Characterization of the genome-wide TLX1 binding profile in T-cell acute lymphoblastic leukemia View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2015-12

AUTHORS

K Durinck, W Van Loocke, J Van der Meulen, I Van de Walle, M Ongenaert, P Rondou, A Wallaert, C E de Bock, N Van Roy, B Poppe, J Cools, J Soulier, T Taghon, F Speleman, P Van Vlierberghe

ABSTRACT

The TLX1 transcription factor is critically involved in the multi-step pathogenesis of T-cell acute lymphoblastic leukemia (T-ALL) and often cooperates with NOTCH1 activation during malignant T-cell transformation. However, the exact molecular mechanism by which these T-cell specific oncogenes cooperate during transformation remains to be established. Here, we used chromatin immunoprecipitation followed by sequencing to establish the genome-wide binding pattern of TLX1 in human T-ALL. This integrative genomics approach showed that ectopic TLX1 expression drives repression of T cell-specific enhancers and mediates an unexpected transcriptional antagonism with NOTCH1 at critical target genes, including IL7R and NOTCH3. These phenomena coordinately trigger a TLX1-driven pre-leukemic phenotype in human thymic precursor cells, reminiscent of the thymus regression observed in murine TLX1 tumor models, and create a strong genetic pressure for acquiring activating NOTCH1 mutations as a prerequisite for full leukemic transformation. In conclusion, our results uncover a functional antagonism between cooperative oncogenes during the earliest phases of tumor development and provide novel insights in the multi-step pathogenesis of TLX1-driven human leukemia. More... »

