Chromatin modifications induced by the AML1-ETO fusion protein reversibly silence its genomic targets through AML1 and Sp1 binding motifs View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2012-06

AUTHORS

A Maiques-Diaz, F S Chou, M Wunderlich, G Gómez-López, F V Jacinto, S Rodriguez-Perales, M J Larrayoz, M J Calasanz, J C Mulloy, J C Cigudosa, S Alvarez

ABSTRACT

The AML1-ETO fusion protein, which is present in 10-15% of cases of acute myeloid leukemia, is known to repress myeloid differentiation genes through DNA binding and recruitment of chromatin-modifying proteins and transcription factors in target genes. ChIP-chip analysis of human hematopoietic stem/progenitor cells transduced with the AML1-ETO fusion gene enabled us to identify 1168 AML1-ETO target genes, 103 of which were co-occupied by histone deacetylase 1 (HDAC1) and had lost the hyperacetylation mark at histone H4, and 264 showed a K9 trimethylation at histone H3. Enrichment of genes involved in hematopoietic differentiation and in specific signaling pathways was observed in the presence of these epigenetic modifications associated with an 'inactive' chromatin status. Furthermore, AML1-ETO target genes had a significant correlation between the chromatin marks studied and transcriptional silencing. Interestingly, AML1 binding sites were absent on a large number of selected AML1-ETO promoters and an Sp1 binding site was found in over 50% of them. Reversible silencing induced by the fusion protein in the presence of AML1 and/or Sp1 transcription factor binding site was confirmed. Therefore, this study provides a global analysis of AML1-ETO functional chromatin modifications and identifies the important role of Sp1 in the DNA binding pattern of AML1-ETO, suggesting a role for Sp1-targeted therapy in this leukemia subtype. More... »

