Validation of WHO classification-based Prognostic Scoring System (WPSS) for myelodysplastic syndromes and comparison with the revised International Prognostic Scoring System ... View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2015-02-27

AUTHORS

M G Della Porta, H Tuechler, L Malcovati, J Schanz, G Sanz, G Garcia-Manero, F Solé, J M Bennett, D Bowen, P Fenaux, F Dreyfus, H Kantarjian, A Kuendgen, A Levis, J Cermak, C Fonatsch, M M Le Beau, M L Slovak, O Krieger, M Luebbert, J Maciejewski, S M M Magalhaes, Y Miyazaki, M Pfeilstöcker, M A Sekeres, W R Sperr, R Stauder, S Tauro, P Valent, T Vallespi, A A van de Loosdrecht, U Germing, D Haase, P L Greenberg, M Cazzola

ABSTRACT

A risk-adapted treatment strategy is mandatory for myelodysplastic syndromes (MDS). We refined the World Health Organization (WHO)-classification-based Prognostic Scoring System (WPSS) by determining the impact of the newer clinical and cytogenetic features, and we compared its prognostic power to that of the revised International Prognostic Scoring System (IPSS-R). A population of 5326 untreated MDS was considered. We analyzed single WPSS parameters and confirmed that the WHO classification and severe anemia provide important prognostic information in MDS. A strong correlation was found between the WPSS including the new cytogenetic risk stratification and WPSS adopting original criteria. We then compared WPSS with the IPSS-R prognostic system. A highly significant correlation was found between the WPSS and IPSS-R risk classifications. Discrepancies did occur among lower-risk patients in whom the number of dysplastic hematopoietic lineages as assessed by morphology did not reflect the severity of peripheral blood cytopenias and/or increased marrow blast count. Moreover, severe anemia has higher prognostic weight in the WPSS versus IPSS-R model. Overall, both systems well represent the prognostic risk of MDS patients defined by WHO morphologic criteria. This study provides relevant in formation for the implementation of risk-adapted strategies in MDS. More... »

PAGES

1502-1513

Journal

TITLE

Leukemia

ISSUE

7

VOLUME

29

Author Affiliations

  • Department of Internal Medicine, University of Pavia, Pavia, Italy
  • Hanusch Hospital, Boltzmann Institute for Leukemia Research, Vienna, Austria
  • Department of Molecular Medicine, University of Pavia, Pavia, Italy
  • Georg August Universität, Göttingen, Germany
  • Hospital Universitario La Fe, Valencia, Spain
  • The University of Texas, MD Anderson Cancer Center, Houston, TX, USA
  • Institut de Recerca contra la Leucèmia Josep Carreras, Barcelona, Spain
  • James P. Wilmot Cancer Institute, University of Rochester Medical Center, Rochester, NY, USA
  • St James's University Hospital, Leeds, UK
  • Hôpital Avicenne, Assistance Publique–Hôpitaux de Paris (AP-HP)/University Paris XIII, Bobigny, France
  • Hôpital Cochin, AP-HP University of Paris V, Paris, France
  • Heinrich-Heine University Hospital, Düsseldorf, Germany
  • Fondazione Italiana Sindromi Mielodisplastiche c/o SS Antonio e Biagio Hospital, Alessandria, Italy
  • Institute of Hematology and Blood Transfusion, Praha, Czech Republic
  • Medical University of Vienna, Vienna, Austria
  • University of Chicago Comprehensive Cancer Research Center, Chicago, IL, USA
  • Quest Diagnostics Nichols Institute, Chantilly, VA, USA
  • Elisabethinen Hospital, Linz, Austria
  • University of Freiburg Medical Center, Freiburg, Germany
  • Cleveland Clinic, Cleveland, OH, USA
  • Federal University of Ceara, Fortaleza, Brazil
  • Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan
  • Hanusch Hospital and L. Boltzmann Cluster Oncology, Vienna, Austria
  • University of Dundee, Dundee, Scotland, UK
  • Hospital Universitario Vall d'Hebron, Barcelona, Spain
  • Department of Hematology, VU University Medical Center, Amsterdam, The Netherlands
  • Division of Hematology, Stanford University Cancer Center, Stanford, CA, USA
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/leu.2015.55

    DOI

    http://dx.doi.org/10.1038/leu.2015.55

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1000188573

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/25721895


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