Treatment-free remission following frontline nilotinib in patients with chronic myeloid leukemia in chronic phase: results from the ENESTfreedom study View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2017-02-20

AUTHORS

A Hochhaus, T Masszi, F J Giles, J P Radich, D M Ross, M T Gómez Casares, A Hellmann, J Stentoft, E Conneally, V García-Gutiérrez, N Gattermann, W Wiktor-Jedrzejczak, P D le Coutre, B Martino, S Saussele, H D Menssen, W Deng, N Krunic, V Bedoucha, G Saglio

ABSTRACT

The single-arm, phase 2 ENESTfreedom trial assessed the potential for treatment-free remission (TFR; i.e., the ability to maintain a molecular response after stopping therapy) following frontline nilotinib treatment. Patients with Philadelphia chromosome-positive chronic myeloid leukemia in chronic phase with MR4.5 (BCR-ABL1⩽0.0032% on the International Scale (BCR-ABL1IS)) and ⩾2 years of frontline nilotinib therapy were enrolled. Patients with sustained deep molecular response during the 1-year nilotinib consolidation phase were eligible to stop treatment and enter the TFR phase. Patients with loss of major molecular response (MMR; BCR-ABL1IS⩽0.1%) during the TFR phase reinitiated nilotinib. In total, 215 patients entered the consolidation phase, of whom 190 entered the TFR phase. The median duration of nilotinib before stopping treatment was 43.5 months. At 48 weeks after stopping nilotinib, 98 patients (51.6%; 95% confidence interval, 44.2–58.9%) remained in MMR or better (primary end point). Of the 86 patients who restarted nilotinib in the treatment reinitiation phase after loss of MMR, 98.8% and 88.4%, respectively, regained MMR and MR4.5 by the data cutoff date. Consistent with prior reports of imatinib-treated patients, musculoskeletal pain-related events were reported in 24.7% of patients in the TFR phase (consolidation phase, 16.3%). More... »

