ASXL1 exon 12 mutations are frequent in AML with intermediate risk karyotype and are independently associated with an adverse outcome View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2013-01

AUTHORS

S Schnittger, C Eder, S Jeromin, T Alpermann, A Fasan, V Grossmann, A Kohlmann, T Illig, N Klopp, H-E Wichmann, K-A Kreuzer, C Schmid, P Staib, R Peceny, N Schmitz, W Kern, C Haferlach, T Haferlach

ABSTRACT

We aimed at evaluating ASXL1mut in 740 AML with intermediate risk karyotype for frequency, association with other mutations and impact on outcome. Five hundred fifty-three cases had a normal karyotype (NK) and 187 had intermediate risk aberrant cytogenetics. Overall, ASXL1mut were detected in 127/740 patients (17.2%). ASXL1mut were more frequent in males than in females (23.5% vs 9.9%, P<0.001). They were associated with higher age (median: 71.8 vs 61.8, P<0.001), a history of preceding myelodysplastic syndromes, and with a more immature immunophenotype compared with patients with wild-type ASXL1 (ASXL1wt). ASXL1mut were more frequent in patients with aberrant karyotype (58/187; 31.0%), especially in cases with trisomy 8 (39/74; 52.7%), than in those with NK (69/553; 12.5%; P<0.001). ASXL1mut were observed more frequent in RUNX1mut (P<0.001), and less frequent in NPM1mut (P<0.001), FLT3-internal tandem duplication (ITD) (P<0.001), FLT3-TKD (P=0.001) and DNMT3Amut (P<0.001). Patients with ASXL1mut had a shorter overall survival (OS) (P<0.001) and event free survival (P=0.012) compared with ASXL1wt. In multivariable analysis, ASXL1mut was an independent adverse factor for OS (P=0.032, relative risk: 1.70). In conclusion, ASXL1mut belong to the most frequent mutations in intermediate risk group AML. Their strong and independent dismal prognostic impact suggests the inclusion into the diagnostic work-up of AML. More... »

