Genetics of ancestry-specific risk for relapse in acute lymphoblastic leukemia View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2017-06

AUTHORS

S E Karol, E Larsen, C Cheng, X Cao, W Yang, L B Ramsey, C A Fernandez, J R McCorkle, S W Paugh, R J Autry, E Lopez-Lopez, B Diouf, S Jeha, C-H Pui, E A Raetz, N J Winick, W L Carroll, S P Hunger, M L Loh, M Devidas, W E Evans, J J Yang, M V Relling

ABSTRACT

The causes of individual relapses in children with acute lymphoblastic leukemia (ALL) remain incompletely understood. We evaluated the contribution of germline genetic factors to relapse in 2225 children treated on Children's Oncology Group trial AALL0232. We identified 302 germline single-nucleotide polymorphisms (SNPs) associated with relapse after adjusting for treatment and ancestry and 715 additional SNPs associated with relapse in an ancestry-specific manner. We tested for replication of these relapse-associated SNPs in external data sets of antileukemic drug pharmacokinetics and pharmacodynamics and an independent clinical cohort. 224 SNPs were associated with rapid drug clearance or drug resistance, and 32 were replicated in the independent cohort. The adverse risk associated with black and Hispanic ancestries was attenuated by addition of the 4 SNPs most strongly associated with relapse in these populations (for blacks: model without SNPs hazard ratio (HR)=2.32, P=2.27 × 10-4, model with SNPs HR=1.07, P=0.79; for Hispanics: model without SNPs HR=1.7, P=8.23 × 10-5, model with SNPs HR=1.31, P=0.065). Relapse SNPs associated with asparaginase resistance or allergy were overrepresented among SNPs associated with relapse in the more asparaginase intensive treatment arm (20/54 in Capizzi-methorexate arm vs 8/54 in high-dose methotrexate arm, P=0.015). Inherited genetic variation contributes to race-specific and treatment-specific relapse risk. More... »

