MYD88 L265P is a marker highly characteristic of, but not restricted to, Waldenström’s macroglobulinemia View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2013-08

AUTHORS

C Jiménez, E Sebastián, M C Chillón, P Giraldo, J Mariano Hernández, F Escalante, T J González-López, C Aguilera, A G de Coca, I Murillo, M Alcoceba, A Balanzategui, M E Sarasquete, R Corral, L A Marín, B Paiva, E M Ocio, N C Gutiérrez, M González, J F San Miguel, R García-Sanz

ABSTRACT

We evaluated the MYD88 L265P mutation in Waldenström's macroglobulinemia (WM) and B-cell lymphoproliferative disorders by specific polymerase chain reaction (PCR) (sensitivity ∼10(-3)). No mutation was seen in normal donors, while it was present in 101/117 (86%) WM patients, 27/31 (87%) IgM monoclonal gammapathies of uncertain significance (MGUS), 3/14 (21%) splenic marginal zone lymphomas and 9/48 (19%) non-germinal center (GC) diffuse large B-cell lymphomas (DLBCLs). The mutation was absent in all 28 GC-DLBCLs, 13 DLBCLs not subclassified, 35 hairy cell leukemias, 39 chronic lymphocytic leukemias (16 with M-component), 25 IgA or IgG-MGUS, 24 multiple myeloma (3 with an IgM isotype), 6 amyloidosis, 9 lymphoplasmacytic lymphomas and 1 IgM-related neuropathy. Among WM and IgM-MGUS, MYD88 L265P mutation was associated with some differences in clinical and biological characteristics, although usually minor; wild-type MYD88 cases had smaller M-component (1.77 vs 2.72 g/dl, P=0.022), more lymphocytosis (24 vs 5%, P=0.006), higher lactate dehydrogenase level (371 vs 265 UI/L, P=0.002), atypical immunophenotype (CD23-CD27+ +FMC7+ +), less Immunoglobulin Heavy Chain Variable gene (IGHV) somatic hypermutation (57 vs 97%, P=0.012) and less IGHV3-23 gene selection (9 vs 27%, P=0.014). These small differences did not lead to different time to first therapy, response to treatment or progression-free or overall survival. More... »

PAGES

1722

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/leu.2013.62

DOI

http://dx.doi.org/10.1038/leu.2013.62

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1023243054

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/23446312


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