MicroRNA expression at diagnosis adds relevant prognostic information to molecular categorization in patients with intermediate-risk cytogenetic acute myeloid leukemia View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2014-04

AUTHORS

M Díaz-Beyá, S Brunet, J Nomdedéu, R Tejero, T Díaz, M Pratcorona, M Tormo, J M Ribera, L Escoda, R Duarte, D Gallardo, I Heras, M P Queipo de Llano, J Bargay, M Monzo, J Sierra, A Navarro, J Esteve

ABSTRACT

Acute myeloid leukemia (AML) is a heterogeneous disease, and optimal treatment varies according to cytogenetic risk factors and molecular markers. Several studies have demonstrated the prognostic importance of microRNAs (miRNAs) in AML. Here we report a potential association between miRNA expression and clinical outcome in 238 intermediate-risk cytogenetic AML (IR-AML) patients from 16 institutions in the CETLAM cooperative group. We first profiled 670 miRNAs in a subset of 85 IR-AML patients from a single institution and identified 10 outcome-related miRNAs. We then validated these 10 miRNAs by individual assays in the total cohort and confirmed the prognostic impact of 4 miRNAs. High levels of miR-196b and miR-644 were independently associated with shorter overall survival, and low levels of miR-135a and miR-409-3p with a higher risk of relapse. Interestingly, miR-135a and miR-409-3p maintained their independent prognostic value within the unfavorable molecular subcategory (wild-type NPM1 and CEBPA and/or FLT3-ITD), and miR-644 retained its value within the favorable molecular subcategory. miR-409-3p, miR-135a, miR-196b and mir-644 arose as prognostic markers for IR-AML, both overall and within specific molecular subgroups. More... »

PAGES

804

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  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/leu.2013.281

    DOI

    http://dx.doi.org/10.1038/leu.2013.281

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1012271907

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/24072101


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