The feed-forward loop between YB-1 and MYC is essential for multiple myeloma cell survival View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2013-02

AUTHORS

K S Bommert, M Effenberger, E Leich, M Küspert, D Murphy, C Langer, R Moll, S Janz, A Mottok, S Weissbach, A Rosenwald, R Bargou, K Bommert

ABSTRACT

Y-box binding protein 1 (YB-1) functions as a translational regulator and has been suggested to elevate MYC mRNA translation via an internal ribosome entry segment (IRES) point mutation in multiple myeloma (MM). We show that YB-1-mediated translation of MYC mRNA occurs independently of the reported IRES mutation, as 87 MM patients (n=88) and all tested human MM cell lines (HMCLs) were negative for the mutation. We show for the first time that positive MYC staining predicts YB-1 co-expression in malignant plasma cells and YB-1/MYC co-expression increases from 30% in medullary to 70% in extramedullary MM. YB-1 knockdown in HMCLs reduced both MYC protein levels and MYC mRNA in the polysomal fraction, providing a mechanism by which YB-1 controls MYC translation. MYC transcription of YB-1 is demonstrated in HMCLs as MYC knockdown resulted in reduced YB-1 protein and mRNA levels. Furthermore, MYC activation in non-malignant mouse embryonic fibroblasts (MEFs) increased YB-1 mRNA, clearly indicating that MYC drives YB-1 transcription. Importantly, perturbation of the MYC/YB-1 oncogenic circuit leads to apoptosis in HMCLs. Here, we demonstrate that these two proteins co-regulate each other via combined transcriptional/translational activity establishing their pivotal role in MM cell survival. We therefore suggest that targeting the YB-1/mRNA interaction provides a new strategy for MM drug development. More... »