PAGES

1325

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/leu.2017.24

DOI

http://dx.doi.org/10.1038/leu.2017.24

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1012419571

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/28096535


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1112", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Oncology and Carcinogenesis", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Adult", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Biomarkers, Tumor", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Female", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Follow-Up Studies", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Genetic Predisposition to Disease", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Genotype", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Male", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Neoplasm Recurrence, Local", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Neoplasm Staging", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Polymorphism, Single Nucleotide", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Precursor Cell Lymphoblastic Leukemia-Lymphoma", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Prognosis", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Risk Factors", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "St. Jude Children's Research Hospital", 
          "id": "https://www.grid.ac/institutes/grid.240871.8", 
          "name": [
            "Comprehensive Cancer Center, St Jude Children's Research Hospital, Memphis, TN, USA.", 
            "Department of Oncology, St Jude Children's Research Hospital, Memphis, TN, USA."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Karol", 
        "givenName": "S E", 
        "id": "sg:person.01055222022.08", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01055222022.08"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Maine Medical Center", 
          "id": "https://www.grid.ac/institutes/grid.240160.1", 
          "name": [
            "Department of Pediatrics, Maine Medical Center, Portland, ME, USA."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Larsen", 
        "givenName": "E", 
        "id": "sg:person.07531205322.49", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.07531205322.49"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "St. Jude Children's Research Hospital", 
          "id": "https://www.grid.ac/institutes/grid.240871.8", 
          "name": [
            "Department of Biostatistics, St Jude Children's Research Hospital, Memphis, TN, USA."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Cheng", 
        "givenName": "C", 
        "id": "sg:person.01016575200.05", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01016575200.05"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "St. Jude Children's Research Hospital", 
          "id": "https://www.grid.ac/institutes/grid.240871.8", 
          "name": [
            "Department of Biostatistics, St Jude Children's Research Hospital, Memphis, TN, USA."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Cao", 
        "givenName": "X", 
        "id": "sg:person.015277676607.09", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015277676607.09"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "St. Jude Children's Research Hospital", 
          "id": "https://www.grid.ac/institutes/grid.240871.8", 
          "name": [
            "Department of Pharmaceutical Sciences, St Jude Children's Research Hospital, Memphis, TN, USA."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Yang", 
        "givenName": "W", 
        "id": "sg:person.013053214134.99", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013053214134.99"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Cincinnati Children's Hospital Medical Center", 
          "id": "https://www.grid.ac/institutes/grid.239573.9", 
          "name": [
            "Department of Pharmacy Research, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Ramsey", 
        "givenName": "L B", 
        "id": "sg:person.01353776400.13", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01353776400.13"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Pittsburgh", 
          "id": "https://www.grid.ac/institutes/grid.21925.3d", 
          "name": [
            "Department of Pharmaceutical Sciences, University of Pittsburgh, Pittsburgh, PA, USA."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Fernandez", 
        "givenName": "C A", 
        "id": "sg:person.015305605122.09", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015305605122.09"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "St. Jude Children's Research Hospital", 
          "id": "https://www.grid.ac/institutes/grid.240871.8", 
          "name": [
            "Department of Pharmaceutical Sciences, St Jude Children's Research Hospital, Memphis, TN, USA."
          ], 
          "type": "Organization"
        }, 
        "familyName": "McCorkle", 
        "givenName": "J R", 
        "id": "sg:person.01143125242.15", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01143125242.15"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "St. Jude Children's Research Hospital", 
          "id": "https://www.grid.ac/institutes/grid.240871.8", 
          "name": [
            "Department of Pharmaceutical Sciences, St Jude Children's Research Hospital, Memphis, TN, USA."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Paugh", 
        "givenName": "S W", 
        "id": "sg:person.0650334747.74", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0650334747.74"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "St. Jude Children's Research Hospital", 
          "id": "https://www.grid.ac/institutes/grid.240871.8", 
          "name": [
            "Department of Pharmaceutical Sciences, St Jude Children's Research Hospital, Memphis, TN, USA."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Autry", 
        "givenName": "R J", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "St. Jude Children's Research Hospital", 
          "id": "https://www.grid.ac/institutes/grid.240871.8", 
          "name": [
            "Department of Pharmaceutical Sciences, St Jude Children's Research Hospital, Memphis, TN, USA."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Lopez-Lopez", 
        "givenName": "E", 
        "id": "sg:person.0764354146.59", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0764354146.59"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "St. Jude Children's Research Hospital", 
          "id": "https://www.grid.ac/institutes/grid.240871.8", 
          "name": [
            "Department of Pharmaceutical Sciences, St Jude Children's Research Hospital, Memphis, TN, USA."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Diouf", 
        "givenName": "B", 
        "id": "sg:person.01157253214.37", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01157253214.37"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "St. Jude Children's Research Hospital", 
          "id": "https://www.grid.ac/institutes/grid.240871.8", 
          "name": [
            "Department of Oncology, St Jude Children's Research Hospital, Memphis, TN, USA."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Jeha", 
        "givenName": "S", 
        "id": "sg:person.014010602277.02", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.014010602277.02"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "St. Jude Children's Research Hospital", 
          "id": "https://www.grid.ac/institutes/grid.240871.8", 
          "name": [
            "Department of Oncology, St Jude Children's Research Hospital, Memphis, TN, USA."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Pui", 
        "givenName": "C-H", 
        "id": "sg:person.012202026677.65", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012202026677.65"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Utah", 
          "id": "https://www.grid.ac/institutes/grid.223827.e", 
          "name": [
            "Department of Pediatrics, University of Utah, Salt Lake City, UT, USA."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Raetz", 
        "givenName": "E A", 
        "id": "sg:person.01342145361.24", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01342145361.24"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "The University of Texas Southwestern Medical Center", 
          "id": "https://www.grid.ac/institutes/grid.267313.2", 
          "name": [
            "Department of Pediatrics, University of Texas, Southwestern Medical Center, Dallas, TX, USA."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Winick", 
        "givenName": "N J", 
        "id": "sg:person.01067545323.77", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01067545323.77"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "New York University Langone Medical Center", 
          "id": "https://www.grid.ac/institutes/grid.240324.3", 
          "name": [
            "Perlmutter Cancer Center, Department of Pediatrics and Pathology, New York University Langone Medical Center, New York, NY, USA."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Carroll", 
        "givenName": "W L", 
        "id": "sg:person.01244066051.55", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01244066051.55"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Children's Hospital of Philadelphia", 
          "id": "https://www.grid.ac/institutes/grid.239552.a", 
          "name": [
            "Department of Pediatrics, Children's Hospital of Philadelphia, Philadelphia, PA, USA."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Hunger", 
        "givenName": "S P", 
        "id": "sg:person.011506117034.48", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011506117034.48"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of California System", 
          "id": "https://www.grid.ac/institutes/grid.30389.31", 
          "name": [
            "Department of Pediatrics, University of California School of Medicine, San Francisco, CA, USA."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Loh", 
        "givenName": "M L", 
        "id": "sg:person.012247270664.41", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012247270664.41"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Florida", 
          "id": "https://www.grid.ac/institutes/grid.15276.37", 
          "name": [
            "Department of Biostatistics, Colleges of Medicine, Public Health and Health Professions, University of Florida, Gainesville, FL, USA."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Devidas", 
        "givenName": "M", 
        "id": "sg:person.0705203523.35", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0705203523.35"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "St. Jude Children's Research Hospital", 
          "id": "https://www.grid.ac/institutes/grid.240871.8", 
          "name": [
            "Department of Pharmaceutical Sciences, St Jude Children's Research Hospital, Memphis, TN, USA."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Evans", 
        "givenName": "W E", 
        "id": "sg:person.01147125147.00", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01147125147.00"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "St. Jude Children's Research Hospital", 
          "id": "https://www.grid.ac/institutes/grid.240871.8", 
          "name": [
            "Department of Pharmaceutical Sciences, St Jude Children's Research Hospital, Memphis, TN, USA."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Yang", 
        "givenName": "J J", 
        "id": "sg:person.016373210004.51", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.016373210004.51"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "St. Jude Children's Research Hospital", 
          "id": "https://www.grid.ac/institutes/grid.240871.8", 
          "name": [
            "Department of Pharmaceutical Sciences, St Jude Children's Research Hospital, Memphis, TN, USA."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Relling", 
        "givenName": "M V", 
        "id": "sg:person.01041051470.29", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01041051470.29"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.1001/jama.2015.0894", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1001522312"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ng.763", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1002200371", 
