NOTCH1-mutated chronic lymphocytic leukemia cells are characterized by a MYC-related overexpression of nucleophosmin 1 and ribosome-associated components View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2017-11

AUTHORS

F Pozzo, T Bittolo, E Vendramini, R Bomben, P Bulian, F M Rossi, A Zucchetto, E Tissino, M Degan, G D’Arena, F Di Raimondo, F Zaja, G Pozzato, D Rossi, G Gaidano, G Del Poeta, V Gattei, M Dal Bo

ABSTRACT

In chronic lymphocytic leukemia (CLL), the mechanisms controlling cell growth and proliferation in the presence of NOTCH1 mutations remain largely unexplored. By performing a gene expression profile of NOTCH1-mutated (NOTCH1-mut) versus NOTCH1 wild-type CLL, we identified a gene signature of NOTCH1-mut CLL characterized by the upregulation of genes related to ribosome biogenesis, such as nucleophosmin 1 (NPM1) and ribosomal proteins (RNPs). Activation of NOTCH1 signaling by ethylenediaminetetraacetic acid or by coculture with JAGGED1-expressing stromal cells increased NPM1 expression, and inhibition of NOTCH1 signaling by either NOTCH1-specific small interfering RNA (siRNA) or γ-secretase inhibitor reduced NPM1 expression. Bioinformatic analyses and in vitro activation/inhibition of NOTCH1 signaling suggested a role of MYC as a mediator of NOTCH1 effects over NPM1 and RNP expression in NOTCH1-mut CLL. Chromatin immunoprecipitation experiments performed on NOTCH1 intracellular domain (NICD)-transfected CLL-like cells showed the direct binding of NOTCH1 to the MYC promoter, and transfection with MYC-specific siRNA reduced NPM1 expression. In turn, NPM1 determined a proliferation advantage of CLL-like cells, as demonstrated by NPM1-specific siRNA transfection. In conclusion, NOTCH1 mutations in CLL are associated with the overexpression of MYC and MYC-related genes involved in protein biosynthesis including NPM1, which are allegedly responsible for cell growth and/or proliferation advantages of NOTCH1-mut CLL. More... »

PAGES

2407

References to SciGraph publications

  • 2014-05. Functional impact of NOTCH1 mutations in chronic lymphocytic leukemia in LEUKEMIA
  • 2006-09. Notch signalling: a simple pathway becomes complex in NATURE REVIEWS MOLECULAR CELL BIOLOGY
  • 1998-05. Human deltex is a conserved regulator of Notch signalling in NATURE GENETICS
  • 2004-12. GOTree Machine (GOTM): a web-based platform for interpreting sets of interesting genes using Gene Ontology hierarchies in BMC BIOINFORMATICS
  • 2016-11. Notch signalling in context in NATURE REVIEWS MOLECULAR CELL BIOLOGY
  • 2014-10. A NOTCH1-driven MYC enhancer promotes T cell development, transformation and acute lymphoblastic leukemia in NATURE MEDICINE
  • 2015-10. Non-coding recurrent mutations in chronic lymphocytic leukaemia in NATURE
  • 2011-07. Whole-genome sequencing identifies recurrent mutations in chronic lymphocytic leukaemia in NATURE
  • 2014-10. NOTCH1 mutations identify a chronic lymphocytic leukemia patient subset with worse prognosis in the setting of a rituximab-based induction and consolidation treatment in ANNALS OF HEMATOLOGY
  • 2010-04. MYC as a regulator of ribosome biogenesis and protein synthesis in NATURE REVIEWS CANCER
  • 2013-07. Toll-like receptor agonists induce apoptosis in mouse B-cell lymphoma cells by altering NF-κB activation in CELLULAR & MOLECULAR IMMUNOLOGY
  • 2016-10. CD49d prevails over the novel recurrent mutations as independent prognosticator of overall survival in chronic lymphocytic leukemia in LEUKEMIA
  • 2016-01. NOTCH1 mutations associate with low CD20 level in chronic lymphocytic leukemia: evidence for a NOTCH1 mutation-driven epigenetic dysregulation in LEUKEMIA
  • 1985-10. c-myc gene is transcribed at high rate in G0-arrested fibroblasts and is post-transcriptionally regulated in response to growth factors in NATURE
  • 2012-07. The miR-17∼92 family regulates the response to Toll-like receptor 9 triggering of CLL cells with unmutated IGHV genes in LEUKEMIA
  • 2008-12. Reflecting on 25 years with MYC in NATURE REVIEWS CANCER
  • 2010-05. Cis-interactions between Notch and Delta generate mutually exclusive signalling states in NATURE
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/leu.2017.90

    DOI

    http://dx.doi.org/10.1038/leu.2017.90

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1084128357

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/28321119


    Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
    Incoming Citations Browse incoming citations for this publication using opencitations.net

    JSON-LD is the canonical representation for SciGraph data.

    TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

    [
      {
        "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
        "about": [
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/0601", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Biochemistry and Cell Biology", 
            "type": "DefinedTerm"
          }, 
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/06", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Biological Sciences", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Cell Proliferation", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Coculture Techniques", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Genes, myc", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Humans", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Leukemia, Lymphocytic, Chronic, B-Cell", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Mutation", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Nuclear Proteins", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Receptor, Notch1", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Ribosomes", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Signal Transduction", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Tumor Cells, Cultured", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Up-Regulation", 
            "type": "DefinedTerm"
          }
        ], 
        "author": [
          {
            "affiliation": {
              "alternateName": "Centro di Riferimento Oncologico", 
              "id": "https://www.grid.ac/institutes/grid.418321.d", 
              "name": [
                "Clinical and Experimental Onco-Hematology Unit, Centro di Riferimento Oncologico, IRCCS, Aviano, Italy"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Pozzo", 
            "givenName": "F", 
            "id": "sg:person.01330372634.18", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01330372634.18"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Centro di Riferimento Oncologico", 
              "id": "https://www.grid.ac/institutes/grid.418321.d", 
              "name": [
                "Clinical and Experimental Onco-Hematology Unit, Centro di Riferimento Oncologico, IRCCS, Aviano, Italy"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Bittolo", 
            "givenName": "T", 
            "id": "sg:person.01022375471.46", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01022375471.46"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Centro di Riferimento Oncologico", 
              "id": "https://www.grid.ac/institutes/grid.418321.d", 
              "name": [
                "Clinical and Experimental Onco-Hematology Unit, Centro di Riferimento Oncologico, IRCCS, Aviano, Italy"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Vendramini", 
            "givenName": "E", 
            "id": "sg:person.01315617415.43", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01315617415.43"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Centro di Riferimento Oncologico", 
              "id": "https://www.grid.ac/institutes/grid.418321.d", 
              "name": [
                "Clinical and Experimental Onco-Hematology Unit, Centro di Riferimento Oncologico, IRCCS, Aviano, Italy"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Bomben", 
            "givenName": "R", 
            "id": "sg:person.01322137250.44", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01322137250.44"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Centro di Riferimento Oncologico", 
              "id": "https://www.grid.ac/institutes/grid.418321.d", 
              "name": [
                "Clinical and Experimental Onco-Hematology Unit, Centro di Riferimento Oncologico, IRCCS, Aviano, Italy"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Bulian", 
            "givenName": "P", 
            "id": "sg:person.01034067601.01", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01034067601.01"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Centro di Riferimento Oncologico", 
              "id": "https://www.grid.ac/institutes/grid.418321.d", 
              "name": [
                "Clinical and Experimental Onco-Hematology Unit, Centro di Riferimento Oncologico, IRCCS, Aviano, Italy"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Rossi", 
            "givenName": "F M", 
            "id": "sg:person.0736156231.38", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0736156231.38"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Centro di Riferimento Oncologico", 
              "id": "https://www.grid.ac/institutes/grid.418321.d", 
              "name": [
                "Clinical and Experimental Onco-Hematology Unit, Centro di Riferimento Oncologico, IRCCS, Aviano, Italy"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Zucchetto", 
            "givenName": "A", 
            "id": "sg:person.0717641201.56", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0717641201.56"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Centro di Riferimento Oncologico", 
              "id": "https://www.grid.ac/institutes/grid.418321.d", 
              "name": [
                "Clinical and Experimental Onco-Hematology Unit, Centro di Riferimento Oncologico, IRCCS, Aviano, Italy"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Tissino", 
            "givenName": "E", 
            "id": "sg:person.0623265777.76", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0623265777.76"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Centro di Riferimento Oncologico", 
              "id": "https://www.grid.ac/institutes/grid.418321.d", 
              "name": [
                "Clinical and Experimental Onco-Hematology Unit, Centro di Riferimento Oncologico, IRCCS, Aviano, Italy"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Degan", 
            "givenName": "M", 
            "id": "sg:person.01216431401.01", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01216431401.01"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Centro di Riferimento Oncologico della Basilicata", 
              "id": "https://www.grid.ac/institutes/grid.418322.e", 
              "name": [
                "Department of Onco-Hematology, IRCCS \u2018Centro di Riferimento Oncologico della Basilicata\u2019, Rionero in Vulture, Italy"
              ], 
              "type": "Organization"
            }, 
            "familyName": "D\u2019Arena", 
            "givenName": "G", 
            "id": "sg:person.01044147206.05", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01044147206.05"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Ferrarotto Hospital", 
              "id": "https://www.grid.ac/institutes/grid.414867.8", 
              "name": [
                "Division of Hematology, Ferrarotto Hospital, Catania, Italy"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Di Raimondo", 
            "givenName": "F", 
            "id": "sg:person.01203444476.32", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01203444476.32"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "name": [
                "Clinica Ematologica, Centro Trapianti e Terapie Cellulari \u2018Carlo Melzi\u2019 DISM, Azienda Ospedaliera Universitaria S Maria Misericordia, Udine, Italy"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Zaja", 
            "givenName": "F", 
            "id": "sg:person.0701003563.43", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0701003563.43"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "University of Trieste", 
              "id": "https://www.grid.ac/institutes/grid.5133.4", 
              "name": [
                "Department of Internal Medicine and Hematology, Maggiore General Hospital, University of Trieste, Trieste, Italy"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Pozzato", 
            "givenName": "G", 
            "id": "sg:person.01131211004.63", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01131211004.63"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Institute of Oncology Research", 
              "id": "https://www.grid.ac/institutes/grid.419922.5", 
              "name": [
                "Hematology, Institute of Oncology Research and Oncology Institute of Southern Switzerland, Bellinzona, Switzerland"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Rossi", 
            "givenName": "D", 
            "id": "sg:person.0774445555.51", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0774445555.51"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "University of Eastern Piedmont Amadeo Avogadro", 
              "id": "https://www.grid.ac/institutes/grid.16563.37", 
              "name": [
                "Department of Translational Medicine, Division of Hematology, University of Eastern Piedmont, Novara, Italy"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Gaidano", 
            "givenName": "G", 
            "id": "sg:person.01167052400.48", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01167052400.48"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "University of Rome Tor Vergata", 
              "id": "https://www.grid.ac/institutes/grid.6530.0", 
              "name": [
                "Division of Hematology, S Eugenio Hospital and University of Tor Vergata, Rome, Italy"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Del Poeta", 
            "givenName": "G", 
            "id": "sg:person.01024626622.33", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01024626622.33"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Centro di Riferimento Oncologico", 
              "id": "https://www.grid.ac/institutes/grid.418321.d", 
              "name": [
                "Clinical and Experimental Onco-Hematology Unit, Centro di Riferimento Oncologico, IRCCS, Aviano, Italy"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Gattei", 
            "givenName": "V", 
            "id": "sg:person.01351414200.61", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01351414200.61"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Centro di Riferimento Oncologico", 
              "id": "https://www.grid.ac/institutes/grid.418321.d", 
              "name": [
                "Clinical and Experimental Onco-Hematology Unit, Centro di Riferimento Oncologico, IRCCS, Aviano, Italy"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Dal Bo", 
            "givenName": "M", 
            "id": "sg:person.01140474230.46", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01140474230.46"
            ], 
            "type": "Person"
          }
        ], 
        "citation": [
          {
            "id": "https://doi.org/10.1182/blood-2012-09-458265", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1001266749"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1111/j.1365-2141.2010.08368.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1001849184"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1111/j.1365-2141.2010.08368.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1001849184"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1074/jbc.274.46.32961", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1002168887"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.0603371103", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1002332373"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1111/j.1365-2141.2009.07979.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1002494045"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1111/j.1365-2141.2009.07979.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1002494045"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1146/annurev.immunol.021908.132719", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1002875879"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.4049/jimmunol.164.2.944", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1003044627"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ng0598-74", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1003787207", 
              "https://doi.org/10.1038/ng0598-74"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1182/blood-2007-06-093906", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1006649234"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0301-472x(00)00144-2", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1007272427"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1111/bjh.13188", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1008480444"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature10113", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1008698030", 