PAGES

1329

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/leu.2011.376

DOI

http://dx.doi.org/10.1038/leu.2011.376

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1021603723

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/22289984


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/0604", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Genetics", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/06", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Biological Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Acetylation", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Binding Sites", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cells, Cultured", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Chromatin", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Chromatin Immunoprecipitation", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Core Binding Factor Alpha 2 Subunit", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Epigenesis, Genetic", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Genomics", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Hematopoietic Stem Cells", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Histone Deacetylase 1", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Histones", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Leukemia, Myeloid, Acute", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Oncogene Proteins, Fusion", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Promoter Regions, Genetic", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "RNA, Messenger", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "RUNX1 Translocation Partner 1 Protein", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Real-Time Polymerase Chain Reaction", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Sp1 Transcription Factor", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Umbilical Cord", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Spanish National Cancer Research Centre", 
          "id": "https://www.grid.ac/institutes/grid.7719.8", 
          "name": [
            "Molecular Cytogenetics Group, Human Cancer Genetics programme, Centro Nacional Investigaciones Oncologicas (CNIO), Centro de Investigaciones de Enfermedades Raras (CIBERER), Madrid, Spain"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Maiques-Diaz", 
        "givenName": "A", 
        "id": "sg:person.01132576551.47", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01132576551.47"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Cincinnati Children's Hospital Medical Center", 
          "id": "https://www.grid.ac/institutes/grid.239573.9", 
          "name": [
            "Division of Experimental Hematology and Cancer Biology, Cancer and Blood Diseases Institute, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Chou", 
        "givenName": "F S", 
        "id": "sg:person.01003020014.83", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01003020014.83"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Cincinnati Children's Hospital Medical Center", 
          "id": "https://www.grid.ac/institutes/grid.239573.9", 
          "name": [
            "Division of Experimental Hematology and Cancer Biology, Cancer and Blood Diseases Institute, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Wunderlich", 
        "givenName": "M", 
        "id": "sg:person.01104334755.37", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01104334755.37"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Spanish National Cancer Research Centre", 
          "id": "https://www.grid.ac/institutes/grid.7719.8", 
          "name": [
            "Bioinformatics Unit, Structural Biology and Biocomputing Programme, Centro Nacional Investigaciones Onc\u00f3logicas (CNIO), Madrid, Spain"
          ], 
          "type": "Organization"
        }, 
        "familyName": "G\u00f3mez-L\u00f3pez", 
        "givenName": "G", 
        "id": "sg:person.0700636421.39", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0700636421.39"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Institut d'Investigaci\u00f3 Biom\u00e9dica de Bellvitge", 
          "id": "https://www.grid.ac/institutes/grid.418284.3", 
          "name": [
            "Chromatin and Disease Group, Cancer Epigenetics and Biology Program (PEBC), Bellvitge Biomedical Research Institute (IDIBELL), Barcelona, Spain"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Jacinto", 
        "givenName": "F V", 
        "id": "sg:person.01236366404.17", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01236366404.17"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Spanish National Cancer Research Centre", 
          "id": "https://www.grid.ac/institutes/grid.7719.8", 
          "name": [
            "Molecular Cytogenetics Group, Human Cancer Genetics programme, Centro Nacional Investigaciones Oncologicas (CNIO), Centro de Investigaciones de Enfermedades Raras (CIBERER), Madrid, Spain"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Rodriguez-Perales", 
        "givenName": "S", 
        "id": "sg:person.01363253551.54", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01363253551.54"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Navarra", 
          "id": "https://www.grid.ac/institutes/grid.5924.a", 
          "name": [
            "Department of Genetics, University of Navarra, Pamplona, Spain"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Larrayoz", 
        "givenName": "M J", 
        "id": "sg:person.01370676206.20", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01370676206.20"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Navarra", 
          "id": "https://www.grid.ac/institutes/grid.5924.a", 
          "name": [
            "Department of Genetics, University of Navarra, Pamplona, Spain"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Calasanz", 
        "givenName": "M J", 
        "id": "sg:person.011262623704.18", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011262623704.18"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Cincinnati Children's Hospital Medical Center", 
          "id": "https://www.grid.ac/institutes/grid.239573.9", 
          "name": [