PAGES

1525-1531

Journal

TITLE

Leukemia

ISSUE

7

VOLUME

31

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/leu.2017.63

DOI

http://dx.doi.org/10.1038/leu.2017.63

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1083850241

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/28218239


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1102", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Cardiorespiratory Medicine and Haematology", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Adult", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Aged", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Aged, 80 and over", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Female", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Leukemia, Myelogenous, Chronic, BCR-ABL Positive", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Male", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Middle Aged", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Protein Kinase Inhibitors", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Pyrimidines", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Quality of Life", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Abteilung H\u00e4matologie/Onkologie, Universit\u00e4tsklinikum Jena, Jena, Germany", 
          "id": "http://www.grid.ac/institutes/grid.275559.9", 
          "name": [
            "Abteilung H\u00e4matologie/Onkologie, Universit\u00e4tsklinikum Jena, Jena, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Hochhaus", 
        "givenName": "A", 
        "id": "sg:person.01064615503.48", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01064615503.48"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Haematology and Stem Cell Transplantation St Istv\u00e1n and St L\u00e1szl\u00f3 Hospital, Budapest, Hungary", 
          "id": "http://www.grid.ac/institutes/grid.452768.a", 
          "name": [
            "Department of Haematology and Stem Cell Transplantation St Istv\u00e1n and St L\u00e1szl\u00f3 Hospital, Budapest, Hungary"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Masszi", 
        "givenName": "T", 
        "id": "sg:person.0751651512.21", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0751651512.21"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Developmental Therapeutics Program, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA", 
          "id": "http://www.grid.ac/institutes/grid.16753.36", 
          "name": [
            "Developmental Therapeutics Program, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Giles", 
        "givenName": "F J", 
        "id": "sg:person.010046107662.90", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.010046107662.90"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, WA, USA", 
          "id": "http://www.grid.ac/institutes/grid.270240.3", 
          "name": [
            "Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, WA, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Radich", 
        "givenName": "J P", 
        "id": "sg:person.011362420057.85", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011362420057.85"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "SA Pathology, Adelaide, SA, Australia", 
          "id": "http://www.grid.ac/institutes/grid.414733.6", 
          "name": [
            "SA Pathology, Adelaide, SA, Australia"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Ross", 
        "givenName": "D M", 
        "id": "sg:person.01110323637.14", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01110323637.14"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Hospital Universitario Doctor Negrin, Las Palmas de Gran Canaria, Spain", 
          "id": "http://www.grid.ac/institutes/None", 
          "name": [
            "Hospital Universitario Doctor Negrin, Las Palmas de Gran Canaria, Spain"
          ], 
          "type": "Organization"
        }, 
        "familyName": "G\u00f3mez Casares", 
        "givenName": "M T", 
        "id": "sg:person.0716710447.44", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0716710447.44"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Medical University of Gda\u0144sk, Gda\u0144sk, Poland", 
          "id": "http://www.grid.ac/institutes/grid.11451.30", 
          "name": [
            "Medical University of Gda\u0144sk, Gda\u0144sk, Poland"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Hellmann", 
        "givenName": "A", 
        "id": "sg:person.01154416326.31", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01154416326.31"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Aarhus University Hospital, Aarhus, Denmark", 
          "id": "http://www.grid.ac/institutes/grid.154185.c", 
          "name": [
            "Aarhus University Hospital, Aarhus, Denmark"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Stentoft", 
        "givenName": "J", 
        "id": "sg:person.016036621425.38", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.016036621425.38"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "St James Hospital, Dublin, Ireland", 
          "id": "http://www.grid.ac/institutes/grid.416409.e", 
          "name": [
            "St James Hospital, Dublin, Ireland"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Conneally", 
        "givenName": "E", 
        "id": "sg:person.01132647406.49", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01132647406.49"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Servicio de Hematolog\u00eda, Hospital Universitario Ram\u00f3n y Cajal (IRYCIS), Madrid, Spain", 
          "id": "http://www.grid.ac/institutes/grid.411347.4", 
          "name": [
            "Servicio de Hematolog\u00eda, Hospital Universitario Ram\u00f3n y Cajal (IRYCIS), Madrid, Spain"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Garc\u00eda-Guti\u00e9rrez", 
        "givenName": "V", 
        "id": "sg:person.01322203274.19", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01322203274.19"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Universit\u00e4tsklinikum D\u00fcsseldorf, D\u00fcsseldorf, Germany", 
          "id": "http://www.grid.ac/institutes/grid.14778.3d", 
          "name": [
            "Universit\u00e4tsklinikum D\u00fcsseldorf, D\u00fcsseldorf, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Gattermann", 
        "givenName": "N", 
        "id": "sg:person.01273447501.34", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01273447501.34"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Hematology, Medical University of Warsaw, Warsaw, Poland", 
          "id": "http://www.grid.ac/institutes/grid.13339.3b", 
          "name": [
            "Department of Hematology, Medical University of Warsaw, Warsaw, Poland"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Wiktor-Jedrzejczak", 
        "givenName": "W", 
        "id": "sg:person.0102003725.36", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0102003725.36"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Charit\u00e9 Universit\u00e4tsmedizin Berlin, Berlin, Germany", 
          "id": "http://www.grid.ac/institutes/grid.6363.0", 
          "name": [
            "Charit\u00e9 Universit\u00e4tsmedizin Berlin, Berlin, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "le Coutre", 
        "givenName": "P D", 
        "id": "sg:person.01344447222.75", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01344447222.75"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Azienda Ospedaliera Bianchi Melacrino Morelli, Reggio Calabria, Italy", 
          "id": "http://www.grid.ac/institutes/grid.414504.0", 
          "name": [
            "Azienda Ospedaliera Bianchi Melacrino Morelli, Reggio Calabria, Italy"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Martino", 
        "givenName": "B", 
        "id": "sg:person.01105522434.09", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01105522434.09"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "III. Med. Klinik, Medizinische Fakult\u00e4t Mannheim der Universit\u00e4t Heidelberg, Mannheim, Germany", 
