Calcineurin and GSK-3 inhibition sensitizes T-cell acute lymphoblastic leukemia cells to apoptosis through X-linked inhibitor of apoptosis protein degradation View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2016-04

AUTHORS

V Tosello, F Bordin, J Yu, V Agnusdei, S Indraccolo, G Basso, A Amadori, E Piovan

ABSTRACT

The calcineurin (Cn)-nuclear factor of activated T cells signaling pathway is critically involved in many aspects of normal T-cell physiology; however, its direct implication in leukemogenesis is still ill-defined. Glycogen synthase kinase-3β (GSK-3β) has recently been reported to interact with Cn in neuronal cells and is implicated in MLL leukemia. Our biochemical studies clearly demonstrated that Cn was able to interact with GSK-3β in T-cell acute lymphoblastic leukemia (T-ALL) cells, and that this interaction was direct, leading to an increased catalytic activity of GSK-3β, possibly through autophosphorylation of Y216. Sensitivity to GSK-3 inhibitor treatment correlated with altered GSK-3β phosphorylation and was more prominent in T-ALL with Pre/Pro immunophenotype. In addition, dual Cn and GSK-3 inhibitor treatment in T-ALL cells promoted sensitization to apoptosis through proteasomal degradation of X-linked inhibitor of apoptosis protein (XIAP). Consistently, resistance to drug treatments in primary samples was strongly associated with higher XIAP protein levels. Finally, we showed that dual Cn and GSK-3 inhibitor treatment in vitro and in vivo is effective against available models of T-ALL, indicating an insofar untapped therapeutic opportunity. More... »

