Over 30% of patients with splenic marginal zone lymphoma express the same immunoglobulin heavy variable gene: ontogenetic implications View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2012-01-06

AUTHORS

V Bikos, N Darzentas, A Hadzidimitriou, Z Davis, S Hockley, A Traverse-Glehen, P Algara, A Santoro, D Gonzalez, M Mollejo, A Dagklis, F Gangemi, D S Bosler, G Bourikas, A Anagnostopoulos, A Tsaftaris, E Iannitto, M Ponzoni, P Felman, F Berger, C Belessi, P Ghia, T Papadaki, A Dogan, M Degano, E Matutes, M A Piris, D Oscier, K Stamatopoulos

ABSTRACT

We performed an immunogenetic analysis of 345 IGHV–IGHD–IGHJ rearrangements from 337 cases with primary splenic small B-cell lymphomas of marginal-zone origin. Three immunoglobulin (IG) heavy variable (IGHV) genes accounted for 45.8% of the cases (IGHV1-2, 24.9%; IGHV4-34, 12.8%; IGHV3-23, 8.1%). Particularly for the IGHV1-2 gene, strong biases were evident regarding utilization of different alleles, with 79/86 rearrangements (92%) using allele *04. Among cases more stringently classified as splenic marginal-zone lymphoma (SMZL) thanks to the availability of splenic histopathological specimens, the frequency of IGHV1-2*04 peaked at 31%. The IGHV1-2*04 rearrangements carried significantly longer complementarity-determining region-3 (CDR3) than all other cases and showed biased IGHD gene usage, leading to CDR3s with common motifs. The great majority of analyzed rearrangements (299/345, 86.7%) carried IGHV genes with some impact of somatic hypermutation, from minimal to pronounced. Noticeably, 75/79 (95%) IGHV1-2*04 rearrangements were mutated; however, they mostly (56/75 cases; 74.6%) carried few mutations (97–99.9% germline identity) of conservative nature and restricted distribution. These distinctive features of the IG receptors indicate selection by (super)antigenic element(s) in the pathogenesis of SMZL. Furthermore, they raise the possibility that certain SMZL subtypes could derive from progenitor populations adapted to particular antigenic challenges through selection of VH domain specificities, in particular the IGHV1-2*04 allele. More... »