PAGES

2317

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/leu.2015.162

DOI

http://dx.doi.org/10.1038/leu.2015.162

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1025959355

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/26108691


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/0604", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Genetics", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/06", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Biological Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cell Line, Tumor", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Chromatin Immunoprecipitation", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Homeodomain Proteins", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Oncogenes", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Precursor T-Cell Lymphoblastic Leukemia-Lymphoma", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Proto-Oncogene Proteins", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Receptor, Notch1", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Ghent University", 
          "id": "https://www.grid.ac/institutes/grid.5342.0", 
          "name": [
            "Center for Medical Genetics, Department of Pediatrics and Genetics, Ghent University, Ghent, Belgium"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Durinck", 
        "givenName": "K", 
        "id": "sg:person.0777600754.06", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0777600754.06"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Ghent University", 
          "id": "https://www.grid.ac/institutes/grid.5342.0", 
          "name": [
            "Center for Medical Genetics, Department of Pediatrics and Genetics, Ghent University, Ghent, Belgium"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Van Loocke", 
        "givenName": "W", 
        "id": "sg:person.01325177706.05", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01325177706.05"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Ghent University", 
          "id": "https://www.grid.ac/institutes/grid.5342.0", 
          "name": [
            "Center for Medical Genetics, Department of Pediatrics and Genetics, Ghent University, Ghent, Belgium"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Van der Meulen", 
        "givenName": "J", 
        "id": "sg:person.01113574155.77", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01113574155.77"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Ghent University", 
          "id": "https://www.grid.ac/institutes/grid.5342.0", 
          "name": [
            "Department of Clinical Chemistry, Microbiology and Immunology, Ghent University, Ghent, Belgium"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Van de Walle", 
        "givenName": "I", 
        "id": "sg:person.01021304126.61", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01021304126.61"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Ghent University", 
          "id": "https://www.grid.ac/institutes/grid.5342.0", 
          "name": [
            "Center for Medical Genetics, Department of Pediatrics and Genetics, Ghent University, Ghent, Belgium"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Ongenaert", 
        "givenName": "M", 
        "id": "sg:person.01123177750.89", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01123177750.89"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Ghent University", 
          "id": "https://www.grid.ac/institutes/grid.5342.0", 
          "name": [
            "Center for Medical Genetics, Department of Pediatrics and Genetics, Ghent University, Ghent, Belgium"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Rondou", 
        "givenName": "P", 
        "id": "sg:person.0636106235.47", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0636106235.47"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Ghent University", 
          "id": "https://www.grid.ac/institutes/grid.5342.0", 
          "name": [
            "Center for Medical Genetics, Department of Pediatrics and Genetics, Ghent University, Ghent, Belgium"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Wallaert", 
        "givenName": "A", 
        "id": "sg:person.01210751306.08", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01210751306.08"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "KU Leuven", 
          "id": "https://www.grid.ac/institutes/grid.5596.f", 
          "name": [
            "Laboratory for the Molecular Biology of Leukemia, Center for Human Genetics, KU Leuven and Center for the Biology of Disease, VIB, Leuven, Belgium"
          ], 
          "type": "Organization"
        }, 
        "familyName": "de Bock", 
        "givenName": "C E", 
        "id": "sg:person.0577037250.75", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0577037250.75"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Ghent University", 
          "id": "https://www.grid.ac/institutes/grid.5342.0", 
          "name": [
            "Center for Medical Genetics, Department of Pediatrics and Genetics, Ghent University, Ghent, Belgium"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Van Roy", 
        "givenName": "N", 
        "id": "sg:person.0756500604.32", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0756500604.32"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Ghent University", 
          "id": "https://www.grid.ac/institutes/grid.5342.0", 
          "name": [
            "Center for Medical Genetics, Department of Pediatrics and Genetics, Ghent University, Ghent, Belgium"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Poppe", 
        "givenName": "B", 
        "id": "sg:person.01204242653.58", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01204242653.58"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "KU Leuven", 
          "id": "https://www.grid.ac/institutes/grid.5596.f", 
          "name": [
            "Laboratory for the Molecular Biology of Leukemia, Center for Human Genetics, KU Leuven and Center for the Biology of Disease, VIB, Leuven, Belgium"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Cools", 
        "givenName": "J", 
        "id": "sg:person.01367254577.12", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01367254577.12"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "H\u00f4pital Saint-Louis", 
          "id": "https://www.grid.ac/institutes/grid.413328.f", 
          "name": [
            "Genome Rearrangements and Cancer Laboratory, U944 INSERM, University Paris Diderot and Hematology Laboratory, Saint-Louis Hospital, Paris, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Soulier", 
        "givenName": "J", 
        "id": "sg:person.01155407542.97", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01155407542.97"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Ghent University", 
          "id": "https://www.grid.ac/institutes/grid.5342.0", 
          "name": [
            "Department of Clinical Chemistry, Microbiology and Immunology, Ghent University, Ghent, Belgium"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Taghon", 
        "givenName": "T", 
        "id": "sg:person.01015363356.66", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01015363356.66"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Ghent University", 
          "id": "https://www.grid.ac/institutes/grid.5342.0", 
          "name": [
            "Center for Medical Genetics, Department of Pediatrics and Genetics, Ghent University, Ghent, Belgium"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Speleman", 
        "givenName": "F", 
        "id": "sg:person.01300660453.35", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01300660453.35"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Ghent University", 
          "id": "https://www.grid.ac/institutes/grid.5342.0", 
          "name": [
            "Center for Medical Genetics, Department of Pediatrics and Genetics, Ghent University, Ghent, Belgium"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Van Vlierberghe", 