PAGES

812

References to SciGraph publications

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/leu.2015.335

DOI

http://dx.doi.org/10.1038/leu.2015.335

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1018163384

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/26648536


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/0601", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Biochemistry and Cell Biology", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/06", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Biological Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Animals", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Apoptosis", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Blotting, Western", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Calcineurin", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cell Proliferation", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Flow Cytometry", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Glycogen Synthase Kinase 3", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Glycogen Synthase Kinase 3 beta", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Immunoenzyme Techniques", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Mice", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "NF-kappa B", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Phosphorylation", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Precursor T-Cell Lymphoblastic Leukemia-Lymphoma", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Proteolysis", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Tumor Cells, Cultured", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "X-Linked Inhibitor of Apoptosis Protein", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Xenograft Model Antitumor Assays", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Istituto Oncologico Veneto", 
          "id": "https://www.grid.ac/institutes/grid.419546.b", 
          "name": [
            "UOC Immunologia e Diagnostica Molecolare Oncologica, Istituto Oncologico Veneto IOV-IRCCS, Padova, Italy"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Tosello", 
        "givenName": "V", 
        "id": "sg:person.01074326371.52", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01074326371.52"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Padua", 
          "id": "https://www.grid.ac/institutes/grid.5608.b", 
          "name": [
            "Dipartimento di Scienze Chirurgiche, Oncologiche e Gastroenterologiche, Universita\u2019 di Padova, Padova, Italy"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Bordin", 
        "givenName": "F", 
        "id": "sg:person.0665045254.60", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0665045254.60"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Columbia University", 
          "id": "https://www.grid.ac/institutes/grid.21729.3f", 
          "name": [
            "Department of Biomedical Informatics, Columbia University, New York, NY, USA", 
            "Department of Systems Biology, Columbia University, New York, NY, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Yu", 
        "givenName": "J", 
        "id": "sg:person.0727647220.35", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0727647220.35"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Istituto Oncologico Veneto", 
          "id": "https://www.grid.ac/institutes/grid.419546.b", 
          "name": [
            "UOC Immunologia e Diagnostica Molecolare Oncologica, Istituto Oncologico Veneto IOV-IRCCS, Padova, Italy"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Agnusdei", 
        "givenName": "V", 
        "id": "sg:person.0602173663.34", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0602173663.34"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Istituto Oncologico Veneto", 
          "id": "https://www.grid.ac/institutes/grid.419546.b", 
          "name": [
            "UOC Immunologia e Diagnostica Molecolare Oncologica, Istituto Oncologico Veneto IOV-IRCCS, Padova, Italy"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Indraccolo", 
        "givenName": "S", 
        "id": "sg:person.0616766330.85", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0616766330.85"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Padua", 
          "id": "https://www.grid.ac/institutes/grid.5608.b", 
          "name": [
            "Dipartimento di Salute della Donna e del Bambino, Universit\u00e0 di Padova, Padova, Italy"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Basso", 
        "givenName": "G", 
        "id": "sg:person.013164672102.80", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013164672102.80"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Padua", 
          "id": "https://www.grid.ac/institutes/grid.5608.b", 
          "name": [
            "UOC Immunologia e Diagnostica Molecolare Oncologica, Istituto Oncologico Veneto IOV-IRCCS, Padova, Italy", 
            "Dipartimento di Scienze Chirurgiche, Oncologiche e Gastroenterologiche, Universita\u2019 di Padova, Padova, Italy"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Amadori", 
        "givenName": "A", 
        "id": "sg:person.0600652745.06", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0600652745.06"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Padua", 
          "id": "https://www.grid.ac/institutes/grid.5608.b", 
          "name": [
            "UOC Immunologia e Diagnostica Molecolare Oncologica, Istituto Oncologico Veneto IOV-IRCCS, Padova, Italy", 
            "Dipartimento di Scienze Chirurgiche, Oncologiche e Gastroenterologiche, Universita\u2019 di Padova, Padova, Italy"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Piovan", 
        "givenName": "E", 
        "id": "sg:person.0642621605.98", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0642621605.98"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "sg:pub.10.1038/nm979", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1000301825", 
          "https://doi.org/10.1038/nm979"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nm979", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1000301825", 
          "https://doi.org/10.1038/nm979"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/leu.2013.156", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1000701633", 
          "https://doi.org/10.1038/leu.2013.156"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1042/bj20061837", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1004077030"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1042/bj20061837", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1004077030"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/science.288.5467.874", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1005753668"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/emboj/20.16.4349", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1008028528"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1471-4159.2009.06318.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1010029332"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1471-4159.2009.06318.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1010029332"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature09732", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1012125651", 
          "https://doi.org/10.1038/nature09732"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nm1588", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1015603110", 