              "https://doi.org/10.1038/nature10113"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.1407079111", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1009082374"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1182/blood-2007-05-089037", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1009200594"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/jcp.10208", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1010691091"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.0606108103", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1012787860"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1056/nejmoa1109016", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1012874418"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/leu.2012.44", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1013109661", 
              "https://doi.org/10.1038/leu.2012.44"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1182/blood-2014-01-546150", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1013315597"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/ajh.23491", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1014248122"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1182/blood-2005-03-0899", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1014557043"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nm.3665", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1014690315", 
              "https://doi.org/10.1038/nm.3665"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1261/rna.1043908", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1016238105"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature14666", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1017405010", 
              "https://doi.org/10.1038/nature14666"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nrc2231", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1017741214", 
              "https://doi.org/10.1038/nrc2231"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nrm2009", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1019849472", 
              "https://doi.org/10.1038/nrm2009"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nrm2009", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1019849472", 
              "https://doi.org/10.1038/nrm2009"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1101/gad.211912.112", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1020249267"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/317443a0", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1021342612", 
              "https://doi.org/10.1038/317443a0"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/leu.2013.319", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1022115155", 
              "https://doi.org/10.1038/leu.2013.319"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/leu.2013.319", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1022115155", 
              "https://doi.org/10.1038/leu.2013.319"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.3892/or.2015.3762", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1022790777"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.3892/or.2015.3762", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1022790777"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nrm.2016.94", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1023567838", 
              "https://doi.org/10.1038/nrm.2016.94"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1182/blood-2014-10-607036", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1026440944"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1182/blood-2011-09-379966", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1029051910"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/bib/bbs017", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1029766327"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1084/jem.20110921", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1029963193"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.3324/haematol.2011.060129", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1030030076"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1182/blood-2007-05-092486", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1031739399"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/1471-2105-5-16", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1033139728", 
              "https://doi.org/10.1186/1471-2105-5-16"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/1471-2105-5-16", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1033139728", 
              "https://doi.org/10.1186/1471-2105-5-16"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1126/science.7725102", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1033427895"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.1109023108", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1033771501"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/leu.2015.182", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1035647758", 
              "https://doi.org/10.1038/leu.2015.182"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1182/blood-2014-11-611459", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1036891082"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.0506580102", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1037705714"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.0506580102", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1037705714"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00277-014-2117-x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1039091657", 
              "https://doi.org/10.1007/s00277-014-2117-x"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/cmi.2013.14", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1039273648", 
              "https://doi.org/10.1038/cmi.2013.14"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.97.7.3260", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1040420087"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1128/mcb.20.5.1825-1835.2000", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1041536311"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature08959", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1043282818", 
              "https://doi.org/10.1038/nature08959"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature08959", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1043282818", 
              "https://doi.org/10.1038/nature08959"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.18632/oncotarget.9596", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1043633531"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nrc2819", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1044173871", 
              "https://doi.org/10.1038/nrc2819"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nrc2819", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1044173871", 
              "https://doi.org/10.1038/nrc2819"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/jbmr.60", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1044343918"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/jbmr.60", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1044343918"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1128/mcb.7.12.4513", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1045273237"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1182/blood-2010-08-299990", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1045977030"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/leu.2016.88", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1048653491", 
              "https://doi.org/10.1038/leu.2016.88"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1359/jbmr.091024", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1048970008"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1128/mcb.02078-07", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1050319435"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1101/gad.1450406", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1050324447"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1155/2011/195209", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1050357598"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1182/blood-2008-02-139725", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1051153413"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1056/nejm200012283432602", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1051287807"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1082397982", 
            "type": "CreativeWork"
          }
        ], 
        "datePublished": "2017-11", 
        "datePublishedReg": "2017-11-01", 
        "description": "In chronic lymphocytic leukemia (CLL), the mechanisms controlling cell growth and proliferation in the presence of NOTCH1 mutations remain largely unexplored. By performing a gene expression profile of NOTCH1-mutated (NOTCH1-mut) versus NOTCH1 wild-type CLL, we identified a gene signature of NOTCH1-mut CLL characterized by the upregulation of genes related to ribosome biogenesis, such as nucleophosmin 1 (NPM1) and ribosomal proteins (RNPs). Activation of NOTCH1 signaling by ethylenediaminetetraacetic acid or by coculture with JAGGED1-expressing stromal cells increased NPM1 expression, and inhibition of NOTCH1 signaling by either NOTCH1-specific small interfering RNA (siRNA) or \u03b3-secretase inhibitor reduced NPM1 expression. Bioinformatic analyses and in vitro activation/inhibition of NOTCH1 signaling suggested a role of MYC as a mediator of NOTCH1 effects over NPM1 and RNP expression in NOTCH1-mut CLL. Chromatin immunoprecipitation experiments performed on NOTCH1 intracellular domain (NICD)-transfected CLL-like cells showed the direct binding of NOTCH1 to the MYC promoter, and transfection with MYC-specific siRNA reduced NPM1 expression. In turn, NPM1 determined a proliferation advantage of CLL-like cells, as demonstrated by NPM1-specific siRNA transfection. In conclusion, NOTCH1 mutations in CLL are associated with the overexpression of MYC and MYC-related genes involved in protein biosynthesis including NPM1, which are allegedly responsible for cell growth and/or proliferation advantages of NOTCH1-mut CLL.", 
        "genre": "research_article", 
        "id": "sg:pub.10.1038/leu.2017.90", 
        "inLanguage": [
          "en"
        ], 
        "isAccessibleForFree": false, 
        "isPartOf": [
          {
            "id": "sg:journal.1097065", 
            "issn": [
              "0887-6924", 
              "1476-5551"
            ], 
            "name": "Leukemia", 
            "type": "Periodical"
          }, 
          {
            "issueNumber": "11", 
            "type": "PublicationIssue"
          }, 
          {
            "type": "PublicationVolume", 
            "volumeNumber": "31"
          }
        ], 
        "name": "NOTCH1-mutated chronic lymphocytic leukemia cells are characterized by a MYC-related overexpression of nucleophosmin 1 and ribosome-associated components", 
        "pagination": "2407", 
        "productId": [
          {
            "name": "readcube_id", 
            "type": "PropertyValue", 
            "value": [
              "7ff191ab8ff521a7b82e9c79f81c43ff92e7a1e108af7f0444f6252f8d14cab2"
            ]
          }, 
          {
            "name": "pubmed_id", 
            "type": "PropertyValue", 
            "value": [
              "28321119"
            ]
          }, 
          {
            "name": "nlm_unique_id", 
            "type": "PropertyValue", 
            "value": [
              "8704895"
            ]
          }, 
          {
            "name": "doi", 
            "type": "PropertyValue", 
            "value": [
              "10.1038/leu.2017.90"
            ]
          }, 
          {
            "name": "dimensions_id", 
            "type": "PropertyValue", 
            "value": [
              "pub.1084128357"
            ]
          }
        ], 
        "sameAs": [
          "https://doi.org/10.1038/leu.2017.90", 
          "https://app.dimensions.ai/details/publication/pub.1084128357"
        ], 
        "sdDataset": "articles", 
        "sdDatePublished": "2019-04-10T17:20", 
        "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
        "sdPublisher": {
          "name": "Springer Nature - SN SciGraph project", 
          "type": "Organization"
        }, 
        "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8672_00000434.jsonl", 
        "type": "ScholarlyArticle", 
        "url": "https://www.nature.com/articles/leu201790"
      }
    ]
     

