Lamin B1 regulates somatic mutations and progression of B-cell malignancies View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2018-02

AUTHORS

T Klymenko, J Bloehdorn, J Bahlo, S Robrecht, G Akylzhanova, K Cox, S Estenfelder, J Wang, J Edelmann, J C Strefford, T K Wojdacz, K Fischer, M Hallek, S Stilgenbauer, M Cragg, J Gribben, A Braun

ABSTRACT

Somatic hypermutation (SHM) is a pivotal process in adaptive immunity that occurs in the germinal centre and allows B cells to change their primary DNA sequence and diversify their antigen receptors. Here, we report that genome binding of Lamin B1, a component of the nuclear envelope involved in epigenetic chromatin regulation, is reduced during B-cell activation and formation of lymphoid germinal centres. Chromatin immunoprecipitation-Seq analysis showed that kappa and heavy variable immunoglobulin domains were released from the Lamin B1 suppressive environment when SHM was induced in B cells. RNA interference-mediated reduction of Lamin B1 resulted in spontaneous SHM as well as kappa-light chain aberrant surface expression. Finally, Lamin B1 expression level correlated with progression-free and overall survival in chronic lymphocytic leukaemia, and was strongly involved in the transformation of follicular lymphoma. In summary, here we report that Lamin B1 is a negative epigenetic regulator of SHM in normal B-cells and a 'mutational gatekeeper', suppressing the aberrant mutations that drive lymphoid malignancy. More... »