          "https://doi.org/10.1038/nm1588"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1182/blood-2005-03-1167", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1015935475"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1200/jco.2010.30.1382", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1017850303"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3109/10428199909145744", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1020217924"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1172/jci35090", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1020618401"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.4061/2011/479249", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1022137646"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1158/1078-0432.ccr-03-0642", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1023241051"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/44378", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1023364448", 
          "https://doi.org/10.1038/44378"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/44378", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1023364448", 
          "https://doi.org/10.1038/44378"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.4061/2011/505607", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1024937254"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1074/jbc.m109.024844", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1025080741"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0065-2571(84)90007-4", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1026371633"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0065-2571(84)90007-4", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1026371633"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature07284", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1026377853", 
          "https://doi.org/10.1038/nature07284"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/1476-4598-9-144", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1026968414", 
          "https://doi.org/10.1186/1476-4598-9-144"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/382370a0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1031781423", 
          "https://doi.org/10.1038/382370a0"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.122062299", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1036729156"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.cdd.4401826", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037715622", 
          "https://doi.org/10.1038/sj.cdd.4401826"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.cdd.4401826", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037715622", 
          "https://doi.org/10.1038/sj.cdd.4401826"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ncb816", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1039455273", 
          "https://doi.org/10.1038/ncb816"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ncb816", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1039455273", 
          "https://doi.org/10.1038/ncb816"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1182/blood-2013-05-500918", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1041648123"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/378785a0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1042289302", 
          "https://doi.org/10.1038/378785a0"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1172/jci40572", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1043163492"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1172/jci40572", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1043163492"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s11064-006-9128-5", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1043905982", 
          "https://doi.org/10.1007/s11064-006-9128-5"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1038/sj.emboj.7601246", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1046696995"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/onc.2009.111", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1048286829", 
          "https://doi.org/10.1038/onc.2009.111"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/onc.2009.111", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1048286829", 
          "https://doi.org/10.1038/onc.2009.111"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/pbc.22541", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1050159697"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/pbc.22541", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1050159697"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.4161/cc.6.1.3650", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1072298919"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.4161/cc.7.3.5357", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1072299829"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1078403176", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1082414891", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1083204501", 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2016-04", 
    "datePublishedReg": "2016-04-01", 
    "description": "The calcineurin (Cn)-nuclear factor of activated T cells signaling pathway is critically involved in many aspects of normal T-cell physiology; however, its direct implication in leukemogenesis is still ill-defined. Glycogen synthase kinase-3\u03b2 (GSK-3\u03b2) has recently been reported to interact with Cn in neuronal cells and is implicated in MLL leukemia. Our biochemical studies clearly demonstrated that Cn was able to interact with GSK-3\u03b2 in T-cell acute lymphoblastic leukemia (T-ALL) cells, and that this interaction was direct, leading to an increased catalytic activity of GSK-3\u03b2, possibly through autophosphorylation of Y216. Sensitivity to GSK-3 inhibitor treatment correlated with altered GSK-3\u03b2 phosphorylation and was more prominent in T-ALL with Pre/Pro immunophenotype. In addition, dual Cn and GSK-3 inhibitor treatment in T-ALL cells promoted sensitization to apoptosis through proteasomal degradation of X-linked inhibitor of apoptosis protein (XIAP). Consistently, resistance to drug treatments in primary samples was strongly associated with higher XIAP protein levels. Finally, we showed that dual Cn and GSK-3 inhibitor treatment in vitro and in vivo is effective against available models of T-ALL, indicating an insofar untapped therapeutic opportunity. ", 
    "genre": "research_article", 
    "id": "sg:pub.10.1038/leu.2015.335", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": false, 
    "isPartOf": [
      {
        "id": "sg:journal.1097065", 
        "issn": [
          "0887-6924", 
          "1476-5551"
        ], 
        "name": "Leukemia", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "4", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "30"
      }
    ], 
    "name": "Calcineurin and GSK-3 inhibition sensitizes T-cell acute lymphoblastic leukemia cells to apoptosis through X-linked inhibitor of apoptosis protein degradation", 
    "pagination": "812", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "568b0ff18dd5af12f61813038fa953b2123783ac4fe8d9fb3eb612f4e42ea4cd"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "26648536"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "8704895"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1038/leu.2015.335"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1018163384"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1038/leu.2015.335", 
      "https://app.dimensions.ai/details/publication/pub.1018163384"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-10T16:30", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8669_00000435.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://www.nature.com/articles/leu2015335"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/leu.2015.335'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/leu.2015.335'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/leu.2015.335'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/leu.2015.335'


