Ontology type: schema:ScholarlyArticle
2012-02-06
AUTHORSA Vilas-Zornoza, X Agirre, G Abizanda, C Moreno, V Segura, A De Martino Rodriguez, E S José-Eneriz, E Miranda, J I Martín-Subero, L Garate, M J Blanco-Prieto, J A García de Jalón, P Rio, J Rifón, J C Cigudosa, J A Martinez-Climent, J Román-Gómez, M J Calasanz, J M Ribera, F Prósper
ABSTRACTHistone deacetylases (HDACs) have been identified as therapeutic targets due to their regulatory function in chromatin structure and organization. Here, we analyzed the therapeutic effect of LBH589, a class I–II HDAC inhibitor, in acute lymphoblastic leukemia (ALL). In vitro, LBH589 induced dose-dependent antiproliferative and apoptotic effects, which were associated with increased H3 and H4 histone acetylation. Intravenous administration of LBH589 in immunodeficient BALB/c-RAG2−/−γc−/− mice in which human-derived T and B-ALL cell lines were injected induced a significant reduction in tumor growth. Using primary ALL cells, a xenograft model of human leukemia in BALB/c-RAG2−/−γc−/− mice was established, allowing continuous passages of transplanted cells to several mouse generations. Treatment of mice engrafted with T or B-ALL cells with LBH589 induced an in vivo increase in the acetylation of H3 and H4, which was accompanied with prolonged survival of LBH589-treated mice in comparison with those receiving vincristine and dexamethasone. Notably, the therapeutic efficacy of LBH589 was significantly enhanced in combination with vincristine and dexamethasone. Our results show the therapeutic activity of LBH589 in combination with standard chemotherapy in pre-clinical models of ALL and suggest that this combination may be of clinical value in the treatment of patients with ALL. More... »
PAGES1517-1526
http://scigraph.springernature.com/pub.10.1038/leu.2012.31
DOIhttp://dx.doi.org/10.1038/leu.2012.31
DIMENSIONShttps://app.dimensions.ai/details/publication/pub.1031162923
PUBMEDhttps://www.ncbi.nlm.nih.gov/pubmed/22307227
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]Download the RDF metadata as: json-ld nt turtle xml License info
JSON-LD is a popular format for linked data which is fully compatible with JSON.
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curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/leu.2012.31'
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This table displays all metadata directly associated to this object as RDF triples.
449 TRIPLES
22 PREDICATES
133 URIs
117 LITERALS
38 BLANK NODES