PAGES

364

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/leu.2017.255

DOI

http://dx.doi.org/10.1038/leu.2017.255

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1091206991

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/28804121


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/0604", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Genetics", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/06", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Biological Sciences", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Queen Mary University of London", 
          "id": "https://www.grid.ac/institutes/grid.4868.2", 
          "name": [
            "Centre for Haemato-Oncology, Barts Cancer Institute, Queen Mary University, London, UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Klymenko", 
        "givenName": "T", 
        "id": "sg:person.01005202477.29", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01005202477.29"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Ulm", 
          "id": "https://www.grid.ac/institutes/grid.6582.9", 
          "name": [
            "Department of Internal Medicine III, University of Ulm, Ulm, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Bloehdorn", 
        "givenName": "J", 
        "id": "sg:person.0706051366.15", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0706051366.15"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University Hospital Cologne", 
          "id": "https://www.grid.ac/institutes/grid.411097.a", 
          "name": [
            "Department I of Internal Medicine, Center for Integrated Oncology Cologne, University Hospital of Cologne, Cologne, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Bahlo", 
        "givenName": "J", 
        "id": "sg:person.01071023477.25", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01071023477.25"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University Hospital Cologne", 
          "id": "https://www.grid.ac/institutes/grid.411097.a", 
          "name": [
            "Department I of Internal Medicine, Center for Integrated Oncology Cologne, University Hospital of Cologne, Cologne, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Robrecht", 
        "givenName": "S", 
        "id": "sg:person.011722375631.72", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011722375631.72"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Queen Mary University of London", 
          "id": "https://www.grid.ac/institutes/grid.4868.2", 
          "name": [
            "Centre for Haemato-Oncology, Barts Cancer Institute, Queen Mary University, London, UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Akylzhanova", 
        "givenName": "G", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Southampton", 
          "id": "https://www.grid.ac/institutes/grid.5491.9", 
          "name": [
            "Academic Unit of Cancer Sciences, Faculty of Medicine, Cancer Research UK Centre and Experimental Cancer Medicine Centre, University of Southampton, Southampton, UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Cox", 
        "givenName": "K", 
        "id": "sg:person.01334130107.64", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01334130107.64"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Ulm", 
          "id": "https://www.grid.ac/institutes/grid.6582.9", 
          "name": [
            "Department of Internal Medicine III, University of Ulm, Ulm, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Estenfelder", 
        "givenName": "S", 
        "id": "sg:person.010722214767.27", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.010722214767.27"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Queen Mary University of London", 
          "id": "https://www.grid.ac/institutes/grid.4868.2", 
          "name": [
            "Centre for Haemato-Oncology, Barts Cancer Institute, Queen Mary University, London, UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Wang", 
        "givenName": "J", 
        "id": "sg:person.01003310355.24", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01003310355.24"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Queen Mary University of London", 
          "id": "https://www.grid.ac/institutes/grid.4868.2", 
          "name": [
            "Centre for Haemato-Oncology, Barts Cancer Institute, Queen Mary University, London, UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Edelmann", 
        "givenName": "J", 
        "id": "sg:person.01362520746.11", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01362520746.11"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Southampton", 
          "id": "https://www.grid.ac/institutes/grid.5491.9", 
          "name": [
            "Academic Unit of Cancer Sciences, Faculty of Medicine, Cancer Research UK Centre and Experimental Cancer Medicine Centre, University of Southampton, Southampton, UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Strefford", 
        "givenName": "J C", 
        "id": "sg:person.01120734350.41", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01120734350.41"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Aarhus University", 
          "id": "https://www.grid.ac/institutes/grid.7048.b", 
          "name": [
            "Academic Unit of Cancer Sciences, Faculty of Medicine, Cancer Research UK Centre and Experimental Cancer Medicine Centre, University of Southampton, Southampton, UK", 
            "Aarhus Institute of Advanced Studies, Aarhus University, Aarhus, Denmark"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Wojdacz", 
        "givenName": "T K", 
        "id": "sg:person.01150756062.04", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01150756062.04"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University Hospital Cologne", 
          "id": "https://www.grid.ac/institutes/grid.411097.a", 
          "name": [
            "Department I of Internal Medicine, Center for Integrated Oncology Cologne, University Hospital of Cologne, Cologne, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Fischer", 
        "givenName": "K", 
        "id": "sg:person.01115500203.21", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01115500203.21"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University Hospital Cologne", 
          "id": "https://www.grid.ac/institutes/grid.411097.a", 
          "name": [
            "Department I of Internal Medicine, Center for Integrated Oncology Cologne, University Hospital of Cologne, Cologne, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Hallek", 
        "givenName": "M", 
        "id": "sg:person.01025161256.58", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01025161256.58"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Ulm", 
          "id": "https://www.grid.ac/institutes/grid.6582.9", 
          "name": [
            "Department of Internal Medicine III, University of Ulm, Ulm, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Stilgenbauer", 
        "givenName": "S", 
        "id": "sg:person.01034520037.14", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01034520037.14"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Southampton", 
          "id": "https://www.grid.ac/institutes/grid.5491.9", 
          "name": [
            "Academic Unit of Cancer Sciences, Faculty of Medicine, Cancer Research UK Centre and Experimental Cancer Medicine Centre, University of Southampton, Southampton, UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Cragg", 
        "givenName": "M", 
        "id": "sg:person.01305636134.68", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01305636134.68"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Queen Mary University of London", 
          "id": "https://www.grid.ac/institutes/grid.4868.2", 
          "name": [
            "Centre for Haemato-Oncology, Barts Cancer Institute, Queen Mary University, London, UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Gribben", 
        "givenName": "J", 
        "id": "sg:person.0746457640.86", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0746457640.86"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Queen Mary University of London", 
          "id": "https://www.grid.ac/institutes/grid.4868.2", 
          "name": [
            "Centre for Haemato-Oncology, Barts Cancer Institute, Queen Mary University, London, UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Braun", 
        "givenName": "A", 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.1016/j.molcel.2010.03.016", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1004413613"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature06947", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1004427899", 
          "https://doi.org/10.1038/nature06947"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1084/jem.20110118", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1006085544"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.4049/jimmunol.1001155", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1006169710"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1084/jem.20120833", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1006459858"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nmeth.1923", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1006541515", 
          "https://doi.org/10.1038/nmeth.1923"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1182/blood.v99.11.4087", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1008562310"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.cell.2013.02.028", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1008857878"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1083/jcb.200607054", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1010463402"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1101/gr.141028.112", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1012572251"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1182/blood-2014-01-546150", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1013315597"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ni0901-848", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1014663842", 
