Ontology type: schema:ScholarlyArticle
2013-03-29
AUTHORSS Geyh, S Öz, R-P Cadeddu, J Fröbel, B Brückner, A Kündgen, R Fenk, I Bruns, C Zilkens, D Hermsen, N Gattermann, G Kobbe, U Germing, F Lyko, R Haas, T Schroeder
ABSTRACTIneffective hematopoiesis is a major characteristic of myelodysplastic syndromes (MDS) causing relevant morbidity and mortality. Mesenchymal stromal cells (MSC) have been shown to physiologically support hematopoiesis, but their contribution to the pathogenesis of MDS remains elusive. We show that MSC from patients across all MDS subtypes (n=106) exhibit significantly reduced growth and proliferative capacities accompanied by premature replicative senescence. Osteogenic differentiation was significantly reduced in MDS-derived MSC, indicated by cytochemical stainings and reduced expressions of Osterix and Osteocalcin. This was associated with specific methylation patterns that clearly separated MDS–MSC from healthy controls and showed a strong enrichment for biological processes associated with cellular phenotypes and transcriptional regulation. Furthermore, in MDS–MSC, we detected altered expression of key molecules involved in the interaction with hematopoietic stem and progenitor cells (HSPC), in particular Osteopontin, Jagged1, Kit-ligand and Angiopoietin as well as several chemokines. Functionally, this translated into a significantly diminished ability of MDS-derived MSC to support CD34+ HSPC in long-term culture-initiating cell assays associated with a reduced cell cycle activity. Taken together, our comprehensive analysis shows that MSC from all MDS subtypes are structurally, epigenetically and functionally altered, which leads to impaired stromal support and seems to contribute to deficient hematopoiesis in MDS. More... »
PAGES1841-1851
http://scigraph.springernature.com/pub.10.1038/leu.2013.193
DOIhttp://dx.doi.org/10.1038/leu.2013.193
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PUBMEDhttps://www.ncbi.nlm.nih.gov/pubmed/23797473
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"type": "ScholarlyArticle",
"url": "https://doi.org/10.1038/leu.2013.193"
}
]Download the RDF metadata as: json-ld nt turtle xml License info
JSON-LD is a popular format for linked data which is fully compatible with JSON.
curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/leu.2013.193'
N-Triples is a line-based linked data format ideal for batch operations.
curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/leu.2013.193'
Turtle is a human-readable linked data format.
curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/leu.2013.193'
RDF/XML is a standard XML format for linked data.
curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/leu.2013.193'
This table displays all metadata directly associated to this object as RDF triples.
407 TRIPLES
21 PREDICATES
140 URIs
116 LITERALS
28 BLANK NODES