BCL2 mutations in diffuse large B-cell lymphoma View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2012-06

AUTHORS

J M Schuetz, N A Johnson, R D Morin, D W Scott, K Tan, S Ben-Nierah, M Boyle, G W Slack, M A Marra, J M Connors, A R Brooks-Wilson, R D Gascoyne

ABSTRACT

BCL2 is deregulated in diffuse large B-cell lymphoma (DLBCL) by the t(14;18) translocation, gene amplification and/or nuclear factor-κB signaling. RNA-seq data have recently shown that BCL2 is the most highly mutated gene in germinal center B-cell (GCB) DLBCL. We have sequenced BCL2 in 298 primary DLBCL biopsies, 131 additional non-Hodgkin lymphoma biopsies, 24 DLBCL cell lines and 51 germline DNAs. We found frequent BCL2 mutations in follicular lymphoma (FL) and GCB DLBCL, but low levels of BCL2 mutations in activated B-cell DLBCL, mantle cell lymphoma, small lymphocytic leukemia and peripheral T-cell lymphoma. We found no BCL2 mutations in GC centroblasts. Many mutations were non-synonymous; they were preferentially located in the flexible loop domain, with few in BCL2-homology domains. An elevated transition/transversions ratio supports that the mutations result from somatic hypermutation. BCL2 translocations correlate with, and are likely important in acquisition of, additional BCL2 mutations in GCB DLBCL and FL. DLBCL mutations were not independently associated with survival. Although previous studies of BCL2 mutations in FL have reported mutations to result in pseudo-negative BCL2 protein expression, we find this rare in de-novo DLBCL. More... »

