Allogeneic hematopoietic stem cell transplantation for adult AML patients with granulocytic sarcoma View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2012-06-13

AUTHORS

H Shimizu, T Saitoh, M Tanaka, T Mori, T Sakura, N Kawai, Y Kanda, C Nakaseko, S Yano, H Fujita, S Fujisawa, S Miyawaki, H Kanamori, S Okamoto

ABSTRACT

We recently reported that adult acute myeloid leukemia (AML) patients with granulocytic sarcoma (GS) possessed unique clinical features and poor prognosis. However, the optimal therapeutic strategy for this entity has not been established. Therefore, the aim of this study was to assess the efficacy of allogeneic hematopoietic stem cell transplantation (allo-HSCT) for the management of AML with GS. We retrospectively analyzed 503 consecutive adult AML patients (median age, 44 years; range, 15–73 years) who received allo-HSCT. A total of 44 patients (8.7%) had GS before transplantation. Patients with GS achieved comparable survival to those without GS (5-year overall survival (OS), 47% vs 44%, respectively, P=0.621). In patients with GS, excellent outcomes were seen in those that underwent allo-HSCT while in complete remission, whereas nine out of ten patients with GS at the time of transplant experienced a relapse within 6 months after allo-HSCT. Local irradiation for GS prior to allo-HSCT and acute and chronic graft-versus-host disease did not affect survival significantly. Multivariate analysis identified age, disease status and the use of myeloablative conditioning as independent prognostic factors for OS. These data suggest that better control of GS prior to allo-HSCT is crucial to improve the outcome of transplantation for those with GS. More... »

PAGES

2469-2473

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/leu.2012.156

DOI

http://dx.doi.org/10.1038/leu.2012.156

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1053273526

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/22699453


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30 schema:description We recently reported that adult acute myeloid leukemia (AML) patients with granulocytic sarcoma (GS) possessed unique clinical features and poor prognosis. However, the optimal therapeutic strategy for this entity has not been established. Therefore, the aim of this study was to assess the efficacy of allogeneic hematopoietic stem cell transplantation (allo-HSCT) for the management of AML with GS. We retrospectively analyzed 503 consecutive adult AML patients (median age, 44 years; range, 15–73 years) who received allo-HSCT. A total of 44 patients (8.7%) had GS before transplantation. Patients with GS achieved comparable survival to those without GS (5-year overall survival (OS), 47% vs 44%, respectively, P=0.621). In patients with GS, excellent outcomes were seen in those that underwent allo-HSCT while in complete remission, whereas nine out of ten patients with GS at the time of transplant experienced a relapse within 6 months after allo-HSCT. Local irradiation for GS prior to allo-HSCT and acute and chronic graft-versus-host disease did not affect survival significantly. Multivariate analysis identified age, disease status and the use of myeloablative conditioning as independent prognostic factors for OS. These data suggest that better control of GS prior to allo-HSCT is crucial to improve the outcome of transplantation for those with GS.
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37 AML patients
38 OS
39 acute myeloid leukemia patients
40 adult AML patients
41 adult acute myeloid leukemia patients
42 age
43 aim
44 allo-HSCT
45 allogeneic hematopoietic stem cell transplantation
46 analysis
47 better control
48 cell transplantation
49 chronic graft
50 clinical features
51 comparable survival
52 complete remission
53 conditioning
54 consecutive adult AML patients
55 control
56 data
57 disease
58 disease status
59 efficacy
60 entities
61 excellent outcomes
62 factors
63 features
64 graft
65 granulocytic sarcoma
66 hematopoietic stem cell transplantation
67 host disease
68 independent prognostic factor
69 irradiation
70 leukemia patients
71 local irradiation
72 management
73 management of AML
74 months
75 multivariate analysis
76 myeloablative conditioning
77 myeloid leukemia patients
78 optimal therapeutic strategy
79 outcome of transplantation
80 outcomes
81 patients
82 poor prognosis
83 prognosis
84 prognostic factors
85 relapse
86 remission
87 sarcoma
88 status
89 stem cell transplantation
90 strategies
91 study
92 survival
93 therapeutic strategies
94 time
95 time of transplant
96 total
97 transplant
98 transplantation
99 unique clinical features
100 use
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