          "https://doi.org/10.1038/ni0901-848"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ni0901-848", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1014663842", 
          "https://doi.org/10.1038/ni0901-848"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0140-6736(10)61381-5", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1016656695"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1182/blood-2015-06-651125", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1016700379"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s1074-7613(03)00261-9", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1017670830"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.cell.2014.10.028", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1019042259"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nbt.1754", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1019307928", 
          "https://doi.org/10.1038/nbt.1754"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1084/jem.182.2.559", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1019497632"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1074/jbc.m112.351569", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1019707451"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/science.1068768", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1019914341"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ni826", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1020948149", 
          "https://doi.org/10.1038/ni826"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ni826", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1020948149", 
          "https://doi.org/10.1038/ni826"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/science.1241146", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1023962432"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/bioinformatics/btq431", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1027500995"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1101/gad.217281.113", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1029734943"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1083/jcb.201205103", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1031085371"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nrm1550", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1031692521", 
          "https://doi.org/10.1038/nrm1550"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nrm1550", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1031692521", 
          "https://doi.org/10.1038/nrm1550"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature06727", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1033021479", 
          "https://doi.org/10.1038/nature06727"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1101/gr.083881.108", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1036133744"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature15395", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037615856", 
          "https://doi.org/10.1038/nature15395"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.0506580102", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037705714"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.0506580102", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037705714"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/nar/gku630", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1038822123"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.cell.2012.04.035", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1039604484"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1074/jbc.271.25.14653", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1041136540"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.it.2013.03.006", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1041333447"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1128/mcb.01145-14", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1041487525"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature01574", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1042422670", 
          "https://doi.org/10.1038/nature01574"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature01574", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1042422670", 
          "https://doi.org/10.1038/nature01574"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1600-065x.2012.01124.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1042463950"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature01117", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1043216199", 
          "https://doi.org/10.1038/nature01117"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1084/jem.194.11.1625", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1043960328"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1101/gad.223834.113", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1044298681"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1084/jem.20121387", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1045805394"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/bioinformatics/18.1.207", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1046806163"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1182/blood-2014-04-516815", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1047369675"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1101/gad.237479.114", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1047493252"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.immuni.2005.05.007", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1048231242"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature15548", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1049378033", 
          "https://doi.org/10.1038/nature15548"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.ccr.2009.11.019", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1049400026"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.0808462105", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1049887990"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.tig.2011.05.006", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1052561424"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2018-02", 
    "datePublishedReg": "2018-02-01", 
    "description": "Somatic hypermutation (SHM) is a pivotal process in adaptive immunity that occurs in the germinal centre and allows B cells to change their primary DNA sequence and diversify their antigen receptors. Here, we report that genome binding of Lamin B1, a component of the nuclear envelope involved in epigenetic chromatin regulation, is reduced during B-cell activation and formation of lymphoid germinal centres. Chromatin immunoprecipitation-Seq analysis showed that kappa and heavy variable immunoglobulin domains were released from the Lamin B1 suppressive environment when SHM was induced in B cells. RNA interference-mediated reduction of Lamin B1 resulted in spontaneous SHM as well as kappa-light chain aberrant surface expression. Finally, Lamin B1 expression level correlated with progression-free and overall survival in chronic lymphocytic leukaemia, and was strongly involved in the transformation of follicular lymphoma. In summary, here we report that Lamin B1 is a negative epigenetic regulator of SHM in normal B-cells and a 'mutational gatekeeper', suppressing the aberrant mutations that drive lymphoid malignancy.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1038/leu.2017.255", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": true, 
    "isFundedItemOf": [
      {
        "id": "sg:grant.7551250", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.5137546", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.7551198", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.5142972", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.5135195", 
        "type": "MonetaryGrant"
      }
    ], 
    "isPartOf": [
      {
        "id": "sg:journal.1097065", 
        "issn": [
          "0887-6924", 
          "1476-5551"
        ], 
        "name": "Leukemia", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "2", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "32"
      }
    ], 
    "name": "Lamin B1 regulates somatic mutations and progression of B-cell malignancies", 
    "pagination": "364", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "0bae7e073010822cbc5ee58facaee1261af2c6c27bef1442eb1093d1f33e0508"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "28804121"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "8704895"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1038/leu.2017.255"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1091206991"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1038/leu.2017.255", 
      "https://app.dimensions.ai/details/publication/pub.1091206991"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-10T14:47", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8663_00000422.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://www.nature.com/articles/leu2017255"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/leu.2017.255'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/leu.2017.255'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/leu.2017.255'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/leu.2017.255'


