02830dfe8
208 anzsrc-for:06 schema:inDefinedTermSet anzsrc-for:
209 schema:name Biological Sciences
210 rdf:type schema:DefinedTerm
211 anzsrc-for:0604 schema:inDefinedTermSet anzsrc-for:
212 schema:name Genetics
213 rdf:type schema:DefinedTerm
214 sg:grant.2438997 http://pending.schema.org/fundedItem sg:pub.10.1038/mi.2007.15
215 rdf:type schema:MonetaryGrant
216 sg:grant.2456929 http://pending.schema.org/fundedItem sg:pub.10.1038/mi.2007.15
217 rdf:type schema:MonetaryGrant
218 sg:grant.2498015 http://pending.schema.org/fundedItem sg:pub.10.1038/mi.2007.15
219 rdf:type schema:MonetaryGrant
220 sg:grant.2690017 http://pending.schema.org/fundedItem sg:pub.10.1038/mi.2007.15
221 rdf:type schema:MonetaryGrant
222 sg:grant.2690019 http://pending.schema.org/fundedItem sg:pub.10.1038/mi.2007.15
223 rdf:type schema:MonetaryGrant
224 sg:grant.2690020 http://pending.schema.org/fundedItem sg:pub.10.1038/mi.2007.15
225 rdf:type schema:MonetaryGrant
226 sg:grant.2690021 http://pending.schema.org/fundedItem sg:pub.10.1038/mi.2007.15
227 rdf:type schema:MonetaryGrant
228 sg:grant.2690022 http://pending.schema.org/fundedItem sg:pub.10.1038/mi.2007.15
229 rdf:type schema:MonetaryGrant
230 sg:grant.2690023 http://pending.schema.org/fundedItem sg:pub.10.1038/mi.2007.15
231 rdf:type schema:MonetaryGrant
232 sg:grant.2690024 http://pending.schema.org/fundedItem sg:pub.10.1038/mi.2007.15
233 rdf:type schema:MonetaryGrant
234 sg:journal.1038363 schema:issn 1933-0219
235 1935-3456
236 schema:name Mucosal Immunology
237 rdf:type schema:Periodical
238 sg:person.010100255137.24 schema:affiliation https://www.grid.ac/institutes/grid.21925.3d
239 schema:familyName Duerr
240 schema:givenName R H
241 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.010100255137.24
242 rdf:type schema:Person
243 sg:person.010452447462.48 schema:affiliation https://www.grid.ac/institutes/grid.50956.3f
244 schema:familyName Taylor
245 schema:givenName K D
246 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.010452447462.48
247 rdf:type schema:Person
248 sg:person.011054712507.07 schema:affiliation https://www.grid.ac/institutes/grid.47100.32
249 schema:familyName Cho
250 schema:givenName J H
251 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011054712507.07
252 rdf:type schema:Person
253 sg:person.01120653610.55 schema:affiliation https://www.grid.ac/institutes/grid.414216.4
254 schema:familyName Aumais
255 schema:givenName G
256 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01120653610.55
257 rdf:type schema:Person
258 sg:person.011517303117.07 schema:affiliation https://www.grid.ac/institutes/grid.66859.34
259 schema:familyName Daly
260 schema:givenName M J
261 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011517303117.07
262 rdf:type schema:Person
263 sg:person.01165201714.56 schema:affiliation https://www.grid.ac/institutes/grid.411418.9
264 schema:familyName Deslandres
265 schema:givenName C
266 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01165201714.56
267 rdf:type schema:Person
268 sg:person.01241436477.05 schema:affiliation https://www.grid.ac/institutes/grid.63984.30
269 schema:familyName Lefebvre
270 schema:givenName C
271 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01241436477.05
272 rdf:type schema:Person
273 sg:person.01262212013.68 schema:affiliation https://www.grid.ac/institutes/grid.17063.33
274 schema:familyName Silverberg
275 schema:givenName M S
276 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01262212013.68
277 rdf:type schema:Person
278 sg:person.01263200673.64 schema:affiliation https://www.grid.ac/institutes/grid.63984.30
279 schema:familyName Goyette
280 schema:givenName P
281 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01263200673.64
282 rdf:type schema:Person
283 sg:person.01266053113.52 schema:affiliation https://www.grid.ac/institutes/grid.66859.34
284 schema:familyName Rioux
285 schema:givenName J D
286 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01266053113.52
287 rdf:type schema:Person