PAGES

441

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/leu.2012.185

DOI

http://dx.doi.org/10.1038/leu.2012.185

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1035419804

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/22772059


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/0601", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Biochemistry and Cell Biology", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/06", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Biological Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Animals", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Apoptosis", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Biomarkers, Tumor", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Blotting, Western", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cell Proliferation", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cells, Cultured", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Embryo, Mammalian", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Fibroblasts", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Gene Expression Profiling", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Gene Expression Regulation, Neoplastic", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Immunoenzyme Techniques", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Mice", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Multiple Myeloma", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Oligonucleotide Array Sequence Analysis", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Point Mutation", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Polyribosomes", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Protein Biosynthesis", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Proto-Oncogene Proteins c-myc", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "RNA, Messenger", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "RNA, Small Interfering", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Real-Time Polymerase Chain Reaction", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Reverse Transcriptase Polymerase Chain Reaction", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Y-Box-Binding Protein 1", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "University Hospital of W\u00fcrzburg", 
          "id": "https://www.grid.ac/institutes/grid.411760.5", 
          "name": [
            "Division of Haematology and Medical Oncology, Department of Internal Medicine II, Comprehensive Cancer Centre Mainfranken, University Hospital W\u00fcrzburg, W\u00fcrzburg, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Bommert", 
        "givenName": "K S", 
        "id": "sg:person.01200355130.11", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01200355130.11"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University Hospital of W\u00fcrzburg", 
          "id": "https://www.grid.ac/institutes/grid.411760.5", 
          "name": [
            "Division of Haematology and Medical Oncology, Department of Internal Medicine II, Comprehensive Cancer Centre Mainfranken, University Hospital W\u00fcrzburg, W\u00fcrzburg, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Effenberger", 
        "givenName": "M", 
        "id": "sg:person.015347556025.44", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015347556025.44"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of W\u00fcrzburg", 
          "id": "https://www.grid.ac/institutes/grid.8379.5", 
          "name": [
            "Institute of Pathology, University of W\u00fcrzburg, W\u00fcrzburg, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Leich", 
        "givenName": "E", 
        "id": "sg:person.01051554232.24", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01051554232.24"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of W\u00fcrzburg", 
          "id": "https://www.grid.ac/institutes/grid.8379.5", 
          "name": [
            "Theodor Boveri Institute, University of W\u00fcrzburg, W\u00fcrzburg, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "K\u00fcspert", 
        "givenName": "M", 
        "id": "sg:person.0675002031.48", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0675002031.48"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of W\u00fcrzburg", 
          "id": "https://www.grid.ac/institutes/grid.8379.5", 
          "name": [
            "Theodor Boveri Institute, University of W\u00fcrzburg, W\u00fcrzburg, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Murphy", 
        "givenName": "D", 
        "id": "sg:person.01052701763.05", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01052701763.05"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Ulm", 
          "id": "https://www.grid.ac/institutes/grid.6582.9", 
          "name": [
            "Department of Internal Medicine III, University of Ulm, Ulm, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Langer", 
        "givenName": "C", 
        "id": "sg:person.01336076624.54", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01336076624.54"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Giessen", 
          "id": "https://www.grid.ac/institutes/grid.8664.c", 
          "name": [
            "Institute of Pathology, University of Giessen and Marburg, Marburg, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Moll", 
        "givenName": "R", 
        "id": "sg:person.0724513345.37", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0724513345.37"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Iowa", 
          "id": "https://www.grid.ac/institutes/grid.214572.7", 
          "name": [
            "Department of Pathology, University of Iowa Roy J. and Lucille A. Carver College of Medicine, Iowa City, IA, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Janz", 
        "givenName": "S", 
        "id": "sg:person.0766657032.20", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0766657032.20"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of W\u00fcrzburg", 
          "id": "https://www.grid.ac/institutes/grid.8379.5", 
          "name": [
            "Institute of Pathology, University of W\u00fcrzburg, W\u00fcrzburg, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Mottok", 
        "givenName": "A", 
        "id": "sg:person.01032703763.30", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01032703763.30"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of W\u00fcrzburg", 
          "id": "https://www.grid.ac/institutes/grid.8379.5", 
          "name": [
            "Institute of Pathology, University of W\u00fcrzburg, W\u00fcrzburg, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Weissbach", 
        "givenName": "S", 
        "id": "sg:person.01235473510.45", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01235473510.45"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of W\u00fcrzburg", 
          "id": "https://www.grid.ac/institutes/grid.8379.5", 
          "name": [
            "Institute of Pathology, University of W\u00fcrzburg, W\u00fcrzburg, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Rosenwald", 
        "givenName": "A", 
        "id": "sg:person.01334063272.17", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01334063272.17"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University Hospital of W\u00fcrzburg", 
          "id": "https://www.grid.ac/institutes/grid.411760.5", 
          "name": [
            "Division of Haematology and Medical Oncology, Department of Internal Medicine II, Comprehensive Cancer Centre Mainfranken, University Hospital W\u00fcrzburg, W\u00fcrzburg, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Bargou", 
        "givenName": "R", 
        "id": "sg:person.01146675164.26", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01146675164.26"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University Hospital of W\u00fcrzburg", 
          "id": "https://www.grid.ac/institutes/grid.411760.5", 
          "name": [
            "Division of Haematology and Medical Oncology, Department of Internal Medicine II, Comprehensive Cancer Centre Mainfranken, University Hospital W\u00fcrzburg, W\u00fcrzburg, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Bommert", 
        "givenName": "K", 
        "id": "sg:person.01000675424.50", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01000675424.50"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.1158/0008-5472.can-09-3155", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1003954477"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0960-9822(99)80507-7", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1005992429"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1074/jbc.270.8.3527", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1008318882"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nrclinonc.2011.63", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1011622317", 