PAGES

82

References to SciGraph publications

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/leu.2012.262

DOI

http://dx.doi.org/10.1038/leu.2012.262

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1031979360

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/23018865


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1112", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Oncology and Carcinogenesis", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Adolescent", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Adult", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Aged", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Aged, 80 and over", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Case-Control Studies", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Core Binding Factor Alpha 2 Subunit", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "DNA (Cytosine-5-)-Methyltransferases", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Exons", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Female", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Follow-Up Studies", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Immunophenotyping", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Karyotyping", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Leukemia, Myeloid, Acute", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Male", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Middle Aged", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Mutation", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Myelodysplastic Syndromes", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Nuclear Proteins", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Prognosis", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Repressor Proteins", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Risk Factors", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Survival Rate", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Young Adult", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "fms-Like Tyrosine Kinase 3", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Munich Leukemia Laboratory (Germany)", 
          "id": "https://www.grid.ac/institutes/grid.420057.4", 
          "name": [
            "MLL Munich Leukemia Laboratory, Munich, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Schnittger", 
        "givenName": "S", 
        "id": "sg:person.0614717340.09", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0614717340.09"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Munich Leukemia Laboratory (Germany)", 
          "id": "https://www.grid.ac/institutes/grid.420057.4", 
          "name": [
            "MLL Munich Leukemia Laboratory, Munich, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Eder", 
        "givenName": "C", 
        "id": "sg:person.01246656064.29", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01246656064.29"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Munich Leukemia Laboratory (Germany)", 
          "id": "https://www.grid.ac/institutes/grid.420057.4", 
          "name": [
            "MLL Munich Leukemia Laboratory, Munich, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Jeromin", 
        "givenName": "S", 
        "id": "sg:person.01302055262.30", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01302055262.30"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Munich Leukemia Laboratory (Germany)", 
          "id": "https://www.grid.ac/institutes/grid.420057.4", 
          "name": [
            "MLL Munich Leukemia Laboratory, Munich, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Alpermann", 
        "givenName": "T", 
        "id": "sg:person.01041533240.56", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01041533240.56"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Munich Leukemia Laboratory (Germany)", 
          "id": "https://www.grid.ac/institutes/grid.420057.4", 
          "name": [
            "MLL Munich Leukemia Laboratory, Munich, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Fasan", 
        "givenName": "A", 
        "id": "sg:person.01126566364.85", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01126566364.85"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Munich Leukemia Laboratory (Germany)", 
          "id": "https://www.grid.ac/institutes/grid.420057.4", 
          "name": [
            "MLL Munich Leukemia Laboratory, Munich, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Grossmann", 
        "givenName": "V", 
        "id": "sg:person.01002227315.09", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01002227315.09"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Munich Leukemia Laboratory (Germany)", 
          "id": "https://www.grid.ac/institutes/grid.420057.4", 
          "name": [
            "MLL Munich Leukemia Laboratory, Munich, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Kohlmann", 
        "givenName": "A", 
        "id": "sg:person.01116455715.21", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01116455715.21"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Hannover Medical School", 
          "id": "https://www.grid.ac/institutes/grid.10423.34", 
          "name": [
            "Research Unit of Molecular Epidemiology, Helmholtz Zentrum M\u00fcnchen, Munich, Germany", 
            "Hannover Unified Biobank, Hannover Medical School, Hannover, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Illig", 
        "givenName": "T", 
        "id": "sg:person.01364120657.92", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01364120657.92"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Hannover Medical School", 
          "id": "https://www.grid.ac/institutes/grid.10423.34", 
          "name": [
            "Research Unit of Molecular Epidemiology, Helmholtz Zentrum M\u00fcnchen, Munich, Germany", 
            "Hannover Unified Biobank, Hannover Medical School, Hannover, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Klopp", 
        "givenName": "N", 
        "id": "sg:person.01103462233.30", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01103462233.30"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Helmholtz Zentrum M\u00fcnchen", 
          "id": "https://www.grid.ac/institutes/grid.4567.0", 
          "name": [
            "Institute of Epidemiology I, Helmholtz Zentrum M\u00fcnchen, Munich, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Wichmann", 
        "givenName": "H-E", 
        "id": "sg:person.01141622516.63", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01141622516.63"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Cologne", 
          "id": "https://www.grid.ac/institutes/grid.6190.e", 
          "name": [
            "Department I of Internal Medicine, University at Cologne, Cologne, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Kreuzer", 
        "givenName": "K-A", 
        "id": "sg:person.01207306133.88", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01207306133.88"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Augsburg Hospital", 
          "id": "https://www.grid.ac/institutes/grid.419801.5", 
          "name": [
            "Department of Internal Medicine II, Klinikum Augsburg, Augsburg, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Schmid", 
        "givenName": "C", 
        "id": "sg:person.010141404252.46", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.010141404252.46"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Sankt-Antonius-Hospital Eschweiler", 
          "id": "https://www.grid.ac/institutes/grid.459927.4", 
          "name": [
            "Clinic for Hematology and Oncology, St Antonius Hospital, Eschweiler, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Staib", 
        "givenName": "P", 
        "id": "sg:person.01337170222.03", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01337170222.03"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Klinikum Osnabr\u00fcck", 
          "id": "https://www.grid.ac/institutes/grid.500028.f", 
          "name": [
            "Department for Hematology and Oncology, Klinikum Osnabr\u00fcck, Osnabr\u00fcck, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Peceny", 
        "givenName": "R", 
        "id": "sg:person.01203153562.38", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01203153562.38"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Asklepios Klinik St. Georg", 
          "id": "https://www.grid.ac/institutes/grid.459389.a", 
          "name": [
            "Department for Hematology and Stemcell Transplantation, Asklepios Klinik St Georg, Hamburg, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Schmitz", 
        "givenName": "N", 
        "id": "sg:person.01222770646.02", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01222770646.02"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Munich Leukemia Laboratory (Germany)", 
          "id": "https://www.grid.ac/institutes/grid.420057.4", 
          "name": [
            "MLL Munich Leukemia Laboratory, Munich, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Kern", 
        "givenName": "W", 
        "id": "sg:person.016053332122.16", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.016053332122.16"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Munich Leukemia Laboratory (Germany)", 
          "id": "https://www.grid.ac/institutes/grid.420057.4", 
          "name": [
            "MLL Munich Leukemia Laboratory, Munich, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Haferlach", 
        "givenName": "C", 
        "id": "sg:person.01340323440.45", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01340323440.45"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Munich Leukemia Laboratory (Germany)", 
          "id": "https://www.grid.ac/institutes/grid.420057.4", 
          "name": [
            "MLL Munich Leukemia Laboratory, Munich, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Haferlach", 
        "givenName": "T", 
        "id": "sg:person.01237731352.62", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01237731352.62"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.1001/jama.2011.473", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1001176831"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ng.507", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1003091868", 
          "https://doi.org/10.1038/ng.507"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ng.507", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1003091868", 
          "https://doi.org/10.1038/ng.507"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.jmoldx.2010.09.001", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1004141951"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/leu.2009.218", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1004469296", 
          "https://doi.org/10.1038/leu.2009.218"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nmeth0410-248", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1007489634", 