        "givenName": "P", 
        "id": "sg:person.01102371165.51", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01102371165.51"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.1073/pnas.1315023111", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1000274750"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/0471250953.bi0214s34", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1000488121"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature09504", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1001851540", 
          "https://doi.org/10.1038/nature09504"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature09504", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1001851540", 
          "https://doi.org/10.1038/nature09504"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/nar/gks915", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1002477416"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1084/jem.20110105", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1002796486"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.cell.2013.03.035", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1005302017"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3109/10428190009065824", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1005345901"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/bioinformatics/btr189", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1008669948"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nm.2610", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1009127126", 
          "https://doi.org/10.1038/nm.2610"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nprot.2006.98", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1010562203", 
          "https://doi.org/10.1038/nprot.2006.98"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nprot.2006.98", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1010562203", 
          "https://doi.org/10.1038/nprot.2006.98"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1371/journal.pone.0016761", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1010714563"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.cell.2013.09.053", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1011111923"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.molcel.2010.05.004", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1012935976"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nm.3665", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1014690315", 
          "https://doi.org/10.1038/nm.3665"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nm.2246", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1016716428", 
          "https://doi.org/10.1038/nm.2246"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.cell.2013.03.036", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1017590275"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1182/blood-2008-10-184069", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1027730687"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/science.1102160", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1033243130"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.1109023108", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1033771501"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.ccr.2012.02.013", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035654327"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/bioinformatics/btq033", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1036892131"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3324/haematol.2014.115683", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1038173012"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1365-2141.2005.05850.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1043525301"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1365-2141.2005.05850.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1043525301"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.leukres.2009.06.003", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1047196382"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1182/blood-2010-06-290049", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1047667845"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1084/jem.20121798", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1047928247"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/gb-2009-10-3-r25", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1049583368", 
          "https://doi.org/10.1186/gb-2009-10-3-r25"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0140-6736(04)15542-6", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1051150833"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1082559420", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1083033962", 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2015-12", 
    "datePublishedReg": "2015-12-01", 
    "description": "The TLX1 transcription factor is critically involved in the multi-step pathogenesis of T-cell acute lymphoblastic leukemia (T-ALL) and often cooperates with NOTCH1 activation during malignant T-cell transformation. However, the exact molecular mechanism by which these T-cell specific oncogenes cooperate during transformation remains to be established. Here, we used chromatin immunoprecipitation followed by sequencing to establish the genome-wide binding pattern of TLX1 in human T-ALL. This integrative genomics approach showed that ectopic TLX1 expression drives repression of T cell-specific enhancers and mediates an unexpected transcriptional antagonism with NOTCH1 at critical target genes, including IL7R and NOTCH3. These phenomena coordinately trigger a TLX1-driven pre-leukemic phenotype in human thymic precursor cells, reminiscent of the thymus regression observed in murine TLX1 tumor models, and create a strong genetic pressure for acquiring activating NOTCH1 mutations as a prerequisite for full leukemic transformation. In conclusion, our results uncover a functional antagonism between cooperative oncogenes during the earliest phases of tumor development and provide novel insights in the multi-step pathogenesis of TLX1-driven human leukemia. ", 
    "genre": "research_article", 
    "id": "sg:pub.10.1038/leu.2015.162", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": false, 
    "isFundedItemOf": [
      {
        "id": "sg:grant.3791439", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.6948337", 
        "type": "MonetaryGrant"
      }
    ], 
    "isPartOf": [
      {
        "id": "sg:journal.1097065", 
        "issn": [
          "0887-6924", 
          "1476-5551"
        ], 
        "name": "Leukemia", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "12", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "29"
      }
    ], 
    "name": "Characterization of the genome-wide TLX1 binding profile in T-cell acute lymphoblastic leukemia", 
    "pagination": "2317", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "7baba17d7f8f36f69683d409927d2b8edb41617ef3ce661190d74cc0e3410310"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "26108691"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "8704895"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1038/leu.2015.162"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1025959355"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1038/leu.2015.162", 
      "https://app.dimensions.ai/details/publication/pub.1025959355"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-11T00:56", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8697_00000435.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://www.nature.com/articles/leu2015162"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/leu.2015.162'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/leu.2015.162'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/leu.2015.162'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/leu.2015.162'