          "https://doi.org/10.1038/nrclinonc.2011.63"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1128/mcb.01298-07", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1013654335"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1128/mcb.22.18.6375-6383.2002", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1013736869"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1034/j.1600-065x.2003.00061.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1017107283"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/path.2440", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1018900397"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/path.2440", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1018900397"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s10571-010-9541-9", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1024810547", 
          "https://doi.org/10.1007/s10571-010-9541-9"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s10571-010-9541-9", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1024810547", 
          "https://doi.org/10.1007/s10571-010-9541-9"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.cell.2011.08.017", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1026115083"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/leu.2011.53", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1026792748", 
          "https://doi.org/10.1038/leu.2011.53"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.022643999", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1027582111"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1074/jbc.271.4.2307", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1028598309"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1182/blood-2007-05-089151", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1031943994"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/emboj/20.19.5491", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1032373203"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/onc.2010.31", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1032901688", 
          "https://doi.org/10.1038/onc.2010.31"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nm0497-447", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1033417633", 
          "https://doi.org/10.1038/nm0497-447"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.ccr.2008.10.018", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1034097462"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/nar/27.22.4324", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035690610"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.0506580102", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037705714"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.0506580102", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037705714"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.onc.1203791", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1038416343", 
          "https://doi.org/10.1038/sj.onc.1203791"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.onc.1203791", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1038416343", 
          "https://doi.org/10.1038/sj.onc.1203791"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1158/0008-5472.can-04-4056", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1038999000"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.onc.1210719", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1041360193", 
          "https://doi.org/10.1038/sj.onc.1210719"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1006/jmbi.2001.5334", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1045587314"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.onc.1208998", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1046340945", 
          "https://doi.org/10.1038/sj.onc.1208998"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.onc.1208998", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1046340945", 
          "https://doi.org/10.1038/sj.onc.1208998"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.onc.1208998", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1046340945", 
          "https://doi.org/10.1038/sj.onc.1208998"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1158/0008-5472.can-07-2981", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1047011090"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.89.1.232", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1048247148"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1074/jbc.273.6.3574", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1049096913"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1128/mcb.25.8.3317-3323.2005", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1053624688"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1080/01926230701230296", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1058308392"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1080/01926230701230296", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1058308392"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/nar/20.11.2861", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1059931771"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.4161/rna.6.1.7458", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1072310405"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1074892345", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1158/0008-5472.can-05-1222", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1077108289"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1082770715", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1082942101", 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2013-02", 
    "datePublishedReg": "2013-02-01", 
    "description": "Y-box binding protein 1 (YB-1) functions as a translational regulator and has been suggested to elevate MYC mRNA translation via an internal ribosome entry segment (IRES) point mutation in multiple myeloma (MM). We show that YB-1-mediated translation of MYC mRNA occurs independently of the reported IRES mutation, as 87 MM patients (n=88) and all tested human MM cell lines (HMCLs) were negative for the mutation. We show for the first time that positive MYC staining predicts YB-1 co-expression in malignant plasma cells and YB-1/MYC co-expression increases from 30% in medullary to 70% in extramedullary MM. YB-1 knockdown in HMCLs reduced both MYC protein levels and MYC mRNA in the polysomal fraction, providing a mechanism by which YB-1 controls MYC translation. MYC transcription of YB-1 is demonstrated in HMCLs as MYC knockdown resulted in reduced YB-1 protein and mRNA levels. Furthermore, MYC activation in non-malignant mouse embryonic fibroblasts (MEFs) increased YB-1 mRNA, clearly indicating that MYC drives YB-1 transcription. Importantly, perturbation of the MYC/YB-1 oncogenic circuit leads to apoptosis in HMCLs. Here, we demonstrate that these two proteins co-regulate each other via combined transcriptional/translational activity establishing their pivotal role in MM cell survival. We therefore suggest that targeting the YB-1/mRNA interaction provides a new strategy for MM drug development.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1038/leu.2012.185", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": true, 
    "isFundedItemOf": [
      {
        "id": "sg:grant.2480941", 
        "type": "MonetaryGrant"
      }
    ], 
    "isPartOf": [
      {
        "id": "sg:journal.1097065", 
        "issn": [
          "0887-6924", 
          "1476-5551"
        ], 
        "name": "Leukemia", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "2", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "27"
      }
    ], 
    "name": "The feed-forward loop between YB-1 and MYC is essential for multiple myeloma cell survival", 
    "pagination": "441", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "a8b930ecbe81e5eb242c29e41a33aeddb5a9ef73cd67f9d4eb34b4e8aef6c0bc"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "22772059"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "8704895"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1038/leu.2012.185"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1035419804"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1038/leu.2012.185", 
      "https://app.dimensions.ai/details/publication/pub.1035419804"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-10T19:46", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8681_00000436.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://www.nature.com/articles/leu2012185"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/leu.2012.185'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/leu.2012.185'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/leu.2012.185'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/leu.2012.185'