PAGES

1638-1646

Journal

TITLE

Leukemia

ISSUE

7

VOLUME

26

Author Affiliations

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/leu.2012.3

DOI

http://dx.doi.org/10.1038/leu.2012.3

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1034967212

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/22222599


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1103", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Clinical Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1112", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Oncology and Carcinogenesis", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cohort Studies", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Complementarity Determining Regions", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Gene Rearrangement, B-Lymphocyte, Heavy Chain", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Genes, Immunoglobulin Heavy Chain", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Immunoglobulin Variable Region", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Lymphoma, B-Cell, Marginal Zone", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Models, Molecular", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Mutation", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Prognosis", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Splenic Neoplasms", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Democritus University of Thrace, Alexandroupolis, Greece", 
          "id": "http://www.grid.ac/institutes/grid.12284.3d", 
          "name": [
            "Democritus University of Thrace, Alexandroupolis, Greece"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Bikos", 
        "givenName": "V", 
        "id": "sg:person.01357164153.14", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01357164153.14"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Institute of Agrobiotechnology, Center for Research and Technology Hellas, Thessaloniki, Greece", 
          "id": "http://www.grid.ac/institutes/None", 
          "name": [
            "Institute of Agrobiotechnology, Center for Research and Technology Hellas, Thessaloniki, Greece"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Darzentas", 
        "givenName": "N", 
        "id": "sg:person.01244525060.81", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01244525060.81"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Institute of Agrobiotechnology, Center for Research and Technology Hellas, Thessaloniki, Greece", 
          "id": "http://www.grid.ac/institutes/None", 
          "name": [
            "Institute of Agrobiotechnology, Center for Research and Technology Hellas, Thessaloniki, Greece"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Hadzidimitriou", 
        "givenName": "A", 
        "id": "sg:person.0723122240.26", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0723122240.26"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Haematology, Royal Bournemouth Hospital, Bournemouth, UK", 
          "id": "http://www.grid.ac/institutes/grid.416098.2", 
          "name": [
            "Department of Haematology, Royal Bournemouth Hospital, Bournemouth, UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Davis", 
        "givenName": "Z", 
        "id": "sg:person.0720330517.11", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0720330517.11"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Section of Haemato-Oncology, Institute of Cancer Research, London, UK", 
          "id": "http://www.grid.ac/institutes/grid.18886.3f", 
          "name": [
            "Section of Haemato-Oncology, Institute of Cancer Research, London, UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Hockley", 
        "givenName": "S", 
        "id": "sg:person.0666515447.66", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0666515447.66"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Pathology, Hospices Civils de Lyon, Universit\u00e9 Lyon 1, Lyon, France", 
          "id": "http://www.grid.ac/institutes/grid.413852.9", 
          "name": [
            "Department of Pathology, Hospices Civils de Lyon, Universit\u00e9 Lyon 1, Lyon, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Traverse-Glehen", 
        "givenName": "A", 
        "id": "sg:person.01132610000.12", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01132610000.12"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Hospital Virgen de la Salud, Toledo, Spain", 
          "id": "http://www.grid.ac/institutes/grid.413514.6", 
          "name": [
            "Hospital Virgen de la Salud, Toledo, Spain"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Algara", 
        "givenName": "P", 
        "id": "sg:person.0760530715.90", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0760530715.90"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Laboratory of Hematology, Villa Sofia-Cervello Hospital, Palermo, Italy", 
          "id": "http://www.grid.ac/institutes/None", 
          "name": [
            "Laboratory of Hematology, Villa Sofia-Cervello Hospital, Palermo, Italy"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Santoro", 
        "givenName": "A", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Section of Haemato-Oncology, Institute of Cancer Research, London, UK", 
          "id": "http://www.grid.ac/institutes/grid.18886.3f", 
          "name": [
            "Section of Haemato-Oncology, Institute of Cancer Research, London, UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Gonzalez", 
        "givenName": "D", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Hospital Virgen de la Salud, Toledo, Spain", 
          "id": "http://www.grid.ac/institutes/grid.413514.6", 
          "name": [
            "Hospital Virgen de la Salud, Toledo, Spain"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Mollejo", 
        "givenName": "M", 
        "id": "sg:person.01053746063.57", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01053746063.57"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Unit of Lymphoid Malignancies and MAGIC (Microenvironment and Genes in Cancers of the blood) Interdivisional Research Program, Laboratory of B cell Neoplasia, Universit\u00e0 Vita-Salute San Raffaele and Istituto Scientifico San Raffaele, Milan, Italy", 
          "id": "http://www.grid.ac/institutes/grid.18887.3e", 
          "name": [
            "Unit of Lymphoid Malignancies and MAGIC (Microenvironment and Genes in Cancers of the blood) Interdivisional Research Program, Laboratory of B cell Neoplasia, Universit\u00e0 Vita-Salute San Raffaele and Istituto Scientifico San Raffaele, Milan, Italy"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Dagklis", 
        "givenName": "A", 
        "id": "sg:person.01204577503.15", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01204577503.15"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Division of Immunology, Biocrystallography Unit, Transplantation, and Infectious Diseases, Scientific Institute San Raffaele, Milan, Italy", 
          "id": "http://www.grid.ac/institutes/grid.18887.3e", 
          "name": [
            "Division of Immunology, Biocrystallography Unit, Transplantation, and Infectious Diseases, Scientific Institute San Raffaele, Milan, Italy"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Gangemi", 
        "givenName": "F", 
        "id": "sg:person.01000056636.29", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01000056636.29"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Cleveland Clinic, Cleveland, OH, USA", 