          "https://doi.org/10.1038/nmeth0410-248"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nmeth0410-248", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1007489634", 
          "https://doi.org/10.1038/nmeth0410-248"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.beha.2010.06.007", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1007698899"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1365-2141.2010.08381.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1008022542"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1365-2141.2010.08381.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1008022542"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1182/blood-2002-03-0990", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1008614109"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1182/blood-2009-03-213389", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1008844336"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1365-2141.1976.tb03563.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1009619175"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/leu.2011.200", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1009669399", 
          "https://doi.org/10.1038/leu.2011.200"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/leu.2011.200", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1009669399", 
          "https://doi.org/10.1038/leu.2011.200"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1182/blood-2007-05-091215", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1010761990"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1182/blood-2007-02-072595", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1014562054"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/1471-2407-10-401", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1015343459", 
          "https://doi.org/10.1186/1471-2407-10-401"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1074/jbc.m109.065862", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1015579806"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nprot.2009.86", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1015642657", 
          "https://doi.org/10.1038/nprot.2009.86"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/leu.2010.144", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1015952145", 
          "https://doi.org/10.1038/leu.2010.144"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/leu.2010.144", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1015952145", 
          "https://doi.org/10.1038/leu.2010.144"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1182/blood-2005-08-3522", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1017060610"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1182/blood-2010-05-283291", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1020362185"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1182/blood-2011-02-292102", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1021572968"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1182/blood-2009-11-254441", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1021909700"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1074/jbc.m512616200", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1023532806"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1200/jco.2009.27.1361", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1023667382"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1182/blood-2004-03-1036", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1024111969"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1182/asheducation-2004.1.80", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1025549241"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/leu.2010.20", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1031090846", 
          "https://doi.org/10.1038/leu.2010.20"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1182/blood-2009-05-223784", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035378560"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1182/blood-2009-05-223784", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035378560"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1200/jco.2010.28.2285", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035942018"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1365-2141.2009.07697.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1036319854"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1365-2141.2009.07697.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1036319854"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1158/0008-5472.can-09-3783", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1036405420"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1182/blood-2005-06-2248", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1036438078"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1200/jco.2010.33.4938", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1036660359"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/leu.2011.58", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1036721490", 
          "https://doi.org/10.1038/leu.2011.58"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/leu.2009.124", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1036988172", 
          "https://doi.org/10.1038/leu.2009.124"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1182/blood-2009-11-255976", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1038462632"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1182/blood-2010-02-267955", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1039097404"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1056/nejmoa1005143", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1040018409"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3324/haematol.2010.030015", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1041488819"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/leu.2009.141", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1041858819", 
          "https://doi.org/10.1038/leu.2009.141"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1182/blood-2009-07-235358", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1042177075"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1182/blood.v100.1.59", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1042949004"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/1756-8722-5-12", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1044086517", 
          "https://doi.org/10.1186/1756-8722-5-12"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1056/nejmoa0810069", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1045634206"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ng.621", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1045969373", 
          "https://doi.org/10.1038/ng.621"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1182/blood-2011-08-368225", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1047288906"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.leu.2401773", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1049359229", 
          "https://doi.org/10.1038/sj.leu.2401773"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.leu.2401773", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1049359229", 
          "https://doi.org/10.1038/sj.leu.2401773"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/leu.2010.298", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1051734594", 
          "https://doi.org/10.1038/leu.2010.298"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1200/jco.2003.04.036", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1064203515"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1200/jco.2003.99.091", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1064204098"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2013-01", 
    "datePublishedReg": "2013-01-01", 
    "description": "We aimed at evaluating ASXL1mut in 740 AML with intermediate risk karyotype for frequency, association with other mutations and impact on outcome. Five hundred fifty-three cases had a normal karyotype (NK) and 187 had intermediate risk aberrant cytogenetics. Overall, ASXL1mut were detected in 127/740 patients (17.2%). ASXL1mut were more frequent in males than in females (23.5% vs 9.9%, P<0.001). They were associated with higher age (median: 71.8 vs 61.8, P<0.001), a history of preceding myelodysplastic syndromes, and with a more immature immunophenotype compared with patients with wild-type ASXL1 (ASXL1wt). ASXL1mut were more frequent in patients with aberrant karyotype (58/187; 31.0%), especially in cases with trisomy 8 (39/74; 52.7%), than in those with NK (69/553; 12.5%; P<0.001). ASXL1mut were observed more frequent in RUNX1mut (P<0.001), and less frequent in NPM1mut (P<0.001), FLT3-internal tandem duplication (ITD) (P<0.001), FLT3-TKD (P=0.001) and DNMT3Amut (P<0.001). Patients with ASXL1mut had a shorter overall survival (OS) (P<0.001) and event free survival (P=0.012) compared with ASXL1wt. In multivariable analysis, ASXL1mut was an independent adverse factor for OS (P=0.032, relative risk: 1.70). In conclusion, ASXL1mut belong to the most frequent mutations in intermediate risk group AML. Their strong and independent dismal prognostic impact suggests the inclusion into the diagnostic work-up of AML.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1038/leu.2012.262", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": true, 
    "isPartOf": [
      {
        "id": "sg:journal.1097065", 
        "issn": [
          "0887-6924", 
          "1476-5551"
        ], 
        "name": "Leukemia", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "1", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "27"
      }
    ], 
    "name": "ASXL1 exon 12 mutations are frequent in AML with intermediate risk karyotype and are independently associated with an adverse outcome", 
    "pagination": "82", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "9858013c9dbb8f603d01730cd94e8edd40f2b1870dd20a1690ba977eca4eb8df"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "23018865"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "8704895"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1038/leu.2012.262"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1031979360"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1038/leu.2012.262", 
      "https://app.dimensions.ai/details/publication/pub.1031979360"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-11T00:05", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8695_00000435.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://www.nature.com/articles/leu2012262"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/leu.2012.262'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/leu.2012.262'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/leu.2012.262'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/leu.2012.262'


