Preclinical activity of LBH589 alone or in combination with chemotherapy in a xenogeneic mouse model of human acute lymphoblastic leukemia View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2012-02-06

AUTHORS

A Vilas-Zornoza, X Agirre, G Abizanda, C Moreno, V Segura, A De Martino Rodriguez, E S José-Eneriz, E Miranda, J I Martín-Subero, L Garate, M J Blanco-Prieto, J A García de Jalón, P Rio, J Rifón, J C Cigudosa, J A Martinez-Climent, J Román-Gómez, M J Calasanz, J M Ribera, F Prósper

ABSTRACT

Histone deacetylases (HDACs) have been identified as therapeutic targets due to their regulatory function in chromatin structure and organization. Here, we analyzed the therapeutic effect of LBH589, a class I–II HDAC inhibitor, in acute lymphoblastic leukemia (ALL). In vitro, LBH589 induced dose-dependent antiproliferative and apoptotic effects, which were associated with increased H3 and H4 histone acetylation. Intravenous administration of LBH589 in immunodeficient BALB/c-RAG2−/−γc−/− mice in which human-derived T and B-ALL cell lines were injected induced a significant reduction in tumor growth. Using primary ALL cells, a xenograft model of human leukemia in BALB/c-RAG2−/−γc−/− mice was established, allowing continuous passages of transplanted cells to several mouse generations. Treatment of mice engrafted with T or B-ALL cells with LBH589 induced an in vivo increase in the acetylation of H3 and H4, which was accompanied with prolonged survival of LBH589-treated mice in comparison with those receiving vincristine and dexamethasone. Notably, the therapeutic efficacy of LBH589 was significantly enhanced in combination with vincristine and dexamethasone. Our results show the therapeutic activity of LBH589 in combination with standard chemotherapy in pre-clinical models of ALL and suggest that this combination may be of clinical value in the treatment of patients with ALL. More... »