PAGES

1383

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/leu.2011.378

DOI

http://dx.doi.org/10.1038/leu.2011.378

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1028992430

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/22189900


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1112", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Oncology and Carcinogenesis", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cytogenetic Analysis", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Immunoenzyme Techniques", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Leukemia, Lymphocytic, Chronic, B-Cell", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Lymphoma, Large B-Cell, Diffuse", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Lymphoma, Mantle-Cell", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Lymphoma, T-Cell, Peripheral", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Mediastinal Neoplasms", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Mutation", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Protein Transport", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Proto-Oncogene Proteins c-bcl-2", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "University of British Columbia", 
          "id": "https://www.grid.ac/institutes/grid.17091.3e", 
          "name": [
            "Canada's Michael Smith Genome Sciences Center, BC Cancer Agency, University of British Columbia, Vancouver, British Columbia, Canada"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Schuetz", 
        "givenName": "J M", 
        "id": "sg:person.01222076641.72", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01222076641.72"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Jewish General Hospital", 
          "id": "https://www.grid.ac/institutes/grid.414980.0", 
          "name": [
            "Division of Hematology and Oncology, Jewish General Hospital, Montreal, Qu\u00e9bec, Canada"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Johnson", 
        "givenName": "N A", 
        "id": "sg:person.01242370300.29", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01242370300.29"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of British Columbia", 
          "id": "https://www.grid.ac/institutes/grid.17091.3e", 
          "name": [
            "Canada's Michael Smith Genome Sciences Center, BC Cancer Agency, University of British Columbia, Vancouver, British Columbia, Canada"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Morin", 
        "givenName": "R D", 
        "id": "sg:person.01131216113.19", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01131216113.19"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "BC Cancer Agency", 
          "id": "https://www.grid.ac/institutes/grid.248762.d", 
          "name": [
            "Department of Pathology, Centre for Lymphoid Cancer, BC Cancer Agency, Vancouver, British Columbia, Canada"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Scott", 
        "givenName": "D W", 
        "id": "sg:person.01347122425.52", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01347122425.52"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "BC Cancer Agency", 
          "id": "https://www.grid.ac/institutes/grid.248762.d", 
          "name": [
            "Department of Pathology, Centre for Lymphoid Cancer, BC Cancer Agency, Vancouver, British Columbia, Canada"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Tan", 
        "givenName": "K", 
        "id": "sg:person.01122306525.62", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01122306525.62"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "BC Cancer Agency", 
          "id": "https://www.grid.ac/institutes/grid.248762.d", 
          "name": [
            "Department of Pathology, Centre for Lymphoid Cancer, BC Cancer Agency, Vancouver, British Columbia, Canada"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Ben-Nierah", 
        "givenName": "S", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "BC Cancer Agency", 
          "id": "https://www.grid.ac/institutes/grid.248762.d", 
          "name": [
            "Department of Pathology, Centre for Lymphoid Cancer, BC Cancer Agency, Vancouver, British Columbia, Canada"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Boyle", 
        "givenName": "M", 
        "id": "sg:person.01304055513.78", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01304055513.78"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "BC Cancer Agency", 
          "id": "https://www.grid.ac/institutes/grid.248762.d", 
          "name": [
            "Department of Pathology, Centre for Lymphoid Cancer, BC Cancer Agency, Vancouver, British Columbia, Canada"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Slack", 
        "givenName": "G W", 
        "id": "sg:person.01054173325.14", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01054173325.14"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of British Columbia", 
          "id": "https://www.grid.ac/institutes/grid.17091.3e", 
          "name": [
            "Canada's Michael Smith Genome Sciences Center, BC Cancer Agency, University of British Columbia, Vancouver, British Columbia, Canada"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Marra", 
        "givenName": "M A", 
        "id": "sg:person.01150455763.02", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01150455763.02"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "BC Cancer Agency", 
          "id": "https://www.grid.ac/institutes/grid.248762.d", 
          "name": [
            "Division of Medical Oncology, Centre for Lymphoid Cancer, BC Cancer Agency, Vancouver, British Columbia, Canada"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Connors", 
        "givenName": "J M", 
        "id": "sg:person.0677574517.97", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0677574517.97"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Simon Fraser University", 
          "id": "https://www.grid.ac/institutes/grid.61971.38", 
          "name": [
            "Canada's Michael Smith Genome Sciences Center, BC Cancer Agency, University of British Columbia, Vancouver, British Columbia, Canada", 
            "Department of Biomedical Physiology and Kinesiology, Simon Fraser University, Burnaby, British Columbia, Canada"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Brooks-Wilson", 
        "givenName": "A R", 
        "id": "sg:person.01233313645.38", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01233313645.38"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "BC Cancer Agency", 
          "id": "https://www.grid.ac/institutes/grid.248762.d", 
          "name": [
            "Department of Pathology, Centre for Lymphoid Cancer, BC Cancer Agency, Vancouver, British Columbia, Canada"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Gascoyne", 
        "givenName": "R D", 
        "id": "sg:person.014716156604.90", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.014716156604.90"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.3109/00313021003631296", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1000626097"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3109/00313021003631296", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1000626097"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3109/00313021003631296", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1000626097"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.molcel.2008.06.001", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1001623057"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ng.518", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1001723375", 
          "https://doi.org/10.1038/ng.518"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ng.518", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1001723375", 
          "https://doi.org/10.1038/ng.518"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.0903854106", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1001945781"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0014-5793(04)00059-6", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1003764971"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/gcc.1103", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1007249232"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/35000501", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1010898206", 
          "https://doi.org/10.1038/35000501"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/35000501", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1010898206", 
          "https://doi.org/10.1038/35000501"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1074/jbc.m507611200", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1012675384"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/35085588", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1013839107", 
          "https://doi.org/10.1038/35085588"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/35085588", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1013839107", 