    Download the RDF metadata as:  json-ld nt turtle xml License info

    HOW TO GET THIS DATA PROGRAMMATICALLY:

    JSON-LD is a popular format for linked data which is fully compatible with JSON.

    curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/leu.2017.90'

    N-Triples is a line-based linked data format ideal for batch operations.

    curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/leu.2017.90'

    Turtle is a human-readable linked data format.

    curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/leu.2017.90'

    RDF/XML is a standard XML format for linked data.

    curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/leu.2017.90'


     

    This table displays all metadata directly associated to this object as RDF triples.

    455 TRIPLES      21 PREDICATES      102 URIs      33 LITERALS      21 BLANK NODES

    Subject Predicate Object
    1 sg:pub.10.1038/leu.2017.90 schema:about N168f242cfcff483c850deb051f319ec4
    2 N376515305e7940689fa39f6c92deebd0
    3 N3d978c2ecab943358c69ca71aac7a270
    4 N44837b2ab6fa4f189ccf96b0bf285c0b
    5 N555d9b7dd9ab4f448bb5ce81d3e8ca2d
    6 N8748807db709455d95080dd69ebc6f92
    7 Na545621e41da4d479f84099391f1a880
    8 Nadb1d0235fac46608f0a60defd13ebaf
    9 Nae51c20462d64d5bb88a9b05c8ad7f6b
    10 Nd9edb045b4e74ab6b99eafc24e8e1576
    11 Nf4ec469184bf4c66b9a5501b5c65a703
    12 Nf54891e7914b4c40a726a87fafbebd37
    13 anzsrc-for:06
    14 anzsrc-for:0601
    15 schema:author N35360dc5328c43b8819b8e14a3f8fd53
    16 schema:citation sg:pub.10.1007/s00277-014-2117-x
    17 sg:pub.10.1038/317443a0
    18 sg:pub.10.1038/cmi.2013.14
    19 sg:pub.10.1038/leu.2012.44
    20 sg:pub.10.1038/leu.2013.319
    21 sg:pub.10.1038/leu.2015.182
    22 sg:pub.10.1038/leu.2016.88
    23 sg:pub.10.1038/nature08959
    24 sg:pub.10.1038/nature10113
    25 sg:pub.10.1038/nature14666
    26 sg:pub.10.1038/ng0598-74
    27 sg:pub.10.1038/nm.3665
    28 sg:pub.10.1038/nrc2231
    29 sg:pub.10.1038/nrc2819
    30 sg:pub.10.1038/nrm.2016.94
    31 sg:pub.10.1038/nrm2009
    32 sg:pub.10.1186/1471-2105-5-16
    33 https://app.dimensions.ai/details/publication/pub.1082397982
    34 https://doi.org/10.1002/ajh.23491
    35 https://doi.org/10.1002/jbmr.60
    36 https://doi.org/10.1002/jcp.10208
    37 https://doi.org/10.1016/s0301-472x(00)00144-2
    38 https://doi.org/10.1056/nejm200012283432602
    39 https://doi.org/10.1056/nejmoa1109016
    40 https://doi.org/10.1073/pnas.0506580102
    41 https://doi.org/10.1073/pnas.0603371103
    42 https://doi.org/10.1073/pnas.0606108103
    43 https://doi.org/10.1073/pnas.1109023108
    44 https://doi.org/10.1073/pnas.1407079111
    45 https://doi.org/10.1073/pnas.97.7.3260
    46 https://doi.org/10.1074/jbc.274.46.32961
    47 https://doi.org/10.1084/jem.20110921
    48 https://doi.org/10.1093/bib/bbs017
    49 https://doi.org/10.1101/gad.1450406
    50 https://doi.org/10.1101/gad.211912.112
    51 https://doi.org/10.1111/bjh.13188
    52 https://doi.org/10.1111/j.1365-2141.2009.07979.x
    53 https://doi.org/10.1111/j.1365-2141.2010.08368.x
    54 https://doi.org/10.1126/science.7725102
    55 https://doi.org/10.1128/mcb.02078-07
    56 https://doi.org/10.1128/mcb.20.5.1825-1835.2000
    57 https://doi.org/10.1128/mcb.7.12.4513
    58 https://doi.org/10.1146/annurev.immunol.021908.132719
    59 https://doi.org/10.1155/2011/195209
    60 https://doi.org/10.1182/blood-2005-03-0899
    61 https://doi.org/10.1182/blood-2007-05-089037
    62 https://doi.org/10.1182/blood-2007-05-092486
    63 https://doi.org/10.1182/blood-2007-06-093906
    64 https://doi.org/10.1182/blood-2008-02-139725
    65 https://doi.org/10.1182/blood-2010-08-299990
    66 https://doi.org/10.1182/blood-2011-09-379966
    67 https://doi.org/10.1182/blood-2012-09-458265
    68 https://doi.org/10.1182/blood-2014-01-546150
    69 https://doi.org/10.1182/blood-2014-10-607036
    70 https://doi.org/10.1182/blood-2014-11-611459
    71 https://doi.org/10.1261/rna.1043908
    72 https://doi.org/10.1359/jbmr.091024
    73 https://doi.org/10.18632/oncotarget.9596
    74 https://doi.org/10.3324/haematol.2011.060129
    75 https://doi.org/10.3892/or.2015.3762
    76 https://doi.org/10.4049/jimmunol.164.2.944
    77 schema:datePublished 2017-11
    78 schema:datePublishedReg 2017-11-01
    79 schema:description In chronic lymphocytic leukemia (CLL), the mechanisms controlling cell growth and proliferation in the presence of NOTCH1 mutations remain largely unexplored. By performing a gene expression profile of NOTCH1-mutated (NOTCH1-mut) versus NOTCH1 wild-type CLL, we identified a gene signature of NOTCH1-mut CLL characterized by the upregulation of genes related to ribosome biogenesis, such as nucleophosmin 1 (NPM1) and ribosomal proteins (RNPs). Activation of NOTCH1 signaling by ethylenediaminetetraacetic acid or by coculture with JAGGED1-expressing stromal cells increased NPM1 expression, and inhibition of NOTCH1 signaling by either NOTCH1-specific small interfering RNA (siRNA) or γ-secretase inhibitor reduced NPM1 expression. Bioinformatic analyses and in vitro activation/inhibition of NOTCH1 signaling suggested a role of MYC as a mediator of NOTCH1 effects over NPM1 and RNP expression in NOTCH1-mut CLL. Chromatin immunoprecipitation experiments performed on NOTCH1 intracellular domain (NICD)-transfected CLL-like cells showed the direct binding of NOTCH1 to the MYC promoter, and transfection with MYC-specific siRNA reduced NPM1 expression. In turn, NPM1 determined a proliferation advantage of CLL-like cells, as demonstrated by NPM1-specific siRNA transfection. In conclusion, NOTCH1 mutations in CLL are associated with the overexpression of MYC and MYC-related genes involved in protein biosynthesis including NPM1, which are allegedly responsible for cell growth and/or proliferation advantages of NOTCH1-mut CLL.