          "https://doi.org/10.1038/ng.763"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.humpath.2010.12.007", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1003026917"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1182/blood-2008-01-132837", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1003921023"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/leu.2009.252", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1004089572", 
          "https://doi.org/10.1038/leu.2009.252"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/leu.2009.252", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1004089572", 
          "https://doi.org/10.1038/leu.2009.252"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/cncr.30089", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1004820299"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/pbc.22944", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1005387871"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1182/blood-2014-01-552166", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1005667900"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1182/blood-2014-09-595744", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1006657351"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1200/jco.2013.48.6522", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1007967482"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/leu.2013.44", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1009486126", 
          "https://doi.org/10.1038/leu.2013.44"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1056/nejmoa0900386", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1009931450"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/jnci/djt042", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1011021633"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/ajh.21580", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1012429490"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1136/annrheumdis-2011-200463", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1012436383"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1001/jama.290.15.2008", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1013488835"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ng.3508", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1013931386", 
          "https://doi.org/10.1038/ng.3508"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1371/journal.pgen.1003222", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1014654508"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.ygyno.2015.11.018", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1015726098"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.2202/1544-6115.1064", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1017285706"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ncomms2876", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1020317201", 
          "https://doi.org/10.1038/ncomms2876"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00129039-200412000-00005", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1021425130"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00129039-200412000-00005", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1021425130"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ng.226", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1022042808", 
          "https://doi.org/10.1038/ng.226"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1182/blood-2013-10-532598", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1022369994"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1158/1078-0432.ccr-07-5144", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1023321045"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1182/blood-2015-02-628800", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1023331196"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/art.39504", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1026602728"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/art.39504", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1026602728"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s10552-012-9943-8", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1028151738", 
          "https://doi.org/10.1007/s10552-012-9943-8"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1001/jama.2009.7", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030654927"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ejhg.2013.310", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030752809", 
          "https://doi.org/10.1038/ejhg.2013.310"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1182/blood-2011-09-381731", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1031076398"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/pbc.25544", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1031367305"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature14248", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1031836937", 
          "https://doi.org/10.1038/nature14248"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1182/blood-2015-03-633685", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1031905474"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1001/jamaoncol.2015.0245", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1033407914"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1001/jama.290.15.2001", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1034823390"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1200/jco.2010.32.5340", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035615614"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/tpj.2014.81", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1036556056", 
          "https://doi.org/10.1038/tpj.2014.81"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1182/blood-2002-02-0395", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1041662917"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s1470-2045(15)00363-0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1042155018"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1200/jco.2011.37.8018", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1044388481"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0140-6736(84)90411-2", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1045986550"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0140-6736(84)90411-2", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1045986550"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s1470-2045(15)70082-3", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1049420966"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.jaci.2012.03.045", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1049813087"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1182/blood-2012-07-440107", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1052218167"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1055/s-0033-1337966", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1057283454"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1086/518564", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1058791825"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/fpc.0000000000000044", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1060340261"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/fpc.0000000000000044", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1060340261"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/fpc.0000000000000044", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1060340261"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/fpc.0b013e32832c440e", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1060340718"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/fpc.0b013e32832c440e", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1060340718"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/fpc.0b013e32832c440e", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1060340718"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/fpc.0b013e32832c440e", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1060340718"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1200/jco.2015.62.4544", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1064204407"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1200/jco.2000.18.4.813", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1074590100"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1074647594", 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2017-06", 
    "datePublishedReg": "2017-06-01", 
    "description": "The causes of individual relapses in children with acute lymphoblastic leukemia (ALL) remain incompletely understood. We evaluated the contribution of germline genetic factors to relapse in 2225 children treated on Children's Oncology Group trial AALL0232. We identified 302 germline single-nucleotide polymorphisms (SNPs) associated with relapse after adjusting for treatment and ancestry and 715 additional SNPs associated with relapse in an ancestry-specific manner. We tested for replication of these relapse-associated SNPs in external data sets of antileukemic drug pharmacokinetics and pharmacodynamics and an independent clinical cohort. 224 SNPs were associated with rapid drug clearance or drug resistance, and 32 were replicated in the independent cohort. The adverse risk associated with black and Hispanic ancestries was attenuated by addition of the 4 SNPs most strongly associated with relapse in these populations (for blacks: model without SNPs hazard ratio (HR)=2.32, P=2.27 \u00d7 10-4, model with SNPs HR=1.07, P=0.79; for Hispanics: model without SNPs HR=1.7, P=8.23 \u00d7 10-5, model with SNPs HR=1.31, P=0.065). Relapse SNPs associated with asparaginase resistance or allergy were overrepresented among SNPs associated with relapse in the more asparaginase intensive treatment arm (20/54 in Capizzi-methorexate arm vs 8/54 in high-dose methotrexate arm, P=0.015). Inherited genetic variation contributes to race-specific and treatment-specific relapse risk.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1038/leu.2017.24", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": true, 
    "isFundedItemOf": [
      {
        "id": "sg:grant.2669342", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.2467717", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.2691257", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.2480672", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.2693700", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.2545622", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.2693699", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.2696311", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.2634271", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.2669603", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.4102162", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.2690890", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.3536120", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.3536062", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.2438833", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.2683790", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.3535922", 
        "type": "MonetaryGrant"
      }
    ], 
    "isPartOf": [
      {
        "id": "sg:journal.1097065", 
        "issn": [
          "0887-6924", 
          "1476-5551"
        ], 
        "name": "Leukemia", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "6", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "31"
      }
    ], 
    "name": "Genetics of ancestry-specific risk for relapse in acute lymphoblastic leukemia", 
    "pagination": "1325", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "3b2b59bf1eeac521292557bc1787b58df6375fe3252aec850806c0e5b344414f"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "28096535"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "8704895"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1038/leu.2017.24"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1012419571"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1038/leu.2017.24", 
      "https://app.dimensions.ai/details/publication/pub.1012419571"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-11T00:05", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8695_00000436.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://www.nature.com/articles/leu201724"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/leu.2017.24'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/leu.2017.24'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/leu.2017.24'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/leu.2017.24'