            "Division of Experimental Hematology and Cancer Biology, Cancer and Blood Diseases Institute, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Mulloy", 
        "givenName": "J C", 
        "id": "sg:person.01361236221.22", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01361236221.22"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Spanish National Cancer Research Centre", 
          "id": "https://www.grid.ac/institutes/grid.7719.8", 
          "name": [
            "Molecular Cytogenetics Group, Human Cancer Genetics programme, Centro Nacional Investigaciones Oncologicas (CNIO), Centro de Investigaciones de Enfermedades Raras (CIBERER), Madrid, Spain"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Cigudosa", 
        "givenName": "J C", 
        "id": "sg:person.01246512175.01", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01246512175.01"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Spanish National Cancer Research Centre", 
          "id": "https://www.grid.ac/institutes/grid.7719.8", 
          "name": [
            "Molecular Cytogenetics Group, Human Cancer Genetics programme, Centro Nacional Investigaciones Oncologicas (CNIO), Centro de Investigaciones de Enfermedades Raras (CIBERER), Madrid, Spain"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Alvarez", 
        "givenName": "S", 
        "id": "sg:person.01310764275.35", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01310764275.35"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "sg:pub.10.1038/nm726", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1000759129", 
          "https://doi.org/10.1038/nm726"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nm726", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1000759129", 
          "https://doi.org/10.1038/nm726"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/nar/gkl197", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1002452850"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.cell.2011.01.004", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1004516462"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1128/mcb.18.12.7176", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1005099118"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/gb-2007-8-2-r19", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1007077528", 
          "https://doi.org/10.1186/gb-2007-8-2-r19"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1182/blood-2007-08-110171", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1007230674"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1182/blood-2003-05-1762", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1008703469"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/science.1097937", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1009215838"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.leu.2402465", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1010409391", 
          "https://doi.org/10.1038/sj.leu.2402465"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.leu.2402465", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1010409391", 
          "https://doi.org/10.1038/sj.leu.2402465"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.febslet.2008.05.030", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1010560876"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s1535-6108(02)00016-8", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1010808082"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1128/mcb.18.12.7185", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1013882269"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.stem.2010.07.016", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1015642068"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/35065138", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1018164085", 
          "https://doi.org/10.1038/35065138"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/35065138", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1018164085", 
          "https://doi.org/10.1038/35065138"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.onc.1209591", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1018320620", 
          "https://doi.org/10.1038/sj.onc.1209591"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.onc.1209591", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1018320620", 
          "https://doi.org/10.1038/sj.onc.1209591"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1182/blood-2002-04-1199", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1018359754"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1182/blood-2002-06-1732", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1018996230"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1365-2141.2009.07749.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1019438267"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1365-2141.2009.07749.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1019438267"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.171321298", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1019547621"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1128/mcb.19.5.3635", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1019944151"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.stem.2008.01.013", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1022453068"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.cell.2007.02.005", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1022937373"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1182/blood.v99.1.15", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1023618723"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1074/jbc.m501481200", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1024003481"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/onc.2009.361", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1024540877", 