 

This table displays all metadata directly associated to this object as RDF triples.

377 TRIPLES      21 PREDICATES      89 URIs      45 LITERALS      33 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1038/leu.2012.185 schema:about N0ca2c485d47a487f8e4d324845012742
2 N313a01b66aac4bd293306f2d6a8c3942
3 N3aeae63b932045ff94d71491f9081d63
4 N3ef9cb6a92c141c59eec08261af85070
5 N503a62c71f4e45258704e0d04f8a2b8e
6 N5bb927d363de47beb9dcbe9c37ae439d
7 N66daa2d97d034dcfb9b37a4a3830add2
8 N683730d87bf544fea9cf347098dfee75
9 N7a03fbb9a22144f7b6a7082e52337b31
10 N82c7574c8e0d44189b5d9758b097c89e
11 N82f85929f08b40b28fd9ea43a699f436
12 N8343f6295ec8491d8c4a86b986b25ff0
13 N845e11ca26524876b1cd93eda8c1ad6f
14 N89fc3a706da249ad936a0dd6b3ce5454
15 N90e76a5809aa4bfa94872bf0dd531cac
16 N99fb985221db431f966c2470d74dbaf4
17 N9cca8cf68d55408abf324a595525795f
18 N9cfd07542f8f4b38a25f329c14cabb6e
19 Na211c8b2ab6d4cdca50ad82fe313d878
20 Nb8cf663274f048239c52e5c0508b4467
21 Nbf58b1e13f75418096ca2900005cd18c
22 Nd089d1868a5a42749dfab5656f3a7c02
23 Nd679b6d6d7954c97b9eab19dc48310a2
24 Ndb85dfe6fd5d4cada0b91e96fc7258e0
25 anzsrc-for:06
26 anzsrc-for:0601
27 schema:author N36a50cfca22e42d8ac1853d45e6c7d69
28 schema:citation sg:pub.10.1007/s10571-010-9541-9
29 sg:pub.10.1038/leu.2011.53
30 sg:pub.10.1038/nm0497-447
31 sg:pub.10.1038/nrclinonc.2011.63
32 sg:pub.10.1038/onc.2010.31
33 sg:pub.10.1038/sj.onc.1203791
34 sg:pub.10.1038/sj.onc.1208998
35 sg:pub.10.1038/sj.onc.1210719
36 https://app.dimensions.ai/details/publication/pub.1074892345
37 https://app.dimensions.ai/details/publication/pub.1082770715
38 https://app.dimensions.ai/details/publication/pub.1082942101
39 https://doi.org/10.1002/path.2440
40 https://doi.org/10.1006/jmbi.2001.5334
41 https://doi.org/10.1016/j.ccr.2008.10.018
42 https://doi.org/10.1016/j.cell.2011.08.017
43 https://doi.org/10.1016/s0960-9822(99)80507-7
44 https://doi.org/10.1034/j.1600-065x.2003.00061.x
45 https://doi.org/10.1073/pnas.022643999
46 https://doi.org/10.1073/pnas.0506580102
47 https://doi.org/10.1073/pnas.89.1.232
48 https://doi.org/10.1074/jbc.270.8.3527
49 https://doi.org/10.1074/jbc.271.4.2307
50 https://doi.org/10.1074/jbc.273.6.3574
51 https://doi.org/10.1080/01926230701230296
52 https://doi.org/10.1093/emboj/20.19.5491
53 https://doi.org/10.1093/nar/20.11.2861
54 https://doi.org/10.1093/nar/27.22.4324
55 https://doi.org/10.1128/mcb.01298-07
56 https://doi.org/10.1128/mcb.22.18.6375-6383.2002
57 https://doi.org/10.1128/mcb.25.8.3317-3323.2005
58 https://doi.org/10.1158/0008-5472.can-04-4056
59 https://doi.org/10.1158/0008-5472.can-05-1222
60 https://doi.org/10.1158/0008-5472.can-07-2981
61 https://doi.org/10.1158/0008-5472.can-09-3155
62 https://doi.org/10.1182/blood-2007-05-089151
63 https://doi.org/10.4161/rna.6.1.7458
64 schema:datePublished 2013-02
65 schema:datePublishedReg 2013-02-01
66 schema:description Y-box binding protein 1 (YB-1) functions as a translational regulator and has been suggested to elevate MYC mRNA translation via an internal ribosome entry segment (IRES) point mutation in multiple myeloma (MM). We show that YB-1-mediated translation of MYC mRNA occurs independently of the reported IRES mutation, as 87 MM patients (n=88) and all tested human MM cell lines (HMCLs) were negative for the mutation. We show for the first time that positive MYC staining predicts YB-1 co-expression in malignant plasma cells and YB-1/MYC co-expression increases from 30% in medullary to 70% in extramedullary MM. YB-1 knockdown in HMCLs reduced both MYC protein levels and MYC mRNA in the polysomal fraction, providing a mechanism by which YB-1 controls MYC translation. MYC transcription of YB-1 is demonstrated in HMCLs as MYC knockdown resulted in reduced YB-1 protein and mRNA levels. Furthermore, MYC activation in non-malignant mouse embryonic fibroblasts (MEFs) increased YB-1 mRNA, clearly indicating that MYC drives YB-1 transcription. Importantly, perturbation of the MYC/YB-1 oncogenic circuit leads to apoptosis in HMCLs. Here, we demonstrate that these two proteins co-regulate each other via combined transcriptional/translational activity establishing their pivotal role in MM cell survival. We therefore suggest that targeting the YB-1/mRNA interaction provides a new strategy for MM drug development.
67 schema:genre research_article
68 schema:inLanguage en