          "id": "http://www.grid.ac/institutes/grid.7700.0", 
          "name": [
            "III. Med. Klinik, Medizinische Fakult\u00e4t Mannheim der Universit\u00e4t Heidelberg, Mannheim, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Saussele", 
        "givenName": "S", 
        "id": "sg:person.0611020122.69", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0611020122.69"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Novartis Pharma AG, Basel, Switzerland", 
          "id": "http://www.grid.ac/institutes/grid.419481.1", 
          "name": [
            "Novartis Pharma AG, Basel, Switzerland"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Menssen", 
        "givenName": "H D", 
        "id": "sg:person.013706371144.76", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013706371144.76"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Novartis Pharmaceuticals Corporation, East Hanover, NJ, USA", 
          "id": "http://www.grid.ac/institutes/grid.418424.f", 
          "name": [
            "Novartis Pharmaceuticals Corporation, East Hanover, NJ, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Deng", 
        "givenName": "W", 
        "id": "sg:person.01217254625.41", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01217254625.41"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Novartis Institute for Biomedical Research, Cambridge, MA, USA", 
          "id": "http://www.grid.ac/institutes/grid.418424.f", 
          "name": [
            "Novartis Institute for Biomedical Research, Cambridge, MA, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Krunic", 
        "givenName": "N", 
        "id": "sg:person.016402170507.13", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.016402170507.13"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Novartis Pharma AG, Basel, Switzerland", 
          "id": "http://www.grid.ac/institutes/grid.419481.1", 
          "name": [
            "Novartis Pharma AG, Basel, Switzerland"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Bedoucha", 
        "givenName": "V", 
        "id": "sg:person.0761205252.14", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0761205252.14"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Turin, Orbassano, Italy", 
          "id": "http://www.grid.ac/institutes/grid.7605.4", 
          "name": [
            "University of Turin, Orbassano, Italy"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Saglio", 
        "givenName": "G", 
        "id": "sg:person.01334477453.06", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01334477453.06"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "sg:pub.10.1007/s11136-011-9903-x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1044866349", 
          "https://doi.org/10.1007/s11136-011-9903-x"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/leu.2016.115", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1022073613", 
          "https://doi.org/10.1038/leu.2016.115"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/leu.2015.29", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1023059213", 
          "https://doi.org/10.1038/leu.2015.29"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/leu.2016.5", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1041273297", 
          "https://doi.org/10.1038/leu.2016.5"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/978-3-319-33198-0_13", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1000400667", 
          "https://doi.org/10.1007/978-3-319-33198-0_13"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/leu.2015.270", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1005122619", 
          "https://doi.org/10.1038/leu.2015.270"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2017-02-20", 
    "datePublishedReg": "2017-02-20", 
    "description": "The single-arm, phase 2 ENESTfreedom trial assessed the potential for treatment-free remission (TFR; i.e., the ability to maintain a molecular response after stopping therapy) following frontline nilotinib treatment. Patients with Philadelphia chromosome-positive chronic myeloid leukemia in chronic phase with MR4.5 (BCR-ABL1\u2a7d0.0032% on the International Scale (BCR-ABL1IS)) and \u2a7e2 years of frontline nilotinib therapy were enrolled. Patients with sustained deep molecular response during the 1-year nilotinib consolidation phase were eligible to stop treatment and enter the TFR phase. Patients with loss of major molecular response (MMR; BCR-ABL1IS\u2a7d0.1%) during the TFR phase reinitiated nilotinib. In total, 215 patients entered the consolidation phase, of whom 190 entered the TFR phase. The median duration of nilotinib before stopping treatment was 43.5 months. At 48 weeks after stopping nilotinib, 98 patients (51.6%; 95% confidence interval, 44.2\u201358.9%) remained in MMR or better (primary end point). Of the 86 patients who restarted nilotinib in the treatment reinitiation phase after loss of MMR, 98.8% and 88.4%, respectively, regained MMR and MR4.5 by the data cutoff date. Consistent with prior reports of imatinib-treated patients, musculoskeletal pain-related events were reported in 24.7% of patients in the TFR phase (consolidation phase, 16.3%).", 
    "genre": "article", 
    "id": "sg:pub.10.1038/leu.2017.63", 
    "isAccessibleForFree": true, 
    "isPartOf": [
      {
        "id": "sg:journal.1097065", 
        "issn": [
          "0887-6924", 
          "1476-5551"
        ], 
        "name": "Leukemia", 
        "publisher": "Springer Nature", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "7", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "31"
      }
    ], 
    "keywords": [
      "treatment-free remission", 
      "TFR phase", 
      "chronic myeloid leukemia", 
      "chronic phase", 
      "myeloid leukemia", 
      "Philadelphia chromosome-positive chronic myeloid leukemia", 
      "sustained deep molecular response", 
      "chromosome-positive chronic myeloid leukemia", 
      "data cutoff date", 
      "deep molecular response", 
      "major molecular response", 
      "imatinib-treated patients", 
      "pain-related events", 
      "loss of MMR", 
      "consolidation phase", 
      "frontline nilotinib", 
      "nilotinib therapy", 
      "median duration", 
      "nilotinib treatment", 
      "molecular response", 
      "patients", 
      "nilotinib", 
      "prior reports", 
      "remission", 
      "MR4.5", 
      "cutoff date", 
      "leukemia", 
      "treatment", 
      "MMR", 
      "therapy", 
      "trials", 
      "weeks", 
      "months", 
      "response", 
      "duration", 
      "report", 
      "loss", 
      "years", 
      "study", 
      "events", 
      "date", 
      "potential", 
      "phase", 
      "results"
    ], 
    "name": "Treatment-free remission following frontline nilotinib in patients with chronic myeloid leukemia in chronic phase: results from the ENESTfreedom study", 
    "pagination": "1525-1531", 
    "productId": [
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1083850241"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1038/leu.2017.63"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "28218239"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1038/leu.2017.63", 
      "https://app.dimensions.ai/details/publication/pub.1083850241"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2022-08-04T17:05", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-springernature-scigraph/baseset/20220804/entities/gbq_results/article/article_721.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://doi.org/10.1038/leu.2017.63"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/leu.2017.63'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/leu.2017.63'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/leu.2017.63'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/leu.2017.63'