    80 schema:genre research_article
    81 schema:inLanguage en
    82 schema:isAccessibleForFree false
    83 schema:isPartOf N58985f3a60e94097a2a2170e2669a648
    84 N68b825db83034d9889a1ac19a430ec09
    85 sg:journal.1097065
    86 schema:name NOTCH1-mutated chronic lymphocytic leukemia cells are characterized by a MYC-related overexpression of nucleophosmin 1 and ribosome-associated components
    87 schema:pagination 2407
    88 schema:productId N3a1feeb64dfc44a59bd94987ba558a2a
    89 Nb4a768c1ac964b749cd90319cdbe76d8
    90 Nb7f672d204394c149ba73749b9d24dc2
    91 Nee782d47657b464582e5c7e6c4791747
    92 Nef59e3dc561e468b834081617602d99b
    93 schema:sameAs https://app.dimensions.ai/details/publication/pub.1084128357
    94 https://doi.org/10.1038/leu.2017.90
    95 schema:sdDatePublished 2019-04-10T17:20
    96 schema:sdLicense https://scigraph.springernature.com/explorer/license/
    97 schema:sdPublisher N4eef9c0bb1bd4a82ba51fd4b51bdc990
    98 schema:url https://www.nature.com/articles/leu201790
    99 sgo:license sg:explorer/license/
    100 sgo:sdDataset articles
    101 rdf:type schema:ScholarlyArticle
    102 N0df127e59fa943c0a42cf025d8833506 schema:name Clinica Ematologica, Centro Trapianti e Terapie Cellulari ‘Carlo Melzi’ DISM, Azienda Ospedaliera Universitaria S Maria Misericordia, Udine, Italy
    103 rdf:type schema:Organization
    104 N0fc7191f0c564f26b0c65ba35ef64357 rdf:first sg:person.01322137250.44
    105 rdf:rest N89db094b7ef5448d8fd9941f32514e4a
    106 N15c8f984541945f1ba98485112f83181 rdf:first sg:person.01216431401.01
    107 rdf:rest Ncc8b340bbeb74553a9a973219d225d03
    108 N168f242cfcff483c850deb051f319ec4 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    109 schema:name Humans
    110 rdf:type schema:DefinedTerm
    111 N35360dc5328c43b8819b8e14a3f8fd53 rdf:first sg:person.01330372634.18
    112 rdf:rest N45eaa8c15f9a45bdaf972fdcef559af9
    113 N376515305e7940689fa39f6c92deebd0 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    114 schema:name Leukemia, Lymphocytic, Chronic, B-Cell
    115 rdf:type schema:DefinedTerm
    116 N3a1feeb64dfc44a59bd94987ba558a2a schema:name pubmed_id
    117 schema:value 28321119
    118 rdf:type schema:PropertyValue
    119 N3d978c2ecab943358c69ca71aac7a270 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    120 schema:name Signal Transduction
    121 rdf:type schema:DefinedTerm
    122 N3dc37e5aaa1b4d8f9f2adbd04d6ac149 rdf:first sg:person.0736156231.38
    123 rdf:rest N5949021a77734b3dad1bedc5516d0650
    124 N3eba8169aa7d4ce893de444d7a0b4462 rdf:first sg:person.01203444476.32
    125 rdf:rest N9d3fcc59d3f84ea183cea1bd3a8e56aa
    126 N44837b2ab6fa4f189ccf96b0bf285c0b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    127 schema:name Mutation
    128 rdf:type schema:DefinedTerm
    129 N458033fcf8004ad28f5c76c5dea971d1 rdf:first sg:person.01140474230.46
    130 rdf:rest rdf:nil
    131 N45eaa8c15f9a45bdaf972fdcef559af9 rdf:first sg:person.01022375471.46
    132 rdf:rest N4e02932a8b824f1f9bae988cd5e2b75c
    133 N4e02932a8b824f1f9bae988cd5e2b75c rdf:first sg:person.01315617415.43
    134 rdf:rest N0fc7191f0c564f26b0c65ba35ef64357
    135 N4eef9c0bb1bd4a82ba51fd4b51bdc990 schema:name Springer Nature - SN SciGraph project
    136 rdf:type schema:Organization
    137 N555d9b7dd9ab4f448bb5ce81d3e8ca2d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    138 schema:name Receptor, Notch1
    139 rdf:type schema:DefinedTerm
    140 N58985f3a60e94097a2a2170e2669a648 schema:issueNumber 11
    141 rdf:type schema:PublicationIssue
    142 N5949021a77734b3dad1bedc5516d0650 rdf:first sg:person.0717641201.56
    143 rdf:rest Nef1979e7ad5148fe8b7b6d78a84a996a
    144 N68b825db83034d9889a1ac19a430ec09 schema:volumeNumber 31
    145 rdf:type schema:PublicationVolume
    146 N8748807db709455d95080dd69ebc6f92 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    147 schema:name Up-Regulation
    148 rdf:type schema:DefinedTerm
    149 N89db094b7ef5448d8fd9941f32514e4a rdf:first sg:person.01034067601.01
    150 rdf:rest N3dc37e5aaa1b4d8f9f2adbd04d6ac149
    151 N9d3fcc59d3f84ea183cea1bd3a8e56aa rdf:first sg:person.0701003563.43
    152 rdf:rest Nba368c99443141018527e60a3c443274
    153 Na545621e41da4d479f84099391f1a880 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    154 schema:name Genes, myc
    155 rdf:type schema:DefinedTerm
    156 Nadb1d0235fac46608f0a60defd13ebaf schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    157 schema:name Ribosomes
    158 rdf:type schema:DefinedTerm
    159 Nae51c20462d64d5bb88a9b05c8ad7f6b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    160 schema:name Tumor Cells, Cultured
    161 rdf:type schema:DefinedTerm
    162 Nb0aaadb6ac70402f99560caad512ccd0 rdf:first sg:person.01167052400.48
    163 rdf:rest Nfa5e7fe2a2ac4fbeaa85416181a4518a
    164 Nb4a768c1ac964b749cd90319cdbe76d8 schema:name doi
    165 schema:value 10.1038/leu.2017.90
    166 rdf:type schema:PropertyValue
    167 Nb7f672d204394c149ba73749b9d24dc2 schema:name nlm_unique_id
    168 schema:value 8704895
    169 rdf:type schema:PropertyValue
    170 Nba368c99443141018527e60a3c443274 rdf:first sg:person.01131211004.63
    171 rdf:rest Nfc7ddd2c7f0d44faa3441b19c0e0ff0d
    172 Ncc8b340bbeb74553a9a973219d225d03 rdf:first sg:person.01044147206.05
    173 rdf:rest N3eba8169aa7d4ce893de444d7a0b4462
    174 Nd9edb045b4e74ab6b99eafc24e8e1576 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    175 schema:name Nuclear Proteins
    176 rdf:type schema:DefinedTerm
    177 Ndbb322a211d74335b49cd4782760220c rdf:first sg:person.01351414200.61
    178 rdf:rest N458033fcf8004ad28f5c76c5dea971d1
    179 Nee782d47657b464582e5c7e6c4791747 schema:name dimensions_id
    180 schema:value pub.1084128357
    181 rdf:type schema:PropertyValue