          "https://doi.org/10.1038/35085588"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3324/haematol.2009.007203", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1015285625"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1158/1078-0432.ccr-11-0267", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1016169685"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/bioinformatics/btq040", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1016756234"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0092-8674(04)00162-x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1017869374"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1200/jco.2005.03.4264", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1018536746"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature10351", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1019649945", 
          "https://doi.org/10.1038/nature10351"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1182/blood-2003-04-1027", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1023507270"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1385/1-59259-192-2:365", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1023668922", 
          "https://doi.org/10.1385/1-59259-192-2:365"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/emboj/16.5.968", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1024068094"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/path.1689", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1025342006"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1182/blood-2003-05-1545", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1026049587"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature06547", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1026421044", 
          "https://doi.org/10.1038/nature06547"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.cancergencyto.2004.05.012", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1028446285"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.cdd.4401960", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1033331489", 
          "https://doi.org/10.1038/sj.cdd.4401960"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.cdd.4401960", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1033331489", 
          "https://doi.org/10.1038/sj.cdd.4401960"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1128/mcb.01647-05", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1034859107"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1146/annurev.immunol.26.021607.090236", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035975480"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/335440a0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037003177", 
          "https://doi.org/10.1038/335440a0"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/bioinformatics/btp324", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1038266369"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/cdd.2008.25", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1039760462", 
          "https://doi.org/10.1038/cdd.2008.25"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.2533920100", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1040430992"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1182/blood-2009-05-220095", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1040808320"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.96.7.3775", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1043237595"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/nar/gkf493", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1043756780"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nmeth.1226", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1045381177", 
          "https://doi.org/10.1038/nmeth.1226"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.2298/vsp0909738p", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1046785035"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1182/blood-2002-11-3442", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1047221422"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s004390050847", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1049400512", 
          "https://doi.org/10.1007/s004390050847"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s004390050847", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1049400512", 
          "https://doi.org/10.1007/s004390050847"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.febslet.2005.05.015", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1049570815"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.febslet.2005.05.015", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1049570815"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.ccr.2007.07.001", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1050526467"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/emboj/17.5.1268", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1052319978"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1084/jem.183.5.2219", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1052558563"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0002-9440(10)63284-1", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1053530727"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/science.275.5302.983", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1062555789"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/science.278.5345.1966", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1062558974"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/science.6093263", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1062634110"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3892/ijo.11.3.481", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1071510423"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1074544770", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1074673637", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1075697929", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1077084763", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1077811602", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/j.1460-2075.1988.tb02791.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1079416524"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1082854063", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1082895707", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/j.1460-2075.1996.tb01090.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1083035084"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2012-06", 
    "datePublishedReg": "2012-06-01", 
    "description": "BCL2 is deregulated in diffuse large B-cell lymphoma (DLBCL) by the t(14;18) translocation, gene amplification and/or nuclear factor-\u03baB signaling. RNA-seq data have recently shown that BCL2 is the most highly mutated gene in germinal center B-cell (GCB) DLBCL. We have sequenced BCL2 in 298 primary DLBCL biopsies, 131 additional non-Hodgkin lymphoma biopsies, 24 DLBCL cell lines and 51 germline DNAs. We found frequent BCL2 mutations in follicular lymphoma (FL) and GCB DLBCL, but low levels of BCL2 mutations in activated B-cell DLBCL, mantle cell lymphoma, small lymphocytic leukemia and peripheral T-cell lymphoma. We found no BCL2 mutations in GC centroblasts. Many mutations were non-synonymous; they were preferentially located in the flexible loop domain, with few in BCL2-homology domains. An elevated transition/transversions ratio supports that the mutations result from somatic hypermutation. BCL2 translocations correlate with, and are likely important in acquisition of, additional BCL2 mutations in GCB DLBCL and FL. DLBCL mutations were not independently associated with survival. Although previous studies of BCL2 mutations in FL have reported mutations to result in pseudo-negative BCL2 protein expression, we find this rare in de-novo DLBCL.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1038/leu.2011.378", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": true, 
    "isFundedItemOf": [
      {
        "id": "sg:grant.2343593", 
        "type": "MonetaryGrant"
      }
    ], 
    "isPartOf": [
      {
        "id": "sg:journal.1097065", 
        "issn": [
          "0887-6924", 
          "1476-5551"
        ], 
        "name": "Leukemia", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "6", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "26"
      }
    ], 
    "name": "BCL2 mutations in diffuse large B-cell lymphoma", 
    "pagination": "1383", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "8a1d56ff76e6d8781dbea3892830a10d32560349061a1d2bf75a6963da871acc"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "22189900"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "8704895"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1038/leu.2011.378"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1028992430"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1038/leu.2011.378", 
      "https://app.dimensions.ai/details/publication/pub.1028992430"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-10T14:47", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8663_00000425.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://www.nature.com/articles/leu2011378"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/leu.2011.378'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/leu.2011.378'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/leu.2011.378'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/leu.2011.378'