 

This table displays all metadata directly associated to this object as RDF triples.

359 TRIPLES      21 PREDICATES      86 URIs      72 LITERALS      18 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1038/leu.2017.63 schema:about N39c76d51a1944673ab3f984332ebc278
2 N8304a32fb4a14cd7bdf6da50f2c1667b
3 N8dc8e61b72554dc6917e64dd34d3f7be
4 Na2ab1ad90a344e5cadd1b2aec6bca275
5 Nb16c81f84057465aae6809906fa8b0a7
6 Nb49f43e459124b09bfdc2cdf2770e162
7 Nbf87e679296e4b708351d149b36e6568
8 Nc18977ea6bd94fd9920fd93ab015204f
9 Nc6309c0f6ff94ad287833be93f9258c0
10 Nd72579fd32de4d6b8d2df29c8fb03da7
11 Ned86c01f226a426a84783e1033f1a8e0
12 anzsrc-for:11
13 anzsrc-for:1102
14 schema:author N58dc151041244cd5957125b82943a8a3
15 schema:citation sg:pub.10.1007/978-3-319-33198-0_13
16 sg:pub.10.1007/s11136-011-9903-x
17 sg:pub.10.1038/leu.2015.270
18 sg:pub.10.1038/leu.2015.29
19 sg:pub.10.1038/leu.2016.115
20 sg:pub.10.1038/leu.2016.5
21 schema:datePublished 2017-02-20
22 schema:datePublishedReg 2017-02-20
23 schema:description The single-arm, phase 2 ENESTfreedom trial assessed the potential for treatment-free remission (TFR; i.e., the ability to maintain a molecular response after stopping therapy) following frontline nilotinib treatment. Patients with Philadelphia chromosome-positive chronic myeloid leukemia in chronic phase with MR4.5 (BCR-ABL1⩽0.0032% on the International Scale (BCR-ABL1IS)) and ⩾2 years of frontline nilotinib therapy were enrolled. Patients with sustained deep molecular response during the 1-year nilotinib consolidation phase were eligible to stop treatment and enter the TFR phase. Patients with loss of major molecular response (MMR; BCR-ABL1IS⩽0.1%) during the TFR phase reinitiated nilotinib. In total, 215 patients entered the consolidation phase, of whom 190 entered the TFR phase. The median duration of nilotinib before stopping treatment was 43.5 months. At 48 weeks after stopping nilotinib, 98 patients (51.6%; 95% confidence interval, 44.2–58.9%) remained in MMR or better (primary end point). Of the 86 patients who restarted nilotinib in the treatment reinitiation phase after loss of MMR, 98.8% and 88.4%, respectively, regained MMR and MR4.5 by the data cutoff date. Consistent with prior reports of imatinib-treated patients, musculoskeletal pain-related events were reported in 24.7% of patients in the TFR phase (consolidation phase, 16.3%).
24 schema:genre article
25 schema:isAccessibleForFree true
26 schema:isPartOf N9213a4a7acf64243ac3d5c544ea8df16
27 Nb7bf44cb3b1640cdbaa41f4892928731
28 sg:journal.1097065
29 schema:keywords MMR
30 MR4.5
31 Philadelphia chromosome-positive chronic myeloid leukemia
32 TFR phase
33 chromosome-positive chronic myeloid leukemia
34 chronic myeloid leukemia
35 chronic phase
36 consolidation phase
37 cutoff date
38 data cutoff date
39 date
40 deep molecular response
41 duration
42 events
43 frontline nilotinib
44 imatinib-treated patients
45 leukemia
46 loss
47 loss of MMR
48 major molecular response
49 median duration
50 molecular response
51 months
52 myeloid leukemia
53 nilotinib
54 nilotinib therapy
55 nilotinib treatment
56 pain-related events
57 patients
58 phase
59 potential
60 prior reports
61 remission
62 report
63 response
64 results
65 study
66 sustained deep molecular response
67 therapy
68 treatment
69 treatment-free remission
70 trials
71 weeks
72 years
73 schema:name Treatment-free remission following frontline nilotinib in patients with chronic myeloid leukemia in chronic phase: results from the ENESTfreedom study
74 schema:pagination 1525-1531
75 schema:productId N10afab8b80fa47658ea47c6227081a8e
76 Nda2da33f808b4f6bad27d8381f196c8d
77 Nf05ae006e01541fda4a6f99b72ac3a16
78 schema:sameAs https://app.dimensions.ai/details/publication/pub.1083850241
79 https://doi.org/10.1038/leu.2017.63
80 schema:sdDatePublished 2022-08-04T17:05