          "id": "http://www.grid.ac/institutes/grid.239578.2", 
          "name": [
            "Cleveland Clinic, Cleveland, OH, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Bosler", 
        "givenName": "D S", 
        "id": "sg:person.0710147173.09", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0710147173.09"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Democritus University of Thrace, Alexandroupolis, Greece", 
          "id": "http://www.grid.ac/institutes/grid.12284.3d", 
          "name": [
            "Democritus University of Thrace, Alexandroupolis, Greece"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Bourikas", 
        "givenName": "G", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Hematology Department and HCT Unit, G Papanicolaou Hospital, Thessaloniki, Greece", 
          "id": "http://www.grid.ac/institutes/grid.415248.e", 
          "name": [
            "Hematology Department and HCT Unit, G Papanicolaou Hospital, Thessaloniki, Greece"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Anagnostopoulos", 
        "givenName": "A", 
        "id": "sg:person.01043327543.11", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01043327543.11"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Institute of Agrobiotechnology, Center for Research and Technology Hellas, Thessaloniki, Greece", 
          "id": "http://www.grid.ac/institutes/None", 
          "name": [
            "Institute of Agrobiotechnology, Center for Research and Technology Hellas, Thessaloniki, Greece"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Tsaftaris", 
        "givenName": "A", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Hematology, University of Palermo, Palermo, Italy", 
          "id": "http://www.grid.ac/institutes/grid.10776.37", 
          "name": [
            "Department of Hematology, University of Palermo, Palermo, Italy"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Iannitto", 
        "givenName": "E", 
        "id": "sg:person.0676224054.65", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0676224054.65"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Pathology Unit and Unit of Lymphoid Malignancies, Istituto Scientifico San Raffaele, Milan, Italy", 
          "id": "http://www.grid.ac/institutes/grid.18887.3e", 
          "name": [
            "Pathology Unit and Unit of Lymphoid Malignancies, Istituto Scientifico San Raffaele, Milan, Italy"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Ponzoni", 
        "givenName": "M", 
        "id": "sg:person.01141551130.83", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01141551130.83"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Laboratory of Hematology, Hospices Civils de Lyon, Universit\u00e9 Lyon 1, Lyon, France", 
          "id": "http://www.grid.ac/institutes/grid.413852.9", 
          "name": [
            "Laboratory of Hematology, Hospices Civils de Lyon, Universit\u00e9 Lyon 1, Lyon, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Felman", 
        "givenName": "P", 
        "id": "sg:person.01153320635.02", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01153320635.02"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Pathology, Hospices Civils de Lyon, Universit\u00e9 Lyon 1, Lyon, France", 
          "id": "http://www.grid.ac/institutes/grid.413852.9", 
          "name": [
            "Department of Pathology, Hospices Civils de Lyon, Universit\u00e9 Lyon 1, Lyon, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Berger", 
        "givenName": "F", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Hematology Department, Nikea General Hospital, Pireaus, Greece", 
          "id": "http://www.grid.ac/institutes/grid.415449.9", 
          "name": [
            "Hematology Department, Nikea General Hospital, Pireaus, Greece"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Belessi", 
        "givenName": "C", 
        "id": "sg:person.01151530700.45", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01151530700.45"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Unit of Lymphoid Malignancies and MAGIC (Microenvironment and Genes in Cancers of the blood) Interdivisional Research Program, Laboratory of B cell Neoplasia, Universit\u00e0 Vita-Salute San Raffaele and Istituto Scientifico San Raffaele, Milan, Italy", 
          "id": "http://www.grid.ac/institutes/grid.18887.3e", 
          "name": [
            "Unit of Lymphoid Malignancies and MAGIC (Microenvironment and Genes in Cancers of the blood) Interdivisional Research Program, Laboratory of B cell Neoplasia, Universit\u00e0 Vita-Salute San Raffaele and Istituto Scientifico San Raffaele, Milan, Italy"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Ghia", 
        "givenName": "P", 
        "id": "sg:person.01322130253.89", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01322130253.89"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Hematopathology Department, Evangelismos Hospital, Athens, Greece", 
          "id": "http://www.grid.ac/institutes/grid.414655.7", 
          "name": [
            "Hematopathology Department, Evangelismos Hospital, Athens, Greece"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Papadaki", 
        "givenName": "T", 
        "id": "sg:person.01110665614.54", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01110665614.54"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Pathology, Mayo Clinic, Rochester, MN, USA", 
          "id": "http://www.grid.ac/institutes/grid.66875.3a", 
          "name": [
            "Department of Pathology, Mayo Clinic, Rochester, MN, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Dogan", 
        "givenName": "A", 
        "id": "sg:person.01162043155.16", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01162043155.16"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Division of Immunology, Biocrystallography Unit, Transplantation, and Infectious Diseases, Scientific Institute San Raffaele, Milan, Italy", 
          "id": "http://www.grid.ac/institutes/grid.18887.3e", 
          "name": [
            "Division of Immunology, Biocrystallography Unit, Transplantation, and Infectious Diseases, Scientific Institute San Raffaele, Milan, Italy"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Degano", 
        "givenName": "M", 
        "id": "sg:person.0755352635.88", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0755352635.88"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Section of Haemato-Oncology, Institute of Cancer Research, London, UK", 
          "id": "http://www.grid.ac/institutes/grid.18886.3f", 
          "name": [
            "Section of Haemato-Oncology, Institute of Cancer Research, London, UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Matutes", 
        "givenName": "E", 
        "id": "sg:person.01207030342.98", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01207030342.98"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Hospital Universitario Marques de Valdecilla, Santander, Spain", 
          "id": "http://www.grid.ac/institutes/grid.411325.0", 
          "name": [
            "Hospital Universitario Marques de Valdecilla, Santander, Spain"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Piris", 
        "givenName": "M A", 
        "id": "sg:person.07440427070.11", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.07440427070.11"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Haematology, Royal Bournemouth Hospital, Bournemouth, UK", 