 

This table displays all metadata directly associated to this object as RDF triples.

368 TRIPLES      21 PREDICATES      94 URIs      32 LITERALS      20 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1038/leu.2011.378 schema:about N08d1e540157840238292244bed99c234
2 N1a1698cb08be455bbe7ac52a3c697b9b
3 N20127f16c24f4216ad02a2d08afe5214
4 N4302d579db0b4102b5e23e9bb1e9a4fd
5 N49e0eafda6a046d0afe4322123183c3f
6 N5bf5ca3bf0764e7d9f8171606371136b
7 Nc3a9ce32d6a94ddebe86749f60d08a5d
8 Ncf14528937604993a8e1a5e353561d6f
9 Ndf8653ac07c446b2b102a6f2bab3178d
10 Ne3d437b4916645d6adf95edb5410d2c3
11 Ne4ac90379824492392972b26b2e6a2ff
12 anzsrc-for:11
13 anzsrc-for:1112
14 schema:author N15712f4095eb4fcaa8484aab4cfe6a0a
15 schema:citation sg:pub.10.1007/s004390050847
16 sg:pub.10.1038/335440a0
17 sg:pub.10.1038/35000501
18 sg:pub.10.1038/35085588
19 sg:pub.10.1038/cdd.2008.25
20 sg:pub.10.1038/nature06547
21 sg:pub.10.1038/nature10351
22 sg:pub.10.1038/ng.518
23 sg:pub.10.1038/nmeth.1226
24 sg:pub.10.1038/sj.cdd.4401960
25 sg:pub.10.1385/1-59259-192-2:365
26 https://app.dimensions.ai/details/publication/pub.1074544770
27 https://app.dimensions.ai/details/publication/pub.1074673637
28 https://app.dimensions.ai/details/publication/pub.1075697929
29 https://app.dimensions.ai/details/publication/pub.1077084763
30 https://app.dimensions.ai/details/publication/pub.1077811602
31 https://app.dimensions.ai/details/publication/pub.1082854063
32 https://app.dimensions.ai/details/publication/pub.1082895707
33 https://doi.org/10.1002/gcc.1103
34 https://doi.org/10.1002/j.1460-2075.1988.tb02791.x
35 https://doi.org/10.1002/j.1460-2075.1996.tb01090.x
36 https://doi.org/10.1002/path.1689
37 https://doi.org/10.1016/j.cancergencyto.2004.05.012
38 https://doi.org/10.1016/j.ccr.2007.07.001
39 https://doi.org/10.1016/j.febslet.2005.05.015
40 https://doi.org/10.1016/j.molcel.2008.06.001
41 https://doi.org/10.1016/s0002-9440(10)63284-1
42 https://doi.org/10.1016/s0014-5793(04)00059-6
43 https://doi.org/10.1016/s0092-8674(04)00162-x
44 https://doi.org/10.1073/pnas.0903854106
45 https://doi.org/10.1073/pnas.2533920100
46 https://doi.org/10.1073/pnas.96.7.3775
47 https://doi.org/10.1074/jbc.m507611200
48 https://doi.org/10.1084/jem.183.5.2219
49 https://doi.org/10.1093/bioinformatics/btp324
50 https://doi.org/10.1093/bioinformatics/btq040
51 https://doi.org/10.1093/emboj/16.5.968
52 https://doi.org/10.1093/emboj/17.5.1268
53 https://doi.org/10.1093/nar/gkf493
54 https://doi.org/10.1126/science.275.5302.983
55 https://doi.org/10.1126/science.278.5345.1966
56 https://doi.org/10.1126/science.6093263
57 https://doi.org/10.1128/mcb.01647-05
58 https://doi.org/10.1146/annurev.immunol.26.021607.090236
59 https://doi.org/10.1158/1078-0432.ccr-11-0267
60 https://doi.org/10.1182/blood-2002-11-3442
61 https://doi.org/10.1182/blood-2003-04-1027
62 https://doi.org/10.1182/blood-2003-05-1545
63 https://doi.org/10.1182/blood-2009-05-220095
64 https://doi.org/10.1200/jco.2005.03.4264
65 https://doi.org/10.2298/vsp0909738p
66 https://doi.org/10.3109/00313021003631296
67 https://doi.org/10.3324/haematol.2009.007203
68 https://doi.org/10.3892/ijo.11.3.481
69 schema:datePublished 2012-06
70 schema:datePublishedReg 2012-06-01
71 schema:description BCL2 is deregulated in diffuse large B-cell lymphoma (DLBCL) by the t(14;18) translocation, gene amplification and/or nuclear factor-κB signaling. RNA-seq data have recently shown that BCL2 is the most highly mutated gene in germinal center B-cell (GCB) DLBCL. We have sequenced BCL2 in 298 primary DLBCL biopsies, 131 additional non-Hodgkin lymphoma biopsies, 24 DLBCL cell lines and 51 germline DNAs. We found frequent BCL2 mutations in follicular lymphoma (FL) and GCB DLBCL, but low levels of BCL2 mutations in activated B-cell DLBCL, mantle cell lymphoma, small lymphocytic leukemia and peripheral T-cell lymphoma. We found no BCL2 mutations in GC centroblasts. Many mutations were non-synonymous; they were preferentially located in the flexible loop domain, with few in BCL2-homology domains. An elevated transition/transversions ratio supports that the mutations result from somatic hypermutation. BCL2 translocations correlate with, and are likely important in acquisition of, additional BCL2 mutations in GCB DLBCL and FL. DLBCL mutations were not independently associated with survival. Although previous studies of BCL2 mutations in FL have reported mutations to result in pseudo-negative BCL2 protein expression, we find this rare in de-novo DLBCL.