81 schema:sdLicense https://scigraph.springernature.com/explorer/license/
82 schema:sdPublisher N5a0b56e6291742b5ab4fbfcd93acf245
83 schema:url https://doi.org/10.1038/leu.2017.63
84 sgo:license sg:explorer/license/
85 sgo:sdDataset articles
86 rdf:type schema:ScholarlyArticle
87 N0d360abd15174c99926bd3d6bc9ede2d rdf:first sg:person.01344447222.75
88 rdf:rest N9767b285b92b4b1097b989bda350e9bd
89 N10afab8b80fa47658ea47c6227081a8e schema:name doi
90 schema:value 10.1038/leu.2017.63
91 rdf:type schema:PropertyValue
92 N2a6e823881e041a48ee7f048b13f966c rdf:first sg:person.0611020122.69
93 rdf:rest N3a6f6592e3c648009970905414872179
94 N2e43b9c5496a4e83b2ee2e16393fefee rdf:first sg:person.016402170507.13
95 rdf:rest Nec7b36b6cecd46f9980cf75f2315bef2
96 N34edf4fe54534933819e6507f13779a5 rdf:first sg:person.0716710447.44
97 rdf:rest Nb38236500ddc44dcbb44686ce0e897cc
98 N3859306c73944d91837e97a31b688f84 rdf:first sg:person.011362420057.85
99 rdf:rest N625457cad39543719c5a09495dd3e844
100 N39c76d51a1944673ab3f984332ebc278 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
101 schema:name Pyrimidines
102 rdf:type schema:DefinedTerm
103 N3a6f6592e3c648009970905414872179 rdf:first sg:person.013706371144.76
104 rdf:rest N6f8d856990384112a6c319c17505f8b6
105 N4bcd50c33a314ccf81e110f33db19f58 rdf:first sg:person.01334477453.06
106 rdf:rest rdf:nil
107 N58dc151041244cd5957125b82943a8a3 rdf:first sg:person.01064615503.48
108 rdf:rest N764f3b24f4394fb3be21860c2d0a09ce
109 N5a0b56e6291742b5ab4fbfcd93acf245 schema:name Springer Nature - SN SciGraph project
110 rdf:type schema:Organization
111 N625457cad39543719c5a09495dd3e844 rdf:first sg:person.01110323637.14
112 rdf:rest N34edf4fe54534933819e6507f13779a5
113 N6f8d856990384112a6c319c17505f8b6 rdf:first sg:person.01217254625.41
114 rdf:rest N2e43b9c5496a4e83b2ee2e16393fefee
115 N764f3b24f4394fb3be21860c2d0a09ce rdf:first sg:person.0751651512.21
116 rdf:rest Nfc602b8c4ea64516bf890b550b7708c9
117 N8304a32fb4a14cd7bdf6da50f2c1667b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
118 schema:name Male
119 rdf:type schema:DefinedTerm
120 N8dc8e61b72554dc6917e64dd34d3f7be schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
121 schema:name Quality of Life
122 rdf:type schema:DefinedTerm
123 N9213a4a7acf64243ac3d5c544ea8df16 schema:volumeNumber 31
124 rdf:type schema:PublicationVolume
125 N9767b285b92b4b1097b989bda350e9bd rdf:first sg:person.01105522434.09
126 rdf:rest N2a6e823881e041a48ee7f048b13f966c
127 Na2ab1ad90a344e5cadd1b2aec6bca275 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
128 schema:name Aged
129 rdf:type schema:DefinedTerm
130 Na3debd1a98164b6ca5c8c060a21840bf rdf:first sg:person.0102003725.36
131 rdf:rest N0d360abd15174c99926bd3d6bc9ede2d
132 Na9f738410eee49ff95c8729b0ac4b18a rdf:first sg:person.016036621425.38
133 rdf:rest Nb11332dfd21444dfbf4e8f8aafe6f3f9
134 Naa7dc6c2e6884e9f9b6388cafe40c3da rdf:first sg:person.01322203274.19
135 rdf:rest Nd9f52cc9a14e4ef6828d8e260b8c30bc
136 Nb11332dfd21444dfbf4e8f8aafe6f3f9 rdf:first sg:person.01132647406.49
137 rdf:rest Naa7dc6c2e6884e9f9b6388cafe40c3da
138 Nb16c81f84057465aae6809906fa8b0a7 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
139 schema:name Aged, 80 and over
140 rdf:type schema:DefinedTerm
141 Nb38236500ddc44dcbb44686ce0e897cc rdf:first sg:person.01154416326.31
142 rdf:rest Na9f738410eee49ff95c8729b0ac4b18a
143 Nb49f43e459124b09bfdc2cdf2770e162 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
144 schema:name Protein Kinase Inhibitors
145 rdf:type schema:DefinedTerm
146 Nb7bf44cb3b1640cdbaa41f4892928731 schema:issueNumber 7
147 rdf:type schema:PublicationIssue
148 Nbf87e679296e4b708351d149b36e6568 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
149 schema:name Adult
150 rdf:type schema:DefinedTerm
151 Nc18977ea6bd94fd9920fd93ab015204f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