          "id": "http://www.grid.ac/institutes/grid.416098.2", 
          "name": [
            "Department of Haematology, Royal Bournemouth Hospital, Bournemouth, UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Oscier", 
        "givenName": "D", 
        "id": "sg:person.01333301733.69", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01333301733.69"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Hematology Department and HCT Unit, G Papanicolaou Hospital, Thessaloniki, Greece", 
          "id": "http://www.grid.ac/institutes/grid.415248.e", 
          "name": [
            "Institute of Agrobiotechnology, Center for Research and Technology Hellas, Thessaloniki, Greece", 
            "Hematology Department and HCT Unit, G Papanicolaou Hospital, Thessaloniki, Greece"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Stamatopoulos", 
        "givenName": "K", 
        "id": "sg:person.0610466400.38", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0610466400.38"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "sg:pub.10.1007/s000180300026", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1027481770", 
          "https://doi.org/10.1007/s000180300026"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.2119/2005-00001.stamatopoulos", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1068964902", 
          "https://doi.org/10.2119/2005-00001.stamatopoulos"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/leu.2009.186", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1043519279", 
          "https://doi.org/10.1038/leu.2009.186"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.leu.2405068", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1041532471", 
          "https://doi.org/10.1038/sj.leu.2405068"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.2119/2005-00044.belessi", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1068964911", 
          "https://doi.org/10.2119/2005-00044.belessi"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/leu.2011.49", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1005769936", 
          "https://doi.org/10.1038/leu.2011.49"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2012-01-06", 
    "datePublishedReg": "2012-01-06", 
    "description": "We performed an immunogenetic analysis of 345 IGHV\u2013IGHD\u2013IGHJ rearrangements from 337 cases with primary splenic small B-cell lymphomas of marginal-zone origin. Three immunoglobulin (IG) heavy variable (IGHV) genes accounted for 45.8% of the cases (IGHV1-2, 24.9%; IGHV4-34, 12.8%; IGHV3-23, 8.1%). Particularly for the IGHV1-2 gene, strong biases were evident regarding utilization of different alleles, with 79/86 rearrangements (92%) using allele *04. Among cases more stringently classified as splenic marginal-zone lymphoma (SMZL) thanks to the availability of splenic histopathological specimens, the frequency of IGHV1-2*04 peaked at 31%. The IGHV1-2*04 rearrangements carried significantly longer complementarity-determining region-3 (CDR3) than all other cases and showed biased IGHD gene usage, leading to CDR3s with common motifs. The great majority of analyzed rearrangements (299/345, 86.7%) carried IGHV genes with some impact of somatic hypermutation, from minimal to pronounced. Noticeably, 75/79 (95%) IGHV1-2*04 rearrangements were mutated; however, they mostly (56/75 cases; 74.6%) carried few mutations (97\u201399.9% germline identity) of conservative nature and restricted distribution. These distinctive features of the IG receptors indicate selection by (super)antigenic element(s) in the pathogenesis of SMZL. Furthermore, they raise the possibility that certain SMZL subtypes could derive from progenitor populations adapted to particular antigenic challenges through selection of VH domain specificities, in particular the IGHV1-2*04 allele.", 
    "genre": "article", 
    "id": "sg:pub.10.1038/leu.2012.3", 
    "inLanguage": "en", 
    "isAccessibleForFree": true, 
    "isPartOf": [
      {
        "id": "sg:journal.1097065", 
        "issn": [
          "0887-6924", 
          "1476-5551"
        ], 
        "name": "Leukemia", 
        "publisher": "Springer Nature", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "7", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "26"
      }
    ], 
    "keywords": [
      "variable genes", 
      "progenitor populations", 
      "restricted distribution", 
      "long complementarity-determining region 3", 
      "different alleles", 
      "genes", 
      "common motif", 
      "somatic hypermutation", 
      "immunoglobulin heavy variable (IGHV) genes", 
      "complementarity-determining region 3", 
      "alleles", 
      "rearrangement", 
      "IGHV1-2", 
      "strong biases", 
      "region 3", 
      "IGHV genes", 
      "ontogenetic implications", 
      "gene usage", 
      "Ig receptor", 
      "conservative nature", 
      "motif", 
      "immunogenetic analysis", 
      "mutations", 
      "hypermutation", 
      "selection", 
      "domain specificity", 
      "receptors", 
      "great majority", 
      "specificity", 
      "availability", 
      "population", 
      "cell lymphoma", 
      "origin", 
      "pathogenesis", 
      "antigenic challenge", 
      "distinctive features", 
      "Express", 
      "subtypes", 
      "SMZL", 
      "analysis", 
      "specimens", 
      "distribution", 
      "majority", 
      "implications", 
      "marginal zone origin", 
      "utilization", 
      "possibility", 
      "nature", 
      "features", 
      "impact", 
      "lymphoma", 
      "biases", 
      "frequency", 
      "challenges", 
      "usage", 
      "histopathological specimens", 
      "cases", 
      "thanks", 
      "patients", 
      "IGHV\u2013IGHD\u2013IGHJ rearrangements", 
      "heavy variable (IGHV) genes", 
      "IGHV1-2 gene", 
      "splenic marginal-zone lymphoma (SMZL) thanks", 
      "marginal-zone lymphoma (SMZL) thanks", 
      "lymphoma (SMZL) thanks", 
      "splenic histopathological specimens", 
      "biased IGHD gene usage", 
      "IGHD gene usage", 
      "pathogenesis of SMZL", 
      "certain SMZL subtypes", 
      "SMZL subtypes", 
      "particular antigenic challenges", 
      "VH domain specificities", 
      "splenic marginal zone lymphoma express", 
      "marginal zone lymphoma express", 
      "zone lymphoma express", 
      "lymphoma express", 
      "same immunoglobulin heavy variable gene"
    ], 
    "name": "Over 30% of patients with splenic marginal zone lymphoma express the same immunoglobulin heavy variable gene: ontogenetic implications", 
    "pagination": "1638-1646", 
    "productId": [
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1034967212"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1038/leu.2012.3"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "22222599"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1038/leu.2012.3", 
      "https://app.dimensions.ai/details/publication/pub.1034967212"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2022-01-01T18:29", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-springernature-scigraph/baseset/20220101/entities/gbq_results/article/article_574.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://doi.org/10.1038/leu.2012.3"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/leu.2012.3'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/leu.2012.3'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/leu.2012.3'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/leu.2012.3'