    182 Nef1979e7ad5148fe8b7b6d78a84a996a rdf:first sg:person.0623265777.76
    183 rdf:rest N15c8f984541945f1ba98485112f83181
    184 Nef59e3dc561e468b834081617602d99b schema:name readcube_id
    185 schema:value 7ff191ab8ff521a7b82e9c79f81c43ff92e7a1e108af7f0444f6252f8d14cab2
    186 rdf:type schema:PropertyValue
    187 Nf4ec469184bf4c66b9a5501b5c65a703 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    188 schema:name Coculture Techniques
    189 rdf:type schema:DefinedTerm
    190 Nf54891e7914b4c40a726a87fafbebd37 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    191 schema:name Cell Proliferation
    192 rdf:type schema:DefinedTerm
    193 Nfa5e7fe2a2ac4fbeaa85416181a4518a rdf:first sg:person.01024626622.33
    194 rdf:rest Ndbb322a211d74335b49cd4782760220c
    195 Nfc7ddd2c7f0d44faa3441b19c0e0ff0d rdf:first sg:person.0774445555.51
    196 rdf:rest Nb0aaadb6ac70402f99560caad512ccd0
    197 anzsrc-for:06 schema:inDefinedTermSet anzsrc-for:
    198 schema:name Biological Sciences
    199 rdf:type schema:DefinedTerm
    200 anzsrc-for:0601 schema:inDefinedTermSet anzsrc-for:
    201 schema:name Biochemistry and Cell Biology
    202 rdf:type schema:DefinedTerm
    203 sg:journal.1097065 schema:issn 0887-6924
    204 1476-5551
    205 schema:name Leukemia
    206 rdf:type schema:Periodical
    207 sg:person.01022375471.46 schema:affiliation https://www.grid.ac/institutes/grid.418321.d
    208 schema:familyName Bittolo
    209 schema:givenName T
    210 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01022375471.46
    211 rdf:type schema:Person
    212 sg:person.01024626622.33 schema:affiliation https://www.grid.ac/institutes/grid.6530.0
    213 schema:familyName Del Poeta
    214 schema:givenName G
    215 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01024626622.33
    216 rdf:type schema:Person
    217 sg:person.01034067601.01 schema:affiliation https://www.grid.ac/institutes/grid.418321.d
    218 schema:familyName Bulian
    219 schema:givenName P
    220 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01034067601.01
    221 rdf:type schema:Person
    222 sg:person.01044147206.05 schema:affiliation https://www.grid.ac/institutes/grid.418322.e
    223 schema:familyName D’Arena
    224 schema:givenName G
    225 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01044147206.05
    226 rdf:type schema:Person
    227 sg:person.01131211004.63 schema:affiliation https://www.grid.ac/institutes/grid.5133.4
    228 schema:familyName Pozzato
    229 schema:givenName G
    230 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01131211004.63
    231 rdf:type schema:Person
    232 sg:person.01140474230.46 schema:affiliation https://www.grid.ac/institutes/grid.418321.d
    233 schema:familyName Dal Bo
    234 schema:givenName M
    235 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01140474230.46
    236 rdf:type schema:Person
    237 sg:person.01167052400.48 schema:affiliation https://www.grid.ac/institutes/grid.16563.37
    238 schema:familyName Gaidano
    239 schema:givenName G
    240 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01167052400.48
    241 rdf:type schema:Person
    242 sg:person.01203444476.32 schema:affiliation https://www.grid.ac/institutes/grid.414867.8
    243 schema:familyName Di Raimondo
    244 schema:givenName F
    245 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01203444476.32
    246 rdf:type schema:Person
    247 sg:person.01216431401.01 schema:affiliation https://www.grid.ac/institutes/grid.418321.d
    248 schema:familyName Degan
    249 schema:givenName M
    250 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01216431401.01
    251 rdf:type schema:Person
    252 sg:person.01315617415.43 schema:affiliation https://www.grid.ac/institutes/grid.418321.d
    253 schema:familyName Vendramini
    254 schema:givenName E
    255 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01315617415.43
    256 rdf:type schema:Person
    257 sg:person.01322137250.44 schema:affiliation https://www.grid.ac/institutes/grid.418321.d
    258 schema:familyName Bomben
    259 schema:givenName R
    260 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01322137250.44
    261 rdf:type schema:Person
    262 sg:person.01330372634.18 schema:affiliation https://www.grid.ac/institutes/grid.418321.d
    263 schema:familyName Pozzo
    264 schema:givenName F
    265 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01330372634.18
    266 rdf:type schema:Person
    267 sg:person.01351414200.61 schema:affiliation https://www.grid.ac/institutes/grid.418321.d
    268 schema:familyName Gattei
    269 schema:givenName V
    270 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01351414200.61
    271 rdf:type schema:Person
    272 sg:person.0623265777.76 schema:affiliation https://www.grid.ac/institutes/grid.418321.d
    273 schema:familyName Tissino
    274 schema:givenName E
    275 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0623265777.76
    276 rdf:type schema:Person
    277 sg:person.0701003563.43 schema:affiliation N0df127e59fa943c0a42cf025d8833506
    278 schema:familyName Zaja
    279 schema:givenName F
    280 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0701003563.43
    281 rdf:type schema:Person
    282 sg:person.0717641201.56 schema:affiliation https://www.grid.ac/institutes/grid.418321.d
    283 schema:familyName Zucchetto
    284 schema:givenName A
    285 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0717641201.56
    286 rdf:type schema:Person
    287 sg:person.0736156231.38 schema:affiliation https://www.grid.ac/institutes/grid.418321.d
    288 schema:familyName Rossi
    289 schema:givenName F M
    290 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0736156231.38
    291 rdf:type schema:Person