PAGES

1517-1526

Journal

TITLE

Leukemia

ISSUE

7

VOLUME

26

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/leu.2012.31

DOI

http://dx.doi.org/10.1038/leu.2012.31

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1031162923

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/22307227


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1112", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Oncology and Carcinogenesis", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Animals", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Antineoplastic Agents, Hormonal", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Antineoplastic Agents, Phytogenic", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Antineoplastic Combined Chemotherapy Protocols", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Apoptosis", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Biomarkers, Tumor", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cell Proliferation", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "DNA Methylation", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "DNA-Binding Proteins", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Dexamethasone", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Drug Synergism", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Female", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Gene Expression Profiling", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Histone Deacetylase Inhibitors", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Histones", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Hydroxamic Acids", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Immunoenzyme Techniques", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Indoles", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Mice", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Mice, Inbred BALB C", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Oligonucleotide Array Sequence Analysis", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Panobinostat", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Polymorphism, Single Nucleotide", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Precursor Cell Lymphoblastic Leukemia-Lymphoma", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "RNA, Messenger", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Real-Time Polymerase Chain Reaction", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Reverse Transcriptase Polymerase Chain Reaction", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Tumor Cells, Cultured", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Vincristine", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Xenograft Model Antitumor Assays", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Oncology Division, University of Navarra, Pamplona, Spain", 
          "id": "http://www.grid.ac/institutes/grid.5924.a", 
          "name": [
            "Oncology Division, University of Navarra, Pamplona, Spain"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Vilas-Zornoza", 
        "givenName": "A", 
        "id": "sg:person.01116545321.47", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01116545321.47"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Oncology Division, University of Navarra, Pamplona, Spain", 
          "id": "http://www.grid.ac/institutes/grid.5924.a", 
          "name": [
            "Oncology Division, University of Navarra, Pamplona, Spain"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Agirre", 
        "givenName": "X", 
        "id": "sg:person.01227065733.32", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01227065733.32"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Hematology Service, Cl\u00ednica Universidad de Navarra, University of Navarra, Pamplona, Spain", 
          "id": "http://www.grid.ac/institutes/grid.411730.0", 
          "name": [
            "Oncology Division, University of Navarra, Pamplona, Spain", 
            "Hematology Service, Cl\u00ednica Universidad de Navarra, University of Navarra, Pamplona, Spain"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Abizanda", 
        "givenName": "G", 
        "id": "sg:person.01222134213.65", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01222134213.65"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Immunology, University of Navarra, Pamplona, Spain", 
          "id": "http://www.grid.ac/institutes/grid.5924.a", 
          "name": [
            "Department of Immunology, University of Navarra, Pamplona, Spain"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Moreno", 
        "givenName": "C", 
        "id": "sg:person.01073523227.06", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01073523227.06"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Bioinformatics, Foundation for Applied Medical Research, University of Navarra, Pamplona, Spain", 
          "id": "http://www.grid.ac/institutes/grid.5924.a", 
          "name": [
            "Department of Bioinformatics, Foundation for Applied Medical Research, University of Navarra, Pamplona, Spain"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Segura", 
        "givenName": "V", 
        "id": "sg:person.01331442402.34", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01331442402.34"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Animal Pathology, Veterinary Faculty, University of Zaragoza, Zaragoza, Spain", 
          "id": "http://www.grid.ac/institutes/grid.11205.37", 
          "name": [
            "Department of Animal Pathology, Veterinary Faculty, University of Zaragoza, Zaragoza, Spain"
          ], 
          "type": "Organization"
        }, 
        "familyName": "De Martino Rodriguez", 
        "givenName": "A", 
        "id": "sg:person.01340233403.80", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01340233403.80"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Oncology Division, University of Navarra, Pamplona, Spain", 
          "id": "http://www.grid.ac/institutes/grid.5924.a", 
          "name": [
            "Oncology Division, University of Navarra, Pamplona, Spain"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Jos\u00e9-Eneriz", 
        "givenName": "E S", 
        "id": "sg:person.0674571673.35", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0674571673.35"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Oncology Division, University of Navarra, Pamplona, Spain", 
          "id": "http://www.grid.ac/institutes/grid.5924.a", 
          "name": [
            "Oncology Division, University of Navarra, Pamplona, Spain"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Miranda", 
        "givenName": "E", 
        "id": "sg:person.01026574627.20", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01026574627.20"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Anatomic Pathology, Pharmacology and Microbiology, University of Barcelona, Barcelona, Spain", 
          "id": "http://www.grid.ac/institutes/grid.5841.8", 
          "name": [
            "Department of Anatomic Pathology, Pharmacology and Microbiology, University of Barcelona, Barcelona, Spain"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Mart\u00edn-Subero", 
        "givenName": "J I", 
        "id": "sg:person.01372655533.68", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01372655533.68"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Oncology Division, University of Navarra, Pamplona, Spain", 
          "id": "http://www.grid.ac/institutes/grid.5924.a", 
          "name": [
            "Oncology Division, University of Navarra, Pamplona, Spain"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Garate", 
        "givenName": "L", 
        "id": "sg:person.0617710233.44", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0617710233.44"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Pharmacy and Pharmaceutical Technology, School of Pharmacy, University of Navarra, Pamplona, Spain", 
          "id": "http://www.grid.ac/institutes/grid.5924.a", 
          "name": [
            "Department of Pharmacy and Pharmaceutical Technology, School of Pharmacy, University of Navarra, Pamplona, Spain"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Blanco-Prieto", 
        "givenName": "M J", 
        "id": "sg:person.01130507471.65", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01130507471.65"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Animal Pathology, Veterinary Faculty, University of Zaragoza, Zaragoza, Spain", 
          "id": "http://www.grid.ac/institutes/grid.11205.37", 
          "name": [
            "Department of Animal Pathology, Veterinary Faculty, University of Zaragoza, Zaragoza, Spain"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Garc\u00eda de Jal\u00f3n", 
        "givenName": "J A", 
        "id": "sg:person.01354555417.62", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01354555417.62"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Centro de Investigaciones Energ\u00e9ticas, Medioambientales y Tecnol\u00f3gicas (CIEMAT), Madrid, Spain", 
          "id": "http://www.grid.ac/institutes/grid.420019.e", 
          "name": [
            "Centro de Investigaciones Energ\u00e9ticas, Medioambientales y Tecnol\u00f3gicas (CIEMAT), Madrid, Spain"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Rio", 
        "givenName": "P", 
        "id": "sg:person.01003416220.09", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01003416220.09"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Hematology Service, Cl\u00ednica Universidad de Navarra, University of Navarra, Pamplona, Spain", 
          "id": "http://www.grid.ac/institutes/grid.411730.0", 
          "name": [
            "Hematology Service, Cl\u00ednica Universidad de Navarra, University of Navarra, Pamplona, Spain"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Rif\u00f3n", 