72 schema:genre research_article
73 schema:inLanguage en
74 schema:isAccessibleForFree true
75 schema:isPartOf N41e7164a75224633b8498ef850fb9a72
76 Nac62425d9fbc4779adb6084c1be6c08e
77 sg:journal.1097065
78 schema:name BCL2 mutations in diffuse large B-cell lymphoma
79 schema:pagination 1383
80 schema:productId N47ef0b1deea94d2eb40ef7a7540272d4
81 N6f1321d947464d70a7fb803a80831982
82 Nb9bad540fe1d46ef88888828378548d1
83 Nca82c9fe894b4b929dad3166bfd630a7
84 Ndc55805c7a184175b3b9aa9e3df5d133
85 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028992430
86 https://doi.org/10.1038/leu.2011.378
87 schema:sdDatePublished 2019-04-10T14:47
88 schema:sdLicense https://scigraph.springernature.com/explorer/license/
89 schema:sdPublisher N9aecb24000e9412c9e9e45e6111b64c0
90 schema:url https://www.nature.com/articles/leu2011378
91 sgo:license sg:explorer/license/
92 sgo:sdDataset articles
93 rdf:type schema:ScholarlyArticle
94 N00052828e05f4478a26ca3a9b16569b7 rdf:first sg:person.01131216113.19
95 rdf:rest Ndbcfc5231e744a9b8f9fabc7bef0b3a6
96 N0792e3a7333241b4ad73c25833c015f8 schema:affiliation https://www.grid.ac/institutes/grid.248762.d
97 schema:familyName Ben-Nierah
98 schema:givenName S
99 rdf:type schema:Person
100 N08d1e540157840238292244bed99c234 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
101 schema:name Immunoenzyme Techniques
102 rdf:type schema:DefinedTerm
103 N15712f4095eb4fcaa8484aab4cfe6a0a rdf:first sg:person.01222076641.72
104 rdf:rest N6321847eee234f9fa216747f7e482af0
105 N1a1698cb08be455bbe7ac52a3c697b9b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
106 schema:name Mutation
107 rdf:type schema:DefinedTerm
108 N20127f16c24f4216ad02a2d08afe5214 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
109 schema:name Cytogenetic Analysis
110 rdf:type schema:DefinedTerm
111 N3c7a2768a87944628bf19845594e82e5 rdf:first sg:person.01054173325.14
112 rdf:rest Nd3e7283c62254d2da2194b4d792dfa69
113 N41e7164a75224633b8498ef850fb9a72 schema:volumeNumber 26
114 rdf:type schema:PublicationVolume
115 N4302d579db0b4102b5e23e9bb1e9a4fd schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
116 schema:name Lymphoma, Mantle-Cell
117 rdf:type schema:DefinedTerm
118 N44a5197f87484a04a665525414085e16 rdf:first N0792e3a7333241b4ad73c25833c015f8
119 rdf:rest Nbc1bcc34d74d404ab4d847ea9817c445
120 N47ef0b1deea94d2eb40ef7a7540272d4 schema:name dimensions_id
121 schema:value pub.1028992430
122 rdf:type schema:PropertyValue
123 N49e0eafda6a046d0afe4322123183c3f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
124 schema:name Humans
125 rdf:type schema:DefinedTerm
126 N5bf5ca3bf0764e7d9f8171606371136b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
127 schema:name Leukemia, Lymphocytic, Chronic, B-Cell
128 rdf:type schema:DefinedTerm
129 N6321847eee234f9fa216747f7e482af0 rdf:first sg:person.01242370300.29
130 rdf:rest N00052828e05f4478a26ca3a9b16569b7
131 N6f1321d947464d70a7fb803a80831982 schema:name doi
132 schema:value 10.1038/leu.2011.378
133 rdf:type schema:PropertyValue
134 N9112c83aa20246448ce6e09bb6f10f39 rdf:first sg:person.01122306525.62
135 rdf:rest N44a5197f87484a04a665525414085e16
136 N9aecb24000e9412c9e9e45e6111b64c0 schema:name Springer Nature - SN SciGraph project
137 rdf:type schema:Organization
138 Nac62425d9fbc4779adb6084c1be6c08e schema:issueNumber 6
139 rdf:type schema:PublicationIssue
140 Nb9bad540fe1d46ef88888828378548d1 schema:name pubmed_id
141 schema:value 22189900
142 rdf:type schema:PropertyValue
143 Nbc1bcc34d74d404ab4d847ea9817c445 rdf:first sg:person.01304055513.78
144 rdf:rest N3c7a2768a87944628bf19845594e82e5
145 Nc3a9ce32d6a94ddebe86749f60d08a5d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
146 schema:name Mediastinal Neoplasms
147 rdf:type schema:DefinedTerm
148 Nca82c9fe894b4b929dad3166bfd630a7 schema:name readcube_id
149 schema:value 8a1d56ff76e6d8781dbea3892830a10d32560349061a1d2bf75a6963da871acc
150 rdf:type schema:PropertyValue
151 Ncf14528937604993a8e1a5e353561d6f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
152 schema:name Lymphoma, Large B-Cell, Diffuse
153 rdf:type schema:DefinedTerm
154 Nd1049ae895944384b090b74baa4c4886 rdf:first sg:person.014716156604.90
155 rdf:rest rdf:nil
156 Nd3e7283c62254d2da2194b4d792dfa69 rdf:first sg:person.01150455763.02