 

This table displays all metadata directly associated to this object as RDF triples.

451 TRIPLES      22 PREDICATES      122 URIs      107 LITERALS      18 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1038/leu.2012.3 schema:about N176c3454679643a29168f42bcf518c2d
2 N2be49439ad1842bf8121c1ca3743ce4a
3 N2d892498204c4b91b4c2efcb674a5779
4 N49187964e0a547929e295d0c5daaad0e
5 N55f41b12f0234459a568e42772a89e93
6 N78db1742fe094c6f8096772d3f42a27a
7 N7bf500720db9489798ce6e3e46c91821
8 N7f7c7ba1693842c4838a2e16c5daa68d
9 N939aaccd76794592ab5e2196fe96609f
10 Nd174b8c20c6348ac895e0fe9d1ca8d92
11 Nd34ce53977af434d86198f39a5f9b47f
12 anzsrc-for:11
13 anzsrc-for:1103
14 anzsrc-for:1112
15 schema:author N5a3d52721e5040fa9df761e8fe09ab5d
16 schema:citation sg:pub.10.1007/s000180300026
17 sg:pub.10.1038/leu.2009.186
18 sg:pub.10.1038/leu.2011.49
19 sg:pub.10.1038/sj.leu.2405068
20 sg:pub.10.2119/2005-00001.stamatopoulos
21 sg:pub.10.2119/2005-00044.belessi
22 schema:datePublished 2012-01-06
23 schema:datePublishedReg 2012-01-06
24 schema:description We performed an immunogenetic analysis of 345 IGHV–IGHD–IGHJ rearrangements from 337 cases with primary splenic small B-cell lymphomas of marginal-zone origin. Three immunoglobulin (IG) heavy variable (IGHV) genes accounted for 45.8% of the cases (IGHV1-2, 24.9%; IGHV4-34, 12.8%; IGHV3-23, 8.1%). Particularly for the IGHV1-2 gene, strong biases were evident regarding utilization of different alleles, with 79/86 rearrangements (92%) using allele *04. Among cases more stringently classified as splenic marginal-zone lymphoma (SMZL) thanks to the availability of splenic histopathological specimens, the frequency of IGHV1-2*04 peaked at 31%. The IGHV1-2*04 rearrangements carried significantly longer complementarity-determining region-3 (CDR3) than all other cases and showed biased IGHD gene usage, leading to CDR3s with common motifs. The great majority of analyzed rearrangements (299/345, 86.7%) carried IGHV genes with some impact of somatic hypermutation, from minimal to pronounced. Noticeably, 75/79 (95%) IGHV1-2*04 rearrangements were mutated; however, they mostly (56/75 cases; 74.6%) carried few mutations (97–99.9% germline identity) of conservative nature and restricted distribution. These distinctive features of the IG receptors indicate selection by (super)antigenic element(s) in the pathogenesis of SMZL. Furthermore, they raise the possibility that certain SMZL subtypes could derive from progenitor populations adapted to particular antigenic challenges through selection of VH domain specificities, in particular the IGHV1-2*04 allele.
25 schema:genre article
26 schema:inLanguage en
27 schema:isAccessibleForFree true
28 schema:isPartOf N6f16d080a37643219b9c7c170e7c472f
29 N7cb64ea994cc471abfce2832ce50d228
30 sg:journal.1097065
31 schema:keywords Express
32 IGHD gene usage
33 IGHV genes
34 IGHV1-2
35 IGHV1-2 gene
36 IGHV–IGHD–IGHJ rearrangements
37 Ig receptor
38 SMZL
39 SMZL subtypes
40 VH domain specificities
41 alleles
42 analysis
43 antigenic challenge
44 availability
45 biased IGHD gene usage
46 biases
47 cases
48 cell lymphoma
49 certain SMZL subtypes
50 challenges
51 common motif
52 complementarity-determining region 3
53 conservative nature
54 different alleles
55 distinctive features
56 distribution
57 domain specificity
58 features
59 frequency
60 gene usage
61 genes
62 great majority
63 heavy variable (IGHV) genes
64 histopathological specimens
65 hypermutation
66 immunogenetic analysis
67 immunoglobulin heavy variable (IGHV) genes
68 impact
69 implications
70 long complementarity-determining region 3
71 lymphoma
72 lymphoma (SMZL) thanks
73 lymphoma express
74 majority
75 marginal zone lymphoma express
76 marginal zone origin
77 marginal-zone lymphoma (SMZL) thanks
78 motif
79 mutations
80 nature
81 ontogenetic implications
82 origin
83 particular antigenic challenges
84 pathogenesis
85 pathogenesis of SMZL
86 patients
87 population
88 possibility
89 progenitor populations
90 rearrangement
91 receptors
92 region 3
93 restricted distribution
94 same immunoglobulin heavy variable gene
95 selection
96 somatic hypermutation
97 specificity
98 specimens
99 splenic histopathological specimens
100 splenic marginal zone lymphoma express
101 splenic marginal-zone lymphoma (SMZL) thanks
102 strong biases
103 subtypes
104 thanks
105 usage
106 utilization
107 variable genes
108 zone lymphoma express
109 schema:name Over 30% of patients with splenic marginal zone lymphoma express the same immunoglobulin heavy variable gene: ontogenetic implications
110 schema:pagination 1638-1646
111 schema:productId N0b0f91f229584bc58634973585a70440
112 N2fe6c49ae6ed4742ac7bfef9f05170ee
113 N897930c90c1544378fcb02dd4e8e4176
114 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034967212
115 https://doi.org/10.1038/leu.2012.3
116 schema:sdDatePublished 2022-01-01T18:29
117 schema:sdLicense https://scigraph.springernature.com/explorer/license/
118 schema:sdPublisher Nb44d4537c2ba4511817ac6c75798c5eb
119 schema:url https://doi.org/10.1038/leu.2012.3
120 sgo:license sg:explorer/license/
121 sgo:sdDataset articles
122 rdf:type schema:ScholarlyArticle
123 N06884bd8e6d242b596920c4b4b190e45 rdf:first sg:person.0723122240.26
124 rdf:rest Nc33d388656a541568a9c8bcc6cd3e36f
125 N0b0f91f229584bc58634973585a70440 schema:name doi
126 schema:value 10.1038/leu.2012.3
127 rdf:type schema:PropertyValue
128 N11cf70fc693b45cea1575a35990f3e0f rdf:first sg:person.01043327543.11
129 rdf:rest Nf0bd7c22ccb54c1fb8a100b8afe0a8a9
130 N1541e479d5724b779c26996f768f28c3 rdf:first sg:person.01053746063.57
131 rdf:rest N9cc5c0962ae84f228e5ca6ba6f9946fc
132 N1558e878da914e0cb41eb6ce07db7df3 rdf:first Nddf250dd3f37470a9a21eb963453242a
133 rdf:rest N60d30c036733449caf2bbe6179c047f5
134 N176c3454679643a29168f42bcf518c2d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
135 schema:name Genes, Immunoglobulin Heavy Chain