 

This table displays all metadata directly associated to this object as RDF triples.

304 TRIPLES      21 PREDICATES      67 URIs      29 LITERALS      17 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1038/leu.2015.162 schema:about N1a61a3ca472c46bfa2ef1ac2a7b0f29f
2 N4c1eeba3e86c46d5bb0e345b69f316fa
3 N776d2fe735484cd0928cf49403f8bd5b
4 N969d568a0ec74c42bed9f9e3fea621f5
5 N98c78e4d34bc4aaa98e3986ff348bf30
6 Nd488da2897b64989a19475099a063d77
7 Ne6e3f71a078940a99d969bdc95cfd121
8 Nf3a4a2935388461f9c0246db7e0a34dd
9 anzsrc-for:06
10 anzsrc-for:0604
11 schema:author N9e67e1262b254560af51839429d62593
12 schema:citation sg:pub.10.1038/nature09504
13 sg:pub.10.1038/nm.2246
14 sg:pub.10.1038/nm.2610
15 sg:pub.10.1038/nm.3665
16 sg:pub.10.1038/nprot.2006.98
17 sg:pub.10.1186/gb-2009-10-3-r25
18 https://app.dimensions.ai/details/publication/pub.1082559420
19 https://app.dimensions.ai/details/publication/pub.1083033962
20 https://doi.org/10.1002/0471250953.bi0214s34
21 https://doi.org/10.1016/j.ccr.2012.02.013
22 https://doi.org/10.1016/j.cell.2013.03.035
23 https://doi.org/10.1016/j.cell.2013.03.036
24 https://doi.org/10.1016/j.cell.2013.09.053
25 https://doi.org/10.1016/j.leukres.2009.06.003
26 https://doi.org/10.1016/j.molcel.2010.05.004
27 https://doi.org/10.1016/s0140-6736(04)15542-6
28 https://doi.org/10.1073/pnas.1109023108
29 https://doi.org/10.1073/pnas.1315023111
30 https://doi.org/10.1084/jem.20110105
31 https://doi.org/10.1084/jem.20121798
32 https://doi.org/10.1093/bioinformatics/btq033
33 https://doi.org/10.1093/bioinformatics/btr189
34 https://doi.org/10.1093/nar/gks915
35 https://doi.org/10.1111/j.1365-2141.2005.05850.x
36 https://doi.org/10.1126/science.1102160
37 https://doi.org/10.1182/blood-2008-10-184069
38 https://doi.org/10.1182/blood-2010-06-290049
39 https://doi.org/10.1371/journal.pone.0016761
40 https://doi.org/10.3109/10428190009065824
41 https://doi.org/10.3324/haematol.2014.115683
42 schema:datePublished 2015-12
43 schema:datePublishedReg 2015-12-01
44 schema:description The TLX1 transcription factor is critically involved in the multi-step pathogenesis of T-cell acute lymphoblastic leukemia (T-ALL) and often cooperates with NOTCH1 activation during malignant T-cell transformation. However, the exact molecular mechanism by which these T-cell specific oncogenes cooperate during transformation remains to be established. Here, we used chromatin immunoprecipitation followed by sequencing to establish the genome-wide binding pattern of TLX1 in human T-ALL. This integrative genomics approach showed that ectopic TLX1 expression drives repression of T cell-specific enhancers and mediates an unexpected transcriptional antagonism with NOTCH1 at critical target genes, including IL7R and NOTCH3. These phenomena coordinately trigger a TLX1-driven pre-leukemic phenotype in human thymic precursor cells, reminiscent of the thymus regression observed in murine TLX1 tumor models, and create a strong genetic pressure for acquiring activating NOTCH1 mutations as a prerequisite for full leukemic transformation. In conclusion, our results uncover a functional antagonism between cooperative oncogenes during the earliest phases of tumor development and provide novel insights in the multi-step pathogenesis of TLX1-driven human leukemia.
45 schema:genre research_article
46 schema:inLanguage en
47 schema:isAccessibleForFree false
48 schema:isPartOf N3b0e3f679fef41f8aaf585a3495ce4af
49 Nc98d3db58cff4f33aa5b1292c65b89f8
50 sg:journal.1097065
51 schema:name Characterization of the genome-wide TLX1 binding profile in T-cell acute lymphoblastic leukemia
52 schema:pagination 2317
53 schema:productId N357db4817d824bc6b0f87292e47de9f7
54 N542bc2edff93464babf2b43e3ea776de
55 Nccdd9e44d95a434489c78af534fb8c48
56 Nd74dbe5c4d45423f97a126fcce973efd
57 Ndf292cf60a6d4417b7bfec145fedea70
58 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025959355
59 https://doi.org/10.1038/leu.2015.162
60 schema:sdDatePublished 2019-04-11T00:56
61 schema:sdLicense https://scigraph.springernature.com/explorer/license/
62 schema:sdPublisher N03bed94a066a4761acae61f6e675756b
63 schema:url https://www.nature.com/articles/leu2015162
64 sgo:license sg:explorer/license/
65 sgo:sdDataset articles
66 rdf:type schema:ScholarlyArticle
67 N03bed94a066a4761acae61f6e675756b schema:name Springer Nature - SN SciGraph project
68 rdf:type schema:Organization
69 N1a61a3ca472c46bfa2ef1ac2a7b0f29f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