        "givenName": "J", 
        "id": "sg:person.01320212377.00", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01320212377.00"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Molecular Cytogenetics Group, Centro Nacional Investigaciones Oncol\u00f3gicas (CNIO), Madrid, Spain", 
          "id": "http://www.grid.ac/institutes/grid.7719.8", 
          "name": [
            "Molecular Cytogenetics Group, Centro Nacional Investigaciones Oncol\u00f3gicas (CNIO), Madrid, Spain"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Cigudosa", 
        "givenName": "J C", 
        "id": "sg:person.01246512175.01", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01246512175.01"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Oncology Division, University of Navarra, Pamplona, Spain", 
          "id": "http://www.grid.ac/institutes/grid.5924.a", 
          "name": [
            "Oncology Division, University of Navarra, Pamplona, Spain"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Martinez-Climent", 
        "givenName": "J A", 
        "id": "sg:person.014626267654.79", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.014626267654.79"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Hematology Department, Reina Sofia Hospital, Maimonides Institute for Biomedical Research, Cordoba, Spain", 
          "id": "http://www.grid.ac/institutes/grid.411349.a", 
          "name": [
            "Hematology Department, Reina Sofia Hospital, Maimonides Institute for Biomedical Research, Cordoba, Spain"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Rom\u00e1n-G\u00f3mez", 
        "givenName": "J", 
        "id": "sg:person.01072006063.32", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01072006063.32"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Genetics, University of Navarra, Pamplona, Spain", 
          "id": "http://www.grid.ac/institutes/grid.5924.a", 
          "name": [
            "Department of Genetics, University of Navarra, Pamplona, Spain"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Calasanz", 
        "givenName": "M J", 
        "id": "sg:person.011262623704.18", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011262623704.18"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Hematology Service, Institut Catal\u00e0 d'Oncologia, Hospital Universitari Germans Trias i Pujol, Universitat Aut\u00f2noma de Barcelona, Badalona, Barcelona, Spain", 
          "id": "http://www.grid.ac/institutes/grid.7080.f", 
          "name": [
            "Hematology Service, Institut Catal\u00e0 d'Oncologia, Hospital Universitari Germans Trias i Pujol, Universitat Aut\u00f2noma de Barcelona, Badalona, Barcelona, Spain"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Ribera", 
        "givenName": "J M", 
        "id": "sg:person.01054600404.53", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01054600404.53"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Hematology Service, Cl\u00ednica Universidad de Navarra, University of Navarra, Pamplona, Spain", 
          "id": "http://www.grid.ac/institutes/grid.411730.0", 
          "name": [
            "Oncology Division, University of Navarra, Pamplona, Spain", 
            "Hematology Service, Cl\u00ednica Universidad de Navarra, University of Navarra, Pamplona, Spain"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Pr\u00f3sper", 
        "givenName": "F", 
        "id": "sg:person.01262144070.75", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01262144070.75"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "sg:pub.10.1038/leu.2008.130", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1036246806", 
          "https://doi.org/10.1038/leu.2008.130"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/leu.2009.58", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1052059551", 
          "https://doi.org/10.1038/leu.2009.58"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/1755-8794-2-67", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1025134642", 
          "https://doi.org/10.1186/1755-8794-2-67"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.leu.2404173", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1036796846", 
          "https://doi.org/10.1038/sj.leu.2404173"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nm.1900", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1031341478", 
          "https://doi.org/10.1038/nm.1900"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.onc.1209236", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1042872905", 
          "https://doi.org/10.1038/sj.onc.1209236"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.leu.2404282", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1048643499", 
          "https://doi.org/10.1038/sj.leu.2404282"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/cdd.2009.188", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1034956032", 
          "https://doi.org/10.1038/cdd.2009.188"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2012-02-06", 
    "datePublishedReg": "2012-02-06", 
    "description": "Histone deacetylases (HDACs) have been identified as therapeutic targets due to their regulatory function in chromatin structure and organization. Here, we analyzed the therapeutic effect of LBH589, a class I\u2013II HDAC inhibitor, in acute lymphoblastic leukemia (ALL). In vitro, LBH589 induced dose-dependent antiproliferative and apoptotic effects, which were associated with increased H3 and H4 histone acetylation. Intravenous administration of LBH589 in immunodeficient BALB/c-RAG2\u2212/\u2212\u03b3c\u2212/\u2212 mice in which human-derived T and B-ALL cell lines were injected induced a significant reduction in tumor growth. Using primary ALL cells, a xenograft model of human leukemia in BALB/c-RAG2\u2212/\u2212\u03b3c\u2212/\u2212 mice was established, allowing continuous passages of transplanted cells to several mouse generations. Treatment of mice engrafted with T or B-ALL cells with LBH589 induced an in vivo increase in the acetylation of H3 and H4, which was accompanied with prolonged survival of LBH589-treated mice in comparison with those receiving vincristine and dexamethasone. Notably, the therapeutic efficacy of LBH589 was significantly enhanced in combination with vincristine and dexamethasone. Our results show the therapeutic activity of LBH589 in combination with standard chemotherapy in pre-clinical models of ALL and suggest that this combination may be of clinical value in the treatment of patients with ALL.", 
    "genre": "article", 
    "id": "sg:pub.10.1038/leu.2012.31", 
    "inLanguage": "en", 
    "isAccessibleForFree": false, 
    "isPartOf": [
      {
        "id": "sg:journal.1097065", 
        "issn": [
          "0887-6924", 
          "1476-5551"
        ], 
        "name": "Leukemia", 
        "publisher": "Springer Nature", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "7", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "26"
      }
    ], 
    "keywords": [
      "acute lymphoblastic leukemia", 
      "BALB/c", 
      "lymphoblastic leukemia", 
      "immunodeficient BALB/c", 
      "human acute lymphoblastic leukemia", 
      "Treatment of mice", 
      "treatment of patients", 
      "pre-clinical models", 
      "xenogeneic mouse model", 
      "standard chemotherapy", 
      "H4 histone acetylation", 
      "preclinical activity", 
      "therapeutic effect", 
      "intravenous administration", 
      "clinical value", 
      "mouse model", 
      "xenograft model", 
      "therapeutic target", 
      "therapeutic efficacy", 
      "LBH589", 
      "tumor growth", 
      "HDAC inhibitors", 
      "therapeutic activity", 
      "vivo increase", 
      "class I", 
      "mice", 
      "leukemia", 
      "apoptotic effects", 
      "chemotherapy", 
      "human leukemia", 
      "cell lines", 
      "significant reduction", 
      "dexamethasone", 
      "acetylation of H3", 
      "histone acetylation", 
      "treatment", 
      "cells", 
      "continuous passage", 
      "mouse generation", 
      "regulatory functions", 
      "patients", 
      "vincristine", 
      "administration", 
      "efficacy", 
      "survival", 
      "acetylation", 
      "inhibitors", 
      "activity", 
      "combination", 
      "effect", 
      "target", 
      "increase", 
      "reduction", 
      "H3", 
      "function", 
      "histones", 
      "H4", 
      "lines", 
      "passage", 
      "model", 
      "comparison", 
      "results", 
      "growth", 
      "values", 
      "chromatin structure", 
      "organization", 
      "generation", 
      "structure"
    ], 
    "name": "Preclinical activity of LBH589 alone or in combination with chemotherapy in a xenogeneic mouse model of human acute lymphoblastic leukemia", 
    "pagination": "1517-1526", 
    "productId": [
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1031162923"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1038/leu.2012.31"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "22307227"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1038/leu.2012.31", 
      "https://app.dimensions.ai/details/publication/pub.1031162923"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2022-05-20T07:27", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-springernature-scigraph/baseset/20220519/entities/gbq_results/article/article_558.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://doi.org/10.1038/leu.2012.31"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/leu.2012.31'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/leu.2012.31'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/leu.2012.31'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/leu.2012.31'