69 schema:isAccessibleForFree true
70 schema:isPartOf Nab05ac20eb594d04915ea8ee49c32cb0
71 Nc5e1d70dde2540128315a2154d6c1980
72 sg:journal.1097065
73 schema:name The feed-forward loop between YB-1 and MYC is essential for multiple myeloma cell survival
74 schema:pagination 441
75 schema:productId N0e07c137d74d46ada1c1e6b785769d25
76 N56bbeeabbdbb42ed9104ff9e9c520949
77 N69a515e8e70246f0b2bf4dce61d20de4
78 Nbcffc70afcbc4da2a3d27029ae9a7b6c
79 Ne1821a9660924df486d779a05874a2b6
80 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035419804
81 https://doi.org/10.1038/leu.2012.185
82 schema:sdDatePublished 2019-04-10T19:46
83 schema:sdLicense https://scigraph.springernature.com/explorer/license/
84 schema:sdPublisher Ne2e222d272ef4abaa91aa54b70d7d225
85 schema:url https://www.nature.com/articles/leu2012185
86 sgo:license sg:explorer/license/
87 sgo:sdDataset articles
88 rdf:type schema:ScholarlyArticle
89 N0ca2c485d47a487f8e4d324845012742 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
90 schema:name Biomarkers, Tumor
91 rdf:type schema:DefinedTerm
92 N0e07c137d74d46ada1c1e6b785769d25 schema:name nlm_unique_id
93 schema:value 8704895
94 rdf:type schema:PropertyValue
95 N313a01b66aac4bd293306f2d6a8c3942 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
96 schema:name RNA, Messenger
97 rdf:type schema:DefinedTerm
98 N36a50cfca22e42d8ac1853d45e6c7d69 rdf:first sg:person.01200355130.11
99 rdf:rest Ne2332c3b892242d1aeea12ad0f143e01
100 N3aeae63b932045ff94d71491f9081d63 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
101 schema:name Oligonucleotide Array Sequence Analysis
102 rdf:type schema:DefinedTerm
103 N3ef9cb6a92c141c59eec08261af85070 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
104 schema:name Mice
105 rdf:type schema:DefinedTerm
106 N4582512612544b74a1b8e48e75592b8a rdf:first sg:person.01334063272.17
107 rdf:rest Na12064b6ee6c4670bacccbeb55c92953
108 N45b224a1082947dabf478584ec395e85 rdf:first sg:person.0766657032.20
109 rdf:rest N5e42ab25b3cf424aa5493c5478004d55
110 N4d2072514ae045a7aa3a4b19478f5ad4 rdf:first sg:person.01000675424.50
111 rdf:rest rdf:nil
112 N503a62c71f4e45258704e0d04f8a2b8e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
113 schema:name Gene Expression Profiling
114 rdf:type schema:DefinedTerm
115 N56bbeeabbdbb42ed9104ff9e9c520949 schema:name doi
116 schema:value 10.1038/leu.2012.185
117 rdf:type schema:PropertyValue
118 N596163b38ffa44b787932b8b2c0ec2c2 rdf:first sg:person.01052701763.05
119 rdf:rest N6de77349fe4a48df8d4264c4cfaac37b
120 N5bb927d363de47beb9dcbe9c37ae439d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
121 schema:name Gene Expression Regulation, Neoplastic
122 rdf:type schema:DefinedTerm
123 N5e42ab25b3cf424aa5493c5478004d55 rdf:first sg:person.01032703763.30
124 rdf:rest N859eaee2f5cb4731a821b1f4eee50eeb
125 N66daa2d97d034dcfb9b37a4a3830add2 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
126 schema:name Cells, Cultured
127 rdf:type schema:DefinedTerm
128 N683730d87bf544fea9cf347098dfee75 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
129 schema:name Cell Proliferation
130 rdf:type schema:DefinedTerm
131 N69a515e8e70246f0b2bf4dce61d20de4 schema:name pubmed_id
132 schema:value 22772059
133 rdf:type schema:PropertyValue
134 N6de77349fe4a48df8d4264c4cfaac37b rdf:first sg:person.01336076624.54
135 rdf:rest Nbbf46c74f04a478d9a6d65cac2366aea
136 N7a03fbb9a22144f7b6a7082e52337b31 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
137 schema:name Embryo, Mammalian
138 rdf:type schema:DefinedTerm
139 N82c7574c8e0d44189b5d9758b097c89e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
140 schema:name Apoptosis
141 rdf:type schema:DefinedTerm
142 N82f85929f08b40b28fd9ea43a699f436 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
143 schema:name Animals
144 rdf:type schema:DefinedTerm
145 N8343f6295ec8491d8c4a86b986b25ff0 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
146 schema:name Real-Time Polymerase Chain Reaction
147 rdf:type schema:DefinedTerm
148 N845e11ca26524876b1cd93eda8c1ad6f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
149 schema:name Proto-Oncogene Proteins c-myc
150 rdf:type schema:DefinedTerm
151 N859eaee2f5cb4731a821b1f4eee50eeb rdf:first sg:person.01235473510.45
152 rdf:rest N4582512612544b74a1b8e48e75592b8a
153 N890f3e4a35ea4b7caad85032b26b3579 rdf:first sg:person.01051554232.24