136 rdf:type schema:DefinedTerm
137 N1d913e1e4ecb41eb9ec9666f4d4b12d9 schema:affiliation grid-institutes:grid.18886.3f
138 schema:familyName Gonzalez
139 schema:givenName D
140 rdf:type schema:Person
141 N2be49439ad1842bf8121c1ca3743ce4a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
142 schema:name Gene Rearrangement, B-Lymphocyte, Heavy Chain
143 rdf:type schema:DefinedTerm
144 N2d892498204c4b91b4c2efcb674a5779 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
145 schema:name Cohort Studies
146 rdf:type schema:DefinedTerm
147 N2fe6c49ae6ed4742ac7bfef9f05170ee schema:name dimensions_id
148 schema:value pub.1034967212
149 rdf:type schema:PropertyValue
150 N43a12189e79640c580515507a3ac1b14 rdf:first sg:person.01141551130.83
151 rdf:rest N64b7783d34234525bbf8989aabc62a0f
152 N49187964e0a547929e295d0c5daaad0e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
153 schema:name Immunoglobulin Variable Region
154 rdf:type schema:DefinedTerm
155 N49e76e52b9e24f7c97b3839cd944529d rdf:first N7f634ac1df8c41bb961d31710b87d457
156 rdf:rest N11cf70fc693b45cea1575a35990f3e0f
157 N55f41b12f0234459a568e42772a89e93 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
158 schema:name Mutation
159 rdf:type schema:DefinedTerm
160 N5a3d52721e5040fa9df761e8fe09ab5d rdf:first sg:person.01357164153.14
161 rdf:rest N5ab756a240ce4a2a833e5f095009b9d9
162 N5ab756a240ce4a2a833e5f095009b9d9 rdf:first sg:person.01244525060.81
163 rdf:rest N06884bd8e6d242b596920c4b4b190e45
164 N5b672faf11ed4dbea8a22e313c7dc5b1 rdf:first sg:person.01151530700.45
165 rdf:rest Nb388584aec404c23a6a126284069ab92
166 N60d30c036733449caf2bbe6179c047f5 rdf:first N1d913e1e4ecb41eb9ec9666f4d4b12d9
167 rdf:rest N1541e479d5724b779c26996f768f28c3
168 N64b7783d34234525bbf8989aabc62a0f rdf:first sg:person.01153320635.02
169 rdf:rest Nafe95e77c85e42819381cd09ea01e64a
170 N64c0f6b625e14b6b87f72ff6078265f7 schema:affiliation grid-institutes:grid.413852.9
171 schema:familyName Berger
172 schema:givenName F
173 rdf:type schema:Person
174 N6f16d080a37643219b9c7c170e7c472f schema:issueNumber 7
175 rdf:type schema:PublicationIssue
176 N7319a050ce2649048555135a569009e5 rdf:first sg:person.07440427070.11
177 rdf:rest Ndbd726c2a33a4da6ad80aec1e35f1133
178 N78db1742fe094c6f8096772d3f42a27a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
179 schema:name Lymphoma, B-Cell, Marginal Zone
180 rdf:type schema:DefinedTerm
181 N7bf500720db9489798ce6e3e46c91821 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
182 schema:name Models, Molecular
183 rdf:type schema:DefinedTerm
184 N7cb64ea994cc471abfce2832ce50d228 schema:volumeNumber 26
185 rdf:type schema:PublicationVolume
186 N7f634ac1df8c41bb961d31710b87d457 schema:affiliation grid-institutes:grid.12284.3d
187 schema:familyName Bourikas
188 schema:givenName G
189 rdf:type schema:Person
190 N7f7c7ba1693842c4838a2e16c5daa68d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
191 schema:name Prognosis
192 rdf:type schema:DefinedTerm
193 N897930c90c1544378fcb02dd4e8e4176 schema:name pubmed_id
194 schema:value 22222599
195 rdf:type schema:PropertyValue
196 N8fe1b4b629e04ba5876a176ed4a736d6 rdf:first sg:person.01110665614.54
197 rdf:rest Ndad39ee082454ff1ac9379ed5c08269f
198 N939aaccd76794592ab5e2196fe96609f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
199 schema:name Splenic Neoplasms
200 rdf:type schema:DefinedTerm
201 N9b989c6e1ce74821862a369e880cd766 rdf:first sg:person.0710147173.09
202 rdf:rest N49e76e52b9e24f7c97b3839cd944529d
203 N9cc5c0962ae84f228e5ca6ba6f9946fc rdf:first sg:person.01204577503.15
204 rdf:rest Na8229ff396934007918adb306680c9ee
205 N9e0bec7f99d742858d58a45a09d740e2 rdf:first sg:person.0666515447.66
206 rdf:rest Ne445f6e806864f429eb016570f82101c
207 Na5d08d04c10d422388fd33f32911d6b5 rdf:first sg:person.01207030342.98
208 rdf:rest N7319a050ce2649048555135a569009e5
209 Na8229ff396934007918adb306680c9ee rdf:first sg:person.01000056636.29
210 rdf:rest N9b989c6e1ce74821862a369e880cd766
211 Na8f66c6d626945868753978b6c6a6d2a schema:affiliation grid-institutes:None
212 schema:familyName Tsaftaris
213 schema:givenName A
214 rdf:type schema:Person
215 Nae73be68c30b4f30b4fac4f447ff7888 rdf:first sg:person.0755352635.88
216 rdf:rest Na5d08d04c10d422388fd33f32911d6b5
217 Nafe95e77c85e42819381cd09ea01e64a rdf:first N64c0f6b625e14b6b87f72ff6078265f7
218 rdf:rest N5b672faf11ed4dbea8a22e313c7dc5b1
219 Nb29183d60e9e481db3d5f148a84beb84 rdf:first sg:person.0610466400.38
220 rdf:rest rdf:nil
221 Nb388584aec404c23a6a126284069ab92 rdf:first sg:person.01322130253.89
222 rdf:rest N8fe1b4b629e04ba5876a176ed4a736d6
223 Nb44d4537c2ba4511817ac6c75798c5eb schema:name Springer Nature - SN SciGraph project
224 rdf:type schema:Organization
225 Nb9349b47fcb44025855a2e8d5dd89a76 rdf:first sg:person.0676224054.65
226 rdf:rest N43a12189e79640c580515507a3ac1b14
227 Nc33d388656a541568a9c8bcc6cd3e36f rdf:first sg:person.0720330517.11
228 rdf:rest N9e0bec7f99d742858d58a45a09d740e2
229 Nd174b8c20c6348ac895e0fe9d1ca8d92 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
230 schema:name Humans
231 rdf:type schema:DefinedTerm
232 Nd34ce53977af434d86198f39a5f9b47f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
233 schema:name Complementarity Determining Regions
234 rdf:type schema:DefinedTerm
235 Ndad39ee082454ff1ac9379ed5c08269f rdf:first sg:person.01162043155.16
236 rdf:rest Nae73be68c30b4f30b4fac4f447ff7888
237 Ndbd726c2a33a4da6ad80aec1e35f1133 rdf:first sg:person.01333301733.69
238 rdf:rest Nb29183d60e9e481db3d5f148a84beb84
239 Nddf250dd3f37470a9a21eb963453242a schema:affiliation grid-institutes:None
240 schema:familyName Santoro
241 schema:givenName A
242 rdf:type schema:Person
243 Ne445f6e806864f429eb016570f82101c rdf:first sg:person.01132610000.12
244 rdf:rest Nf23c68993c0b4647b02bd2af4f13ac53
245 Nf0bd7c22ccb54c1fb8a100b8afe0a8a9 rdf:first Na8f66c6d626945868753978b6c6a6d2a
246 rdf:rest Nb9349b47fcb44025855a2e8d5dd89a76