 

This table displays all metadata directly associated to this object as RDF triples.

449 TRIPLES      22 PREDICATES      133 URIs      117 LITERALS      38 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1038/leu.2012.31 schema:about N01e20aacfa1246f3a48074405975f02d
2 N0259d36d249a4d20aaf4295504176e18
3 N0b6104c83e924b66985966683004ad0c
4 N0d745018895a42e5bc02b50b5205e271
5 N20816427f67940ed926474ee6aa6d300
6 N34493486ec304c319cb4bf22f5c6410d
7 N44bcbde0152b4c478f9a7106034905e5
8 N48634e8e58f5429c8fb8a859d04c1ec1
9 N59473eb45f96465db44d73165347999f
10 N650d80cfb1e644c6af88cf01956a0065
11 N6e9ce4009feb4a3d8c0656d801799d7c
12 N72d19b3cf46d440ab1c3a9c27b5dce9a
13 N8ac6c22691b4473e8f4f0b6110690e63
14 N8ca3824dd63d444b9e1d551deb9f97c3
15 N9a18e20db6694af88ffea5cfaba97ed0
16 N9b3d4b7c11d948c39836ddad1a4c0be2
17 N9e591e0ad71d4d30baa5dbd0784ec721
18 Nb1d8e102ad88482c85200f7ef36e9623
19 Nb77aa7632b78493490b5754db965b8ba
20 Nbd93201d90eb4bce95294475a0ab8a08
21 Nbfa33b2cdd514a368e47825c6b5e2d09
22 Nc3c5d126f0e4495c921ba6a1a041acfc
23 Nc48352038ac8419a90ea4f15b6096a26
24 Ncb6c130bb8404a69b05c45a7b559b239
25 Nd5a167db8cb04c46a5c6128fcd363ca1
26 Ne4f695844236425cbe38da1f0bf5d3d8
27 Neee56d19a23a4b9fad6912fc3b0c2373
28 Nf425df67546f42f68e45086c008047a2
29 Nf57e238fafa54686aa0a3847b4bf3fe8
30 Nf6c253de12254ff69d2532f5d30e22cb
31 Nf802104236f042268a9ed8b0ad90e620
32 anzsrc-for:11
33 anzsrc-for:1112
34 schema:author N9a0005baa5dd47f98505b57c38b45168
35 schema:citation sg:pub.10.1038/cdd.2009.188
36 sg:pub.10.1038/leu.2008.130
37 sg:pub.10.1038/leu.2009.58
38 sg:pub.10.1038/nm.1900
39 sg:pub.10.1038/sj.leu.2404173
40 sg:pub.10.1038/sj.leu.2404282
41 sg:pub.10.1038/sj.onc.1209236
42 sg:pub.10.1186/1755-8794-2-67
43 schema:datePublished 2012-02-06
44 schema:datePublishedReg 2012-02-06
45 schema:description Histone deacetylases (HDACs) have been identified as therapeutic targets due to their regulatory function in chromatin structure and organization. Here, we analyzed the therapeutic effect of LBH589, a class I–II HDAC inhibitor, in acute lymphoblastic leukemia (ALL). In vitro, LBH589 induced dose-dependent antiproliferative and apoptotic effects, which were associated with increased H3 and H4 histone acetylation. Intravenous administration of LBH589 in immunodeficient BALB/c-RAG2−/−γc−/− mice in which human-derived T and B-ALL cell lines were injected induced a significant reduction in tumor growth. Using primary ALL cells, a xenograft model of human leukemia in BALB/c-RAG2−/−γc−/− mice was established, allowing continuous passages of transplanted cells to several mouse generations. Treatment of mice engrafted with T or B-ALL cells with LBH589 induced an in vivo increase in the acetylation of H3 and H4, which was accompanied with prolonged survival of LBH589-treated mice in comparison with those receiving vincristine and dexamethasone. Notably, the therapeutic efficacy of LBH589 was significantly enhanced in combination with vincristine and dexamethasone. Our results show the therapeutic activity of LBH589 in combination with standard chemotherapy in pre-clinical models of ALL and suggest that this combination may be of clinical value in the treatment of patients with ALL.
46 schema:genre article
47 schema:inLanguage en
48 schema:isAccessibleForFree false
49 schema:isPartOf N53f6126e2e9d4d74a6d3ba8b5de240d0
50 Na3afdf5f257b45c989e18fea4b37dbe7
51 sg:journal.1097065
52 schema:keywords BALB/c
53 H3
54 H4
55 H4 histone acetylation
56 HDAC inhibitors
57 LBH589
58 Treatment of mice
59 acetylation
60 acetylation of H3
61 activity
62 acute lymphoblastic leukemia
63 administration
64 apoptotic effects
65 cell lines
66 cells
67 chemotherapy
68 chromatin structure
69 class I
70 clinical value
71 combination
72 comparison
73 continuous passage
74 dexamethasone
75 effect
76 efficacy
77 function
78 generation
79 growth
80 histone acetylation
81 histones
82 human acute lymphoblastic leukemia
83 human leukemia
84 immunodeficient BALB/c
85 increase
86 inhibitors
87 intravenous administration
88 leukemia
89 lines
90 lymphoblastic leukemia
91 mice
92 model
93 mouse generation
94 mouse model
95 organization
96 passage
97 patients
98 pre-clinical models
99 preclinical activity
100 reduction
101 regulatory functions
102 results
103 significant reduction
104 standard chemotherapy
105 structure
106 survival
107 target
108 therapeutic activity
109 therapeutic effect
110 therapeutic efficacy
111 therapeutic target
112 treatment
113 treatment of patients
114 tumor growth
115 values
116 vincristine
117 vivo increase
118 xenogeneic mouse model
119 xenograft model