154 rdf:rest Ncebda8a628f5439ab8deca084896324d
155 N89fc3a706da249ad936a0dd6b3ce5454 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
156 schema:name Multiple Myeloma
157 rdf:type schema:DefinedTerm
158 N90e76a5809aa4bfa94872bf0dd531cac schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
159 schema:name Humans
160 rdf:type schema:DefinedTerm
161 N99fb985221db431f966c2470d74dbaf4 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
162 schema:name Protein Biosynthesis
163 rdf:type schema:DefinedTerm
164 N9cca8cf68d55408abf324a595525795f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
165 schema:name Blotting, Western
166 rdf:type schema:DefinedTerm
167 N9cfd07542f8f4b38a25f329c14cabb6e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
168 schema:name Y-Box-Binding Protein 1
169 rdf:type schema:DefinedTerm
170 Na12064b6ee6c4670bacccbeb55c92953 rdf:first sg:person.01146675164.26
171 rdf:rest N4d2072514ae045a7aa3a4b19478f5ad4
172 Na211c8b2ab6d4cdca50ad82fe313d878 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
173 schema:name Point Mutation
174 rdf:type schema:DefinedTerm
175 Nab05ac20eb594d04915ea8ee49c32cb0 schema:volumeNumber 27
176 rdf:type schema:PublicationVolume
177 Nb8cf663274f048239c52e5c0508b4467 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
178 schema:name RNA, Small Interfering
179 rdf:type schema:DefinedTerm
180 Nbbf46c74f04a478d9a6d65cac2366aea rdf:first sg:person.0724513345.37
181 rdf:rest N45b224a1082947dabf478584ec395e85
182 Nbcffc70afcbc4da2a3d27029ae9a7b6c schema:name dimensions_id
183 schema:value pub.1035419804
184 rdf:type schema:PropertyValue
185 Nbf58b1e13f75418096ca2900005cd18c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
186 schema:name Fibroblasts
187 rdf:type schema:DefinedTerm
188 Nc5e1d70dde2540128315a2154d6c1980 schema:issueNumber 2
189 rdf:type schema:PublicationIssue
190 Ncebda8a628f5439ab8deca084896324d rdf:first sg:person.0675002031.48
191 rdf:rest N596163b38ffa44b787932b8b2c0ec2c2
192 Nd089d1868a5a42749dfab5656f3a7c02 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
193 schema:name Polyribosomes
194 rdf:type schema:DefinedTerm
195 Nd679b6d6d7954c97b9eab19dc48310a2 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
196 schema:name Immunoenzyme Techniques
197 rdf:type schema:DefinedTerm
198 Ndb85dfe6fd5d4cada0b91e96fc7258e0 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
199 schema:name Reverse Transcriptase Polymerase Chain Reaction
200 rdf:type schema:DefinedTerm
201 Ne1821a9660924df486d779a05874a2b6 schema:name readcube_id
202 schema:value a8b930ecbe81e5eb242c29e41a33aeddb5a9ef73cd67f9d4eb34b4e8aef6c0bc
203 rdf:type schema:PropertyValue
204 Ne2332c3b892242d1aeea12ad0f143e01 rdf:first sg:person.015347556025.44
205 rdf:rest N890f3e4a35ea4b7caad85032b26b3579
206 Ne2e222d272ef4abaa91aa54b70d7d225 schema:name Springer Nature - SN SciGraph project
207 rdf:type schema:Organization
208 anzsrc-for:06 schema:inDefinedTermSet anzsrc-for:
209 schema:name Biological Sciences
210 rdf:type schema:DefinedTerm
211 anzsrc-for:0601 schema:inDefinedTermSet anzsrc-for:
212 schema:name Biochemistry and Cell Biology
213 rdf:type schema:DefinedTerm
214 sg:grant.2480941 http://pending.schema.org/fundedItem sg:pub.10.1038/leu.2012.185
215 rdf:type schema:MonetaryGrant
216 sg:journal.1097065 schema:issn 0887-6924
217 1476-5551
218 schema:name Leukemia
219 rdf:type schema:Periodical
220 sg:person.01000675424.50 schema:affiliation https://www.grid.ac/institutes/grid.411760.5
221 schema:familyName Bommert
222 schema:givenName K
223 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01000675424.50
224 rdf:type schema:Person
225 sg:person.01032703763.30 schema:affiliation https://www.grid.ac/institutes/grid.8379.5
226 schema:familyName Mottok
227 schema:givenName A
228 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01032703763.30
229 rdf:type schema:Person
230 sg:person.01051554232.24 schema:affiliation https://www.grid.ac/institutes/grid.8379.5
231 schema:familyName Leich
232 schema:givenName E
233 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01051554232.24
234 rdf:type schema:Person
235 sg:person.01052701763.05 schema:affiliation https://www.grid.ac/institutes/grid.8379.5
236 schema:familyName Murphy
237 schema:givenName D
238 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01052701763.05
239 rdf:type schema:Person