    292 sg:person.0774445555.51 schema:affiliation https://www.grid.ac/institutes/grid.419922.5
    293 schema:familyName Rossi
    294 schema:givenName D
    295 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0774445555.51
    296 rdf:type schema:Person
    297 sg:pub.10.1007/s00277-014-2117-x schema:sameAs https://app.dimensions.ai/details/publication/pub.1039091657
    298 https://doi.org/10.1007/s00277-014-2117-x
    299 rdf:type schema:CreativeWork
    300 sg:pub.10.1038/317443a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021342612
    301 https://doi.org/10.1038/317443a0
    302 rdf:type schema:CreativeWork
    303 sg:pub.10.1038/cmi.2013.14 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039273648
    304 https://doi.org/10.1038/cmi.2013.14
    305 rdf:type schema:CreativeWork
    306 sg:pub.10.1038/leu.2012.44 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013109661
    307 https://doi.org/10.1038/leu.2012.44
    308 rdf:type schema:CreativeWork
    309 sg:pub.10.1038/leu.2013.319 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022115155
    310 https://doi.org/10.1038/leu.2013.319
    311 rdf:type schema:CreativeWork
    312 sg:pub.10.1038/leu.2015.182 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035647758
    313 https://doi.org/10.1038/leu.2015.182
    314 rdf:type schema:CreativeWork
    315 sg:pub.10.1038/leu.2016.88 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048653491
    316 https://doi.org/10.1038/leu.2016.88
    317 rdf:type schema:CreativeWork
    318 sg:pub.10.1038/nature08959 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043282818
    319 https://doi.org/10.1038/nature08959
    320 rdf:type schema:CreativeWork
    321 sg:pub.10.1038/nature10113 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008698030
    322 https://doi.org/10.1038/nature10113
    323 rdf:type schema:CreativeWork
    324 sg:pub.10.1038/nature14666 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017405010
    325 https://doi.org/10.1038/nature14666
    326 rdf:type schema:CreativeWork
    327 sg:pub.10.1038/ng0598-74 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003787207
    328 https://doi.org/10.1038/ng0598-74
    329 rdf:type schema:CreativeWork
    330 sg:pub.10.1038/nm.3665 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014690315
    331 https://doi.org/10.1038/nm.3665
    332 rdf:type schema:CreativeWork
    333 sg:pub.10.1038/nrc2231 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017741214
    334 https://doi.org/10.1038/nrc2231
    335 rdf:type schema:CreativeWork
    336 sg:pub.10.1038/nrc2819 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044173871
    337 https://doi.org/10.1038/nrc2819
    338 rdf:type schema:CreativeWork
    339 sg:pub.10.1038/nrm.2016.94 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023567838
    340 https://doi.org/10.1038/nrm.2016.94
    341 rdf:type schema:CreativeWork
    342 sg:pub.10.1038/nrm2009 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019849472
    343 https://doi.org/10.1038/nrm2009
    344 rdf:type schema:CreativeWork
    345 sg:pub.10.1186/1471-2105-5-16 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033139728
    346 https://doi.org/10.1186/1471-2105-5-16
    347 rdf:type schema:CreativeWork
    348 https://app.dimensions.ai/details/publication/pub.1082397982 schema:CreativeWork
    349 https://doi.org/10.1002/ajh.23491 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014248122
    350 rdf:type schema:CreativeWork
    351 https://doi.org/10.1002/jbmr.60 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044343918
    352 rdf:type schema:CreativeWork
    353 https://doi.org/10.1002/jcp.10208 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010691091
    354 rdf:type schema:CreativeWork
    355 https://doi.org/10.1016/s0301-472x(00)00144-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007272427
    356 rdf:type schema:CreativeWork
    357 https://doi.org/10.1056/nejm200012283432602 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051287807
    358 rdf:type schema:CreativeWork
    359 https://doi.org/10.1056/nejmoa1109016 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012874418
    360 rdf:type schema:CreativeWork
    361 https://doi.org/10.1073/pnas.0506580102 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037705714
    362 rdf:type schema:CreativeWork
    363 https://doi.org/10.1073/pnas.0603371103 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002332373
    364 rdf:type schema:CreativeWork
    365 https://doi.org/10.1073/pnas.0606108103 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012787860
    366 rdf:type schema:CreativeWork
    367 https://doi.org/10.1073/pnas.1109023108 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033771501
    368 rdf:type schema:CreativeWork
    369 https://doi.org/10.1073/pnas.1407079111 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009082374
    370 rdf:type schema:CreativeWork
    371 https://doi.org/10.1073/pnas.97.7.3260 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040420087
    372 rdf:type schema:CreativeWork
    373 https://doi.org/10.1074/jbc.274.46.32961 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002168887
    374 rdf:type schema:CreativeWork
    375 https://doi.org/10.1084/jem.20110921 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029963193
    376 rdf:type schema:CreativeWork
    377 https://doi.org/10.1093/bib/bbs017 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029766327
    378 rdf:type schema:CreativeWork
    379 https://doi.org/10.1101/gad.1450406 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050324447
    380 rdf:type schema:CreativeWork
    381 https://doi.org/10.1101/gad.211912.112 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020249267
    382 rdf:type schema:CreativeWork