120 schema:name Preclinical activity of LBH589 alone or in combination with chemotherapy in a xenogeneic mouse model of human acute lymphoblastic leukemia
121 schema:pagination 1517-1526
122 schema:productId N10ebc93a6d644e82ae03906fe27d9a71
123 Nb6f520972f1d440ea33dd5afd749eabe
124 Nf92c40f32d3f486ab16c6a8c372d2566
125 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031162923
126 https://doi.org/10.1038/leu.2012.31
127 schema:sdDatePublished 2022-05-20T07:27
128 schema:sdLicense https://scigraph.springernature.com/explorer/license/
129 schema:sdPublisher N7a64e6b0a44b46efa3fb57ecd865708b
130 schema:url https://doi.org/10.1038/leu.2012.31
131 sgo:license sg:explorer/license/
132 sgo:sdDataset articles
133 rdf:type schema:ScholarlyArticle
134 N01e20aacfa1246f3a48074405975f02d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
135 schema:name Oligonucleotide Array Sequence Analysis
136 rdf:type schema:DefinedTerm
137 N0259d36d249a4d20aaf4295504176e18 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
138 schema:name Cell Proliferation
139 rdf:type schema:DefinedTerm
140 N05adf31f306e4a9cbd019781a5d1799a rdf:first sg:person.01054600404.53
141 rdf:rest Nd079dcd96558480486a01b12e8cf7dca
142 N0b6104c83e924b66985966683004ad0c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
143 schema:name Panobinostat
144 rdf:type schema:DefinedTerm
145 N0d745018895a42e5bc02b50b5205e271 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
146 schema:name Indoles
147 rdf:type schema:DefinedTerm
148 N0dab6340a4a041c496e4a344a9637e3d rdf:first sg:person.01354555417.62
149 rdf:rest N18b61cc48cd94d54816a39af7560199f
150 N10ebc93a6d644e82ae03906fe27d9a71 schema:name pubmed_id
151 schema:value 22307227
152 rdf:type schema:PropertyValue
153 N18b61cc48cd94d54816a39af7560199f rdf:first sg:person.01003416220.09
154 rdf:rest N80d0d0a45b144345a49f609f95a53310
155 N20816427f67940ed926474ee6aa6d300 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
156 schema:name Mice, Inbred BALB C
157 rdf:type schema:DefinedTerm
158 N34493486ec304c319cb4bf22f5c6410d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
159 schema:name Apoptosis
160 rdf:type schema:DefinedTerm
161 N39d63f1c0dbd4f489528f4365ca10c41 rdf:first sg:person.01072006063.32
162 rdf:rest N95c6895aa57148dea067398a5dbecff1
163 N3ad3333130684379b12032203ecad6b2 rdf:first sg:person.01073523227.06
164 rdf:rest Nb8f258e3875d4c92871b89cb27b16a85
165 N44bcbde0152b4c478f9a7106034905e5 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
166 schema:name Tumor Cells, Cultured
167 rdf:type schema:DefinedTerm
168 N4787f46c31a8478194598bae00733fe6 rdf:first sg:person.01227065733.32
169 rdf:rest Nc31538a29bcf47e4ae1d1c614c535ded
170 N48634e8e58f5429c8fb8a859d04c1ec1 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
171 schema:name Gene Expression Profiling
172 rdf:type schema:DefinedTerm
173 N53f6126e2e9d4d74a6d3ba8b5de240d0 schema:issueNumber 7
174 rdf:type schema:PublicationIssue
175 N59473eb45f96465db44d73165347999f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
176 schema:name Real-Time Polymerase Chain Reaction
177 rdf:type schema:DefinedTerm
178 N603faff35fd845af97b4bbcb6590a1b7 rdf:first sg:person.014626267654.79
179 rdf:rest N39d63f1c0dbd4f489528f4365ca10c41
180 N650d80cfb1e644c6af88cf01956a0065 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
181 schema:name Drug Synergism
182 rdf:type schema:DefinedTerm
183 N6e9ce4009feb4a3d8c0656d801799d7c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
184 schema:name Humans
185 rdf:type schema:DefinedTerm
186 N72d19b3cf46d440ab1c3a9c27b5dce9a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
187 schema:name Mice
188 rdf:type schema:DefinedTerm
189 N7a64e6b0a44b46efa3fb57ecd865708b schema:name Springer Nature - SN SciGraph project
190 rdf:type schema:Organization
191 N80d0d0a45b144345a49f609f95a53310 rdf:first sg:person.01320212377.00
192 rdf:rest Na76018a2f71948748393c079bbf8e549
193 N886869fef918409596377c7877038ce0 rdf:first sg:person.0617710233.44
194 rdf:rest N98a04fc6fed9426ba8f903279959888e
195 N8ac6c22691b4473e8f4f0b6110690e63 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
196 schema:name RNA, Messenger
197 rdf:type schema:DefinedTerm
198 N8ca3824dd63d444b9e1d551deb9f97c3 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
199 schema:name Xenograft Model Antitumor Assays
200 rdf:type schema:DefinedTerm
201 N95c6895aa57148dea067398a5dbecff1 rdf:first sg:person.011262623704.18
202 rdf:rest N05adf31f306e4a9cbd019781a5d1799a
203 N98a04fc6fed9426ba8f903279959888e rdf:first sg:person.01130507471.65
204 rdf:rest N0dab6340a4a041c496e4a344a9637e3d