 

This table displays all metadata directly associated to this object as RDF triples.

507 TRIPLES      21 PREDICATES      95 URIs      35 LITERALS      23 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1038/leu.2017.24 schema:about N1b0550ac329a4368b3eb7dcb7a550b38
2 N27ecf2cf3a3c4a4daa83bda361c05ccd
3 N3e507b4b6e804492a7959b3760299cf4
4 N5cd1721a33d141cc9c28315d693c39e3
5 N5e17ea99ee8c489b8b00c897cf080989
6 N68bc58727ed4433e8fc20af50af232f7
7 N702d3f01c8be44acac8ac15d85d0704d
8 N760cb1839e3941c08acda62bdf015b06
9 N8521724aa9964eec890c8282615d9ae1
10 N8c1a8f6517ce4df69ae6fcfb67a5a0a9
11 N994444cb5ee64d9e9143a41c0f946125
12 Nb58d47c164354021b7b1799534c451e0
13 Nbcd7ca69bdad43e59dfe92bae07c1072
14 Ndd5ebd4f31524dd99153ef9fff1d9d99
15 anzsrc-for:11
16 anzsrc-for:1112
17 schema:author N4d9f1cb2e89e485481a4eaea2552c4e2
18 schema:citation sg:pub.10.1007/s10552-012-9943-8
19 sg:pub.10.1038/ejhg.2013.310
20 sg:pub.10.1038/leu.2009.252
21 sg:pub.10.1038/leu.2013.44
22 sg:pub.10.1038/nature14248
23 sg:pub.10.1038/ncomms2876
24 sg:pub.10.1038/ng.226
25 sg:pub.10.1038/ng.3508
26 sg:pub.10.1038/ng.763
27 sg:pub.10.1038/tpj.2014.81
28 https://app.dimensions.ai/details/publication/pub.1074647594
29 https://doi.org/10.1001/jama.2009.7
30 https://doi.org/10.1001/jama.2015.0894
31 https://doi.org/10.1001/jama.290.15.2001
32 https://doi.org/10.1001/jama.290.15.2008
33 https://doi.org/10.1001/jamaoncol.2015.0245
34 https://doi.org/10.1002/ajh.21580
35 https://doi.org/10.1002/art.39504
36 https://doi.org/10.1002/cncr.30089
37 https://doi.org/10.1002/pbc.22944
38 https://doi.org/10.1002/pbc.25544
39 https://doi.org/10.1016/j.humpath.2010.12.007
40 https://doi.org/10.1016/j.jaci.2012.03.045
41 https://doi.org/10.1016/j.ygyno.2015.11.018
42 https://doi.org/10.1016/s0140-6736(84)90411-2
43 https://doi.org/10.1016/s1470-2045(15)00363-0
44 https://doi.org/10.1016/s1470-2045(15)70082-3
45 https://doi.org/10.1055/s-0033-1337966
46 https://doi.org/10.1056/nejmoa0900386
47 https://doi.org/10.1086/518564
48 https://doi.org/10.1093/jnci/djt042
49 https://doi.org/10.1097/00129039-200412000-00005
50 https://doi.org/10.1097/fpc.0000000000000044
51 https://doi.org/10.1097/fpc.0b013e32832c440e
52 https://doi.org/10.1136/annrheumdis-2011-200463
53 https://doi.org/10.1158/1078-0432.ccr-07-5144
54 https://doi.org/10.1182/blood-2002-02-0395
55 https://doi.org/10.1182/blood-2008-01-132837
56 https://doi.org/10.1182/blood-2011-09-381731
57 https://doi.org/10.1182/blood-2012-07-440107
58 https://doi.org/10.1182/blood-2013-10-532598
59 https://doi.org/10.1182/blood-2014-01-552166
60 https://doi.org/10.1182/blood-2014-09-595744
61 https://doi.org/10.1182/blood-2015-02-628800
62 https://doi.org/10.1182/blood-2015-03-633685
63 https://doi.org/10.1200/jco.2000.18.4.813
64 https://doi.org/10.1200/jco.2010.32.5340
65 https://doi.org/10.1200/jco.2011.37.8018
66 https://doi.org/10.1200/jco.2013.48.6522
67 https://doi.org/10.1200/jco.2015.62.4544
68 https://doi.org/10.1371/journal.pgen.1003222
69 https://doi.org/10.2202/1544-6115.1064
70 schema:datePublished 2017-06
71 schema:datePublishedReg 2017-06-01
72 schema:description The causes of individual relapses in children with acute lymphoblastic leukemia (ALL) remain incompletely understood. We evaluated the contribution of germline genetic factors to relapse in 2225 children treated on Children's Oncology Group trial AALL0232. We identified 302 germline single-nucleotide polymorphisms (SNPs) associated with relapse after adjusting for treatment and ancestry and 715 additional SNPs associated with relapse in an ancestry-specific manner. We tested for replication of these relapse-associated SNPs in external data sets of antileukemic drug pharmacokinetics and pharmacodynamics and an independent clinical cohort. 224 SNPs were associated with rapid drug clearance or drug resistance, and 32 were replicated in the independent cohort. The adverse risk associated with black and Hispanic ancestries was attenuated by addition of the 4 SNPs most strongly associated with relapse in these populations (for blacks: model without SNPs hazard ratio (HR)=2.32, P=2.27 × 10<sup>-4</sup>, model with SNPs HR=1.07, P=0.79; for Hispanics: model without SNPs HR=1.7, P=8.23 × 10<sup>-</sup><sup>5</sup>, model with SNPs HR=1.31, P=0.065). Relapse SNPs associated with asparaginase resistance or allergy were overrepresented among SNPs associated with relapse in the more asparaginase intensive treatment arm (20/54 in Capizzi-methorexate arm vs 8/54 in high-dose methotrexate arm, P=0.015). Inherited genetic variation contributes to race-specific and treatment-specific relapse risk.
73 schema:genre research_article
74 schema:inLanguage en
75 schema:isAccessibleForFree true
76 schema:isPartOf N335ef5656bf34e989d4b0341bb387cd8
77 N53c291c56a0e4460958469f63e96e5f6
78 sg:journal.1097065
79 schema:name Genetics of ancestry-specific risk for relapse in acute lymphoblastic leukemia
80 schema:pagination 1325
81 schema:productId N25a49d1369ce4146a7143b83c5cb32f5
82 N3fa65878da814d98bdcee67e62d75df5
83 N8bf420617fde4412926cb482f9626c7b
84 N9ce482163dd845dfb73b2c634640478a
85 Nfe1810e88d5a4cb9bdd6a1e8ed277917
86 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012419571
87 https://doi.org/10.1038/leu.2017.24
88 schema:sdDatePublished 2019-04-11T00:05
89 schema:sdLicense https://scigraph.springernature.com/explorer/license/
90 schema:sdPublisher N7fd917e4083f43a1b404a886bbd63aa7
91 schema:url https://www.nature.com/articles/leu201724
92 sgo:license sg:explorer/license/
93 sgo:sdDataset articles
94 rdf:type schema:ScholarlyArticle
95 N03343a9b155b449bb67e61f4966c422b rdf:first sg:person.01143125242.15
96 rdf:rest N35284f364c2c437b9b24cdbb62b505f5
97 N1aa954a06d8b4d9a8e47ab7f56de5303 rdf:first sg:person.01342145361.24
98 rdf:rest Nac6b133a98df4a7f8ad5fbd117bde761
99 N1b0550ac329a4368b3eb7dcb7a550b38 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
100 schema:name Female
101 rdf:type schema:DefinedTerm