 

This table displays all metadata directly associated to this object as RDF triples.

472 TRIPLES      21 PREDICATES      103 URIs      46 LITERALS      34 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1038/leu.2012.262 schema:about N00c082b56495417e9dbe3c1c6e6c72fd
2 N010e46dcdb1944a797d4f0fb7ea0da33
3 N04b4cab7be044534a04882f8c4d0fe62
4 N10348a21f59149e7afef3acea2d8ac0a
5 N110a05532b3d4c31b839e5eed7f5ca20
6 N2c61fe0e9d6c43b2a7993403ab5fcf08
7 N36b25a2c6f0446769b6e2c56b273429a
8 N3ac295a084c6401cacfb6d7126828bb1
9 N4d09818f2a48453aa87ac9cb057515b5
10 N5774ec6927694f888767d27ff9234ef0
11 N591bd1f710d74b0a83de05b2ba4e4107
12 N78f1275409b74675af8c2b2216267dec
13 N8e044bd2e17a4980bb5c045fcd72f482
14 N9a9a01251b81492d902c7b38bd3efb3a
15 Na442dc79e85443ad8187bddb92d43065
16 Na8a2280afa0843fabe6bef819031b560
17 Na9796466fb99408985c0ce5bccb182f9
18 Naf539b904adb455bb3a13087b819b1ca
19 Nb4c259f505f447b69f27255484e83024
20 Nc58378bf00ec4f64a00c064b2da37958
21 Nc8f7e93089cd457eb8baa6587691ef79
22 Nd7c5730677614d719ad270a9715c6956
23 Nf63eaff819d4417b9cc8e6772111fa96
24 Nfa4c537ab1124b04b74bbf7a6c092e4d
25 Nfb157205b60248e1a5ff7fbde9f24af7
26 anzsrc-for:11
27 anzsrc-for:1112
28 schema:author N6e035b8f4a7846aa88d5202af1324c52
29 schema:citation sg:pub.10.1038/leu.2009.124
30 sg:pub.10.1038/leu.2009.141
31 sg:pub.10.1038/leu.2009.218
32 sg:pub.10.1038/leu.2010.144
33 sg:pub.10.1038/leu.2010.20
34 sg:pub.10.1038/leu.2010.298
35 sg:pub.10.1038/leu.2011.200
36 sg:pub.10.1038/leu.2011.58
37 sg:pub.10.1038/ng.507
38 sg:pub.10.1038/ng.621
39 sg:pub.10.1038/nmeth0410-248
40 sg:pub.10.1038/nprot.2009.86
41 sg:pub.10.1038/sj.leu.2401773
42 sg:pub.10.1186/1471-2407-10-401
43 sg:pub.10.1186/1756-8722-5-12
44 https://doi.org/10.1001/jama.2011.473
45 https://doi.org/10.1016/j.beha.2010.06.007
46 https://doi.org/10.1016/j.jmoldx.2010.09.001
47 https://doi.org/10.1056/nejmoa0810069
48 https://doi.org/10.1056/nejmoa1005143
49 https://doi.org/10.1074/jbc.m109.065862
50 https://doi.org/10.1074/jbc.m512616200
51 https://doi.org/10.1111/j.1365-2141.1976.tb03563.x
52 https://doi.org/10.1111/j.1365-2141.2009.07697.x
53 https://doi.org/10.1111/j.1365-2141.2010.08381.x
54 https://doi.org/10.1158/0008-5472.can-09-3783
55 https://doi.org/10.1182/asheducation-2004.1.80
56 https://doi.org/10.1182/blood-2002-03-0990
57 https://doi.org/10.1182/blood-2004-03-1036
58 https://doi.org/10.1182/blood-2005-06-2248
59 https://doi.org/10.1182/blood-2005-08-3522
60 https://doi.org/10.1182/blood-2007-02-072595
61 https://doi.org/10.1182/blood-2007-05-091215
62 https://doi.org/10.1182/blood-2009-03-213389
63 https://doi.org/10.1182/blood-2009-05-223784
64 https://doi.org/10.1182/blood-2009-07-235358
65 https://doi.org/10.1182/blood-2009-11-254441
66 https://doi.org/10.1182/blood-2009-11-255976
67 https://doi.org/10.1182/blood-2010-02-267955
68 https://doi.org/10.1182/blood-2010-05-283291
69 https://doi.org/10.1182/blood-2011-02-292102
70 https://doi.org/10.1182/blood-2011-08-368225
71 https://doi.org/10.1182/blood.v100.1.59
72 https://doi.org/10.1200/jco.2003.04.036
73 https://doi.org/10.1200/jco.2003.99.091
74 https://doi.org/10.1200/jco.2009.27.1361
75 https://doi.org/10.1200/jco.2010.28.2285
76 https://doi.org/10.1200/jco.2010.33.4938
77 https://doi.org/10.3324/haematol.2010.030015
78 schema:datePublished 2013-01
79 schema:datePublishedReg 2013-01-01
80 schema:description We aimed at evaluating ASXL1mut in 740 AML with intermediate risk karyotype for frequency, association with other mutations and impact on outcome. Five hundred fifty-three cases had a normal karyotype (NK) and 187 had intermediate risk aberrant cytogenetics. Overall, ASXL1mut were detected in 127/740 patients (17.2%). ASXL1mut were more frequent in males than in females (23.5% vs 9.9%, P<0.001). They were associated with higher age (median: 71.8 vs 61.8, P<0.001), a history of preceding myelodysplastic syndromes, and with a more immature immunophenotype compared with patients with wild-type ASXL1 (ASXL1wt). ASXL1mut were more frequent in patients with aberrant karyotype (58/187; 31.0%), especially in cases with trisomy 8 (39/74; 52.7%), than in those with NK (69/553; 12.5%; P<0.001). ASXL1mut were observed more frequent in RUNX1mut (P<0.001), and less frequent in NPM1mut (P<0.001), FLT3-internal tandem duplication (ITD) (P<0.001), FLT3-TKD (P=0.001) and DNMT3Amut (P<0.001). Patients with ASXL1mut had a shorter overall survival (OS) (P<0.001) and event free survival (P=0.012) compared with ASXL1wt. In multivariable analysis, ASXL1mut was an independent adverse factor for OS (P=0.032, relative risk: 1.70). In conclusion, ASXL1mut belong to the most frequent mutations in intermediate risk group AML. Their strong and independent dismal prognostic impact suggests the inclusion into the diagnostic work-up of AML.
81 schema:genre research_article
82 schema:inLanguage en
83 schema:isAccessibleForFree true
84 schema:isPartOf N37d2e1cfec2e417b9c8f4e8995e0fccf
85 N3a18b6d84e8c4ac8a967ab0eecbee0c8
86 sg:journal.1097065
87 schema:name ASXL1 exon 12 mutations are frequent in AML with intermediate risk karyotype and are independently associated with an adverse outcome
88 schema:pagination 82
89 schema:productId N115e8a6535f54a5ba2e4268eeed9b299
90 N249e0da691cd4fd0ad72c0283bfb5e66
91 N3f4f1261693946019ce03b910175a122
92 N4adc0528c19048e3b1a7cd284a1590f1
93 N9fa2ba89cbd441b391a9c215666a46f9