288 sg:person.014711463364.57 schema:affiliation https://www.grid.ac/institutes/grid.21107.35
289 schema:familyName Brant
290 schema:givenName S R
291 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.014711463364.57
292 rdf:type schema:Person
293 sg:person.0602015303.44 schema:affiliation Nf2b056473d0e4f19aa855b1eb82810fa
294 schema:familyName Latiano
295 schema:givenName A
296 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0602015303.44
297 rdf:type schema:Person
298 sg:person.0645153566.99 schema:affiliation N18ff9ce9560c483ca7c274d2a849932c
299 schema:familyName Ng
300 schema:givenName A
301 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0645153566.99
302 rdf:type schema:Person
303 sg:person.0655214656.73 schema:affiliation N78ea0fab456a442e897e8435834d1663
304 schema:familyName Annese
305 schema:givenName V
306 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0655214656.73
307 rdf:type schema:Person
308 sg:person.0700143712.08 schema:affiliation https://www.grid.ac/institutes/grid.414216.4
309 schema:familyName Jobin
310 schema:givenName G
311 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0700143712.08
312 rdf:type schema:Person
313 sg:person.0717130066.82 schema:affiliation N251644753b1f43ab80183fec4ff6213f
314 schema:familyName Xavier
315 schema:givenName R J
316 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0717130066.82
317 rdf:type schema:Person
318 sg:pub.10.1023/a:1018849405922 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024775392
319 https://doi.org/10.1023/a:1018849405922
320 rdf:type schema:CreativeWork
321 sg:pub.10.1038/35079107 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031360950
322 https://doi.org/10.1038/35079107
323 rdf:type schema:CreativeWork
324 sg:pub.10.1038/35079114 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030806509
325 https://doi.org/10.1038/35079114
326 rdf:type schema:CreativeWork
327 sg:pub.10.1038/379821a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021473922
328 https://doi.org/10.1038/379821a0
329 rdf:type schema:CreativeWork
330 sg:pub.10.1038/nature05911 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004556449
331 https://doi.org/10.1038/nature05911
332 rdf:type schema:CreativeWork
333 sg:pub.10.1038/ng1001-223 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004202019
334 https://doi.org/10.1038/ng1001-223
335 rdf:type schema:CreativeWork
336 sg:pub.10.1038/ng1096-199 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050602394
337 https://doi.org/10.1038/ng1096-199
338 rdf:type schema:CreativeWork
339 sg:pub.10.1038/ng1669 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042975627
340 https://doi.org/10.1038/ng1669
341 rdf:type schema:CreativeWork
342 sg:pub.10.1038/ng1954 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020669934
343 https://doi.org/10.1038/ng1954
344 rdf:type schema:CreativeWork
345 sg:pub.10.1038/ng2032 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003006579
346 https://doi.org/10.1038/ng2032
347 rdf:type schema:CreativeWork
348 sg:pub.10.1038/ng2061 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032812994
349 https://doi.org/10.1038/ng2061
350 rdf:type schema:CreativeWork
351 sg:pub.10.1038/sj.ejhg.5200626 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023875099
352 https://doi.org/10.1038/sj.ejhg.5200626
353 rdf:type schema:CreativeWork
354 sg:pub.10.1038/sj.ejhg.5201612 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040512666
355 https://doi.org/10.1038/sj.ejhg.5201612
356 rdf:type schema:CreativeWork
357 sg:pub.10.1038/sj.gene.6364398 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041412826
358 https://doi.org/10.1038/sj.gene.6364398
359 rdf:type schema:CreativeWork
360 https://app.dimensions.ai/details/publication/pub.1074558470 schema:CreativeWork
361 https://app.dimensions.ai/details/publication/pub.1082422062 schema:CreativeWork
362 https://app.dimensions.ai/details/publication/pub.1082693168 schema:CreativeWork