205 N9a0005baa5dd47f98505b57c38b45168 rdf:first sg:person.01116545321.47
206 rdf:rest N4787f46c31a8478194598bae00733fe6
207 N9a18e20db6694af88ffea5cfaba97ed0 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
208 schema:name Antineoplastic Agents, Phytogenic
209 rdf:type schema:DefinedTerm
210 N9b3d4b7c11d948c39836ddad1a4c0be2 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
211 schema:name Animals
212 rdf:type schema:DefinedTerm
213 N9e591e0ad71d4d30baa5dbd0784ec721 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
214 schema:name Biomarkers, Tumor
215 rdf:type schema:DefinedTerm
216 Na33a0f91425d407697306fe764b26b82 rdf:first sg:person.0674571673.35
217 rdf:rest Nf3dae59bb18547bb9ed6c9a344ebd877
218 Na3afdf5f257b45c989e18fea4b37dbe7 schema:volumeNumber 26
219 rdf:type schema:PublicationVolume
220 Na6be48b630eb48c4ae9f89f80154d6cc rdf:first sg:person.01372655533.68
221 rdf:rest N886869fef918409596377c7877038ce0
222 Na76018a2f71948748393c079bbf8e549 rdf:first sg:person.01246512175.01
223 rdf:rest N603faff35fd845af97b4bbcb6590a1b7
224 Nb1d8e102ad88482c85200f7ef36e9623 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
225 schema:name Female
226 rdf:type schema:DefinedTerm
227 Nb6f520972f1d440ea33dd5afd749eabe schema:name doi
228 schema:value 10.1038/leu.2012.31
229 rdf:type schema:PropertyValue
230 Nb77aa7632b78493490b5754db965b8ba schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
231 schema:name Histones
232 rdf:type schema:DefinedTerm
233 Nb8f258e3875d4c92871b89cb27b16a85 rdf:first sg:person.01331442402.34
234 rdf:rest Nf5bcccb1d1aa4067a9b9bd0095a8676b
235 Nbd93201d90eb4bce95294475a0ab8a08 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
236 schema:name DNA Methylation
237 rdf:type schema:DefinedTerm
238 Nbfa33b2cdd514a368e47825c6b5e2d09 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
239 schema:name Antineoplastic Agents, Hormonal
240 rdf:type schema:DefinedTerm
241 Nc31538a29bcf47e4ae1d1c614c535ded rdf:first sg:person.01222134213.65
242 rdf:rest N3ad3333130684379b12032203ecad6b2
243 Nc3c5d126f0e4495c921ba6a1a041acfc schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
244 schema:name Polymorphism, Single Nucleotide
245 rdf:type schema:DefinedTerm
246 Nc48352038ac8419a90ea4f15b6096a26 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
247 schema:name DNA-Binding Proteins
248 rdf:type schema:DefinedTerm
249 Ncb6c130bb8404a69b05c45a7b559b239 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
250 schema:name Reverse Transcriptase Polymerase Chain Reaction
251 rdf:type schema:DefinedTerm
252 Nd079dcd96558480486a01b12e8cf7dca rdf:first sg:person.01262144070.75
253 rdf:rest rdf:nil
254 Nd5a167db8cb04c46a5c6128fcd363ca1 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
255 schema:name Hydroxamic Acids
256 rdf:type schema:DefinedTerm
257 Ne4f695844236425cbe38da1f0bf5d3d8 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
258 schema:name Antineoplastic Combined Chemotherapy Protocols
259 rdf:type schema:DefinedTerm
260 Neee56d19a23a4b9fad6912fc3b0c2373 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
261 schema:name Precursor Cell Lymphoblastic Leukemia-Lymphoma
262 rdf:type schema:DefinedTerm
263 Nf3dae59bb18547bb9ed6c9a344ebd877 rdf:first sg:person.01026574627.20
264 rdf:rest Na6be48b630eb48c4ae9f89f80154d6cc
265 Nf425df67546f42f68e45086c008047a2 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
266 schema:name Dexamethasone
267 rdf:type schema:DefinedTerm
268 Nf57e238fafa54686aa0a3847b4bf3fe8 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
269 schema:name Histone Deacetylase Inhibitors
270 rdf:type schema:DefinedTerm
271 Nf5bcccb1d1aa4067a9b9bd0095a8676b rdf:first sg:person.01340233403.80
272 rdf:rest Na33a0f91425d407697306fe764b26b82
273 Nf6c253de12254ff69d2532f5d30e22cb schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
274 schema:name Immunoenzyme Techniques
275 rdf:type schema:DefinedTerm
276 Nf802104236f042268a9ed8b0ad90e620 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
277 schema:name Vincristine
278 rdf:type schema:DefinedTerm
279 Nf92c40f32d3f486ab16c6a8c372d2566 schema:name dimensions_id
280 schema:value pub.1031162923
281 rdf:type schema:PropertyValue
282 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
283 schema:name Medical and Health Sciences
284 rdf:type schema:DefinedTerm
285 anzsrc-for:1112 schema:inDefinedTermSet anzsrc-for:
286 schema:name Oncology and Carcinogenesis
287 rdf:type schema:DefinedTerm
288 sg:journal.1097065 schema:issn 0887-6924
289 1476-5551
290 schema:name Leukemia
291 schema:publisher Springer Nature
292 rdf:type schema:Periodical