102 N1e7efbd199934a719e5c3b248edb6cf4 rdf:first sg:person.014010602277.02
103 rdf:rest Ncaad5a46b8d844418354f307e17d4dcc
104 N25a49d1369ce4146a7143b83c5cb32f5 schema:name dimensions_id
105 schema:value pub.1012419571
106 rdf:type schema:PropertyValue
107 N27ecf2cf3a3c4a4daa83bda361c05ccd schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
108 schema:name Polymorphism, Single Nucleotide
109 rdf:type schema:DefinedTerm
110 N2b7cb213b89e4415952ee0d9f0f80938 schema:affiliation https://www.grid.ac/institutes/grid.240871.8
111 schema:familyName Autry
112 schema:givenName R J
113 rdf:type schema:Person
114 N329056b629974d198abcf0ad5dac48b9 rdf:first sg:person.01147125147.00
115 rdf:rest N8895450999704f619f0c3c4dcb384abe
116 N335ef5656bf34e989d4b0341bb387cd8 schema:issueNumber 6
117 rdf:type schema:PublicationIssue
118 N34672478b44843c987226801273b7012 rdf:first sg:person.01041051470.29
119 rdf:rest rdf:nil
120 N35284f364c2c437b9b24cdbb62b505f5 rdf:first sg:person.0650334747.74
121 rdf:rest Nd57ff5af4c9247f492aee42d123173ba
122 N3e507b4b6e804492a7959b3760299cf4 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
123 schema:name Prognosis
124 rdf:type schema:DefinedTerm
125 N3fa65878da814d98bdcee67e62d75df5 schema:name nlm_unique_id
126 schema:value 8704895
127 rdf:type schema:PropertyValue
128 N409f720e9e804075a3ad38fcbb008a27 rdf:first sg:person.01016575200.05
129 rdf:rest N8d88c8b21f12456ab248c31925229fb6
130 N4d9f1cb2e89e485481a4eaea2552c4e2 rdf:first sg:person.01055222022.08
131 rdf:rest Nd6451be1efc94e43bbfd6dc2a5bb086f
132 N53c291c56a0e4460958469f63e96e5f6 schema:volumeNumber 31
133 rdf:type schema:PublicationVolume
134 N5cd1721a33d141cc9c28315d693c39e3 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
135 schema:name Genetic Predisposition to Disease
136 rdf:type schema:DefinedTerm
137 N5e17ea99ee8c489b8b00c897cf080989 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
138 schema:name Follow-Up Studies
139 rdf:type schema:DefinedTerm
140 N5eae98a59aa94c0a873471e645c2693f rdf:first sg:person.012247270664.41
141 rdf:rest N8d4bb0f3ec5f4e3ca8f53dbd57bcdcc8
142 N68bc58727ed4433e8fc20af50af232f7 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
143 schema:name Neoplasm Recurrence, Local
144 rdf:type schema:DefinedTerm
145 N702d3f01c8be44acac8ac15d85d0704d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
146 schema:name Genotype
147 rdf:type schema:DefinedTerm
148 N760cb1839e3941c08acda62bdf015b06 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
149 schema:name Humans
150 rdf:type schema:DefinedTerm
151 N7fd917e4083f43a1b404a886bbd63aa7 schema:name Springer Nature - SN SciGraph project
152 rdf:type schema:Organization
153 N8521724aa9964eec890c8282615d9ae1 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
154 schema:name Neoplasm Staging
155 rdf:type schema:DefinedTerm
156 N8895450999704f619f0c3c4dcb384abe rdf:first sg:person.016373210004.51
157 rdf:rest N34672478b44843c987226801273b7012
158 N8bf420617fde4412926cb482f9626c7b schema:name readcube_id
159 schema:value 3b2b59bf1eeac521292557bc1787b58df6375fe3252aec850806c0e5b344414f
160 rdf:type schema:PropertyValue
161 N8c1a8f6517ce4df69ae6fcfb67a5a0a9 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
162 schema:name Adult
163 rdf:type schema:DefinedTerm
164 N8d4bb0f3ec5f4e3ca8f53dbd57bcdcc8 rdf:first sg:person.0705203523.35
165 rdf:rest N329056b629974d198abcf0ad5dac48b9
166 N8d88c8b21f12456ab248c31925229fb6 rdf:first sg:person.015277676607.09
167 rdf:rest Naba27812c3a245e78b1657a9a28183cc
168 N935f9fe6654f4237b647903148296887 rdf:first sg:person.01353776400.13
169 rdf:rest Ncef2d62b005a4f178e7e82d4906ad67f
170 N994444cb5ee64d9e9143a41c0f946125 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
171 schema:name Risk Factors
172 rdf:type schema:DefinedTerm
173 N9ce482163dd845dfb73b2c634640478a schema:name pubmed_id
174 schema:value 28096535
175 rdf:type schema:PropertyValue
176 Naba27812c3a245e78b1657a9a28183cc rdf:first sg:person.013053214134.99
177 rdf:rest N935f9fe6654f4237b647903148296887
178 Nac6b133a98df4a7f8ad5fbd117bde761 rdf:first sg:person.01067545323.77
179 rdf:rest Nb2e862a8ff4949f0b0a59ca52d9fb572
180 Nb2e862a8ff4949f0b0a59ca52d9fb572 rdf:first sg:person.01244066051.55
181 rdf:rest Ncb05ea33656744d8a87c0928ace0254a
182 Nb44f984cf685435ea01cec5d4d04eeb6 rdf:first sg:person.01157253214.37
183 rdf:rest N1e7efbd199934a719e5c3b248edb6cf4
184 Nb58d47c164354021b7b1799534c451e0 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
185 schema:name Precursor Cell Lymphoblastic Leukemia-Lymphoma
186 rdf:type schema:DefinedTerm
187 Nba7f9b2896b34df8b6b567c6f9d8c854 rdf:first sg:person.0764354146.59
188 rdf:rest Nb44f984cf685435ea01cec5d4d04eeb6
189 Nbcd7ca69bdad43e59dfe92bae07c1072 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
190 schema:name Male
191 rdf:type schema:DefinedTerm
192 Ncaad5a46b8d844418354f307e17d4dcc rdf:first sg:person.012202026677.65
193 rdf:rest N1aa954a06d8b4d9a8e47ab7f56de5303
194 Ncb05ea33656744d8a87c0928ace0254a rdf:first sg:person.011506117034.48
195 rdf:rest N5eae98a59aa94c0a873471e645c2693f
196 Ncef2d62b005a4f178e7e82d4906ad67f rdf:first sg:person.015305605122.09
197 rdf:rest N03343a9b155b449bb67e61f4966c422b
198 Nd57ff5af4c9247f492aee42d123173ba rdf:first N2b7cb213b89e4415952ee0d9f0f80938
199 rdf:rest Nba7f9b2896b34df8b6b567c6f9d8c854
200 Nd6451be1efc94e43bbfd6dc2a5bb086f rdf:first sg:person.07531205322.49
201 rdf:rest N409f720e9e804075a3ad38fcbb008a27
202 Ndd5ebd4f31524dd99153ef9fff1d9d99 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
203 schema:name Biomarkers, Tumor
204 rdf:type schema:DefinedTerm
205 Nfe1810e88d5a4cb9bdd6a1e8ed277917 schema:name doi
206 schema:value 10.1038/leu.2017.24
207 rdf:type schema:PropertyValue
208 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
209 schema:name Medical and Health Sciences
210 rdf:type schema:DefinedTerm
211 anzsrc-for:1112 schema:inDefinedTermSet anzsrc-for:
212 schema:name Oncology and Carcinogenesis