70 schema:name Cell Line, Tumor
71 rdf:type schema:DefinedTerm
72 N357db4817d824bc6b0f87292e47de9f7 schema:name dimensions_id
73 schema:value pub.1025959355
74 rdf:type schema:PropertyValue
75 N3b0e3f679fef41f8aaf585a3495ce4af schema:volumeNumber 29
76 rdf:type schema:PublicationVolume
77 N48be5d97cf384bfb90c1c4d811f0c59f rdf:first sg:person.01300660453.35
78 rdf:rest N9f011c6360374811a08557ac4e743c23
79 N4aaedc02dfc546dbbb80835f6d4addf4 rdf:first sg:person.01367254577.12
80 rdf:rest Na06e40d82990405a8e441971aa61a2c5
81 N4c1eeba3e86c46d5bb0e345b69f316fa schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
82 schema:name Precursor T-Cell Lymphoblastic Leukemia-Lymphoma
83 rdf:type schema:DefinedTerm
84 N542bc2edff93464babf2b43e3ea776de schema:name pubmed_id
85 schema:value 26108691
86 rdf:type schema:PropertyValue
87 N56a521568b9241b2a9c483125216e538 rdf:first sg:person.0636106235.47
88 rdf:rest N7fee807288bb4968aeeb845dc72bc1f7
89 N66782bb0e7c149498b929684d40a0449 rdf:first sg:person.01015363356.66
90 rdf:rest N48be5d97cf384bfb90c1c4d811f0c59f
91 N6bf6dbd3b03545be931532377d609236 rdf:first sg:person.0577037250.75
92 rdf:rest N9073f9a9c0fc4346b22a8920c9571164
93 N776d2fe735484cd0928cf49403f8bd5b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
94 schema:name Oncogenes
95 rdf:type schema:DefinedTerm
96 N7c27b30dc15941c79a72835d9c3c073b rdf:first sg:person.01204242653.58
97 rdf:rest N4aaedc02dfc546dbbb80835f6d4addf4
98 N7fee807288bb4968aeeb845dc72bc1f7 rdf:first sg:person.01210751306.08
99 rdf:rest N6bf6dbd3b03545be931532377d609236
100 N9073f9a9c0fc4346b22a8920c9571164 rdf:first sg:person.0756500604.32
101 rdf:rest N7c27b30dc15941c79a72835d9c3c073b
102 N94a3d197a1f1452799368ac55696eb43 rdf:first sg:person.01113574155.77
103 rdf:rest Ndae98984f5164cd49406b20e2af18adf
104 N969d568a0ec74c42bed9f9e3fea621f5 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
105 schema:name Receptor, Notch1
106 rdf:type schema:DefinedTerm
107 N98c78e4d34bc4aaa98e3986ff348bf30 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
108 schema:name Homeodomain Proteins
109 rdf:type schema:DefinedTerm
110 N9e67e1262b254560af51839429d62593 rdf:first sg:person.0777600754.06
111 rdf:rest Ndd5373a2a7aa4e6bbfb2205b1de7d62b
112 N9f011c6360374811a08557ac4e743c23 rdf:first sg:person.01102371165.51
113 rdf:rest rdf:nil
114 Na06e40d82990405a8e441971aa61a2c5 rdf:first sg:person.01155407542.97
115 rdf:rest N66782bb0e7c149498b929684d40a0449
116 Nc98d3db58cff4f33aa5b1292c65b89f8 schema:issueNumber 12
117 rdf:type schema:PublicationIssue
118 Nccdd9e44d95a434489c78af534fb8c48 schema:name readcube_id
119 schema:value 7baba17d7f8f36f69683d409927d2b8edb41617ef3ce661190d74cc0e3410310
120 rdf:type schema:PropertyValue
121 Nd488da2897b64989a19475099a063d77 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
122 schema:name Proto-Oncogene Proteins
123 rdf:type schema:DefinedTerm
124 Nd74dbe5c4d45423f97a126fcce973efd schema:name nlm_unique_id
125 schema:value 8704895
126 rdf:type schema:PropertyValue
127 Ndae98984f5164cd49406b20e2af18adf rdf:first sg:person.01021304126.61
128 rdf:rest Nf4422c1c12df4807a4384d62a2f6bbd7
129 Ndd5373a2a7aa4e6bbfb2205b1de7d62b rdf:first sg:person.01325177706.05
130 rdf:rest N94a3d197a1f1452799368ac55696eb43
131 Ndf292cf60a6d4417b7bfec145fedea70 schema:name doi
132 schema:value 10.1038/leu.2015.162
133 rdf:type schema:PropertyValue
134 Ne6e3f71a078940a99d969bdc95cfd121 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
135 schema:name Humans
136 rdf:type schema:DefinedTerm
137 Nf3a4a2935388461f9c0246db7e0a34dd schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
138 schema:name Chromatin Immunoprecipitation
139 rdf:type schema:DefinedTerm
140 Nf4422c1c12df4807a4384d62a2f6bbd7 rdf:first sg:person.01123177750.89
141 rdf:rest N56a521568b9241b2a9c483125216e538
142 anzsrc-for:06 schema:inDefinedTermSet anzsrc-for:
143 schema:name Biological Sciences
144 rdf:type schema:DefinedTerm
145 anzsrc-for:0604 schema:inDefinedTermSet anzsrc-for:
146 schema:name Genetics
147 rdf:type schema:DefinedTerm
148 sg:grant.3791439 http://pending.schema.org/fundedItem sg:pub.10.1038/leu.2015.162
149 rdf:type schema:MonetaryGrant
150 sg:grant.6948337 http://pending.schema.org/fundedItem sg:pub.10.1038/leu.2015.162
151 rdf:type schema:MonetaryGrant
152 sg:journal.1097065 schema:issn 0887-6924
153 1476-5551
154 schema:name Leukemia
155 rdf:type schema:Periodical