293 sg:person.01003416220.09 schema:affiliation grid-institutes:grid.420019.e
294 schema:familyName Rio
295 schema:givenName P
296 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01003416220.09
297 rdf:type schema:Person
298 sg:person.01026574627.20 schema:affiliation grid-institutes:grid.5924.a
299 schema:familyName Miranda
300 schema:givenName E
301 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01026574627.20
302 rdf:type schema:Person
303 sg:person.01054600404.53 schema:affiliation grid-institutes:grid.7080.f
304 schema:familyName Ribera
305 schema:givenName J M
306 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01054600404.53
307 rdf:type schema:Person
308 sg:person.01072006063.32 schema:affiliation grid-institutes:grid.411349.a
309 schema:familyName Román-Gómez
310 schema:givenName J
311 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01072006063.32
312 rdf:type schema:Person
313 sg:person.01073523227.06 schema:affiliation grid-institutes:grid.5924.a
314 schema:familyName Moreno
315 schema:givenName C
316 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01073523227.06
317 rdf:type schema:Person
318 sg:person.01116545321.47 schema:affiliation grid-institutes:grid.5924.a
319 schema:familyName Vilas-Zornoza
320 schema:givenName A
321 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01116545321.47
322 rdf:type schema:Person
323 sg:person.011262623704.18 schema:affiliation grid-institutes:grid.5924.a
324 schema:familyName Calasanz
325 schema:givenName M J
326 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011262623704.18
327 rdf:type schema:Person
328 sg:person.01130507471.65 schema:affiliation grid-institutes:grid.5924.a
329 schema:familyName Blanco-Prieto
330 schema:givenName M J
331 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01130507471.65
332 rdf:type schema:Person
333 sg:person.01222134213.65 schema:affiliation grid-institutes:grid.411730.0
334 schema:familyName Abizanda
335 schema:givenName G
336 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01222134213.65
337 rdf:type schema:Person
338 sg:person.01227065733.32 schema:affiliation grid-institutes:grid.5924.a
339 schema:familyName Agirre
340 schema:givenName X
341 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01227065733.32
342 rdf:type schema:Person
343 sg:person.01246512175.01 schema:affiliation grid-institutes:grid.7719.8
344 schema:familyName Cigudosa
345 schema:givenName J C
346 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01246512175.01
347 rdf:type schema:Person
348 sg:person.01262144070.75 schema:affiliation grid-institutes:grid.411730.0
349 schema:familyName Prósper
350 schema:givenName F
351 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01262144070.75
352 rdf:type schema:Person
353 sg:person.01320212377.00 schema:affiliation grid-institutes:grid.411730.0
354 schema:familyName Rifón
355 schema:givenName J
356 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01320212377.00
357 rdf:type schema:Person
358 sg:person.01331442402.34 schema:affiliation grid-institutes:grid.5924.a
359 schema:familyName Segura
360 schema:givenName V
361 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01331442402.34
362 rdf:type schema:Person
363 sg:person.01340233403.80 schema:affiliation grid-institutes:grid.11205.37
364 schema:familyName De Martino Rodriguez
365 schema:givenName A
366 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01340233403.80
367 rdf:type schema:Person
368 sg:person.01354555417.62 schema:affiliation grid-institutes:grid.11205.37
369 schema:familyName García de Jalón
370 schema:givenName J A
371 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01354555417.62
372 rdf:type schema:Person
373 sg:person.01372655533.68 schema:affiliation grid-institutes:grid.5841.8
374 schema:familyName Martín-Subero
375 schema:givenName J I
376 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01372655533.68
377 rdf:type schema:Person
378 sg:person.014626267654.79 schema:affiliation grid-institutes:grid.5924.a
379 schema:familyName Martinez-Climent
380 schema:givenName J A
381 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.014626267654.79
382 rdf:type schema:Person
383 sg:person.0617710233.44 schema:affiliation grid-institutes:grid.5924.a
384 schema:familyName Garate
385 schema:givenName L
386 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0617710233.44
387 rdf:type schema:Person
388 sg:person.0674571673.35 schema:affiliation grid-institutes:grid.5924.a
389 schema:familyName José-Eneriz
390 schema:givenName E S
391 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0674571673.35