213 rdf:type schema:DefinedTerm
214 sg:grant.2438833 http://pending.schema.org/fundedItem sg:pub.10.1038/leu.2017.24
215 rdf:type schema:MonetaryGrant
216 sg:grant.2467717 http://pending.schema.org/fundedItem sg:pub.10.1038/leu.2017.24
217 rdf:type schema:MonetaryGrant
218 sg:grant.2480672 http://pending.schema.org/fundedItem sg:pub.10.1038/leu.2017.24
219 rdf:type schema:MonetaryGrant
220 sg:grant.2545622 http://pending.schema.org/fundedItem sg:pub.10.1038/leu.2017.24
221 rdf:type schema:MonetaryGrant
222 sg:grant.2634271 http://pending.schema.org/fundedItem sg:pub.10.1038/leu.2017.24
223 rdf:type schema:MonetaryGrant
224 sg:grant.2669342 http://pending.schema.org/fundedItem sg:pub.10.1038/leu.2017.24
225 rdf:type schema:MonetaryGrant
226 sg:grant.2669603 http://pending.schema.org/fundedItem sg:pub.10.1038/leu.2017.24
227 rdf:type schema:MonetaryGrant
228 sg:grant.2683790 http://pending.schema.org/fundedItem sg:pub.10.1038/leu.2017.24
229 rdf:type schema:MonetaryGrant
230 sg:grant.2690890 http://pending.schema.org/fundedItem sg:pub.10.1038/leu.2017.24
231 rdf:type schema:MonetaryGrant
232 sg:grant.2691257 http://pending.schema.org/fundedItem sg:pub.10.1038/leu.2017.24
233 rdf:type schema:MonetaryGrant
234 sg:grant.2693699 http://pending.schema.org/fundedItem sg:pub.10.1038/leu.2017.24
235 rdf:type schema:MonetaryGrant
236 sg:grant.2693700 http://pending.schema.org/fundedItem sg:pub.10.1038/leu.2017.24
237 rdf:type schema:MonetaryGrant
238 sg:grant.2696311 http://pending.schema.org/fundedItem sg:pub.10.1038/leu.2017.24
239 rdf:type schema:MonetaryGrant
240 sg:grant.3535922 http://pending.schema.org/fundedItem sg:pub.10.1038/leu.2017.24
241 rdf:type schema:MonetaryGrant
242 sg:grant.3536062 http://pending.schema.org/fundedItem sg:pub.10.1038/leu.2017.24
243 rdf:type schema:MonetaryGrant
244 sg:grant.3536120 http://pending.schema.org/fundedItem sg:pub.10.1038/leu.2017.24
245 rdf:type schema:MonetaryGrant
246 sg:grant.4102162 http://pending.schema.org/fundedItem sg:pub.10.1038/leu.2017.24
247 rdf:type schema:MonetaryGrant
248 sg:journal.1097065 schema:issn 0887-6924
249 1476-5551
250 schema:name Leukemia
251 rdf:type schema:Periodical
252 sg:person.01016575200.05 schema:affiliation https://www.grid.ac/institutes/grid.240871.8
253 schema:familyName Cheng
254 schema:givenName C
255 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01016575200.05
256 rdf:type schema:Person
257 sg:person.01041051470.29 schema:affiliation https://www.grid.ac/institutes/grid.240871.8
258 schema:familyName Relling
259 schema:givenName M V
260 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01041051470.29
261 rdf:type schema:Person
262 sg:person.01055222022.08 schema:affiliation https://www.grid.ac/institutes/grid.240871.8
263 schema:familyName Karol
264 schema:givenName S E
265 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01055222022.08
266 rdf:type schema:Person
267 sg:person.01067545323.77 schema:affiliation https://www.grid.ac/institutes/grid.267313.2
268 schema:familyName Winick
269 schema:givenName N J
270 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01067545323.77
271 rdf:type schema:Person
272 sg:person.01143125242.15 schema:affiliation https://www.grid.ac/institutes/grid.240871.8
273 schema:familyName McCorkle
274 schema:givenName J R
275 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01143125242.15
276 rdf:type schema:Person
277 sg:person.01147125147.00 schema:affiliation https://www.grid.ac/institutes/grid.240871.8
278 schema:familyName Evans
279 schema:givenName W E
280 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01147125147.00
281 rdf:type schema:Person
282 sg:person.011506117034.48 schema:affiliation https://www.grid.ac/institutes/grid.239552.a
283 schema:familyName Hunger
284 schema:givenName S P
285 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011506117034.48
286 rdf:type schema:Person
287 sg:person.01157253214.37 schema:affiliation https://www.grid.ac/institutes/grid.240871.8
288 schema:familyName Diouf
289 schema:givenName B
290 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01157253214.37
291 rdf:type schema:Person
292 sg:person.012202026677.65 schema:affiliation https://www.grid.ac/institutes/grid.240871.8
293 schema:familyName Pui
294 schema:givenName C-H
295 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012202026677.65
296 rdf:type schema:Person
297 sg:person.012247270664.41 schema:affiliation https://www.grid.ac/institutes/grid.30389.31
298 schema:familyName Loh
299 schema:givenName M L
300 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012247270664.41
301 rdf:type schema:Person
302 sg:person.01244066051.55 schema:affiliation https://www.grid.ac/institutes/grid.240324.3
303 schema:familyName Carroll
304 schema:givenName W L
305 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01244066051.55
306 rdf:type schema:Person
307 sg:person.013053214134.99 schema:affiliation https://www.grid.ac/institutes/grid.240871.8
308 schema:familyName Yang
309 schema:givenName W
310 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013053214134.99
311 rdf:type schema:Person
312 sg:person.01342145361.24 schema:affiliation https://www.grid.ac/institutes/grid.223827.e
313 schema:familyName Raetz
314 schema:givenName E A
315 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01342145361.24
316 rdf:type schema:Person
317 sg:person.01353776400.13 schema:affiliation https://www.grid.ac/institutes/grid.239573.9
318 schema:familyName Ramsey
319 schema:givenName L B
320 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01353776400.13
321 rdf:type schema:Person
322 sg:person.014010602277.02 schema:affiliation https://www.grid.ac/institutes/grid.240871.8
323 schema:familyName Jeha
324 schema:givenName S
325 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.014010602277.02
326 rdf:type schema:Person
327 sg:person.015277676607.09 schema:affiliation https://www.grid.ac/institutes/grid.240871.8
328 schema:familyName Cao
329 schema:givenName X