156 sg:person.01015363356.66 schema:affiliation https://www.grid.ac/institutes/grid.5342.0
157 schema:familyName Taghon
158 schema:givenName T
159 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01015363356.66
160 rdf:type schema:Person
161 sg:person.01021304126.61 schema:affiliation https://www.grid.ac/institutes/grid.5342.0
162 schema:familyName Van de Walle
163 schema:givenName I
164 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01021304126.61
165 rdf:type schema:Person
166 sg:person.01102371165.51 schema:affiliation https://www.grid.ac/institutes/grid.5342.0
167 schema:familyName Van Vlierberghe
168 schema:givenName P
169 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01102371165.51
170 rdf:type schema:Person
171 sg:person.01113574155.77 schema:affiliation https://www.grid.ac/institutes/grid.5342.0
172 schema:familyName Van der Meulen
173 schema:givenName J
174 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01113574155.77
175 rdf:type schema:Person
176 sg:person.01123177750.89 schema:affiliation https://www.grid.ac/institutes/grid.5342.0
177 schema:familyName Ongenaert
178 schema:givenName M
179 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01123177750.89
180 rdf:type schema:Person
181 sg:person.01155407542.97 schema:affiliation https://www.grid.ac/institutes/grid.413328.f
182 schema:familyName Soulier
183 schema:givenName J
184 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01155407542.97
185 rdf:type schema:Person
186 sg:person.01204242653.58 schema:affiliation https://www.grid.ac/institutes/grid.5342.0
187 schema:familyName Poppe
188 schema:givenName B
189 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01204242653.58
190 rdf:type schema:Person
191 sg:person.01210751306.08 schema:affiliation https://www.grid.ac/institutes/grid.5342.0
192 schema:familyName Wallaert
193 schema:givenName A
194 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01210751306.08
195 rdf:type schema:Person
196 sg:person.01300660453.35 schema:affiliation https://www.grid.ac/institutes/grid.5342.0
197 schema:familyName Speleman
198 schema:givenName F
199 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01300660453.35
200 rdf:type schema:Person
201 sg:person.01325177706.05 schema:affiliation https://www.grid.ac/institutes/grid.5342.0
202 schema:familyName Van Loocke
203 schema:givenName W
204 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01325177706.05
205 rdf:type schema:Person
206 sg:person.01367254577.12 schema:affiliation https://www.grid.ac/institutes/grid.5596.f
207 schema:familyName Cools
208 schema:givenName J
209 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01367254577.12
210 rdf:type schema:Person
211 sg:person.0577037250.75 schema:affiliation https://www.grid.ac/institutes/grid.5596.f
212 schema:familyName de Bock
213 schema:givenName C E
214 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0577037250.75
215 rdf:type schema:Person
216 sg:person.0636106235.47 schema:affiliation https://www.grid.ac/institutes/grid.5342.0
217 schema:familyName Rondou
218 schema:givenName P
219 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0636106235.47
220 rdf:type schema:Person
221 sg:person.0756500604.32 schema:affiliation https://www.grid.ac/institutes/grid.5342.0
222 schema:familyName Van Roy
223 schema:givenName N
224 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0756500604.32
225 rdf:type schema:Person
226 sg:person.0777600754.06 schema:affiliation https://www.grid.ac/institutes/grid.5342.0
227 schema:familyName Durinck
228 schema:givenName K
229 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0777600754.06
230 rdf:type schema:Person
231 sg:pub.10.1038/nature09504 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001851540
232 https://doi.org/10.1038/nature09504
233 rdf:type schema:CreativeWork
234 sg:pub.10.1038/nm.2246 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016716428
235 https://doi.org/10.1038/nm.2246
236 rdf:type schema:CreativeWork
237 sg:pub.10.1038/nm.2610 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009127126
238 https://doi.org/10.1038/nm.2610
239 rdf:type schema:CreativeWork
240 sg:pub.10.1038/nm.3665 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014690315
241 https://doi.org/10.1038/nm.3665
242 rdf:type schema:CreativeWork
243 sg:pub.10.1038/nprot.2006.98 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010562203
244 https://doi.org/10.1038/nprot.2006.98