 

This table displays all metadata directly associated to this object as RDF triples.

360 TRIPLES      21 PREDICATES      78 URIs      21 LITERALS      9 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1038/leu.2017.255 schema:about anzsrc-for:06
2 anzsrc-for:0604
3 schema:author N5374e32c18344f0eb86f8d49d1fb28a4
4 schema:citation sg:pub.10.1038/nature01117
5 sg:pub.10.1038/nature01574
6 sg:pub.10.1038/nature06727
7 sg:pub.10.1038/nature06947
8 sg:pub.10.1038/nature15395
9 sg:pub.10.1038/nature15548
10 sg:pub.10.1038/nbt.1754
11 sg:pub.10.1038/ni0901-848
12 sg:pub.10.1038/ni826
13 sg:pub.10.1038/nmeth.1923
14 sg:pub.10.1038/nrm1550
15 https://doi.org/10.1016/j.ccr.2009.11.019
16 https://doi.org/10.1016/j.cell.2012.04.035
17 https://doi.org/10.1016/j.cell.2013.02.028
18 https://doi.org/10.1016/j.cell.2014.10.028
19 https://doi.org/10.1016/j.immuni.2005.05.007
20 https://doi.org/10.1016/j.it.2013.03.006
21 https://doi.org/10.1016/j.molcel.2010.03.016
22 https://doi.org/10.1016/j.tig.2011.05.006
23 https://doi.org/10.1016/s0140-6736(10)61381-5
24 https://doi.org/10.1016/s1074-7613(03)00261-9
25 https://doi.org/10.1073/pnas.0506580102
26 https://doi.org/10.1073/pnas.0808462105
27 https://doi.org/10.1074/jbc.271.25.14653
28 https://doi.org/10.1074/jbc.m112.351569
29 https://doi.org/10.1083/jcb.200607054
30 https://doi.org/10.1083/jcb.201205103
31 https://doi.org/10.1084/jem.182.2.559
32 https://doi.org/10.1084/jem.194.11.1625
33 https://doi.org/10.1084/jem.20110118
34 https://doi.org/10.1084/jem.20120833
35 https://doi.org/10.1084/jem.20121387
36 https://doi.org/10.1093/bioinformatics/18.1.207
37 https://doi.org/10.1093/bioinformatics/btq431
38 https://doi.org/10.1093/nar/gku630
39 https://doi.org/10.1101/gad.217281.113
40 https://doi.org/10.1101/gad.223834.113
41 https://doi.org/10.1101/gad.237479.114
42 https://doi.org/10.1101/gr.083881.108
43 https://doi.org/10.1101/gr.141028.112
44 https://doi.org/10.1111/j.1600-065x.2012.01124.x
45 https://doi.org/10.1126/science.1068768
46 https://doi.org/10.1126/science.1241146
47 https://doi.org/10.1128/mcb.01145-14
48 https://doi.org/10.1182/blood-2014-01-546150
49 https://doi.org/10.1182/blood-2014-04-516815
50 https://doi.org/10.1182/blood-2015-06-651125
51 https://doi.org/10.1182/blood.v99.11.4087
52 https://doi.org/10.4049/jimmunol.1001155
53 schema:datePublished 2018-02
54 schema:datePublishedReg 2018-02-01
55 schema:description Somatic hypermutation (SHM) is a pivotal process in adaptive immunity that occurs in the germinal centre and allows B cells to change their primary DNA sequence and diversify their antigen receptors. Here, we report that genome binding of Lamin B1, a component of the nuclear envelope involved in epigenetic chromatin regulation, is reduced during B-cell activation and formation of lymphoid germinal centres. Chromatin immunoprecipitation-Seq analysis showed that kappa and heavy variable immunoglobulin domains were released from the Lamin B1 suppressive environment when SHM was induced in B cells. RNA interference-mediated reduction of Lamin B1 resulted in spontaneous SHM as well as kappa-light chain aberrant surface expression. Finally, Lamin B1 expression level correlated with progression-free and overall survival in chronic lymphocytic leukaemia, and was strongly involved in the transformation of follicular lymphoma. In summary, here we report that Lamin B1 is a negative epigenetic regulator of SHM in normal B-cells and a 'mutational gatekeeper', suppressing the aberrant mutations that drive lymphoid malignancy.
56 schema:genre research_article
57 schema:inLanguage en
58 schema:isAccessibleForFree true
59 schema:isPartOf N2e7e95f3963d421baec695ba84b426e8
60 N7ba181a5d2624d34957f2769c235d310
61 sg:journal.1097065
62 schema:name Lamin B1 regulates somatic mutations and progression of B-cell malignancies
63 schema:pagination 364
64 schema:productId N2a1f31bf375b4f189ddc5ae037e3fc12
65 N45ee0fa0b92b4e8fa9e8b4a0cef10f00
66 N932848fa4afa4b6096caa6b68ee1e371
67 Na939b7a371814e898ab5e896e98a36cc
68 Ncd3956cd63ae44e1b67dbe2237035ff4
69 schema:sameAs https://app.dimensions.ai/details/publication/pub.1091206991
70 https://doi.org/10.1038/leu.2017.255
71 schema:sdDatePublished 2019-04-10T14:47