    383 https://doi.org/10.1111/bjh.13188 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008480444
    384 rdf:type schema:CreativeWork
    385 https://doi.org/10.1111/j.1365-2141.2009.07979.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1002494045
    386 rdf:type schema:CreativeWork
    387 https://doi.org/10.1111/j.1365-2141.2010.08368.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1001849184
    388 rdf:type schema:CreativeWork
    389 https://doi.org/10.1126/science.7725102 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033427895
    390 rdf:type schema:CreativeWork
    391 https://doi.org/10.1128/mcb.02078-07 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050319435
    392 rdf:type schema:CreativeWork
    393 https://doi.org/10.1128/mcb.20.5.1825-1835.2000 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041536311
    394 rdf:type schema:CreativeWork
    395 https://doi.org/10.1128/mcb.7.12.4513 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045273237
    396 rdf:type schema:CreativeWork
    397 https://doi.org/10.1146/annurev.immunol.021908.132719 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002875879
    398 rdf:type schema:CreativeWork
    399 https://doi.org/10.1155/2011/195209 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050357598
    400 rdf:type schema:CreativeWork
    401 https://doi.org/10.1182/blood-2005-03-0899 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014557043
    402 rdf:type schema:CreativeWork
    403 https://doi.org/10.1182/blood-2007-05-089037 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009200594
    404 rdf:type schema:CreativeWork
    405 https://doi.org/10.1182/blood-2007-05-092486 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031739399
    406 rdf:type schema:CreativeWork
    407 https://doi.org/10.1182/blood-2007-06-093906 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006649234
    408 rdf:type schema:CreativeWork
    409 https://doi.org/10.1182/blood-2008-02-139725 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051153413
    410 rdf:type schema:CreativeWork
    411 https://doi.org/10.1182/blood-2010-08-299990 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045977030
    412 rdf:type schema:CreativeWork
    413 https://doi.org/10.1182/blood-2011-09-379966 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029051910
    414 rdf:type schema:CreativeWork
    415 https://doi.org/10.1182/blood-2012-09-458265 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001266749
    416 rdf:type schema:CreativeWork
    417 https://doi.org/10.1182/blood-2014-01-546150 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013315597
    418 rdf:type schema:CreativeWork
    419 https://doi.org/10.1182/blood-2014-10-607036 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026440944
    420 rdf:type schema:CreativeWork
    421 https://doi.org/10.1182/blood-2014-11-611459 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036891082
    422 rdf:type schema:CreativeWork
    423 https://doi.org/10.1261/rna.1043908 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016238105
    424 rdf:type schema:CreativeWork
    425 https://doi.org/10.1359/jbmr.091024 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048970008
    426 rdf:type schema:CreativeWork
    427 https://doi.org/10.18632/oncotarget.9596 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043633531
    428 rdf:type schema:CreativeWork
    429 https://doi.org/10.3324/haematol.2011.060129 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030030076
    430 rdf:type schema:CreativeWork
    431 https://doi.org/10.3892/or.2015.3762 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022790777
    432 rdf:type schema:CreativeWork
    433 https://doi.org/10.4049/jimmunol.164.2.944 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003044627
    434 rdf:type schema:CreativeWork
    435 https://www.grid.ac/institutes/grid.16563.37 schema:alternateName University of Eastern Piedmont Amadeo Avogadro
    436 schema:name Department of Translational Medicine, Division of Hematology, University of Eastern Piedmont, Novara, Italy
    437 rdf:type schema:Organization
    438 https://www.grid.ac/institutes/grid.414867.8 schema:alternateName Ferrarotto Hospital
    439 schema:name Division of Hematology, Ferrarotto Hospital, Catania, Italy
    440 rdf:type schema:Organization
    441 https://www.grid.ac/institutes/grid.418321.d schema:alternateName Centro di Riferimento Oncologico
    442 schema:name Clinical and Experimental Onco-Hematology Unit, Centro di Riferimento Oncologico, IRCCS, Aviano, Italy
    443 rdf:type schema:Organization
    444 https://www.grid.ac/institutes/grid.418322.e schema:alternateName Centro di Riferimento Oncologico della Basilicata
    445 schema:name Department of Onco-Hematology, IRCCS ‘Centro di Riferimento Oncologico della Basilicata’, Rionero in Vulture, Italy
    446 rdf:type schema:Organization
    447 https://www.grid.ac/institutes/grid.419922.5 schema:alternateName Institute of Oncology Research
    448 schema:name Hematology, Institute of Oncology Research and Oncology Institute of Southern Switzerland, Bellinzona, Switzerland
    449 rdf:type schema:Organization
    450 https://www.grid.ac/institutes/grid.5133.4 schema:alternateName University of Trieste
    451 schema:name Department of Internal Medicine and Hematology, Maggiore General Hospital, University of Trieste, Trieste, Italy
    452 rdf:type schema:Organization
    453 https://www.grid.ac/institutes/grid.6530.0 schema:alternateName University of Rome Tor Vergata
    454 schema:name Division of Hematology, S Eugenio Hospital and University of Tor Vergata, Rome, Italy
    455 rdf:type schema:Organization
     




    Preview window. Press ESC to close (or click here)


    ...