 

This table displays all metadata directly associated to this object as RDF triples.

317 TRIPLES      21 PREDICATES      83 URIs      39 LITERALS      27 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1038/leu.2015.335 schema:about N056cc038dda84f8cbb2c63a75d1890a1
2 N2605fc27e7ee45b7ab235f8bc6a5b8bb
3 N4124320148e0423fadc6c8a48cade15f
4 N5bc4983eab234ac79f3dc0d422d0b13e
5 N650a8eaca3a948a69760fff7b296e911
6 N73f017c564364c2696eb19e1b96d4f94
7 N7e12d629fd4c41cfa77e410d25434682
8 N9506721143e44a5e805d5f3930afdcc9
9 N997ca25c5b2342d090f58ebac5287a1e
10 N9cd89c145956494780c4b53adf14647d
11 N9fe7a0ab11e24d40abee06eca8ba2cbd
12 Na8d92bd137524f508dac239d5d9ada4d
13 Nb0a3e4311a7440edbbe29a7d6374e0cf
14 Nb5f0a357a3214161ac59f4967011cad7
15 Nb7a322bcafa84389add9dc8ad888389f
16 Nd1627d5cdeb1493783f6ff478a52fe19
17 Ne6d2c27b3a3b41af98dc7c37cd355f43
18 Ne6d5066157a840a69e834d538764c7a7
19 anzsrc-for:06
20 anzsrc-for:0601
21 schema:author N158600fad01143139bc5d1d9475742c0
22 schema:citation sg:pub.10.1007/s11064-006-9128-5
23 sg:pub.10.1038/378785a0
24 sg:pub.10.1038/382370a0
25 sg:pub.10.1038/44378
26 sg:pub.10.1038/leu.2013.156
27 sg:pub.10.1038/nature07284
28 sg:pub.10.1038/nature09732
29 sg:pub.10.1038/ncb816
30 sg:pub.10.1038/nm1588
31 sg:pub.10.1038/nm979
32 sg:pub.10.1038/onc.2009.111
33 sg:pub.10.1038/sj.cdd.4401826
34 sg:pub.10.1186/1476-4598-9-144
35 https://app.dimensions.ai/details/publication/pub.1078403176
36 https://app.dimensions.ai/details/publication/pub.1082414891
37 https://app.dimensions.ai/details/publication/pub.1083204501
38 https://doi.org/10.1002/pbc.22541
39 https://doi.org/10.1016/0065-2571(84)90007-4
40 https://doi.org/10.1038/sj.emboj.7601246
41 https://doi.org/10.1042/bj20061837
42 https://doi.org/10.1073/pnas.122062299
43 https://doi.org/10.1074/jbc.m109.024844
44 https://doi.org/10.1093/emboj/20.16.4349
45 https://doi.org/10.1111/j.1471-4159.2009.06318.x
46 https://doi.org/10.1126/science.288.5467.874
47 https://doi.org/10.1158/1078-0432.ccr-03-0642
48 https://doi.org/10.1172/jci35090
49 https://doi.org/10.1172/jci40572
50 https://doi.org/10.1182/blood-2005-03-1167
51 https://doi.org/10.1182/blood-2013-05-500918
52 https://doi.org/10.1200/jco.2010.30.1382
53 https://doi.org/10.3109/10428199909145744
54 https://doi.org/10.4061/2011/479249
55 https://doi.org/10.4061/2011/505607
56 https://doi.org/10.4161/cc.6.1.3650
57 https://doi.org/10.4161/cc.7.3.5357
58 schema:datePublished 2016-04
59 schema:datePublishedReg 2016-04-01
60 schema:description The calcineurin (Cn)-nuclear factor of activated T cells signaling pathway is critically involved in many aspects of normal T-cell physiology; however, its direct implication in leukemogenesis is still ill-defined. Glycogen synthase kinase-3β (GSK-3β) has recently been reported to interact with Cn in neuronal cells and is implicated in MLL leukemia. Our biochemical studies clearly demonstrated that Cn was able to interact with GSK-3β in T-cell acute lymphoblastic leukemia (T-ALL) cells, and that this interaction was direct, leading to an increased catalytic activity of GSK-3β, possibly through autophosphorylation of Y216. Sensitivity to GSK-3 inhibitor treatment correlated with altered GSK-3β phosphorylation and was more prominent in T-ALL with Pre/Pro immunophenotype. In addition, dual Cn and GSK-3 inhibitor treatment in T-ALL cells promoted sensitization to apoptosis through proteasomal degradation of X-linked inhibitor of apoptosis protein (XIAP). Consistently, resistance to drug treatments in primary samples was strongly associated with higher XIAP protein levels. Finally, we showed that dual Cn and GSK-3 inhibitor treatment in vitro and in vivo is effective against available models of T-ALL, indicating an insofar untapped therapeutic opportunity.
61 schema:genre research_article
62 schema:inLanguage en
63 schema:isAccessibleForFree false
64 schema:isPartOf N385c500a9a10483aaac7c5810de84c40
65 Nd6d4843829bf4422892041d69e7b8b82
66 sg:journal.1097065
67 schema:name Calcineurin and GSK-3 inhibition sensitizes T-cell acute lymphoblastic leukemia cells to apoptosis through X-linked inhibitor of apoptosis protein degradation
68 schema:pagination 812
69 schema:productId N1961a1f7d9b840f3985f42a5f3bda905
70 N3d16f498d7fb49dd838599386dfd4c96
71 N4e1e90cf6f844c14aac4000017d2b1f2
72 Ne59a8eefb37f4896aebe957a32eda78e
73 Nfcc779f3fdcb4518aab7d349070a80c7
74 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018163384
75 https://doi.org/10.1038/leu.2015.335
76 schema:sdDatePublished 2019-04-10T16:30