          "https://doi.org/10.1038/onc.2009.361"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1128/mcb.21.19.6470-6483.2001", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1024889954"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1128/mcb.26.4.1288-1296.2006", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1025120345"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.95.18.10860", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030002472"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1182/blood-2004-08-3115", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030178817"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1182/blood-2007-06-093682", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1031806044"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/emboj/cdg250", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1033929645"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.0506580102", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037705714"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.0506580102", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037705714"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.onc.1207122", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1042148221", 
          "https://doi.org/10.1038/sj.onc.1207122"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.onc.1207122", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1042148221", 
          "https://doi.org/10.1038/sj.onc.1207122"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1371/journal.pone.0001882", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1043233231"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1189/jlb.0209097", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1044070500"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1128/mcb.13.10.6336", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1044803065"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1074/jbc.c000485200", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1045371511"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1371/journal.pone.0012197", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1045831896"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.ccr.2010.03.008", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1046516907"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.ccr.2009.12.042", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1048235996"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.onc.1207727", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1048733255", 
          "https://doi.org/10.1038/sj.onc.1207727"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.onc.1207727", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1048733255", 
          "https://doi.org/10.1038/sj.onc.1207727"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/emboj/cdg604", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1049428883"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1371/journal.pgen.1000275", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1051769928"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/science.1201662", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1062464428"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2012-06", 
    "datePublishedReg": "2012-06-01", 
    "description": "The AML1-ETO fusion protein, which is present in 10-15% of cases of acute myeloid leukemia, is known to repress myeloid differentiation genes through DNA binding and recruitment of chromatin-modifying proteins and transcription factors in target genes. ChIP-chip analysis of human hematopoietic stem/progenitor cells transduced with the AML1-ETO fusion gene enabled us to identify 1168 AML1-ETO target genes, 103 of which were co-occupied by histone deacetylase 1 (HDAC1) and had lost the hyperacetylation mark at histone H4, and 264 showed a K9 trimethylation at histone H3. Enrichment of genes involved in hematopoietic differentiation and in specific signaling pathways was observed in the presence of these epigenetic modifications associated with an 'inactive' chromatin status. Furthermore, AML1-ETO target genes had a significant correlation between the chromatin marks studied and transcriptional silencing. Interestingly, AML1 binding sites were absent on a large number of selected AML1-ETO promoters and an Sp1 binding site was found in over 50% of them. Reversible silencing induced by the fusion protein in the presence of AML1 and/or Sp1 transcription factor binding site was confirmed. Therefore, this study provides a global analysis of AML1-ETO functional chromatin modifications and identifies the important role of Sp1 in the DNA binding pattern of AML1-ETO, suggesting a role for Sp1-targeted therapy in this leukemia subtype.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1038/leu.2011.376", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": true, 
    "isFundedItemOf": [
      {
        "id": "sg:grant.2478468", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.2439063", 
        "type": "MonetaryGrant"
      }
    ], 
    "isPartOf": [
      {
        "id": "sg:journal.1097065", 
        "issn": [
          "0887-6924", 
          "1476-5551"
        ], 
        "name": "Leukemia", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "6", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "26"
      }
    ], 
    "name": "Chromatin modifications induced by the AML1-ETO fusion protein reversibly silence its genomic targets through AML1 and Sp1 binding motifs", 
    "pagination": "1329", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "66ee61796a11e94b8f3b415a999172f1ac13d536a6652fd28d5dfef7b70d295a"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "22289984"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "8704895"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1038/leu.2011.376"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1021603723"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1038/leu.2011.376", 
      "https://app.dimensions.ai/details/publication/pub.1021603723"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-10T21:25", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8687_00000435.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://www.nature.com/articles/leu2011376"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/leu.2011.376'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/leu.2011.376'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/leu.2011.376'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/leu.2011.376'