330 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015277676607.09
331 rdf:type schema:Person
332 sg:person.015305605122.09 schema:affiliation https://www.grid.ac/institutes/grid.21925.3d
333 schema:familyName Fernandez
334 schema:givenName C A
335 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015305605122.09
336 rdf:type schema:Person
337 sg:person.016373210004.51 schema:affiliation https://www.grid.ac/institutes/grid.240871.8
338 schema:familyName Yang
339 schema:givenName J J
340 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.016373210004.51
341 rdf:type schema:Person
342 sg:person.0650334747.74 schema:affiliation https://www.grid.ac/institutes/grid.240871.8
343 schema:familyName Paugh
344 schema:givenName S W
345 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0650334747.74
346 rdf:type schema:Person
347 sg:person.0705203523.35 schema:affiliation https://www.grid.ac/institutes/grid.15276.37
348 schema:familyName Devidas
349 schema:givenName M
350 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0705203523.35
351 rdf:type schema:Person
352 sg:person.07531205322.49 schema:affiliation https://www.grid.ac/institutes/grid.240160.1
353 schema:familyName Larsen
354 schema:givenName E
355 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.07531205322.49
356 rdf:type schema:Person
357 sg:person.0764354146.59 schema:affiliation https://www.grid.ac/institutes/grid.240871.8
358 schema:familyName Lopez-Lopez
359 schema:givenName E
360 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0764354146.59
361 rdf:type schema:Person
362 sg:pub.10.1007/s10552-012-9943-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028151738
363 https://doi.org/10.1007/s10552-012-9943-8
364 rdf:type schema:CreativeWork
365 sg:pub.10.1038/ejhg.2013.310 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030752809
366 https://doi.org/10.1038/ejhg.2013.310
367 rdf:type schema:CreativeWork
368 sg:pub.10.1038/leu.2009.252 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004089572
369 https://doi.org/10.1038/leu.2009.252
370 rdf:type schema:CreativeWork
371 sg:pub.10.1038/leu.2013.44 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009486126
372 https://doi.org/10.1038/leu.2013.44
373 rdf:type schema:CreativeWork
374 sg:pub.10.1038/nature14248 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031836937
375 https://doi.org/10.1038/nature14248
376 rdf:type schema:CreativeWork
377 sg:pub.10.1038/ncomms2876 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020317201
378 https://doi.org/10.1038/ncomms2876
379 rdf:type schema:CreativeWork
380 sg:pub.10.1038/ng.226 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022042808
381 https://doi.org/10.1038/ng.226
382 rdf:type schema:CreativeWork
383 sg:pub.10.1038/ng.3508 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013931386
384 https://doi.org/10.1038/ng.3508
385 rdf:type schema:CreativeWork
386 sg:pub.10.1038/ng.763 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002200371
387 https://doi.org/10.1038/ng.763
388 rdf:type schema:CreativeWork
389 sg:pub.10.1038/tpj.2014.81 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036556056
390 https://doi.org/10.1038/tpj.2014.81
391 rdf:type schema:CreativeWork
392 https://app.dimensions.ai/details/publication/pub.1074647594 schema:CreativeWork
393 https://doi.org/10.1001/jama.2009.7 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030654927
394 rdf:type schema:CreativeWork
395 https://doi.org/10.1001/jama.2015.0894 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001522312
396 rdf:type schema:CreativeWork
397 https://doi.org/10.1001/jama.290.15.2001 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034823390
398 rdf:type schema:CreativeWork
399 https://doi.org/10.1001/jama.290.15.2008 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013488835
400 rdf:type schema:CreativeWork
401 https://doi.org/10.1001/jamaoncol.2015.0245 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033407914
402 rdf:type schema:CreativeWork
403 https://doi.org/10.1002/ajh.21580 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012429490
404 rdf:type schema:CreativeWork
405 https://doi.org/10.1002/art.39504 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026602728
406 rdf:type schema:CreativeWork
407 https://doi.org/10.1002/cncr.30089 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004820299
408 rdf:type schema:CreativeWork
409 https://doi.org/10.1002/pbc.22944 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005387871
410 rdf:type schema:CreativeWork
411 https://doi.org/10.1002/pbc.25544 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031367305
412 rdf:type schema:CreativeWork
413 https://doi.org/10.1016/j.humpath.2010.12.007 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003026917
414 rdf:type schema:CreativeWork
415 https://doi.org/10.1016/j.jaci.2012.03.045 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049813087
416 rdf:type schema:CreativeWork
417 https://doi.org/10.1016/j.ygyno.2015.11.018 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015726098
418 rdf:type schema:CreativeWork
419 https://doi.org/10.1016/s0140-6736(84)90411-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045986550
420 rdf:type schema:CreativeWork
421 https://doi.org/10.1016/s1470-2045(15)00363-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042155018
422 rdf:type schema:CreativeWork
423 https://doi.org/10.1016/s1470-2045(15)70082-3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049420966
424 rdf:type schema:CreativeWork
425 https://doi.org/10.1055/s-0033-1337966 schema:sameAs https://app.dimensions.ai/details/publication/pub.1057283454
426 rdf:type schema:CreativeWork
427 https://doi.org/10.1056/nejmoa0900386 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009931450
428 rdf:type schema:CreativeWork
429 https://doi.org/10.1086/518564 schema:sameAs https://app.dimensions.ai/details/publication/pub.1058791825
430 rdf:type schema:CreativeWork