245 rdf:type schema:CreativeWork
246 sg:pub.10.1186/gb-2009-10-3-r25 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049583368
247 https://doi.org/10.1186/gb-2009-10-3-r25
248 rdf:type schema:CreativeWork
249 https://app.dimensions.ai/details/publication/pub.1082559420 schema:CreativeWork
250 https://app.dimensions.ai/details/publication/pub.1083033962 schema:CreativeWork
251 https://doi.org/10.1002/0471250953.bi0214s34 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000488121
252 rdf:type schema:CreativeWork
253 https://doi.org/10.1016/j.ccr.2012.02.013 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035654327
254 rdf:type schema:CreativeWork
255 https://doi.org/10.1016/j.cell.2013.03.035 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005302017
256 rdf:type schema:CreativeWork
257 https://doi.org/10.1016/j.cell.2013.03.036 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017590275
258 rdf:type schema:CreativeWork
259 https://doi.org/10.1016/j.cell.2013.09.053 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011111923
260 rdf:type schema:CreativeWork
261 https://doi.org/10.1016/j.leukres.2009.06.003 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047196382
262 rdf:type schema:CreativeWork
263 https://doi.org/10.1016/j.molcel.2010.05.004 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012935976
264 rdf:type schema:CreativeWork
265 https://doi.org/10.1016/s0140-6736(04)15542-6 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051150833
266 rdf:type schema:CreativeWork
267 https://doi.org/10.1073/pnas.1109023108 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033771501
268 rdf:type schema:CreativeWork
269 https://doi.org/10.1073/pnas.1315023111 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000274750
270 rdf:type schema:CreativeWork
271 https://doi.org/10.1084/jem.20110105 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002796486
272 rdf:type schema:CreativeWork
273 https://doi.org/10.1084/jem.20121798 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047928247
274 rdf:type schema:CreativeWork
275 https://doi.org/10.1093/bioinformatics/btq033 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036892131
276 rdf:type schema:CreativeWork
277 https://doi.org/10.1093/bioinformatics/btr189 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008669948
278 rdf:type schema:CreativeWork
279 https://doi.org/10.1093/nar/gks915 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002477416
280 rdf:type schema:CreativeWork
281 https://doi.org/10.1111/j.1365-2141.2005.05850.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1043525301
282 rdf:type schema:CreativeWork
283 https://doi.org/10.1126/science.1102160 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033243130
284 rdf:type schema:CreativeWork
285 https://doi.org/10.1182/blood-2008-10-184069 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027730687
286 rdf:type schema:CreativeWork
287 https://doi.org/10.1182/blood-2010-06-290049 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047667845
288 rdf:type schema:CreativeWork
289 https://doi.org/10.1371/journal.pone.0016761 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010714563
290 rdf:type schema:CreativeWork
291 https://doi.org/10.3109/10428190009065824 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005345901
292 rdf:type schema:CreativeWork
293 https://doi.org/10.3324/haematol.2014.115683 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038173012
294 rdf:type schema:CreativeWork
295 https://www.grid.ac/institutes/grid.413328.f schema:alternateName Hôpital Saint-Louis
296 schema:name Genome Rearrangements and Cancer Laboratory, U944 INSERM, University Paris Diderot and Hematology Laboratory, Saint-Louis Hospital, Paris, France
297 rdf:type schema:Organization
298 https://www.grid.ac/institutes/grid.5342.0 schema:alternateName Ghent University
299 schema:name Center for Medical Genetics, Department of Pediatrics and Genetics, Ghent University, Ghent, Belgium
300 Department of Clinical Chemistry, Microbiology and Immunology, Ghent University, Ghent, Belgium
301 rdf:type schema:Organization
302 https://www.grid.ac/institutes/grid.5596.f schema:alternateName KU Leuven
303 schema:name Laboratory for the Molecular Biology of Leukemia, Center for Human Genetics, KU Leuven and Center for the Biology of Disease, VIB, Leuven, Belgium
304 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...