 

This table displays all metadata directly associated to this object as RDF triples.

373 TRIPLES      21 PREDICATES      93 URIs      41 LITERALS      29 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1038/leu.2011.376 schema:about N02b56174306d4fb4b19206f3f2aac4d7
2 N02f0665890a94f4e8fd8035a64af163c
3 N0ce21538e6684701b3f2ea0cc8e31ab3
4 N0d612bef01724a7b9e29c7e7b8ead5f3
5 N1779cfe03ea44a01a547428f89d3a6d9
6 N1adea6eb581e4c97841cb8847aa282f7
7 N2e1d8dd8a2724dcfa8f9bd445feac4c9
8 N3843c8efa3f146fcbf229b44e45904ad
9 N3b96ab39ea154bd8926c81150009b03c
10 N4328e95e88e54b9dad753700549b2e29
11 N6e9eff76cb5d4bd9959002e3bfbf3427
12 N71902619ef9148d785204c5f2bac0579
13 N774a2e4007e946358815dce2dbfe45dd
14 N9327298704be49f9b3b1cfe0a2d94c5f
15 Nb5fbc00e2966435ab65254b3cea2b748
16 Ncfbca12f9c4b4888a0b32c45c3ffe4e1
17 Ndde71a3e836840d5acbc5ca2eae32eac
18 Ndf2f0f556b7444e79212635ca604306c
19 Nfa04ac6d38f74d14b71c32aab8215386
20 Nfec9797dea1e431895abeab6eb83e0dd
21 anzsrc-for:06
22 anzsrc-for:0604
23 schema:author N8406ed73186f4a81b48b95bdb13eb686
24 schema:citation sg:pub.10.1038/35065138
25 sg:pub.10.1038/nm726
26 sg:pub.10.1038/onc.2009.361
27 sg:pub.10.1038/sj.leu.2402465
28 sg:pub.10.1038/sj.onc.1207122
29 sg:pub.10.1038/sj.onc.1207727
30 sg:pub.10.1038/sj.onc.1209591
31 sg:pub.10.1186/gb-2007-8-2-r19
32 https://doi.org/10.1016/j.ccr.2009.12.042
33 https://doi.org/10.1016/j.ccr.2010.03.008
34 https://doi.org/10.1016/j.cell.2007.02.005
35 https://doi.org/10.1016/j.cell.2011.01.004
36 https://doi.org/10.1016/j.febslet.2008.05.030
37 https://doi.org/10.1016/j.stem.2008.01.013
38 https://doi.org/10.1016/j.stem.2010.07.016
39 https://doi.org/10.1016/s1535-6108(02)00016-8
40 https://doi.org/10.1073/pnas.0506580102
41 https://doi.org/10.1073/pnas.171321298
42 https://doi.org/10.1073/pnas.95.18.10860
43 https://doi.org/10.1074/jbc.c000485200
44 https://doi.org/10.1074/jbc.m501481200
45 https://doi.org/10.1093/emboj/cdg250
46 https://doi.org/10.1093/emboj/cdg604
47 https://doi.org/10.1093/nar/gkl197
48 https://doi.org/10.1111/j.1365-2141.2009.07749.x
49 https://doi.org/10.1126/science.1097937
50 https://doi.org/10.1126/science.1201662
51 https://doi.org/10.1128/mcb.13.10.6336
52 https://doi.org/10.1128/mcb.18.12.7176
53 https://doi.org/10.1128/mcb.18.12.7185
54 https://doi.org/10.1128/mcb.19.5.3635
55 https://doi.org/10.1128/mcb.21.19.6470-6483.2001
56 https://doi.org/10.1128/mcb.26.4.1288-1296.2006
57 https://doi.org/10.1182/blood-2002-04-1199
58 https://doi.org/10.1182/blood-2002-06-1732
59 https://doi.org/10.1182/blood-2003-05-1762
60 https://doi.org/10.1182/blood-2004-08-3115
61 https://doi.org/10.1182/blood-2007-06-093682
62 https://doi.org/10.1182/blood-2007-08-110171
63 https://doi.org/10.1182/blood.v99.1.15
64 https://doi.org/10.1189/jlb.0209097
65 https://doi.org/10.1371/journal.pgen.1000275
66 https://doi.org/10.1371/journal.pone.0001882
67 https://doi.org/10.1371/journal.pone.0012197
68 schema:datePublished 2012-06
69 schema:datePublishedReg 2012-06-01
70 schema:description The AML1-ETO fusion protein, which is present in 10-15% of cases of acute myeloid leukemia, is known to repress myeloid differentiation genes through DNA binding and recruitment of chromatin-modifying proteins and transcription factors in target genes. ChIP-chip analysis of human hematopoietic stem/progenitor cells transduced with the AML1-ETO fusion gene enabled us to identify 1168 AML1-ETO target genes, 103 of which were co-occupied by histone deacetylase 1 (HDAC1) and had lost the hyperacetylation mark at histone H4, and 264 showed a K9 trimethylation at histone H3. Enrichment of genes involved in hematopoietic differentiation and in specific signaling pathways was observed in the presence of these epigenetic modifications associated with an 'inactive' chromatin status. Furthermore, AML1-ETO target genes had a significant correlation between the chromatin marks studied and transcriptional silencing. Interestingly, AML1 binding sites were absent on a large number of selected AML1-ETO promoters and an Sp1 binding site was found in over 50% of them. Reversible silencing induced by the fusion protein in the presence of AML1 and/or Sp1 transcription factor binding site was confirmed. Therefore, this study provides a global analysis of AML1-ETO functional chromatin modifications and identifies the important role of Sp1 in the DNA binding pattern of AML1-ETO, suggesting a role for Sp1-targeted therapy in this leukemia subtype.