363 https://app.dimensions.ai/details/publication/pub.1082788087 schema:CreativeWork
364 https://app.dimensions.ai/details/publication/pub.1083338661 schema:CreativeWork
365 https://doi.org/10.1016/0014-4827(76)90065-3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019302724
366 rdf:type schema:CreativeWork
367 https://doi.org/10.1016/0014-4827(78)90043-5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045267112
368 rdf:type schema:CreativeWork
369 https://doi.org/10.1016/s1074-7613(00)80005-9 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037464381
370 rdf:type schema:CreativeWork
371 https://doi.org/10.1021/bi00104a029 schema:sameAs https://app.dimensions.ai/details/publication/pub.1055161047
372 rdf:type schema:CreativeWork
373 https://doi.org/10.1038/sj.emboj.7600243 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052262305
374 rdf:type schema:CreativeWork
375 https://doi.org/10.1046/j.1365-4624.1997.00009.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1012912203
376 rdf:type schema:CreativeWork
377 https://doi.org/10.1053/j.gastro.2006.09.011 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020820452
378 rdf:type schema:CreativeWork
379 https://doi.org/10.1056/nejm199101103240203 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037723482
380 rdf:type schema:CreativeWork
381 https://doi.org/10.1056/nejm199109263251306 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029031473
382 rdf:type schema:CreativeWork
383 https://doi.org/10.1073/pnas.0706645104 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043827816
384 rdf:type schema:CreativeWork
385 https://doi.org/10.1073/pnas.95.13.7502 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032264404
386 rdf:type schema:CreativeWork
387 https://doi.org/10.1074/jbc.274.42.29937 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029780285
388 rdf:type schema:CreativeWork
389 https://doi.org/10.1074/jbc.m206167200 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049008207
390 rdf:type schema:CreativeWork
391 https://doi.org/10.1074/jbc.m404795200 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015852652
392 rdf:type schema:CreativeWork
393 https://doi.org/10.1084/jem.20061082 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018472097
394 rdf:type schema:CreativeWork
395 https://doi.org/10.1084/jem.20061099 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034826951
396 rdf:type schema:CreativeWork
397 https://doi.org/10.1086/302294 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037792018
398 rdf:type schema:CreativeWork
399 https://doi.org/10.1086/302913 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003295861
400 rdf:type schema:CreativeWork
401 https://doi.org/10.1086/302947 schema:sameAs https://app.dimensions.ai/details/publication/pub.1058610494
402 rdf:type schema:CreativeWork
403 https://doi.org/10.1093/bioinformatics/bth457 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008081196
404 rdf:type schema:CreativeWork
405 https://doi.org/10.1093/hmg/11.21.2599 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003887797
406 rdf:type schema:CreativeWork
407 https://doi.org/10.1097/00054725-199911000-00005 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013907489
408 rdf:type schema:CreativeWork
409 https://doi.org/10.1097/00054725-200108000-00006 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017367725
410 rdf:type schema:CreativeWork
411 https://doi.org/10.1097/01.mib.0000194183.92671.b6 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028502321
412 rdf:type schema:CreativeWork
413 https://doi.org/10.1111/j.0105-2896.2005.00288.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1053074135
414 rdf:type schema:CreativeWork
415 https://doi.org/10.1111/j.1742-4658.2005.04968.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1052128420
416 rdf:type schema:CreativeWork
417 https://doi.org/10.1126/science.1135245 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040685270
418 rdf:type schema:CreativeWork