157 rdf:rest Nd6f19bea9e7f4aec87e39cf6ffdaa034
158 Nd6f19bea9e7f4aec87e39cf6ffdaa034 rdf:first sg:person.0677574517.97
159 rdf:rest Ndb2feb06b9e4444496aa3669ec4be2b3
160 Ndb2feb06b9e4444496aa3669ec4be2b3 rdf:first sg:person.01233313645.38
161 rdf:rest Nd1049ae895944384b090b74baa4c4886
162 Ndbcfc5231e744a9b8f9fabc7bef0b3a6 rdf:first sg:person.01347122425.52
163 rdf:rest N9112c83aa20246448ce6e09bb6f10f39
164 Ndc55805c7a184175b3b9aa9e3df5d133 schema:name nlm_unique_id
165 schema:value 8704895
166 rdf:type schema:PropertyValue
167 Ndf8653ac07c446b2b102a6f2bab3178d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
168 schema:name Proto-Oncogene Proteins c-bcl-2
169 rdf:type schema:DefinedTerm
170 Ne3d437b4916645d6adf95edb5410d2c3 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
171 schema:name Protein Transport
172 rdf:type schema:DefinedTerm
173 Ne4ac90379824492392972b26b2e6a2ff schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
174 schema:name Lymphoma, T-Cell, Peripheral
175 rdf:type schema:DefinedTerm
176 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
177 schema:name Medical and Health Sciences
178 rdf:type schema:DefinedTerm
179 anzsrc-for:1112 schema:inDefinedTermSet anzsrc-for:
180 schema:name Oncology and Carcinogenesis
181 rdf:type schema:DefinedTerm
182 sg:grant.2343593 http://pending.schema.org/fundedItem sg:pub.10.1038/leu.2011.378
183 rdf:type schema:MonetaryGrant
184 sg:journal.1097065 schema:issn 0887-6924
185 1476-5551
186 schema:name Leukemia
187 rdf:type schema:Periodical
188 sg:person.01054173325.14 schema:affiliation https://www.grid.ac/institutes/grid.248762.d
189 schema:familyName Slack
190 schema:givenName G W
191 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01054173325.14
192 rdf:type schema:Person
193 sg:person.01122306525.62 schema:affiliation https://www.grid.ac/institutes/grid.248762.d
194 schema:familyName Tan
195 schema:givenName K
196 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01122306525.62
197 rdf:type schema:Person
198 sg:person.01131216113.19 schema:affiliation https://www.grid.ac/institutes/grid.17091.3e
199 schema:familyName Morin
200 schema:givenName R D
201 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01131216113.19
202 rdf:type schema:Person
203 sg:person.01150455763.02 schema:affiliation https://www.grid.ac/institutes/grid.17091.3e
204 schema:familyName Marra
205 schema:givenName M A
206 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01150455763.02
207 rdf:type schema:Person
208 sg:person.01222076641.72 schema:affiliation https://www.grid.ac/institutes/grid.17091.3e
209 schema:familyName Schuetz
210 schema:givenName J M
211 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01222076641.72
212 rdf:type schema:Person
213 sg:person.01233313645.38 schema:affiliation https://www.grid.ac/institutes/grid.61971.38
214 schema:familyName Brooks-Wilson
215 schema:givenName A R
216 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01233313645.38
217 rdf:type schema:Person
218 sg:person.01242370300.29 schema:affiliation https://www.grid.ac/institutes/grid.414980.0
219 schema:familyName Johnson
220 schema:givenName N A
221 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01242370300.29
222 rdf:type schema:Person
223 sg:person.01304055513.78 schema:affiliation https://www.grid.ac/institutes/grid.248762.d
224 schema:familyName Boyle
225 schema:givenName M
226 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01304055513.78
227 rdf:type schema:Person
228 sg:person.01347122425.52 schema:affiliation https://www.grid.ac/institutes/grid.248762.d
229 schema:familyName Scott
230 schema:givenName D W
231 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01347122425.52
232 rdf:type schema:Person
233 sg:person.014716156604.90 schema:affiliation https://www.grid.ac/institutes/grid.248762.d
234 schema:familyName Gascoyne
235 schema:givenName R D
236 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.014716156604.90
237 rdf:type schema:Person
238 sg:person.0677574517.97 schema:affiliation https://www.grid.ac/institutes/grid.248762.d
239 schema:familyName Connors
240 schema:givenName J M
241 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0677574517.97
242 rdf:type schema:Person
243 sg:pub.10.1007/s004390050847 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049400512