247 Nf23c68993c0b4647b02bd2af4f13ac53 rdf:first sg:person.0760530715.90
248 rdf:rest N1558e878da914e0cb41eb6ce07db7df3
249 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
250 schema:name Medical and Health Sciences
251 rdf:type schema:DefinedTerm
252 anzsrc-for:1103 schema:inDefinedTermSet anzsrc-for:
253 schema:name Clinical Sciences
254 rdf:type schema:DefinedTerm
255 anzsrc-for:1112 schema:inDefinedTermSet anzsrc-for:
256 schema:name Oncology and Carcinogenesis
257 rdf:type schema:DefinedTerm
258 sg:journal.1097065 schema:issn 0887-6924
259 1476-5551
260 schema:name Leukemia
261 schema:publisher Springer Nature
262 rdf:type schema:Periodical
263 sg:person.01000056636.29 schema:affiliation grid-institutes:grid.18887.3e
264 schema:familyName Gangemi
265 schema:givenName F
266 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01000056636.29
267 rdf:type schema:Person
268 sg:person.01043327543.11 schema:affiliation grid-institutes:grid.415248.e
269 schema:familyName Anagnostopoulos
270 schema:givenName A
271 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01043327543.11
272 rdf:type schema:Person
273 sg:person.01053746063.57 schema:affiliation grid-institutes:grid.413514.6
274 schema:familyName Mollejo
275 schema:givenName M
276 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01053746063.57
277 rdf:type schema:Person
278 sg:person.01110665614.54 schema:affiliation grid-institutes:grid.414655.7
279 schema:familyName Papadaki
280 schema:givenName T
281 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01110665614.54
282 rdf:type schema:Person
283 sg:person.01132610000.12 schema:affiliation grid-institutes:grid.413852.9
284 schema:familyName Traverse-Glehen
285 schema:givenName A
286 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01132610000.12
287 rdf:type schema:Person
288 sg:person.01141551130.83 schema:affiliation grid-institutes:grid.18887.3e
289 schema:familyName Ponzoni
290 schema:givenName M
291 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01141551130.83
292 rdf:type schema:Person
293 sg:person.01151530700.45 schema:affiliation grid-institutes:grid.415449.9
294 schema:familyName Belessi
295 schema:givenName C
296 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01151530700.45
297 rdf:type schema:Person
298 sg:person.01153320635.02 schema:affiliation grid-institutes:grid.413852.9
299 schema:familyName Felman
300 schema:givenName P
301 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01153320635.02
302 rdf:type schema:Person
303 sg:person.01162043155.16 schema:affiliation grid-institutes:grid.66875.3a
304 schema:familyName Dogan
305 schema:givenName A
306 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01162043155.16
307 rdf:type schema:Person
308 sg:person.01204577503.15 schema:affiliation grid-institutes:grid.18887.3e
309 schema:familyName Dagklis
310 schema:givenName A
311 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01204577503.15
312 rdf:type schema:Person
313 sg:person.01207030342.98 schema:affiliation grid-institutes:grid.18886.3f
314 schema:familyName Matutes
315 schema:givenName E
316 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01207030342.98
317 rdf:type schema:Person
318 sg:person.01244525060.81 schema:affiliation grid-institutes:None
319 schema:familyName Darzentas
320 schema:givenName N
321 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01244525060.81
322 rdf:type schema:Person
323 sg:person.01322130253.89 schema:affiliation grid-institutes:grid.18887.3e
324 schema:familyName Ghia
325 schema:givenName P
326 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01322130253.89
327 rdf:type schema:Person
328 sg:person.01333301733.69 schema:affiliation grid-institutes:grid.416098.2
329 schema:familyName Oscier
330 schema:givenName D
331 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01333301733.69
332 rdf:type schema:Person
333 sg:person.01357164153.14 schema:affiliation grid-institutes:grid.12284.3d
334 schema:familyName Bikos
335 schema:givenName V
336 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01357164153.14
337 rdf:type schema:Person
338 sg:person.0610466400.38 schema:affiliation grid-institutes:grid.415248.e
339 schema:familyName Stamatopoulos
340 schema:givenName K
341 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0610466400.38
342 rdf:type schema:Person
343 sg:person.0666515447.66 schema:affiliation grid-institutes:grid.18886.3f
344 schema:familyName Hockley
345 schema:givenName S
346 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0666515447.66
347 rdf:type schema:Person
348 sg:person.0676224054.65 schema:affiliation grid-institutes:grid.10776.37
349 schema:familyName Iannitto
350 schema:givenName E
351 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0676224054.65
352 rdf:type schema:Person
353 sg:person.0710147173.09 schema:affiliation grid-institutes:grid.239578.2
354 schema:familyName Bosler
355 schema:givenName D S
356 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0710147173.09
357 rdf:type schema:Person
358 sg:person.0720330517.11 schema:affiliation grid-institutes:grid.416098.2
359 schema:familyName Davis
360 schema:givenName Z
361 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0720330517.11
362 rdf:type schema:Person
363 sg:person.0723122240.26 schema:affiliation grid-institutes:None
364 schema:familyName Hadzidimitriou
365 schema:givenName A
366 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0723122240.26
367 rdf:type schema:Person
368 sg:person.07440427070.11 schema:affiliation grid-institutes:grid.411325.0
369 schema:familyName Piris
370 schema:givenName M A
371 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.07440427070.11
372 rdf:type schema:Person
373 sg:person.0755352635.88 schema:affiliation grid-institutes:grid.18887.3e
374 schema:familyName Degano
375 schema:givenName M
376 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0755352635.88