72 schema:sdLicense https://scigraph.springernature.com/explorer/license/
73 schema:sdPublisher N7fb90458a8494405bbfad9c1f5757bb1
74 schema:url https://www.nature.com/articles/leu2017255
75 sgo:license sg:explorer/license/
76 sgo:sdDataset articles
77 rdf:type schema:ScholarlyArticle
78 N0757c8bedb034deda469d22234b315b2 rdf:first N20c7f706eac64b84b05a071e0282308e
79 rdf:rest rdf:nil
80 N0b97092b3a844b15b86fab77be57e91c rdf:first sg:person.01120734350.41
81 rdf:rest N8d75109d5fb14ea09c7ddb337c4d7aa7
82 N0ca8653e0a0c4a1aa9d4ee1621c1ec4d rdf:first sg:person.01003310355.24
83 rdf:rest Nc7826f4b986c44089aaf5fbd9bfd792b
84 N1aae95fa15ed4d13a22a8ee36c97dcbe rdf:first N4ed735e6f037404c926e264fbf86340f
85 rdf:rest Nc3db123005d844a5bae9be94ca050bd6
86 N20c7f706eac64b84b05a071e0282308e schema:affiliation https://www.grid.ac/institutes/grid.4868.2
87 schema:familyName Braun
88 schema:givenName A
89 rdf:type schema:Person
90 N2a1f31bf375b4f189ddc5ae037e3fc12 schema:name doi
91 schema:value 10.1038/leu.2017.255
92 rdf:type schema:PropertyValue
93 N2e7e95f3963d421baec695ba84b426e8 schema:issueNumber 2
94 rdf:type schema:PublicationIssue
95 N45ee0fa0b92b4e8fa9e8b4a0cef10f00 schema:name nlm_unique_id
96 schema:value 8704895
97 rdf:type schema:PropertyValue
98 N4a9dc40058074ed2b2531a994f69a882 rdf:first sg:person.01305636134.68
99 rdf:rest Nbb52154c938941b6a0155f35874bfc1a
100 N4ed735e6f037404c926e264fbf86340f schema:affiliation https://www.grid.ac/institutes/grid.4868.2
101 schema:familyName Akylzhanova
102 schema:givenName G
103 rdf:type schema:Person
104 N5374e32c18344f0eb86f8d49d1fb28a4 rdf:first sg:person.01005202477.29
105 rdf:rest N736c1f86fdb94baa9067a3f4d976c16e
106 N69afc5d3ab2b4c6f95fc3f7c5f693a3d rdf:first sg:person.010722214767.27
107 rdf:rest N0ca8653e0a0c4a1aa9d4ee1621c1ec4d
108 N736c1f86fdb94baa9067a3f4d976c16e rdf:first sg:person.0706051366.15
109 rdf:rest N88302068225f48208762a6896774ebca
110 N7ba181a5d2624d34957f2769c235d310 schema:volumeNumber 32
111 rdf:type schema:PublicationVolume
112 N7fb90458a8494405bbfad9c1f5757bb1 schema:name Springer Nature - SN SciGraph project
113 rdf:type schema:Organization
114 N88302068225f48208762a6896774ebca rdf:first sg:person.01071023477.25
115 rdf:rest Nac736b6cf171453db379b1b643398a81
116 N8d75109d5fb14ea09c7ddb337c4d7aa7 rdf:first sg:person.01150756062.04
117 rdf:rest Ned24ba4cdd894f03a18e0e9d09f51b35
118 N932848fa4afa4b6096caa6b68ee1e371 schema:name readcube_id
119 schema:value 0bae7e073010822cbc5ee58facaee1261af2c6c27bef1442eb1093d1f33e0508
120 rdf:type schema:PropertyValue
121 Na939b7a371814e898ab5e896e98a36cc schema:name dimensions_id
122 schema:value pub.1091206991
123 rdf:type schema:PropertyValue
124 Nac736b6cf171453db379b1b643398a81 rdf:first sg:person.011722375631.72
125 rdf:rest N1aae95fa15ed4d13a22a8ee36c97dcbe
126 Nbb52154c938941b6a0155f35874bfc1a rdf:first sg:person.0746457640.86
127 rdf:rest N0757c8bedb034deda469d22234b315b2
128 Nbd9dda1166c943969589f6dc960a6af7 rdf:first sg:person.01034520037.14
129 rdf:rest N4a9dc40058074ed2b2531a994f69a882
130 Nc3db123005d844a5bae9be94ca050bd6 rdf:first sg:person.01334130107.64
131 rdf:rest N69afc5d3ab2b4c6f95fc3f7c5f693a3d
132 Nc7826f4b986c44089aaf5fbd9bfd792b rdf:first sg:person.01362520746.11
133 rdf:rest N0b97092b3a844b15b86fab77be57e91c
134 Ncd3956cd63ae44e1b67dbe2237035ff4 schema:name pubmed_id
135 schema:value 28804121
136 rdf:type schema:PropertyValue
137 Nd0d16322bd4b4fe68113354e13116041 rdf:first sg:person.01025161256.58
138 rdf:rest Nbd9dda1166c943969589f6dc960a6af7
139 Ned24ba4cdd894f03a18e0e9d09f51b35 rdf:first sg:person.01115500203.21
140 rdf:rest Nd0d16322bd4b4fe68113354e13116041
141 anzsrc-for:06 schema:inDefinedTermSet anzsrc-for:
142 schema:name Biological Sciences
143 rdf:type schema:DefinedTerm
144 anzsrc-for:0604 schema:inDefinedTermSet anzsrc-for:
145 schema:name Genetics
146 rdf:type schema:DefinedTerm
147 sg:grant.5135195 http://pending.schema.org/fundedItem sg:pub.10.1038/leu.2017.255
148 rdf:type schema:MonetaryGrant
149 sg:grant.5137546 http://pending.schema.org/fundedItem sg:pub.10.1038/leu.2017.255
150 rdf:type schema:MonetaryGrant
151 sg:grant.5142972 http://pending.schema.org/fundedItem sg:pub.10.1038/leu.2017.255