419 https://doi.org/10.1136/gut.34.11.1547 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010867864
420 rdf:type schema:CreativeWork
421 https://doi.org/10.1136/gut.42.4.477 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037865120
422 rdf:type schema:CreativeWork
423 https://doi.org/10.1136/gut.48.2.191 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034484313
424 rdf:type schema:CreativeWork
425 https://doi.org/10.1159/000016891 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037421894
426 rdf:type schema:CreativeWork
427 https://doi.org/10.1172/jci118470 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016371173
428 rdf:type schema:CreativeWork
429 https://doi.org/10.1172/jci11881 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045731226
430 rdf:type schema:CreativeWork
431 https://doi.org/10.1172/jci17464 schema:sameAs https://app.dimensions.ai/details/publication/pub.1063416270
432 rdf:type schema:CreativeWork
433 https://doi.org/10.1172/jci19229 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032205831
434 rdf:type schema:CreativeWork
435 https://doi.org/10.1371/journal.pgen.0030058 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034397645
436 rdf:type schema:CreativeWork
437 https://doi.org/10.3109/00365528909091339 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045122809
438 rdf:type schema:CreativeWork
439 https://doi.org/10.4049/jimmunol.172.3.1825 schema:sameAs https://app.dimensions.ai/details/publication/pub.1076628023
440 rdf:type schema:CreativeWork
441 https://www.grid.ac/institutes/grid.17063.33 schema:alternateName University of Toronto
442 schema:name Mount Sinai Hospital IBD Centre, University of Toronto, Toronto, Ontario, Canada
443 rdf:type schema:Organization
444 https://www.grid.ac/institutes/grid.21107.35 schema:alternateName Johns Hopkins University
445 schema:name Department of Medicine, Johns Hopkins University, Harvey M and Lyn P Meyerhoff Inflammatory Bowel Disease Center, Baltimore, Maryland, USA
446 rdf:type schema:Organization
447 https://www.grid.ac/institutes/grid.21925.3d schema:alternateName University of Pittsburgh
448 schema:name Division of Gastroenterology, Department of Medicine, Hepatology and Nutrition, School of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, USA
449 rdf:type schema:Organization
450 https://www.grid.ac/institutes/grid.411418.9 schema:alternateName Centre Hospitalier Universitaire Sainte-Justine
451 schema:name Department of Gastroenterology, Hôpital Sainte-Justine, Montreal, Québec, Canada
452 rdf:type schema:Organization
453 https://www.grid.ac/institutes/grid.414216.4 schema:alternateName Hôpital Maisonneuve-Rosemont
454 schema:name Department of Gastroenterology, Hôpital Maisonneuve-Rosemont, Montréal, Québec, Canada
455 rdf:type schema:Organization
456 https://www.grid.ac/institutes/grid.47100.32 schema:alternateName Yale University
457 schema:name Division of Gastroenterology, Department of Medicine, Yale University, New Haven, Connecticut, USA
458 rdf:type schema:Organization
459 https://www.grid.ac/institutes/grid.50956.3f schema:alternateName Cedars-Sinai Medical Center
460 schema:name Medical Genetics Institute and IBD Center, Cedars-Sinai Medical Center, Los Angeles, California, USA
461 rdf:type schema:Organization
462 https://www.grid.ac/institutes/grid.63984.30 schema:alternateName McGill University Health Centre
463 schema:name Department of Medicine, Université de Montréal and the Montreal Heart Institute, Research Center, Montreal, Québec, Canada
464 rdf:type schema:Organization
465 https://www.grid.ac/institutes/grid.66859.34 schema:alternateName Broad Institute
466 schema:name Center for Human Genetic Research, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA
467 Department of Medicine, Université de Montréal and the Montreal Heart Institute, Research Center, Montreal, Québec, Canada
468 The Broad Institute of MIT and Harvard, Cambridge, Massachusetts, USA
469 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...