77 schema:sdLicense https://scigraph.springernature.com/explorer/license/
78 schema:sdPublisher Nd7846c25c30c44dd815c3a75bbba1e9d
79 schema:url https://www.nature.com/articles/leu2015335
80 sgo:license sg:explorer/license/
81 sgo:sdDataset articles
82 rdf:type schema:ScholarlyArticle
83 N056cc038dda84f8cbb2c63a75d1890a1 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
84 schema:name Flow Cytometry
85 rdf:type schema:DefinedTerm
86 N0592070dfda94fa589fd08c8c87c4468 rdf:first sg:person.013164672102.80
87 rdf:rest Naea1d8558d104e29bd4583e8e1caf7b5
88 N158600fad01143139bc5d1d9475742c0 rdf:first sg:person.01074326371.52
89 rdf:rest Nf258d64db9ff4b1c82e44c099b2b3a7b
90 N1961a1f7d9b840f3985f42a5f3bda905 schema:name dimensions_id
91 schema:value pub.1018163384
92 rdf:type schema:PropertyValue
93 N2605fc27e7ee45b7ab235f8bc6a5b8bb schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
94 schema:name Humans
95 rdf:type schema:DefinedTerm
96 N37f9bd17aa874e1aa143d2c21aba5c36 rdf:first sg:person.0616766330.85
97 rdf:rest N0592070dfda94fa589fd08c8c87c4468
98 N385c500a9a10483aaac7c5810de84c40 schema:issueNumber 4
99 rdf:type schema:PublicationIssue
100 N3d16f498d7fb49dd838599386dfd4c96 schema:name doi
101 schema:value 10.1038/leu.2015.335
102 rdf:type schema:PropertyValue
103 N4124320148e0423fadc6c8a48cade15f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
104 schema:name Blotting, Western
105 rdf:type schema:DefinedTerm
106 N4e1e90cf6f844c14aac4000017d2b1f2 schema:name readcube_id
107 schema:value 568b0ff18dd5af12f61813038fa953b2123783ac4fe8d9fb3eb612f4e42ea4cd
108 rdf:type schema:PropertyValue
109 N51c24c638d9346039a70a658015d4c59 rdf:first sg:person.0642621605.98
110 rdf:rest rdf:nil
111 N5bc4983eab234ac79f3dc0d422d0b13e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
112 schema:name Tumor Cells, Cultured
113 rdf:type schema:DefinedTerm
114 N650a8eaca3a948a69760fff7b296e911 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
115 schema:name Apoptosis
116 rdf:type schema:DefinedTerm
117 N6ff7c7fa32ff473a848b5ee56e677334 rdf:first sg:person.0602173663.34
118 rdf:rest N37f9bd17aa874e1aa143d2c21aba5c36
119 N73f017c564364c2696eb19e1b96d4f94 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
120 schema:name Animals
121 rdf:type schema:DefinedTerm
122 N7e12d629fd4c41cfa77e410d25434682 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
123 schema:name Phosphorylation
124 rdf:type schema:DefinedTerm
125 N9506721143e44a5e805d5f3930afdcc9 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
126 schema:name Cell Proliferation
127 rdf:type schema:DefinedTerm
128 N997ca25c5b2342d090f58ebac5287a1e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
129 schema:name Glycogen Synthase Kinase 3
130 rdf:type schema:DefinedTerm
131 N9cd89c145956494780c4b53adf14647d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
132 schema:name Calcineurin
133 rdf:type schema:DefinedTerm
134 N9fe7a0ab11e24d40abee06eca8ba2cbd schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
135 schema:name Precursor T-Cell Lymphoblastic Leukemia-Lymphoma
136 rdf:type schema:DefinedTerm
137 Na8d92bd137524f508dac239d5d9ada4d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
138 schema:name X-Linked Inhibitor of Apoptosis Protein
139 rdf:type schema:DefinedTerm
140 Naea1d8558d104e29bd4583e8e1caf7b5 rdf:first sg:person.0600652745.06
141 rdf:rest N51c24c638d9346039a70a658015d4c59
142 Nb0a3e4311a7440edbbe29a7d6374e0cf schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
143 schema:name Glycogen Synthase Kinase 3 beta
144 rdf:type schema:DefinedTerm
145 Nb5f0a357a3214161ac59f4967011cad7 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
146 schema:name Xenograft Model Antitumor Assays
147 rdf:type schema:DefinedTerm
148 Nb7a322bcafa84389add9dc8ad888389f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
149 schema:name NF-kappa B
150 rdf:type schema:DefinedTerm
151 Nc2bab53984a847bfa3cdd80495ac0eaa rdf:first sg:person.0727647220.35
152 rdf:rest N6ff7c7fa32ff473a848b5ee56e677334
153 Nd1627d5cdeb1493783f6ff478a52fe19 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
154 schema:name Immunoenzyme Techniques
155 rdf:type schema:DefinedTerm
156 Nd6d4843829bf4422892041d69e7b8b82 schema:volumeNumber 30
157 rdf:type schema:PublicationVolume
158 Nd7846c25c30c44dd815c3a75bbba1e9d schema:name Springer Nature - SN SciGraph project
159 rdf:type schema:Organization
160 Ne59a8eefb37f4896aebe957a32eda78e schema:name pubmed_id
161 schema:value 26648536
162 rdf:type schema:PropertyValue