94 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031979360
95 https://doi.org/10.1038/leu.2012.262
96 schema:sdDatePublished 2019-04-11T00:05
97 schema:sdLicense https://scigraph.springernature.com/explorer/license/
98 schema:sdPublisher N1ec17729b0e54b3fb2807bbc1950ce0d
99 schema:url https://www.nature.com/articles/leu2012262
100 sgo:license sg:explorer/license/
101 sgo:sdDataset articles
102 rdf:type schema:ScholarlyArticle
103 N00c082b56495417e9dbe3c1c6e6c72fd schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
104 schema:name Exons
105 rdf:type schema:DefinedTerm
106 N010e46dcdb1944a797d4f0fb7ea0da33 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
107 schema:name Myelodysplastic Syndromes
108 rdf:type schema:DefinedTerm
109 N04b4cab7be044534a04882f8c4d0fe62 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
110 schema:name Repressor Proteins
111 rdf:type schema:DefinedTerm
112 N0e5232e718424ae9a2f1256b4acd3418 rdf:first sg:person.01337170222.03
113 rdf:rest Ne6bd708f7a484bf381d6213c36e9b902
114 N10348a21f59149e7afef3acea2d8ac0a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
115 schema:name fms-Like Tyrosine Kinase 3
116 rdf:type schema:DefinedTerm
117 N110a05532b3d4c31b839e5eed7f5ca20 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
118 schema:name Adolescent
119 rdf:type schema:DefinedTerm
120 N115e8a6535f54a5ba2e4268eeed9b299 schema:name dimensions_id
121 schema:value pub.1031979360
122 rdf:type schema:PropertyValue
123 N1ec17729b0e54b3fb2807bbc1950ce0d schema:name Springer Nature - SN SciGraph project
124 rdf:type schema:Organization
125 N249e0da691cd4fd0ad72c0283bfb5e66 schema:name readcube_id
126 schema:value 9858013c9dbb8f603d01730cd94e8edd40f2b1870dd20a1690ba977eca4eb8df
127 rdf:type schema:PropertyValue
128 N2c61fe0e9d6c43b2a7993403ab5fcf08 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
129 schema:name Male
130 rdf:type schema:DefinedTerm
131 N36b25a2c6f0446769b6e2c56b273429a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
132 schema:name Middle Aged
133 rdf:type schema:DefinedTerm
134 N37d2e1cfec2e417b9c8f4e8995e0fccf schema:issueNumber 1
135 rdf:type schema:PublicationIssue
136 N38700af46f9049d2b5599307c5ef460c rdf:first sg:person.01002227315.09
137 rdf:rest Nef1d9ef49325490cbf08427b6b6ab05b
138 N3a18b6d84e8c4ac8a967ab0eecbee0c8 schema:volumeNumber 27
139 rdf:type schema:PublicationVolume
140 N3ac295a084c6401cacfb6d7126828bb1 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
141 schema:name Adult
142 rdf:type schema:DefinedTerm
143 N3f4f1261693946019ce03b910175a122 schema:name pubmed_id
144 schema:value 23018865
145 rdf:type schema:PropertyValue
146 N43d4159b74b44298acca68aee9218c1d rdf:first sg:person.01103462233.30
147 rdf:rest Nd047edd90e0a49e684f5ece7870df5f5
148 N4adc0528c19048e3b1a7cd284a1590f1 schema:name nlm_unique_id
149 schema:value 8704895
150 rdf:type schema:PropertyValue
151 N4d09818f2a48453aa87ac9cb057515b5 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
152 schema:name Aged, 80 and over
153 rdf:type schema:DefinedTerm
154 N5774ec6927694f888767d27ff9234ef0 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
155 schema:name Karyotyping
156 rdf:type schema:DefinedTerm
157 N591bd1f710d74b0a83de05b2ba4e4107 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
158 schema:name Follow-Up Studies
159 rdf:type schema:DefinedTerm
160 N6e035b8f4a7846aa88d5202af1324c52 rdf:first sg:person.0614717340.09
161 rdf:rest N9d1a4248d03c43f9af64d42544f9b11f
162 N7113c35dd0b64b1c837657552c8ee972 rdf:first sg:person.01207306133.88
163 rdf:rest Ne2e90f684e9f4cdf835bca7e1400e825
164 N78f1275409b74675af8c2b2216267dec schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
165 schema:name Humans
166 rdf:type schema:DefinedTerm
167 N8d3f6e675fbb439780a679f5d883fdfa rdf:first sg:person.01364120657.92
168 rdf:rest N43d4159b74b44298acca68aee9218c1d
169 N8e044bd2e17a4980bb5c045fcd72f482 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
170 schema:name Case-Control Studies
171 rdf:type schema:DefinedTerm
172 N941a5bec76614e9db906fe2956dcdc48 rdf:first sg:person.016053332122.16
173 rdf:rest Nd5f1707af8fc4ca49b2477d93791b26c
174 N9a9a01251b81492d902c7b38bd3efb3a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
175 schema:name Female
176 rdf:type schema:DefinedTerm
177 N9d1a4248d03c43f9af64d42544f9b11f rdf:first sg:person.01246656064.29
178 rdf:rest Na4d58d13c2e448319ad16390bff0de79
179 N9fa2ba89cbd441b391a9c215666a46f9 schema:name doi
180 schema:value 10.1038/leu.2012.262
181 rdf:type schema:PropertyValue
182 Na40e34ea0b0e482792bf6dc1caaffe35 rdf:first sg:person.01126566364.85
183 rdf:rest N38700af46f9049d2b5599307c5ef460c
184 Na442dc79e85443ad8187bddb92d43065 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
185 schema:name Core Binding Factor Alpha 2 Subunit
186 rdf:type schema:DefinedTerm
187 Na4d58d13c2e448319ad16390bff0de79 rdf:first sg:person.01302055262.30
188 rdf:rest Ne1ea2a58ba3243c2a151aef69fa2325a
189 Na8a2280afa0843fabe6bef819031b560 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
190 schema:name Risk Factors
191 rdf:type schema:DefinedTerm
192 Na9796466fb99408985c0ce5bccb182f9 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
193 schema:name Nuclear Proteins
194 rdf:type schema:DefinedTerm
195 Naf539b904adb455bb3a13087b819b1ca schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