240 sg:person.01146675164.26 schema:affiliation https://www.grid.ac/institutes/grid.411760.5
241 schema:familyName Bargou
242 schema:givenName R
243 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01146675164.26
244 rdf:type schema:Person
245 sg:person.01200355130.11 schema:affiliation https://www.grid.ac/institutes/grid.411760.5
246 schema:familyName Bommert
247 schema:givenName K S
248 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01200355130.11
249 rdf:type schema:Person
250 sg:person.01235473510.45 schema:affiliation https://www.grid.ac/institutes/grid.8379.5
251 schema:familyName Weissbach
252 schema:givenName S
253 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01235473510.45
254 rdf:type schema:Person
255 sg:person.01334063272.17 schema:affiliation https://www.grid.ac/institutes/grid.8379.5
256 schema:familyName Rosenwald
257 schema:givenName A
258 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01334063272.17
259 rdf:type schema:Person
260 sg:person.01336076624.54 schema:affiliation https://www.grid.ac/institutes/grid.6582.9
261 schema:familyName Langer
262 schema:givenName C
263 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01336076624.54
264 rdf:type schema:Person
265 sg:person.015347556025.44 schema:affiliation https://www.grid.ac/institutes/grid.411760.5
266 schema:familyName Effenberger
267 schema:givenName M
268 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015347556025.44
269 rdf:type schema:Person
270 sg:person.0675002031.48 schema:affiliation https://www.grid.ac/institutes/grid.8379.5
271 schema:familyName Küspert
272 schema:givenName M
273 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0675002031.48
274 rdf:type schema:Person
275 sg:person.0724513345.37 schema:affiliation https://www.grid.ac/institutes/grid.8664.c
276 schema:familyName Moll
277 schema:givenName R
278 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0724513345.37
279 rdf:type schema:Person
280 sg:person.0766657032.20 schema:affiliation https://www.grid.ac/institutes/grid.214572.7
281 schema:familyName Janz
282 schema:givenName S
283 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0766657032.20
284 rdf:type schema:Person
285 sg:pub.10.1007/s10571-010-9541-9 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024810547
286 https://doi.org/10.1007/s10571-010-9541-9
287 rdf:type schema:CreativeWork
288 sg:pub.10.1038/leu.2011.53 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026792748
289 https://doi.org/10.1038/leu.2011.53
290 rdf:type schema:CreativeWork
291 sg:pub.10.1038/nm0497-447 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033417633
292 https://doi.org/10.1038/nm0497-447
293 rdf:type schema:CreativeWork
294 sg:pub.10.1038/nrclinonc.2011.63 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011622317
295 https://doi.org/10.1038/nrclinonc.2011.63
296 rdf:type schema:CreativeWork
297 sg:pub.10.1038/onc.2010.31 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032901688
298 https://doi.org/10.1038/onc.2010.31
299 rdf:type schema:CreativeWork
300 sg:pub.10.1038/sj.onc.1203791 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038416343
301 https://doi.org/10.1038/sj.onc.1203791
302 rdf:type schema:CreativeWork
303 sg:pub.10.1038/sj.onc.1208998 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046340945
304 https://doi.org/10.1038/sj.onc.1208998
305 rdf:type schema:CreativeWork
306 sg:pub.10.1038/sj.onc.1210719 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041360193
307 https://doi.org/10.1038/sj.onc.1210719
308 rdf:type schema:CreativeWork
309 https://app.dimensions.ai/details/publication/pub.1074892345 schema:CreativeWork
310 https://app.dimensions.ai/details/publication/pub.1082770715 schema:CreativeWork
311 https://app.dimensions.ai/details/publication/pub.1082942101 schema:CreativeWork
312 https://doi.org/10.1002/path.2440 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018900397
313 rdf:type schema:CreativeWork
314 https://doi.org/10.1006/jmbi.2001.5334 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045587314
315 rdf:type schema:CreativeWork
316 https://doi.org/10.1016/j.ccr.2008.10.018 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034097462
317 rdf:type schema:CreativeWork
318 https://doi.org/10.1016/j.cell.2011.08.017 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026115083