152 schema:name Middle Aged
153 rdf:type schema:DefinedTerm
154 Nc6309c0f6ff94ad287833be93f9258c0 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
155 schema:name Humans
156 rdf:type schema:DefinedTerm
157 Nd72579fd32de4d6b8d2df29c8fb03da7 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
158 schema:name Female
159 rdf:type schema:DefinedTerm
160 Nd9f52cc9a14e4ef6828d8e260b8c30bc rdf:first sg:person.01273447501.34
161 rdf:rest Na3debd1a98164b6ca5c8c060a21840bf
162 Nda2da33f808b4f6bad27d8381f196c8d schema:name pubmed_id
163 schema:value 28218239
164 rdf:type schema:PropertyValue
165 Nec7b36b6cecd46f9980cf75f2315bef2 rdf:first sg:person.0761205252.14
166 rdf:rest N4bcd50c33a314ccf81e110f33db19f58
167 Ned86c01f226a426a84783e1033f1a8e0 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
168 schema:name Leukemia, Myelogenous, Chronic, BCR-ABL Positive
169 rdf:type schema:DefinedTerm
170 Nf05ae006e01541fda4a6f99b72ac3a16 schema:name dimensions_id
171 schema:value pub.1083850241
172 rdf:type schema:PropertyValue
173 Nfc602b8c4ea64516bf890b550b7708c9 rdf:first sg:person.010046107662.90
174 rdf:rest N3859306c73944d91837e97a31b688f84
175 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
176 schema:name Medical and Health Sciences
177 rdf:type schema:DefinedTerm
178 anzsrc-for:1102 schema:inDefinedTermSet anzsrc-for:
179 schema:name Cardiorespiratory Medicine and Haematology
180 rdf:type schema:DefinedTerm
181 sg:journal.1097065 schema:issn 0887-6924
182 1476-5551
183 schema:name Leukemia
184 schema:publisher Springer Nature
185 rdf:type schema:Periodical
186 sg:person.010046107662.90 schema:affiliation grid-institutes:grid.16753.36
187 schema:familyName Giles
188 schema:givenName F J
189 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.010046107662.90
190 rdf:type schema:Person
191 sg:person.0102003725.36 schema:affiliation grid-institutes:grid.13339.3b
192 schema:familyName Wiktor-Jedrzejczak
193 schema:givenName W
194 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0102003725.36
195 rdf:type schema:Person
196 sg:person.01064615503.48 schema:affiliation grid-institutes:grid.275559.9
197 schema:familyName Hochhaus
198 schema:givenName A
199 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01064615503.48
200 rdf:type schema:Person
201 sg:person.01105522434.09 schema:affiliation grid-institutes:grid.414504.0
202 schema:familyName Martino
203 schema:givenName B
204 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01105522434.09
205 rdf:type schema:Person
206 sg:person.01110323637.14 schema:affiliation grid-institutes:grid.414733.6
207 schema:familyName Ross
208 schema:givenName D M
209 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01110323637.14
210 rdf:type schema:Person
211 sg:person.01132647406.49 schema:affiliation grid-institutes:grid.416409.e
212 schema:familyName Conneally
213 schema:givenName E
214 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01132647406.49
215 rdf:type schema:Person
216 sg:person.011362420057.85 schema:affiliation grid-institutes:grid.270240.3
217 schema:familyName Radich
218 schema:givenName J P
219 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011362420057.85
220 rdf:type schema:Person
221 sg:person.01154416326.31 schema:affiliation grid-institutes:grid.11451.30
222 schema:familyName Hellmann
223 schema:givenName A
224 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01154416326.31
225 rdf:type schema:Person
226 sg:person.01217254625.41 schema:affiliation grid-institutes:grid.418424.f
227 schema:familyName Deng
228 schema:givenName W
229 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01217254625.41
230 rdf:type schema:Person
231 sg:person.01273447501.34 schema:affiliation grid-institutes:grid.14778.3d
232 schema:familyName Gattermann
233 schema:givenName N