392 rdf:type schema:Person
393 sg:pub.10.1038/cdd.2009.188 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034956032
394 https://doi.org/10.1038/cdd.2009.188
395 rdf:type schema:CreativeWork
396 sg:pub.10.1038/leu.2008.130 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036246806
397 https://doi.org/10.1038/leu.2008.130
398 rdf:type schema:CreativeWork
399 sg:pub.10.1038/leu.2009.58 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052059551
400 https://doi.org/10.1038/leu.2009.58
401 rdf:type schema:CreativeWork
402 sg:pub.10.1038/nm.1900 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031341478
403 https://doi.org/10.1038/nm.1900
404 rdf:type schema:CreativeWork
405 sg:pub.10.1038/sj.leu.2404173 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036796846
406 https://doi.org/10.1038/sj.leu.2404173
407 rdf:type schema:CreativeWork
408 sg:pub.10.1038/sj.leu.2404282 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048643499
409 https://doi.org/10.1038/sj.leu.2404282
410 rdf:type schema:CreativeWork
411 sg:pub.10.1038/sj.onc.1209236 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042872905
412 https://doi.org/10.1038/sj.onc.1209236
413 rdf:type schema:CreativeWork
414 sg:pub.10.1186/1755-8794-2-67 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025134642
415 https://doi.org/10.1186/1755-8794-2-67
416 rdf:type schema:CreativeWork
417 grid-institutes:grid.11205.37 schema:alternateName Department of Animal Pathology, Veterinary Faculty, University of Zaragoza, Zaragoza, Spain
418 schema:name Department of Animal Pathology, Veterinary Faculty, University of Zaragoza, Zaragoza, Spain
419 rdf:type schema:Organization
420 grid-institutes:grid.411349.a schema:alternateName Hematology Department, Reina Sofia Hospital, Maimonides Institute for Biomedical Research, Cordoba, Spain
421 schema:name Hematology Department, Reina Sofia Hospital, Maimonides Institute for Biomedical Research, Cordoba, Spain
422 rdf:type schema:Organization
423 grid-institutes:grid.411730.0 schema:alternateName Hematology Service, Clínica Universidad de Navarra, University of Navarra, Pamplona, Spain
424 schema:name Hematology Service, Clínica Universidad de Navarra, University of Navarra, Pamplona, Spain
425 Oncology Division, University of Navarra, Pamplona, Spain
426 rdf:type schema:Organization
427 grid-institutes:grid.420019.e schema:alternateName Centro de Investigaciones Energéticas, Medioambientales y Tecnológicas (CIEMAT), Madrid, Spain
428 schema:name Centro de Investigaciones Energéticas, Medioambientales y Tecnológicas (CIEMAT), Madrid, Spain
429 rdf:type schema:Organization
430 grid-institutes:grid.5841.8 schema:alternateName Department of Anatomic Pathology, Pharmacology and Microbiology, University of Barcelona, Barcelona, Spain
431 schema:name Department of Anatomic Pathology, Pharmacology and Microbiology, University of Barcelona, Barcelona, Spain
432 rdf:type schema:Organization
433 grid-institutes:grid.5924.a schema:alternateName Department of Bioinformatics, Foundation for Applied Medical Research, University of Navarra, Pamplona, Spain
434 Department of Genetics, University of Navarra, Pamplona, Spain
435 Department of Immunology, University of Navarra, Pamplona, Spain
436 Department of Pharmacy and Pharmaceutical Technology, School of Pharmacy, University of Navarra, Pamplona, Spain
437 Oncology Division, University of Navarra, Pamplona, Spain
438 schema:name Department of Bioinformatics, Foundation for Applied Medical Research, University of Navarra, Pamplona, Spain
439 Department of Genetics, University of Navarra, Pamplona, Spain
440 Department of Immunology, University of Navarra, Pamplona, Spain
441 Department of Pharmacy and Pharmaceutical Technology, School of Pharmacy, University of Navarra, Pamplona, Spain
442 Oncology Division, University of Navarra, Pamplona, Spain
443 rdf:type schema:Organization
444 grid-institutes:grid.7080.f schema:alternateName Hematology Service, Institut Català d'Oncologia, Hospital Universitari Germans Trias i Pujol, Universitat Autònoma de Barcelona, Badalona, Barcelona, Spain
445 schema:name Hematology Service, Institut Català d'Oncologia, Hospital Universitari Germans Trias i Pujol, Universitat Autònoma de Barcelona, Badalona, Barcelona, Spain
446 rdf:type schema:Organization
447 grid-institutes:grid.7719.8 schema:alternateName Molecular Cytogenetics Group, Centro Nacional Investigaciones Oncológicas (CNIO), Madrid, Spain
448 schema:name Molecular Cytogenetics Group, Centro Nacional Investigaciones Oncológicas (CNIO), Madrid, Spain
449 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...