163 Ne6d2c27b3a3b41af98dc7c37cd355f43 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
164 schema:name Proteolysis
165 rdf:type schema:DefinedTerm
166 Ne6d5066157a840a69e834d538764c7a7 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
167 schema:name Mice
168 rdf:type schema:DefinedTerm
169 Nf258d64db9ff4b1c82e44c099b2b3a7b rdf:first sg:person.0665045254.60
170 rdf:rest Nc2bab53984a847bfa3cdd80495ac0eaa
171 Nfcc779f3fdcb4518aab7d349070a80c7 schema:name nlm_unique_id
172 schema:value 8704895
173 rdf:type schema:PropertyValue
174 anzsrc-for:06 schema:inDefinedTermSet anzsrc-for:
175 schema:name Biological Sciences
176 rdf:type schema:DefinedTerm
177 anzsrc-for:0601 schema:inDefinedTermSet anzsrc-for:
178 schema:name Biochemistry and Cell Biology
179 rdf:type schema:DefinedTerm
180 sg:journal.1097065 schema:issn 0887-6924
181 1476-5551
182 schema:name Leukemia
183 rdf:type schema:Periodical
184 sg:person.01074326371.52 schema:affiliation https://www.grid.ac/institutes/grid.419546.b
185 schema:familyName Tosello
186 schema:givenName V
187 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01074326371.52
188 rdf:type schema:Person
189 sg:person.013164672102.80 schema:affiliation https://www.grid.ac/institutes/grid.5608.b
190 schema:familyName Basso
191 schema:givenName G
192 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013164672102.80
193 rdf:type schema:Person
194 sg:person.0600652745.06 schema:affiliation https://www.grid.ac/institutes/grid.5608.b
195 schema:familyName Amadori
196 schema:givenName A
197 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0600652745.06
198 rdf:type schema:Person
199 sg:person.0602173663.34 schema:affiliation https://www.grid.ac/institutes/grid.419546.b
200 schema:familyName Agnusdei
201 schema:givenName V
202 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0602173663.34
203 rdf:type schema:Person
204 sg:person.0616766330.85 schema:affiliation https://www.grid.ac/institutes/grid.419546.b
205 schema:familyName Indraccolo
206 schema:givenName S
207 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0616766330.85
208 rdf:type schema:Person
209 sg:person.0642621605.98 schema:affiliation https://www.grid.ac/institutes/grid.5608.b
210 schema:familyName Piovan
211 schema:givenName E
212 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0642621605.98
213 rdf:type schema:Person
214 sg:person.0665045254.60 schema:affiliation https://www.grid.ac/institutes/grid.5608.b
215 schema:familyName Bordin
216 schema:givenName F
217 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0665045254.60
218 rdf:type schema:Person
219 sg:person.0727647220.35 schema:affiliation https://www.grid.ac/institutes/grid.21729.3f
220 schema:familyName Yu
221 schema:givenName J
222 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0727647220.35
223 rdf:type schema:Person
224 sg:pub.10.1007/s11064-006-9128-5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043905982
225 https://doi.org/10.1007/s11064-006-9128-5
226 rdf:type schema:CreativeWork
227 sg:pub.10.1038/378785a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042289302
228 https://doi.org/10.1038/378785a0
229 rdf:type schema:CreativeWork
230 sg:pub.10.1038/382370a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031781423
231 https://doi.org/10.1038/382370a0
232 rdf:type schema:CreativeWork
233 sg:pub.10.1038/44378 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023364448
234 https://doi.org/10.1038/44378
235 rdf:type schema:CreativeWork
236 sg:pub.10.1038/leu.2013.156 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000701633
237 https://doi.org/10.1038/leu.2013.156
238 rdf:type schema:CreativeWork
239 sg:pub.10.1038/nature07284 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026377853
240 https://doi.org/10.1038/nature07284
241 rdf:type schema:CreativeWork
242 sg:pub.10.1038/nature09732 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012125651
243 https://doi.org/10.1038/nature09732
244 rdf:type schema:CreativeWork
245 sg:pub.10.1038/ncb816 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039455273
246 https://doi.org/10.1038/ncb816
247 rdf:type schema:CreativeWork
248 sg:pub.10.1038/nm1588 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015603110
249 https://doi.org/10.1038/nm1588
250 rdf:type schema:CreativeWork
251 sg:pub.10.1038/nm979 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000301825
252 https://doi.org/10.1038/nm979
253 rdf:type schema:CreativeWork
254 sg:pub.10.1038/onc.2009.111 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048286829