234 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01273447501.34
235 rdf:type schema:Person
236 sg:person.01322203274.19 schema:affiliation grid-institutes:grid.411347.4
237 schema:familyName García-Gutiérrez
238 schema:givenName V
239 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01322203274.19
240 rdf:type schema:Person
241 sg:person.01334477453.06 schema:affiliation grid-institutes:grid.7605.4
242 schema:familyName Saglio
243 schema:givenName G
244 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01334477453.06
245 rdf:type schema:Person
246 sg:person.01344447222.75 schema:affiliation grid-institutes:grid.6363.0
247 schema:familyName le Coutre
248 schema:givenName P D
249 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01344447222.75
250 rdf:type schema:Person
251 sg:person.013706371144.76 schema:affiliation grid-institutes:grid.419481.1
252 schema:familyName Menssen
253 schema:givenName H D
254 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013706371144.76
255 rdf:type schema:Person
256 sg:person.016036621425.38 schema:affiliation grid-institutes:grid.154185.c
257 schema:familyName Stentoft
258 schema:givenName J
259 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.016036621425.38
260 rdf:type schema:Person
261 sg:person.016402170507.13 schema:affiliation grid-institutes:grid.418424.f
262 schema:familyName Krunic
263 schema:givenName N
264 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.016402170507.13
265 rdf:type schema:Person
266 sg:person.0611020122.69 schema:affiliation grid-institutes:grid.7700.0
267 schema:familyName Saussele
268 schema:givenName S
269 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0611020122.69
270 rdf:type schema:Person
271 sg:person.0716710447.44 schema:affiliation grid-institutes:None
272 schema:familyName Gómez Casares
273 schema:givenName M T
274 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0716710447.44
275 rdf:type schema:Person
276 sg:person.0751651512.21 schema:affiliation grid-institutes:grid.452768.a
277 schema:familyName Masszi
278 schema:givenName T
279 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0751651512.21
280 rdf:type schema:Person
281 sg:person.0761205252.14 schema:affiliation grid-institutes:grid.419481.1
282 schema:familyName Bedoucha
283 schema:givenName V
284 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0761205252.14
285 rdf:type schema:Person
286 sg:pub.10.1007/978-3-319-33198-0_13 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000400667
287 https://doi.org/10.1007/978-3-319-33198-0_13
288 rdf:type schema:CreativeWork
289 sg:pub.10.1007/s11136-011-9903-x schema:sameAs https://app.dimensions.ai/details/publication/pub.1044866349
290 https://doi.org/10.1007/s11136-011-9903-x
291 rdf:type schema:CreativeWork
292 sg:pub.10.1038/leu.2015.270 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005122619
293 https://doi.org/10.1038/leu.2015.270
294 rdf:type schema:CreativeWork
295 sg:pub.10.1038/leu.2015.29 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023059213
296 https://doi.org/10.1038/leu.2015.29
297 rdf:type schema:CreativeWork
298 sg:pub.10.1038/leu.2016.115 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022073613
299 https://doi.org/10.1038/leu.2016.115
300 rdf:type schema:CreativeWork
301 sg:pub.10.1038/leu.2016.5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041273297
302 https://doi.org/10.1038/leu.2016.5
303 rdf:type schema:CreativeWork
304 grid-institutes:None schema:alternateName Hospital Universitario Doctor Negrin, Las Palmas de Gran Canaria, Spain
305 schema:name Hospital Universitario Doctor Negrin, Las Palmas de Gran Canaria, Spain
306 rdf:type schema:Organization
307 grid-institutes:grid.11451.30 schema:alternateName Medical University of Gdańsk, Gdańsk, Poland
308 schema:name Medical University of Gdańsk, Gdańsk, Poland
309 rdf:type schema:Organization