319 rdf:type schema:CreativeWork
320 https://doi.org/10.1016/s0960-9822(99)80507-7 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005992429
321 rdf:type schema:CreativeWork
322 https://doi.org/10.1034/j.1600-065x.2003.00061.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1017107283
323 rdf:type schema:CreativeWork
324 https://doi.org/10.1073/pnas.022643999 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027582111
325 rdf:type schema:CreativeWork
326 https://doi.org/10.1073/pnas.0506580102 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037705714
327 rdf:type schema:CreativeWork
328 https://doi.org/10.1073/pnas.89.1.232 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048247148
329 rdf:type schema:CreativeWork
330 https://doi.org/10.1074/jbc.270.8.3527 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008318882
331 rdf:type schema:CreativeWork
332 https://doi.org/10.1074/jbc.271.4.2307 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028598309
333 rdf:type schema:CreativeWork
334 https://doi.org/10.1074/jbc.273.6.3574 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049096913
335 rdf:type schema:CreativeWork
336 https://doi.org/10.1080/01926230701230296 schema:sameAs https://app.dimensions.ai/details/publication/pub.1058308392
337 rdf:type schema:CreativeWork
338 https://doi.org/10.1093/emboj/20.19.5491 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032373203
339 rdf:type schema:CreativeWork
340 https://doi.org/10.1093/nar/20.11.2861 schema:sameAs https://app.dimensions.ai/details/publication/pub.1059931771
341 rdf:type schema:CreativeWork
342 https://doi.org/10.1093/nar/27.22.4324 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035690610
343 rdf:type schema:CreativeWork
344 https://doi.org/10.1128/mcb.01298-07 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013654335
345 rdf:type schema:CreativeWork
346 https://doi.org/10.1128/mcb.22.18.6375-6383.2002 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013736869
347 rdf:type schema:CreativeWork
348 https://doi.org/10.1128/mcb.25.8.3317-3323.2005 schema:sameAs https://app.dimensions.ai/details/publication/pub.1053624688
349 rdf:type schema:CreativeWork
350 https://doi.org/10.1158/0008-5472.can-04-4056 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038999000
351 rdf:type schema:CreativeWork
352 https://doi.org/10.1158/0008-5472.can-05-1222 schema:sameAs https://app.dimensions.ai/details/publication/pub.1077108289
353 rdf:type schema:CreativeWork
354 https://doi.org/10.1158/0008-5472.can-07-2981 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047011090
355 rdf:type schema:CreativeWork
356 https://doi.org/10.1158/0008-5472.can-09-3155 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003954477
357 rdf:type schema:CreativeWork
358 https://doi.org/10.1182/blood-2007-05-089151 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031943994
359 rdf:type schema:CreativeWork
360 https://doi.org/10.4161/rna.6.1.7458 schema:sameAs https://app.dimensions.ai/details/publication/pub.1072310405
361 rdf:type schema:CreativeWork
362 https://www.grid.ac/institutes/grid.214572.7 schema:alternateName University of Iowa
363 schema:name Department of Pathology, University of Iowa Roy J. and Lucille A. Carver College of Medicine, Iowa City, IA, USA
364 rdf:type schema:Organization
365 https://www.grid.ac/institutes/grid.411760.5 schema:alternateName University Hospital of Würzburg
366 schema:name Division of Haematology and Medical Oncology, Department of Internal Medicine II, Comprehensive Cancer Centre Mainfranken, University Hospital Würzburg, Würzburg, Germany
367 rdf:type schema:Organization
368 https://www.grid.ac/institutes/grid.6582.9 schema:alternateName University of Ulm
369 schema:name Department of Internal Medicine III, University of Ulm, Ulm, Germany
370 rdf:type schema:Organization
371 https://www.grid.ac/institutes/grid.8379.5 schema:alternateName University of Würzburg
372 schema:name Institute of Pathology, University of Würzburg, Würzburg, Germany
373 Theodor Boveri Institute, University of Würzburg, Würzburg, Germany
374 rdf:type schema:Organization
375 https://www.grid.ac/institutes/grid.8664.c schema:alternateName University of Giessen
376 schema:name Institute of Pathology, University of Giessen and Marburg, Marburg, Germany
377 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...