196 schema:name Aged
197 rdf:type schema:DefinedTerm
198 Nb4c259f505f447b69f27255484e83024 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
199 schema:name Young Adult
200 rdf:type schema:DefinedTerm
201 Nb68fd8c91ad84a1ca4a0c8119cafc637 rdf:first sg:person.01237731352.62
202 rdf:rest rdf:nil
203 Nc58378bf00ec4f64a00c064b2da37958 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
204 schema:name Prognosis
205 rdf:type schema:DefinedTerm
206 Nc8f7e93089cd457eb8baa6587691ef79 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
207 schema:name Leukemia, Myeloid, Acute
208 rdf:type schema:DefinedTerm
209 Nd047edd90e0a49e684f5ece7870df5f5 rdf:first sg:person.01141622516.63
210 rdf:rest N7113c35dd0b64b1c837657552c8ee972
211 Nd5f1707af8fc4ca49b2477d93791b26c rdf:first sg:person.01340323440.45
212 rdf:rest Nb68fd8c91ad84a1ca4a0c8119cafc637
213 Nd7c5730677614d719ad270a9715c6956 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
214 schema:name Mutation
215 rdf:type schema:DefinedTerm
216 Ndc8b77d1306649e98bc4e2985e5ee842 rdf:first sg:person.01222770646.02
217 rdf:rest N941a5bec76614e9db906fe2956dcdc48
218 Ne1ea2a58ba3243c2a151aef69fa2325a rdf:first sg:person.01041533240.56
219 rdf:rest Na40e34ea0b0e482792bf6dc1caaffe35
220 Ne2e90f684e9f4cdf835bca7e1400e825 rdf:first sg:person.010141404252.46
221 rdf:rest N0e5232e718424ae9a2f1256b4acd3418
222 Ne6bd708f7a484bf381d6213c36e9b902 rdf:first sg:person.01203153562.38
223 rdf:rest Ndc8b77d1306649e98bc4e2985e5ee842
224 Nef1d9ef49325490cbf08427b6b6ab05b rdf:first sg:person.01116455715.21
225 rdf:rest N8d3f6e675fbb439780a679f5d883fdfa
226 Nf63eaff819d4417b9cc8e6772111fa96 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
227 schema:name DNA (Cytosine-5-)-Methyltransferases
228 rdf:type schema:DefinedTerm
229 Nfa4c537ab1124b04b74bbf7a6c092e4d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
230 schema:name Immunophenotyping
231 rdf:type schema:DefinedTerm
232 Nfb157205b60248e1a5ff7fbde9f24af7 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
233 schema:name Survival Rate
234 rdf:type schema:DefinedTerm
235 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
236 schema:name Medical and Health Sciences
237 rdf:type schema:DefinedTerm
238 anzsrc-for:1112 schema:inDefinedTermSet anzsrc-for:
239 schema:name Oncology and Carcinogenesis
240 rdf:type schema:DefinedTerm
241 sg:journal.1097065 schema:issn 0887-6924
242 1476-5551
243 schema:name Leukemia
244 rdf:type schema:Periodical
245 sg:person.01002227315.09 schema:affiliation https://www.grid.ac/institutes/grid.420057.4
246 schema:familyName Grossmann
247 schema:givenName V
248 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01002227315.09
249 rdf:type schema:Person
250 sg:person.010141404252.46 schema:affiliation https://www.grid.ac/institutes/grid.419801.5
251 schema:familyName Schmid
252 schema:givenName C
253 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.010141404252.46
254 rdf:type schema:Person
255 sg:person.01041533240.56 schema:affiliation https://www.grid.ac/institutes/grid.420057.4
256 schema:familyName Alpermann
257 schema:givenName T
258 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01041533240.56
259 rdf:type schema:Person
260 sg:person.01103462233.30 schema:affiliation https://www.grid.ac/institutes/grid.10423.34
261 schema:familyName Klopp
262 schema:givenName N
263 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01103462233.30
264 rdf:type schema:Person
265 sg:person.01116455715.21 schema:affiliation https://www.grid.ac/institutes/grid.420057.4
266 schema:familyName Kohlmann
267 schema:givenName A
268 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01116455715.21
269 rdf:type schema:Person
270 sg:person.01126566364.85 schema:affiliation https://www.grid.ac/institutes/grid.420057.4
271 schema:familyName Fasan
272 schema:givenName A
273 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01126566364.85
274 rdf:type schema:Person
275 sg:person.01141622516.63 schema:affiliation https://www.grid.ac/institutes/grid.4567.0
276 schema:familyName Wichmann
277 schema:givenName H-E
278 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01141622516.63
279 rdf:type schema:Person
280 sg:person.01203153562.38 schema:affiliation https://www.grid.ac/institutes/grid.500028.f
281 schema:familyName Peceny
282 schema:givenName R
283 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01203153562.38
284 rdf:type schema:Person
285 sg:person.01207306133.88 schema:affiliation https://www.grid.ac/institutes/grid.6190.e
286 schema:familyName Kreuzer
287 schema:givenName K-A
288 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01207306133.88
289 rdf:type schema:Person
290 sg:person.01222770646.02 schema:affiliation https://www.grid.ac/institutes/grid.459389.a
291 schema:familyName Schmitz
292 schema:givenName N
293 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01222770646.02
294 rdf:type schema:Person
295 sg:person.01237731352.62 schema:affiliation https://www.grid.ac/institutes/grid.420057.4
296 schema:familyName Haferlach
297 schema:givenName T
298 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01237731352.62
299 rdf:type schema:Person
300 sg:person.01246656064.29 schema:affiliation https://www.grid.ac/institutes/grid.420057.4
301 schema:familyName Eder
302 schema:givenName C
303 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01246656064.29