310 grid-institutes:grid.13339.3b schema:alternateName Department of Hematology, Medical University of Warsaw, Warsaw, Poland
311 schema:name Department of Hematology, Medical University of Warsaw, Warsaw, Poland
312 rdf:type schema:Organization
313 grid-institutes:grid.14778.3d schema:alternateName Universitätsklinikum Düsseldorf, Düsseldorf, Germany
314 schema:name Universitätsklinikum Düsseldorf, Düsseldorf, Germany
315 rdf:type schema:Organization
316 grid-institutes:grid.154185.c schema:alternateName Aarhus University Hospital, Aarhus, Denmark
317 schema:name Aarhus University Hospital, Aarhus, Denmark
318 rdf:type schema:Organization
319 grid-institutes:grid.16753.36 schema:alternateName Developmental Therapeutics Program, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA
320 schema:name Developmental Therapeutics Program, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA
321 rdf:type schema:Organization
322 grid-institutes:grid.270240.3 schema:alternateName Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, WA, USA
323 schema:name Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, WA, USA
324 rdf:type schema:Organization
325 grid-institutes:grid.275559.9 schema:alternateName Abteilung Hämatologie/Onkologie, Universitätsklinikum Jena, Jena, Germany
326 schema:name Abteilung Hämatologie/Onkologie, Universitätsklinikum Jena, Jena, Germany
327 rdf:type schema:Organization
328 grid-institutes:grid.411347.4 schema:alternateName Servicio de Hematología, Hospital Universitario Ramón y Cajal (IRYCIS), Madrid, Spain
329 schema:name Servicio de Hematología, Hospital Universitario Ramón y Cajal (IRYCIS), Madrid, Spain
330 rdf:type schema:Organization
331 grid-institutes:grid.414504.0 schema:alternateName Azienda Ospedaliera Bianchi Melacrino Morelli, Reggio Calabria, Italy
332 schema:name Azienda Ospedaliera Bianchi Melacrino Morelli, Reggio Calabria, Italy
333 rdf:type schema:Organization
334 grid-institutes:grid.414733.6 schema:alternateName SA Pathology, Adelaide, SA, Australia
335 schema:name SA Pathology, Adelaide, SA, Australia
336 rdf:type schema:Organization
337 grid-institutes:grid.416409.e schema:alternateName St James Hospital, Dublin, Ireland
338 schema:name St James Hospital, Dublin, Ireland
339 rdf:type schema:Organization
340 grid-institutes:grid.418424.f schema:alternateName Novartis Institute for Biomedical Research, Cambridge, MA, USA
341 Novartis Pharmaceuticals Corporation, East Hanover, NJ, USA
342 schema:name Novartis Institute for Biomedical Research, Cambridge, MA, USA
343 Novartis Pharmaceuticals Corporation, East Hanover, NJ, USA
344 rdf:type schema:Organization
345 grid-institutes:grid.419481.1 schema:alternateName Novartis Pharma AG, Basel, Switzerland
346 schema:name Novartis Pharma AG, Basel, Switzerland
347 rdf:type schema:Organization
348 grid-institutes:grid.452768.a schema:alternateName Department of Haematology and Stem Cell Transplantation St István and St László Hospital, Budapest, Hungary
349 schema:name Department of Haematology and Stem Cell Transplantation St István and St László Hospital, Budapest, Hungary
350 rdf:type schema:Organization
351 grid-institutes:grid.6363.0 schema:alternateName Charité Universitätsmedizin Berlin, Berlin, Germany
352 schema:name Charité Universitätsmedizin Berlin, Berlin, Germany
353 rdf:type schema:Organization
354 grid-institutes:grid.7605.4 schema:alternateName University of Turin, Orbassano, Italy
355 schema:name University of Turin, Orbassano, Italy
356 rdf:type schema:Organization
357 grid-institutes:grid.7700.0 schema:alternateName III. Med. Klinik, Medizinische Fakultät Mannheim der Universität Heidelberg, Mannheim, Germany
358 schema:name III. Med. Klinik, Medizinische Fakultät Mannheim der Universität Heidelberg, Mannheim, Germany
359 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...