244 https://doi.org/10.1007/s004390050847
245 rdf:type schema:CreativeWork
246 sg:pub.10.1038/335440a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037003177
247 https://doi.org/10.1038/335440a0
248 rdf:type schema:CreativeWork
249 sg:pub.10.1038/35000501 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010898206
250 https://doi.org/10.1038/35000501
251 rdf:type schema:CreativeWork
252 sg:pub.10.1038/35085588 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013839107
253 https://doi.org/10.1038/35085588
254 rdf:type schema:CreativeWork
255 sg:pub.10.1038/cdd.2008.25 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039760462
256 https://doi.org/10.1038/cdd.2008.25
257 rdf:type schema:CreativeWork
258 sg:pub.10.1038/nature06547 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026421044
259 https://doi.org/10.1038/nature06547
260 rdf:type schema:CreativeWork
261 sg:pub.10.1038/nature10351 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019649945
262 https://doi.org/10.1038/nature10351
263 rdf:type schema:CreativeWork
264 sg:pub.10.1038/ng.518 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001723375
265 https://doi.org/10.1038/ng.518
266 rdf:type schema:CreativeWork
267 sg:pub.10.1038/nmeth.1226 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045381177
268 https://doi.org/10.1038/nmeth.1226
269 rdf:type schema:CreativeWork
270 sg:pub.10.1038/sj.cdd.4401960 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033331489
271 https://doi.org/10.1038/sj.cdd.4401960
272 rdf:type schema:CreativeWork
273 sg:pub.10.1385/1-59259-192-2:365 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023668922
274 https://doi.org/10.1385/1-59259-192-2:365
275 rdf:type schema:CreativeWork
276 https://app.dimensions.ai/details/publication/pub.1074544770 schema:CreativeWork
277 https://app.dimensions.ai/details/publication/pub.1074673637 schema:CreativeWork
278 https://app.dimensions.ai/details/publication/pub.1075697929 schema:CreativeWork
279 https://app.dimensions.ai/details/publication/pub.1077084763 schema:CreativeWork
280 https://app.dimensions.ai/details/publication/pub.1077811602 schema:CreativeWork
281 https://app.dimensions.ai/details/publication/pub.1082854063 schema:CreativeWork
282 https://app.dimensions.ai/details/publication/pub.1082895707 schema:CreativeWork
283 https://doi.org/10.1002/gcc.1103 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007249232
284 rdf:type schema:CreativeWork
285 https://doi.org/10.1002/j.1460-2075.1988.tb02791.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1079416524
286 rdf:type schema:CreativeWork
287 https://doi.org/10.1002/j.1460-2075.1996.tb01090.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1083035084
288 rdf:type schema:CreativeWork
289 https://doi.org/10.1002/path.1689 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025342006
290 rdf:type schema:CreativeWork
291 https://doi.org/10.1016/j.cancergencyto.2004.05.012 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028446285
292 rdf:type schema:CreativeWork
293 https://doi.org/10.1016/j.ccr.2007.07.001 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050526467
294 rdf:type schema:CreativeWork
295 https://doi.org/10.1016/j.febslet.2005.05.015 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049570815
296 rdf:type schema:CreativeWork
297 https://doi.org/10.1016/j.molcel.2008.06.001 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001623057
298 rdf:type schema:CreativeWork
299 https://doi.org/10.1016/s0002-9440(10)63284-1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1053530727
300 rdf:type schema:CreativeWork
301 https://doi.org/10.1016/s0014-5793(04)00059-6 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003764971
302 rdf:type schema:CreativeWork
303 https://doi.org/10.1016/s0092-8674(04)00162-x schema:sameAs https://app.dimensions.ai/details/publication/pub.1017869374
304 rdf:type schema:CreativeWork
305 https://doi.org/10.1073/pnas.0903854106 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001945781
306 rdf:type schema:CreativeWork
307 https://doi.org/10.1073/pnas.2533920100 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040430992
308 rdf:type schema:CreativeWork
309 https://doi.org/10.1073/pnas.96.7.3775 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043237595
310 rdf:type schema:CreativeWork
311 https://doi.org/10.1074/jbc.m507611200 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012675384