304 rdf:type schema:Person
305 sg:person.01302055262.30 schema:affiliation https://www.grid.ac/institutes/grid.420057.4
306 schema:familyName Jeromin
307 schema:givenName S
308 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01302055262.30
309 rdf:type schema:Person
310 sg:person.01337170222.03 schema:affiliation https://www.grid.ac/institutes/grid.459927.4
311 schema:familyName Staib
312 schema:givenName P
313 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01337170222.03
314 rdf:type schema:Person
315 sg:person.01340323440.45 schema:affiliation https://www.grid.ac/institutes/grid.420057.4
316 schema:familyName Haferlach
317 schema:givenName C
318 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01340323440.45
319 rdf:type schema:Person
320 sg:person.01364120657.92 schema:affiliation https://www.grid.ac/institutes/grid.10423.34
321 schema:familyName Illig
322 schema:givenName T
323 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01364120657.92
324 rdf:type schema:Person
325 sg:person.016053332122.16 schema:affiliation https://www.grid.ac/institutes/grid.420057.4
326 schema:familyName Kern
327 schema:givenName W
328 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.016053332122.16
329 rdf:type schema:Person
330 sg:person.0614717340.09 schema:affiliation https://www.grid.ac/institutes/grid.420057.4
331 schema:familyName Schnittger
332 schema:givenName S
333 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0614717340.09
334 rdf:type schema:Person
335 sg:pub.10.1038/leu.2009.124 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036988172
336 https://doi.org/10.1038/leu.2009.124
337 rdf:type schema:CreativeWork
338 sg:pub.10.1038/leu.2009.141 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041858819
339 https://doi.org/10.1038/leu.2009.141
340 rdf:type schema:CreativeWork
341 sg:pub.10.1038/leu.2009.218 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004469296
342 https://doi.org/10.1038/leu.2009.218
343 rdf:type schema:CreativeWork
344 sg:pub.10.1038/leu.2010.144 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015952145
345 https://doi.org/10.1038/leu.2010.144
346 rdf:type schema:CreativeWork
347 sg:pub.10.1038/leu.2010.20 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031090846
348 https://doi.org/10.1038/leu.2010.20
349 rdf:type schema:CreativeWork
350 sg:pub.10.1038/leu.2010.298 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051734594
351 https://doi.org/10.1038/leu.2010.298
352 rdf:type schema:CreativeWork
353 sg:pub.10.1038/leu.2011.200 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009669399
354 https://doi.org/10.1038/leu.2011.200
355 rdf:type schema:CreativeWork
356 sg:pub.10.1038/leu.2011.58 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036721490
357 https://doi.org/10.1038/leu.2011.58
358 rdf:type schema:CreativeWork
359 sg:pub.10.1038/ng.507 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003091868
360 https://doi.org/10.1038/ng.507
361 rdf:type schema:CreativeWork
362 sg:pub.10.1038/ng.621 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045969373
363 https://doi.org/10.1038/ng.621
364 rdf:type schema:CreativeWork
365 sg:pub.10.1038/nmeth0410-248 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007489634
366 https://doi.org/10.1038/nmeth0410-248
367 rdf:type schema:CreativeWork
368 sg:pub.10.1038/nprot.2009.86 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015642657
369 https://doi.org/10.1038/nprot.2009.86
370 rdf:type schema:CreativeWork
371 sg:pub.10.1038/sj.leu.2401773 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049359229
372 https://doi.org/10.1038/sj.leu.2401773
373 rdf:type schema:CreativeWork
374 sg:pub.10.1186/1471-2407-10-401 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015343459
375 https://doi.org/10.1186/1471-2407-10-401
376 rdf:type schema:CreativeWork
377 sg:pub.10.1186/1756-8722-5-12 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044086517
378 https://doi.org/10.1186/1756-8722-5-12
379 rdf:type schema:CreativeWork
380 https://doi.org/10.1001/jama.2011.473 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001176831
381 rdf:type schema:CreativeWork
382 https://doi.org/10.1016/j.beha.2010.06.007 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007698899
383 rdf:type schema:CreativeWork
384 https://doi.org/10.1016/j.jmoldx.2010.09.001 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004141951
385 rdf:type schema:CreativeWork
386 https://doi.org/10.1056/nejmoa0810069 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045634206
387 rdf:type schema:CreativeWork
388 https://doi.org/10.1056/nejmoa1005143 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040018409
389 rdf:type schema:CreativeWork
390 https://doi.org/10.1074/jbc.m109.065862 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015579806
391 rdf:type schema:CreativeWork
392 https://doi.org/10.1074/jbc.m512616200 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023532806
393 rdf:type schema:CreativeWork
394 https://doi.org/10.1111/j.1365-2141.1976.tb03563.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1009619175
395 rdf:type schema:CreativeWork
396 https://doi.org/10.1111/j.1365-2141.2009.07697.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1036319854
397 rdf:type schema:CreativeWork
398 https://doi.org/10.1111/j.1365-2141.2010.08381.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1008022542