152 rdf:type schema:MonetaryGrant
153 sg:grant.7551198 http://pending.schema.org/fundedItem sg:pub.10.1038/leu.2017.255
154 rdf:type schema:MonetaryGrant
155 sg:grant.7551250 http://pending.schema.org/fundedItem sg:pub.10.1038/leu.2017.255
156 rdf:type schema:MonetaryGrant
157 sg:journal.1097065 schema:issn 0887-6924
158 1476-5551
159 schema:name Leukemia
160 rdf:type schema:Periodical
161 sg:person.01003310355.24 schema:affiliation https://www.grid.ac/institutes/grid.4868.2
162 schema:familyName Wang
163 schema:givenName J
164 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01003310355.24
165 rdf:type schema:Person
166 sg:person.01005202477.29 schema:affiliation https://www.grid.ac/institutes/grid.4868.2
167 schema:familyName Klymenko
168 schema:givenName T
169 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01005202477.29
170 rdf:type schema:Person
171 sg:person.01025161256.58 schema:affiliation https://www.grid.ac/institutes/grid.411097.a
172 schema:familyName Hallek
173 schema:givenName M
174 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01025161256.58
175 rdf:type schema:Person
176 sg:person.01034520037.14 schema:affiliation https://www.grid.ac/institutes/grid.6582.9
177 schema:familyName Stilgenbauer
178 schema:givenName S
179 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01034520037.14
180 rdf:type schema:Person
181 sg:person.01071023477.25 schema:affiliation https://www.grid.ac/institutes/grid.411097.a
182 schema:familyName Bahlo
183 schema:givenName J
184 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01071023477.25
185 rdf:type schema:Person
186 sg:person.010722214767.27 schema:affiliation https://www.grid.ac/institutes/grid.6582.9
187 schema:familyName Estenfelder
188 schema:givenName S
189 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.010722214767.27
190 rdf:type schema:Person
191 sg:person.01115500203.21 schema:affiliation https://www.grid.ac/institutes/grid.411097.a
192 schema:familyName Fischer
193 schema:givenName K
194 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01115500203.21
195 rdf:type schema:Person
196 sg:person.01120734350.41 schema:affiliation https://www.grid.ac/institutes/grid.5491.9
197 schema:familyName Strefford
198 schema:givenName J C
199 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01120734350.41
200 rdf:type schema:Person
201 sg:person.01150756062.04 schema:affiliation https://www.grid.ac/institutes/grid.7048.b
202 schema:familyName Wojdacz
203 schema:givenName T K
204 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01150756062.04
205 rdf:type schema:Person
206 sg:person.011722375631.72 schema:affiliation https://www.grid.ac/institutes/grid.411097.a
207 schema:familyName Robrecht
208 schema:givenName S
209 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011722375631.72
210 rdf:type schema:Person
211 sg:person.01305636134.68 schema:affiliation https://www.grid.ac/institutes/grid.5491.9
212 schema:familyName Cragg
213 schema:givenName M
214 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01305636134.68
215 rdf:type schema:Person
216 sg:person.01334130107.64 schema:affiliation https://www.grid.ac/institutes/grid.5491.9
217 schema:familyName Cox
218 schema:givenName K
219 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01334130107.64
220 rdf:type schema:Person
221 sg:person.01362520746.11 schema:affiliation https://www.grid.ac/institutes/grid.4868.2
222 schema:familyName Edelmann
223 schema:givenName J
224 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01362520746.11
225 rdf:type schema:Person
226 sg:person.0706051366.15 schema:affiliation https://www.grid.ac/institutes/grid.6582.9
227 schema:familyName Bloehdorn
228 schema:givenName J
229 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0706051366.15
230 rdf:type schema:Person
231 sg:person.0746457640.86 schema:affiliation https://www.grid.ac/institutes/grid.4868.2
232 schema:familyName Gribben
233 schema:givenName J
234 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0746457640.86
235 rdf:type schema:Person
236 sg:pub.10.1038/nature01117 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043216199
237 https://doi.org/10.1038/nature01117
238 rdf:type schema:CreativeWork
