Long-term follow-up of imatinib in pediatric Philadelphia chromosome-positive acute lymphoblastic leukemia: Children's Oncology Group Study AALL0031 View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2014-07

AUTHORS

K R Schultz, A Carroll, N A Heerema, W P Bowman, A Aledo, W B Slayton, H Sather, M Devidas, H W Zheng, S M Davies, P S Gaynon, M Trigg, R Rutledge, D Jorstad, N Winick, M J Borowitz, S P Hunger, W L Carroll, B Camitta

ABSTRACT

We previously reported preliminary findings that post induction imatinib mesylate (340 mg/m(2)/day), in combination with intensive chemotherapy, resulted in outcomes similar to blood and marrow transplant (BMT) for pediatric patients with Philadelphia chromosome-positive (Ph+) acute lymphoblastic leukemia (ALL). We now report 5-year outcomes of imatinib plus intensive chemotherapy in 91 children (1-21 years) with and without allogeneic BMT (N=91). We explore the impacts of additional chromosomal abnormalities and minimal residual disease (MRD) by flow cytometry on outcomes. The 5-year disease-free survival was similar for Cohort 5 patients, treated with chemotherapy plus imatinib (70%±12%, n=28), sibling donor BMT patients (65%±11%, n=21) and unrelated donor BMT patients (59±15%; P=0.60, n=13). Patients with additional cytogenetic abnormalities had worse outcomes (P=0.05). End induction (pre-imatinib) MRD was not prognostic for Cohort 5 or allogeneic BMT patients, although limited by small numbers. The re-induction rate following relapse was similar to other higher-risk ALL groups. Longer-term follow-up confirms our initial observation of substantially good outcomes for children and adolescents with Ph+ ALL treated with imatinib plus intensive chemotherapy with no advantage for allogeneic BMT. More... »

PAGES

1467

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/leu.2014.30

DOI

http://dx.doi.org/10.1038/leu.2014.30

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1008558028

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/24441288


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