312 rdf:type schema:CreativeWork
313 https://doi.org/10.1084/jem.183.5.2219 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052558563
314 rdf:type schema:CreativeWork
315 https://doi.org/10.1093/bioinformatics/btp324 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038266369
316 rdf:type schema:CreativeWork
317 https://doi.org/10.1093/bioinformatics/btq040 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016756234
318 rdf:type schema:CreativeWork
319 https://doi.org/10.1093/emboj/16.5.968 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024068094
320 rdf:type schema:CreativeWork
321 https://doi.org/10.1093/emboj/17.5.1268 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052319978
322 rdf:type schema:CreativeWork
323 https://doi.org/10.1093/nar/gkf493 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043756780
324 rdf:type schema:CreativeWork
325 https://doi.org/10.1126/science.275.5302.983 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062555789
326 rdf:type schema:CreativeWork
327 https://doi.org/10.1126/science.278.5345.1966 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062558974
328 rdf:type schema:CreativeWork
329 https://doi.org/10.1126/science.6093263 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062634110
330 rdf:type schema:CreativeWork
331 https://doi.org/10.1128/mcb.01647-05 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034859107
332 rdf:type schema:CreativeWork
333 https://doi.org/10.1146/annurev.immunol.26.021607.090236 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035975480
334 rdf:type schema:CreativeWork
335 https://doi.org/10.1158/1078-0432.ccr-11-0267 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016169685
336 rdf:type schema:CreativeWork
337 https://doi.org/10.1182/blood-2002-11-3442 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047221422
338 rdf:type schema:CreativeWork
339 https://doi.org/10.1182/blood-2003-04-1027 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023507270
340 rdf:type schema:CreativeWork
341 https://doi.org/10.1182/blood-2003-05-1545 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026049587
342 rdf:type schema:CreativeWork
343 https://doi.org/10.1182/blood-2009-05-220095 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040808320
344 rdf:type schema:CreativeWork
345 https://doi.org/10.1200/jco.2005.03.4264 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018536746
346 rdf:type schema:CreativeWork
347 https://doi.org/10.2298/vsp0909738p schema:sameAs https://app.dimensions.ai/details/publication/pub.1046785035
348 rdf:type schema:CreativeWork
349 https://doi.org/10.3109/00313021003631296 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000626097
350 rdf:type schema:CreativeWork
351 https://doi.org/10.3324/haematol.2009.007203 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015285625
352 rdf:type schema:CreativeWork
353 https://doi.org/10.3892/ijo.11.3.481 schema:sameAs https://app.dimensions.ai/details/publication/pub.1071510423
354 rdf:type schema:CreativeWork
355 https://www.grid.ac/institutes/grid.17091.3e schema:alternateName University of British Columbia
356 schema:name Canada's Michael Smith Genome Sciences Center, BC Cancer Agency, University of British Columbia, Vancouver, British Columbia, Canada
357 rdf:type schema:Organization
358 https://www.grid.ac/institutes/grid.248762.d schema:alternateName BC Cancer Agency
359 schema:name Department of Pathology, Centre for Lymphoid Cancer, BC Cancer Agency, Vancouver, British Columbia, Canada
360 Division of Medical Oncology, Centre for Lymphoid Cancer, BC Cancer Agency, Vancouver, British Columbia, Canada
361 rdf:type schema:Organization
362 https://www.grid.ac/institutes/grid.414980.0 schema:alternateName Jewish General Hospital
363 schema:name Division of Hematology and Oncology, Jewish General Hospital, Montreal, Québec, Canada
364 rdf:type schema:Organization
365 https://www.grid.ac/institutes/grid.61971.38 schema:alternateName Simon Fraser University
366 schema:name Canada's Michael Smith Genome Sciences Center, BC Cancer Agency, University of British Columbia, Vancouver, British Columbia, Canada
367 Department of Biomedical Physiology and Kinesiology, Simon Fraser University, Burnaby, British Columbia, Canada
368 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...