377 rdf:type schema:Person
378 sg:person.0760530715.90 schema:affiliation grid-institutes:grid.413514.6
379 schema:familyName Algara
380 schema:givenName P
381 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0760530715.90
382 rdf:type schema:Person
383 sg:pub.10.1007/s000180300026 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027481770
384 https://doi.org/10.1007/s000180300026
385 rdf:type schema:CreativeWork
386 sg:pub.10.1038/leu.2009.186 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043519279
387 https://doi.org/10.1038/leu.2009.186
388 rdf:type schema:CreativeWork
389 sg:pub.10.1038/leu.2011.49 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005769936
390 https://doi.org/10.1038/leu.2011.49
391 rdf:type schema:CreativeWork
392 sg:pub.10.1038/sj.leu.2405068 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041532471
393 https://doi.org/10.1038/sj.leu.2405068
394 rdf:type schema:CreativeWork
395 sg:pub.10.2119/2005-00001.stamatopoulos schema:sameAs https://app.dimensions.ai/details/publication/pub.1068964902
396 https://doi.org/10.2119/2005-00001.stamatopoulos
397 rdf:type schema:CreativeWork
398 sg:pub.10.2119/2005-00044.belessi schema:sameAs https://app.dimensions.ai/details/publication/pub.1068964911
399 https://doi.org/10.2119/2005-00044.belessi
400 rdf:type schema:CreativeWork
401 grid-institutes:None schema:alternateName Institute of Agrobiotechnology, Center for Research and Technology Hellas, Thessaloniki, Greece
402 Laboratory of Hematology, Villa Sofia-Cervello Hospital, Palermo, Italy
403 schema:name Institute of Agrobiotechnology, Center for Research and Technology Hellas, Thessaloniki, Greece
404 Laboratory of Hematology, Villa Sofia-Cervello Hospital, Palermo, Italy
405 rdf:type schema:Organization
406 grid-institutes:grid.10776.37 schema:alternateName Department of Hematology, University of Palermo, Palermo, Italy
407 schema:name Department of Hematology, University of Palermo, Palermo, Italy
408 rdf:type schema:Organization
409 grid-institutes:grid.12284.3d schema:alternateName Democritus University of Thrace, Alexandroupolis, Greece
410 schema:name Democritus University of Thrace, Alexandroupolis, Greece
411 rdf:type schema:Organization
412 grid-institutes:grid.18886.3f schema:alternateName Section of Haemato-Oncology, Institute of Cancer Research, London, UK
413 schema:name Section of Haemato-Oncology, Institute of Cancer Research, London, UK
414 rdf:type schema:Organization
415 grid-institutes:grid.18887.3e schema:alternateName Division of Immunology, Biocrystallography Unit, Transplantation, and Infectious Diseases, Scientific Institute San Raffaele, Milan, Italy
416 Pathology Unit and Unit of Lymphoid Malignancies, Istituto Scientifico San Raffaele, Milan, Italy
417 Unit of Lymphoid Malignancies and MAGIC (Microenvironment and Genes in Cancers of the blood) Interdivisional Research Program, Laboratory of B cell Neoplasia, Università Vita-Salute San Raffaele and Istituto Scientifico San Raffaele, Milan, Italy
418 schema:name Division of Immunology, Biocrystallography Unit, Transplantation, and Infectious Diseases, Scientific Institute San Raffaele, Milan, Italy
419 Pathology Unit and Unit of Lymphoid Malignancies, Istituto Scientifico San Raffaele, Milan, Italy
420 Unit of Lymphoid Malignancies and MAGIC (Microenvironment and Genes in Cancers of the blood) Interdivisional Research Program, Laboratory of B cell Neoplasia, Università Vita-Salute San Raffaele and Istituto Scientifico San Raffaele, Milan, Italy
421 rdf:type schema:Organization
422 grid-institutes:grid.239578.2 schema:alternateName Cleveland Clinic, Cleveland, OH, USA
423 schema:name Cleveland Clinic, Cleveland, OH, USA
424 rdf:type schema:Organization
425 grid-institutes:grid.411325.0 schema:alternateName Hospital Universitario Marques de Valdecilla, Santander, Spain
426 schema:name Hospital Universitario Marques de Valdecilla, Santander, Spain
427 rdf:type schema:Organization
428 grid-institutes:grid.413514.6 schema:alternateName Hospital Virgen de la Salud, Toledo, Spain
429 schema:name Hospital Virgen de la Salud, Toledo, Spain
430 rdf:type schema:Organization
431 grid-institutes:grid.413852.9 schema:alternateName Department of Pathology, Hospices Civils de Lyon, Université Lyon 1, Lyon, France
432 Laboratory of Hematology, Hospices Civils de Lyon, Université Lyon 1, Lyon, France
433 schema:name Department of Pathology, Hospices Civils de Lyon, Université Lyon 1, Lyon, France
434 Laboratory of Hematology, Hospices Civils de Lyon, Université Lyon 1, Lyon, France
435 rdf:type schema:Organization
436 grid-institutes:grid.414655.7 schema:alternateName Hematopathology Department, Evangelismos Hospital, Athens, Greece
437 schema:name Hematopathology Department, Evangelismos Hospital, Athens, Greece
438 rdf:type schema:Organization
439 grid-institutes:grid.415248.e schema:alternateName Hematology Department and HCT Unit, G Papanicolaou Hospital, Thessaloniki, Greece
440 schema:name Hematology Department and HCT Unit, G Papanicolaou Hospital, Thessaloniki, Greece
441 Institute of Agrobiotechnology, Center for Research and Technology Hellas, Thessaloniki, Greece
442 rdf:type schema:Organization
443 grid-institutes:grid.415449.9 schema:alternateName Hematology Department, Nikea General Hospital, Pireaus, Greece
444 schema:name Hematology Department, Nikea General Hospital, Pireaus, Greece
445 rdf:type schema:Organization
446 grid-institutes:grid.416098.2 schema:alternateName Department of Haematology, Royal Bournemouth Hospital, Bournemouth, UK
447 schema:name Department of Haematology, Royal Bournemouth Hospital, Bournemouth, UK
448 rdf:type schema:Organization
449 grid-institutes:grid.66875.3a schema:alternateName Department of Pathology, Mayo Clinic, Rochester, MN, USA
450 schema:name Department of Pathology, Mayo Clinic, Rochester, MN, USA
451 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...