255 https://doi.org/10.1038/onc.2009.111
256 rdf:type schema:CreativeWork
257 sg:pub.10.1038/sj.cdd.4401826 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037715622
258 https://doi.org/10.1038/sj.cdd.4401826
259 rdf:type schema:CreativeWork
260 sg:pub.10.1186/1476-4598-9-144 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026968414
261 https://doi.org/10.1186/1476-4598-9-144
262 rdf:type schema:CreativeWork
263 https://app.dimensions.ai/details/publication/pub.1078403176 schema:CreativeWork
264 https://app.dimensions.ai/details/publication/pub.1082414891 schema:CreativeWork
265 https://app.dimensions.ai/details/publication/pub.1083204501 schema:CreativeWork
266 https://doi.org/10.1002/pbc.22541 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050159697
267 rdf:type schema:CreativeWork
268 https://doi.org/10.1016/0065-2571(84)90007-4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026371633
269 rdf:type schema:CreativeWork
270 https://doi.org/10.1038/sj.emboj.7601246 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046696995
271 rdf:type schema:CreativeWork
272 https://doi.org/10.1042/bj20061837 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004077030
273 rdf:type schema:CreativeWork
274 https://doi.org/10.1073/pnas.122062299 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036729156
275 rdf:type schema:CreativeWork
276 https://doi.org/10.1074/jbc.m109.024844 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025080741
277 rdf:type schema:CreativeWork
278 https://doi.org/10.1093/emboj/20.16.4349 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008028528
279 rdf:type schema:CreativeWork
280 https://doi.org/10.1111/j.1471-4159.2009.06318.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1010029332
281 rdf:type schema:CreativeWork
282 https://doi.org/10.1126/science.288.5467.874 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005753668
283 rdf:type schema:CreativeWork
284 https://doi.org/10.1158/1078-0432.ccr-03-0642 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023241051
285 rdf:type schema:CreativeWork
286 https://doi.org/10.1172/jci35090 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020618401
287 rdf:type schema:CreativeWork
288 https://doi.org/10.1172/jci40572 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043163492
289 rdf:type schema:CreativeWork
290 https://doi.org/10.1182/blood-2005-03-1167 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015935475
291 rdf:type schema:CreativeWork
292 https://doi.org/10.1182/blood-2013-05-500918 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041648123
293 rdf:type schema:CreativeWork
294 https://doi.org/10.1200/jco.2010.30.1382 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017850303
295 rdf:type schema:CreativeWork
296 https://doi.org/10.3109/10428199909145744 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020217924
297 rdf:type schema:CreativeWork
298 https://doi.org/10.4061/2011/479249 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022137646
299 rdf:type schema:CreativeWork
300 https://doi.org/10.4061/2011/505607 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024937254
301 rdf:type schema:CreativeWork
302 https://doi.org/10.4161/cc.6.1.3650 schema:sameAs https://app.dimensions.ai/details/publication/pub.1072298919
303 rdf:type schema:CreativeWork
304 https://doi.org/10.4161/cc.7.3.5357 schema:sameAs https://app.dimensions.ai/details/publication/pub.1072299829
305 rdf:type schema:CreativeWork
306 https://www.grid.ac/institutes/grid.21729.3f schema:alternateName Columbia University
307 schema:name Department of Biomedical Informatics, Columbia University, New York, NY, USA
308 Department of Systems Biology, Columbia University, New York, NY, USA
309 rdf:type schema:Organization
310 https://www.grid.ac/institutes/grid.419546.b schema:alternateName Istituto Oncologico Veneto
311 schema:name UOC Immunologia e Diagnostica Molecolare Oncologica, Istituto Oncologico Veneto IOV-IRCCS, Padova, Italy
312 rdf:type schema:Organization
313 https://www.grid.ac/institutes/grid.5608.b schema:alternateName University of Padua
314 schema:name Dipartimento di Salute della Donna e del Bambino, Università di Padova, Padova, Italy
315 Dipartimento di Scienze Chirurgiche, Oncologiche e Gastroenterologiche, Universita’ di Padova, Padova, Italy
316 UOC Immunologia e Diagnostica Molecolare Oncologica, Istituto Oncologico Veneto IOV-IRCCS, Padova, Italy
317 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...