71 schema:genre research_article
72 schema:inLanguage en
73 schema:isAccessibleForFree true
74 schema:isPartOf N49102d3696794b42b74cc344a69eebf0
75 Ndf17e3fbf55a4670b404192e2404b868
76 sg:journal.1097065
77 schema:name Chromatin modifications induced by the AML1-ETO fusion protein reversibly silence its genomic targets through AML1 and Sp1 binding motifs
78 schema:pagination 1329
79 schema:productId N034b6f55a4e64203a14f8d4986057240
80 N1f008abf68b24c6db8238fd4fa6a046b
81 N223a53dc7b2f4f4d9b9ab11be6fa6a37
82 Na92ade8a322a4f7fb576e83c4bf28c4d
83 Ncebfda8f1eb04b7687fc8a267168c4ed
84 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021603723
85 https://doi.org/10.1038/leu.2011.376
86 schema:sdDatePublished 2019-04-10T21:25
87 schema:sdLicense https://scigraph.springernature.com/explorer/license/
88 schema:sdPublisher Ncd120fc8959142b788c1b46a26fa0829
89 schema:url https://www.nature.com/articles/leu2011376
90 sgo:license sg:explorer/license/
91 sgo:sdDataset articles
92 rdf:type schema:ScholarlyArticle
93 N02b56174306d4fb4b19206f3f2aac4d7 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
94 schema:name Leukemia, Myeloid, Acute
95 rdf:type schema:DefinedTerm
96 N02f0665890a94f4e8fd8035a64af163c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
97 schema:name Sp1 Transcription Factor
98 rdf:type schema:DefinedTerm
99 N034b6f55a4e64203a14f8d4986057240 schema:name doi
100 schema:value 10.1038/leu.2011.376
101 rdf:type schema:PropertyValue
102 N0ce21538e6684701b3f2ea0cc8e31ab3 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
103 schema:name Core Binding Factor Alpha 2 Subunit
104 rdf:type schema:DefinedTerm
105 N0d612bef01724a7b9e29c7e7b8ead5f3 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
106 schema:name RUNX1 Translocation Partner 1 Protein
107 rdf:type schema:DefinedTerm
108 N146fa2ac559f4a31b89b18ba13c7031e rdf:first sg:person.01246512175.01
109 rdf:rest N7f712a4e9d70401d941dc280ffa1f3af
110 N1779cfe03ea44a01a547428f89d3a6d9 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
111 schema:name Histone Deacetylase 1
112 rdf:type schema:DefinedTerm
113 N1adea6eb581e4c97841cb8847aa282f7 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
114 schema:name Chromatin
115 rdf:type schema:DefinedTerm
116 N1f008abf68b24c6db8238fd4fa6a046b schema:name readcube_id
117 schema:value 66ee61796a11e94b8f3b415a999172f1ac13d536a6652fd28d5dfef7b70d295a
118 rdf:type schema:PropertyValue
119 N223a53dc7b2f4f4d9b9ab11be6fa6a37 schema:name nlm_unique_id
120 schema:value 8704895
121 rdf:type schema:PropertyValue
122 N2b255423f4924ccaa495b29c3e74711e rdf:first sg:person.01361236221.22
123 rdf:rest N146fa2ac559f4a31b89b18ba13c7031e
124 N2e1d8dd8a2724dcfa8f9bd445feac4c9 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
125 schema:name Hematopoietic Stem Cells
126 rdf:type schema:DefinedTerm
127 N3843c8efa3f146fcbf229b44e45904ad schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
128 schema:name Acetylation
129 rdf:type schema:DefinedTerm
130 N3b96ab39ea154bd8926c81150009b03c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
131 schema:name Histones
132 rdf:type schema:DefinedTerm
133 N4328e95e88e54b9dad753700549b2e29 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
134 schema:name Binding Sites
135 rdf:type schema:DefinedTerm
136 N49102d3696794b42b74cc344a69eebf0 schema:volumeNumber 26
137 rdf:type schema:PublicationVolume
138 N5161d849676b4f3189ab594b3e7313c4 rdf:first sg:person.01363253551.54
139 rdf:rest N9486e9afd797413b8fdf650a7b012fb6
140 N6ab0ad61c84c487a8eadb54d934bb580 rdf:first sg:person.011262623704.18
141 rdf:rest N2b255423f4924ccaa495b29c3e74711e
142 N6e9eff76cb5d4bd9959002e3bfbf3427 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
143 schema:name Real-Time Polymerase Chain Reaction