239 sg:pub.10.1038/nature01574 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042422670
240 https://doi.org/10.1038/nature01574
241 rdf:type schema:CreativeWork
242 sg:pub.10.1038/nature06727 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033021479
243 https://doi.org/10.1038/nature06727
244 rdf:type schema:CreativeWork
245 sg:pub.10.1038/nature06947 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004427899
246 https://doi.org/10.1038/nature06947
247 rdf:type schema:CreativeWork
248 sg:pub.10.1038/nature15395 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037615856
249 https://doi.org/10.1038/nature15395
250 rdf:type schema:CreativeWork
251 sg:pub.10.1038/nature15548 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049378033
252 https://doi.org/10.1038/nature15548
253 rdf:type schema:CreativeWork
254 sg:pub.10.1038/nbt.1754 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019307928
255 https://doi.org/10.1038/nbt.1754
256 rdf:type schema:CreativeWork
257 sg:pub.10.1038/ni0901-848 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014663842
258 https://doi.org/10.1038/ni0901-848
259 rdf:type schema:CreativeWork
260 sg:pub.10.1038/ni826 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020948149
261 https://doi.org/10.1038/ni826
262 rdf:type schema:CreativeWork
263 sg:pub.10.1038/nmeth.1923 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006541515
264 https://doi.org/10.1038/nmeth.1923
265 rdf:type schema:CreativeWork
266 sg:pub.10.1038/nrm1550 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031692521
267 https://doi.org/10.1038/nrm1550
268 rdf:type schema:CreativeWork
269 https://doi.org/10.1016/j.ccr.2009.11.019 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049400026
270 rdf:type schema:CreativeWork
271 https://doi.org/10.1016/j.cell.2012.04.035 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039604484
272 rdf:type schema:CreativeWork
273 https://doi.org/10.1016/j.cell.2013.02.028 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008857878
274 rdf:type schema:CreativeWork
275 https://doi.org/10.1016/j.cell.2014.10.028 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019042259
276 rdf:type schema:CreativeWork
277 https://doi.org/10.1016/j.immuni.2005.05.007 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048231242
278 rdf:type schema:CreativeWork
279 https://doi.org/10.1016/j.it.2013.03.006 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041333447
280 rdf:type schema:CreativeWork
281 https://doi.org/10.1016/j.molcel.2010.03.016 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004413613
282 rdf:type schema:CreativeWork
283 https://doi.org/10.1016/j.tig.2011.05.006 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052561424
284 rdf:type schema:CreativeWork
285 https://doi.org/10.1016/s0140-6736(10)61381-5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016656695
286 rdf:type schema:CreativeWork
287 https://doi.org/10.1016/s1074-7613(03)00261-9 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017670830
288 rdf:type schema:CreativeWork
289 https://doi.org/10.1073/pnas.0506580102 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037705714
290 rdf:type schema:CreativeWork
291 https://doi.org/10.1073/pnas.0808462105 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049887990
292 rdf:type schema:CreativeWork
293 https://doi.org/10.1074/jbc.271.25.14653 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041136540
294 rdf:type schema:CreativeWork
295 https://doi.org/10.1074/jbc.m112.351569 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019707451
296 rdf:type schema:CreativeWork
297 https://doi.org/10.1083/jcb.200607054 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010463402
298 rdf:type schema:CreativeWork
299 https://doi.org/10.1083/jcb.201205103 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031085371
300 rdf:type schema:CreativeWork
301 https://doi.org/10.1084/jem.182.2.559 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019497632
302 rdf:type schema:CreativeWork
303 https://doi.org/10.1084/jem.194.11.1625 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043960328
304 rdf:type schema:CreativeWork