431 https://doi.org/10.1093/jnci/djt042 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011021633
432 rdf:type schema:CreativeWork
433 https://doi.org/10.1097/00129039-200412000-00005 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021425130
434 rdf:type schema:CreativeWork
435 https://doi.org/10.1097/fpc.0000000000000044 schema:sameAs https://app.dimensions.ai/details/publication/pub.1060340261
436 rdf:type schema:CreativeWork
437 https://doi.org/10.1097/fpc.0b013e32832c440e schema:sameAs https://app.dimensions.ai/details/publication/pub.1060340718
438 rdf:type schema:CreativeWork
439 https://doi.org/10.1136/annrheumdis-2011-200463 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012436383
440 rdf:type schema:CreativeWork
441 https://doi.org/10.1158/1078-0432.ccr-07-5144 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023321045
442 rdf:type schema:CreativeWork
443 https://doi.org/10.1182/blood-2002-02-0395 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041662917
444 rdf:type schema:CreativeWork
445 https://doi.org/10.1182/blood-2008-01-132837 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003921023
446 rdf:type schema:CreativeWork
447 https://doi.org/10.1182/blood-2011-09-381731 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031076398
448 rdf:type schema:CreativeWork
449 https://doi.org/10.1182/blood-2012-07-440107 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052218167
450 rdf:type schema:CreativeWork
451 https://doi.org/10.1182/blood-2013-10-532598 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022369994
452 rdf:type schema:CreativeWork
453 https://doi.org/10.1182/blood-2014-01-552166 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005667900
454 rdf:type schema:CreativeWork
455 https://doi.org/10.1182/blood-2014-09-595744 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006657351
456 rdf:type schema:CreativeWork
457 https://doi.org/10.1182/blood-2015-02-628800 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023331196
458 rdf:type schema:CreativeWork
459 https://doi.org/10.1182/blood-2015-03-633685 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031905474
460 rdf:type schema:CreativeWork
461 https://doi.org/10.1200/jco.2000.18.4.813 schema:sameAs https://app.dimensions.ai/details/publication/pub.1074590100
462 rdf:type schema:CreativeWork
463 https://doi.org/10.1200/jco.2010.32.5340 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035615614
464 rdf:type schema:CreativeWork
465 https://doi.org/10.1200/jco.2011.37.8018 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044388481
466 rdf:type schema:CreativeWork
467 https://doi.org/10.1200/jco.2013.48.6522 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007967482
468 rdf:type schema:CreativeWork
469 https://doi.org/10.1200/jco.2015.62.4544 schema:sameAs https://app.dimensions.ai/details/publication/pub.1064204407
470 rdf:type schema:CreativeWork
471 https://doi.org/10.1371/journal.pgen.1003222 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014654508
472 rdf:type schema:CreativeWork
473 https://doi.org/10.2202/1544-6115.1064 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017285706
474 rdf:type schema:CreativeWork
475 https://www.grid.ac/institutes/grid.15276.37 schema:alternateName University of Florida
476 schema:name Department of Biostatistics, Colleges of Medicine, Public Health and Health Professions, University of Florida, Gainesville, FL, USA.
477 rdf:type schema:Organization
478 https://www.grid.ac/institutes/grid.21925.3d schema:alternateName University of Pittsburgh
479 schema:name Department of Pharmaceutical Sciences, University of Pittsburgh, Pittsburgh, PA, USA.
480 rdf:type schema:Organization
481 https://www.grid.ac/institutes/grid.223827.e schema:alternateName University of Utah
482 schema:name Department of Pediatrics, University of Utah, Salt Lake City, UT, USA.
483 rdf:type schema:Organization
484 https://www.grid.ac/institutes/grid.239552.a schema:alternateName Children's Hospital of Philadelphia
485 schema:name Department of Pediatrics, Children's Hospital of Philadelphia, Philadelphia, PA, USA.
486 rdf:type schema:Organization
487 https://www.grid.ac/institutes/grid.239573.9 schema:alternateName Cincinnati Children's Hospital Medical Center
488 schema:name Department of Pharmacy Research, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA.
489 rdf:type schema:Organization
490 https://www.grid.ac/institutes/grid.240160.1 schema:alternateName Maine Medical Center
491 schema:name Department of Pediatrics, Maine Medical Center, Portland, ME, USA.
492 rdf:type schema:Organization
493 https://www.grid.ac/institutes/grid.240324.3 schema:alternateName New York University Langone Medical Center
494 schema:name Perlmutter Cancer Center, Department of Pediatrics and Pathology, New York University Langone Medical Center, New York, NY, USA.
495 rdf:type schema:Organization
496 https://www.grid.ac/institutes/grid.240871.8 schema:alternateName St. Jude Children's Research Hospital
497 schema:name Comprehensive Cancer Center, St Jude Children's Research Hospital, Memphis, TN, USA.
498 Department of Biostatistics, St Jude Children's Research Hospital, Memphis, TN, USA.
499 Department of Oncology, St Jude Children's Research Hospital, Memphis, TN, USA.
500 Department of Pharmaceutical Sciences, St Jude Children's Research Hospital, Memphis, TN, USA.
501 rdf:type schema:Organization
502 https://www.grid.ac/institutes/grid.267313.2 schema:alternateName The University of Texas Southwestern Medical Center
503 schema:name Department of Pediatrics, University of Texas, Southwestern Medical Center, Dallas, TX, USA.
504 rdf:type schema:Organization
505 https://www.grid.ac/institutes/grid.30389.31 schema:alternateName University of California System
506 schema:name Department of Pediatrics, University of California School of Medicine, San Francisco, CA, USA.
507 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...