144 rdf:type schema:DefinedTerm
145 N71902619ef9148d785204c5f2bac0579 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
146 schema:name Umbilical Cord
147 rdf:type schema:DefinedTerm
148 N774a2e4007e946358815dce2dbfe45dd schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
149 schema:name Promoter Regions, Genetic
150 rdf:type schema:DefinedTerm
151 N7f712a4e9d70401d941dc280ffa1f3af rdf:first sg:person.01310764275.35
152 rdf:rest rdf:nil
153 N7fe6af5d8e5b4499953271dc329bdb61 rdf:first sg:person.01003020014.83
154 rdf:rest N943a9a4cec7949ac82f6815ca15c4c1e
155 N8406ed73186f4a81b48b95bdb13eb686 rdf:first sg:person.01132576551.47
156 rdf:rest N7fe6af5d8e5b4499953271dc329bdb61
157 N88203d555da6488fa70f4d25c682f0dc rdf:first sg:person.0700636421.39
158 rdf:rest Nb88371cc28f34b3084d02b3162e1f3b6
159 N9327298704be49f9b3b1cfe0a2d94c5f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
160 schema:name Oncogene Proteins, Fusion
161 rdf:type schema:DefinedTerm
162 N943a9a4cec7949ac82f6815ca15c4c1e rdf:first sg:person.01104334755.37
163 rdf:rest N88203d555da6488fa70f4d25c682f0dc
164 N9486e9afd797413b8fdf650a7b012fb6 rdf:first sg:person.01370676206.20
165 rdf:rest N6ab0ad61c84c487a8eadb54d934bb580
166 Na92ade8a322a4f7fb576e83c4bf28c4d schema:name pubmed_id
167 schema:value 22289984
168 rdf:type schema:PropertyValue
169 Nb5fbc00e2966435ab65254b3cea2b748 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
170 schema:name RNA, Messenger
171 rdf:type schema:DefinedTerm
172 Nb88371cc28f34b3084d02b3162e1f3b6 rdf:first sg:person.01236366404.17
173 rdf:rest N5161d849676b4f3189ab594b3e7313c4
174 Ncd120fc8959142b788c1b46a26fa0829 schema:name Springer Nature - SN SciGraph project
175 rdf:type schema:Organization
176 Ncebfda8f1eb04b7687fc8a267168c4ed schema:name dimensions_id
177 schema:value pub.1021603723
178 rdf:type schema:PropertyValue
179 Ncfbca12f9c4b4888a0b32c45c3ffe4e1 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
180 schema:name Cells, Cultured
181 rdf:type schema:DefinedTerm
182 Ndde71a3e836840d5acbc5ca2eae32eac schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
183 schema:name Humans
184 rdf:type schema:DefinedTerm
185 Ndf17e3fbf55a4670b404192e2404b868 schema:issueNumber 6
186 rdf:type schema:PublicationIssue
187 Ndf2f0f556b7444e79212635ca604306c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
188 schema:name Genomics
189 rdf:type schema:DefinedTerm
190 Nfa04ac6d38f74d14b71c32aab8215386 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
191 schema:name Epigenesis, Genetic
192 rdf:type schema:DefinedTerm
193 Nfec9797dea1e431895abeab6eb83e0dd schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
194 schema:name Chromatin Immunoprecipitation
195 rdf:type schema:DefinedTerm
196 anzsrc-for:06 schema:inDefinedTermSet anzsrc-for:
197 schema:name Biological Sciences
198 rdf:type schema:DefinedTerm
199 anzsrc-for:0604 schema:inDefinedTermSet anzsrc-for:
200 schema:name Genetics
201 rdf:type schema:DefinedTerm
202 sg:grant.2439063 http://pending.schema.org/fundedItem sg:pub.10.1038/leu.2011.376
203 rdf:type schema:MonetaryGrant
204 sg:grant.2478468 http://pending.schema.org/fundedItem sg:pub.10.1038/leu.2011.376
205 rdf:type schema:MonetaryGrant
206 sg:journal.1097065 schema:issn 0887-6924
207 1476-5551
208 schema:name Leukemia
209 rdf:type schema:Periodical
210 sg:person.01003020014.83 schema:affiliation https://www.grid.ac/institutes/grid.239573.9
211 schema:familyName Chou
212 schema:givenName F S
213 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01003020014.83
214 rdf:type schema:Person
215 sg:person.01104334755.37 schema:affiliation https://www.grid.ac/institutes/grid.239573.9
216 schema:familyName Wunderlich
217 schema:givenName M
218 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01104334755.37
219 rdf:type schema:Person
220 sg:person.011262623704.18 schema:affiliation https://www.grid.ac/institutes/grid.5924.a
221 schema:familyName Calasanz
222 schema:givenName M J
223 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011262623704.18
224 rdf:type schema:Person
225 sg:person.01132576551.47 schema:affiliation https://www.grid.ac/institutes/grid.7719.8