399 rdf:type schema:CreativeWork
400 https://doi.org/10.1158/0008-5472.can-09-3783 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036405420
401 rdf:type schema:CreativeWork
402 https://doi.org/10.1182/asheducation-2004.1.80 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025549241
403 rdf:type schema:CreativeWork
404 https://doi.org/10.1182/blood-2002-03-0990 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008614109
405 rdf:type schema:CreativeWork
406 https://doi.org/10.1182/blood-2004-03-1036 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024111969
407 rdf:type schema:CreativeWork
408 https://doi.org/10.1182/blood-2005-06-2248 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036438078
409 rdf:type schema:CreativeWork
410 https://doi.org/10.1182/blood-2005-08-3522 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017060610
411 rdf:type schema:CreativeWork
412 https://doi.org/10.1182/blood-2007-02-072595 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014562054
413 rdf:type schema:CreativeWork
414 https://doi.org/10.1182/blood-2007-05-091215 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010761990
415 rdf:type schema:CreativeWork
416 https://doi.org/10.1182/blood-2009-03-213389 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008844336
417 rdf:type schema:CreativeWork
418 https://doi.org/10.1182/blood-2009-05-223784 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035378560
419 rdf:type schema:CreativeWork
420 https://doi.org/10.1182/blood-2009-07-235358 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042177075
421 rdf:type schema:CreativeWork
422 https://doi.org/10.1182/blood-2009-11-254441 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021909700
423 rdf:type schema:CreativeWork
424 https://doi.org/10.1182/blood-2009-11-255976 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038462632
425 rdf:type schema:CreativeWork
426 https://doi.org/10.1182/blood-2010-02-267955 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039097404
427 rdf:type schema:CreativeWork
428 https://doi.org/10.1182/blood-2010-05-283291 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020362185
429 rdf:type schema:CreativeWork
430 https://doi.org/10.1182/blood-2011-02-292102 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021572968
431 rdf:type schema:CreativeWork
432 https://doi.org/10.1182/blood-2011-08-368225 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047288906
433 rdf:type schema:CreativeWork
434 https://doi.org/10.1182/blood.v100.1.59 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042949004
435 rdf:type schema:CreativeWork
436 https://doi.org/10.1200/jco.2003.04.036 schema:sameAs https://app.dimensions.ai/details/publication/pub.1064203515
437 rdf:type schema:CreativeWork
438 https://doi.org/10.1200/jco.2003.99.091 schema:sameAs https://app.dimensions.ai/details/publication/pub.1064204098
439 rdf:type schema:CreativeWork
440 https://doi.org/10.1200/jco.2009.27.1361 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023667382
441 rdf:type schema:CreativeWork
442 https://doi.org/10.1200/jco.2010.28.2285 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035942018
443 rdf:type schema:CreativeWork
444 https://doi.org/10.1200/jco.2010.33.4938 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036660359
445 rdf:type schema:CreativeWork
446 https://doi.org/10.3324/haematol.2010.030015 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041488819
447 rdf:type schema:CreativeWork
448 https://www.grid.ac/institutes/grid.10423.34 schema:alternateName Hannover Medical School
449 schema:name Hannover Unified Biobank, Hannover Medical School, Hannover, Germany
450 Research Unit of Molecular Epidemiology, Helmholtz Zentrum München, Munich, Germany
451 rdf:type schema:Organization
452 https://www.grid.ac/institutes/grid.419801.5 schema:alternateName Augsburg Hospital
453 schema:name Department of Internal Medicine II, Klinikum Augsburg, Augsburg, Germany
454 rdf:type schema:Organization
455 https://www.grid.ac/institutes/grid.420057.4 schema:alternateName Munich Leukemia Laboratory (Germany)
456 schema:name MLL Munich Leukemia Laboratory, Munich, Germany
457 rdf:type schema:Organization
458 https://www.grid.ac/institutes/grid.4567.0 schema:alternateName Helmholtz Zentrum München
459 schema:name Institute of Epidemiology I, Helmholtz Zentrum München, Munich, Germany
460 rdf:type schema:Organization
461 https://www.grid.ac/institutes/grid.459389.a schema:alternateName Asklepios Klinik St. Georg
462 schema:name Department for Hematology and Stemcell Transplantation, Asklepios Klinik St Georg, Hamburg, Germany
463 rdf:type schema:Organization
464 https://www.grid.ac/institutes/grid.459927.4 schema:alternateName Sankt-Antonius-Hospital Eschweiler
465 schema:name Clinic for Hematology and Oncology, St Antonius Hospital, Eschweiler, Germany
466 rdf:type schema:Organization
467 https://www.grid.ac/institutes/grid.500028.f schema:alternateName Klinikum Osnabrück
468 schema:name Department for Hematology and Oncology, Klinikum Osnabrück, Osnabrück, Germany
469 rdf:type schema:Organization
470 https://www.grid.ac/institutes/grid.6190.e schema:alternateName University of Cologne
471 schema:name Department I of Internal Medicine, University at Cologne, Cologne, Germany
472 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...