305 https://doi.org/10.1084/jem.20110118 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006085544
306 rdf:type schema:CreativeWork
307 https://doi.org/10.1084/jem.20120833 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006459858
308 rdf:type schema:CreativeWork
309 https://doi.org/10.1084/jem.20121387 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045805394
310 rdf:type schema:CreativeWork
311 https://doi.org/10.1093/bioinformatics/18.1.207 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046806163
312 rdf:type schema:CreativeWork
313 https://doi.org/10.1093/bioinformatics/btq431 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027500995
314 rdf:type schema:CreativeWork
315 https://doi.org/10.1093/nar/gku630 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038822123
316 rdf:type schema:CreativeWork
317 https://doi.org/10.1101/gad.217281.113 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029734943
318 rdf:type schema:CreativeWork
319 https://doi.org/10.1101/gad.223834.113 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044298681
320 rdf:type schema:CreativeWork
321 https://doi.org/10.1101/gad.237479.114 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047493252
322 rdf:type schema:CreativeWork
323 https://doi.org/10.1101/gr.083881.108 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036133744
324 rdf:type schema:CreativeWork
325 https://doi.org/10.1101/gr.141028.112 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012572251
326 rdf:type schema:CreativeWork
327 https://doi.org/10.1111/j.1600-065x.2012.01124.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1042463950
328 rdf:type schema:CreativeWork
329 https://doi.org/10.1126/science.1068768 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019914341
330 rdf:type schema:CreativeWork
331 https://doi.org/10.1126/science.1241146 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023962432
332 rdf:type schema:CreativeWork
333 https://doi.org/10.1128/mcb.01145-14 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041487525
334 rdf:type schema:CreativeWork
335 https://doi.org/10.1182/blood-2014-01-546150 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013315597
336 rdf:type schema:CreativeWork
337 https://doi.org/10.1182/blood-2014-04-516815 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047369675
338 rdf:type schema:CreativeWork
339 https://doi.org/10.1182/blood-2015-06-651125 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016700379
340 rdf:type schema:CreativeWork
341 https://doi.org/10.1182/blood.v99.11.4087 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008562310
342 rdf:type schema:CreativeWork
343 https://doi.org/10.4049/jimmunol.1001155 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006169710
344 rdf:type schema:CreativeWork
345 https://www.grid.ac/institutes/grid.411097.a schema:alternateName University Hospital Cologne
346 schema:name Department I of Internal Medicine, Center for Integrated Oncology Cologne, University Hospital of Cologne, Cologne, Germany
347 rdf:type schema:Organization
348 https://www.grid.ac/institutes/grid.4868.2 schema:alternateName Queen Mary University of London
349 schema:name Centre for Haemato-Oncology, Barts Cancer Institute, Queen Mary University, London, UK
350 rdf:type schema:Organization
351 https://www.grid.ac/institutes/grid.5491.9 schema:alternateName University of Southampton
352 schema:name Academic Unit of Cancer Sciences, Faculty of Medicine, Cancer Research UK Centre and Experimental Cancer Medicine Centre, University of Southampton, Southampton, UK
353 rdf:type schema:Organization
354 https://www.grid.ac/institutes/grid.6582.9 schema:alternateName University of Ulm
355 schema:name Department of Internal Medicine III, University of Ulm, Ulm, Germany
356 rdf:type schema:Organization
357 https://www.grid.ac/institutes/grid.7048.b schema:alternateName Aarhus University
358 schema:name Aarhus Institute of Advanced Studies, Aarhus University, Aarhus, Denmark
359 Academic Unit of Cancer Sciences, Faculty of Medicine, Cancer Research UK Centre and Experimental Cancer Medicine Centre, University of Southampton, Southampton, UK
360 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...