226 schema:familyName Maiques-Diaz
227 schema:givenName A
228 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01132576551.47
229 rdf:type schema:Person
230 sg:person.01236366404.17 schema:affiliation https://www.grid.ac/institutes/grid.418284.3
231 schema:familyName Jacinto
232 schema:givenName F V
233 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01236366404.17
234 rdf:type schema:Person
235 sg:person.01246512175.01 schema:affiliation https://www.grid.ac/institutes/grid.7719.8
236 schema:familyName Cigudosa
237 schema:givenName J C
238 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01246512175.01
239 rdf:type schema:Person
240 sg:person.01310764275.35 schema:affiliation https://www.grid.ac/institutes/grid.7719.8
241 schema:familyName Alvarez
242 schema:givenName S
243 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01310764275.35
244 rdf:type schema:Person
245 sg:person.01361236221.22 schema:affiliation https://www.grid.ac/institutes/grid.239573.9
246 schema:familyName Mulloy
247 schema:givenName J C
248 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01361236221.22
249 rdf:type schema:Person
250 sg:person.01363253551.54 schema:affiliation https://www.grid.ac/institutes/grid.7719.8
251 schema:familyName Rodriguez-Perales
252 schema:givenName S
253 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01363253551.54
254 rdf:type schema:Person
255 sg:person.01370676206.20 schema:affiliation https://www.grid.ac/institutes/grid.5924.a
256 schema:familyName Larrayoz
257 schema:givenName M J
258 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01370676206.20
259 rdf:type schema:Person
260 sg:person.0700636421.39 schema:affiliation https://www.grid.ac/institutes/grid.7719.8
261 schema:familyName Gómez-López
262 schema:givenName G
263 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0700636421.39
264 rdf:type schema:Person
265 sg:pub.10.1038/35065138 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018164085
266 https://doi.org/10.1038/35065138
267 rdf:type schema:CreativeWork
268 sg:pub.10.1038/nm726 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000759129
269 https://doi.org/10.1038/nm726
270 rdf:type schema:CreativeWork
271 sg:pub.10.1038/onc.2009.361 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024540877
272 https://doi.org/10.1038/onc.2009.361
273 rdf:type schema:CreativeWork
274 sg:pub.10.1038/sj.leu.2402465 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010409391
275 https://doi.org/10.1038/sj.leu.2402465
276 rdf:type schema:CreativeWork
277 sg:pub.10.1038/sj.onc.1207122 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042148221
278 https://doi.org/10.1038/sj.onc.1207122
279 rdf:type schema:CreativeWork
280 sg:pub.10.1038/sj.onc.1207727 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048733255
281 https://doi.org/10.1038/sj.onc.1207727
282 rdf:type schema:CreativeWork
283 sg:pub.10.1038/sj.onc.1209591 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018320620
284 https://doi.org/10.1038/sj.onc.1209591
285 rdf:type schema:CreativeWork
286 sg:pub.10.1186/gb-2007-8-2-r19 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007077528
287 https://doi.org/10.1186/gb-2007-8-2-r19
288 rdf:type schema:CreativeWork
289 https://doi.org/10.1016/j.ccr.2009.12.042 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048235996
290 rdf:type schema:CreativeWork
291 https://doi.org/10.1016/j.ccr.2010.03.008 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046516907
292 rdf:type schema:CreativeWork
293 https://doi.org/10.1016/j.cell.2007.02.005 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022937373
294 rdf:type schema:CreativeWork
295 https://doi.org/10.1016/j.cell.2011.01.004 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004516462
296 rdf:type schema:CreativeWork
297 https://doi.org/10.1016/j.febslet.2008.05.030 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010560876
298 rdf:type schema:CreativeWork
299 https://doi.org/10.1016/j.stem.2008.01.013 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022453068
300 rdf:type schema:CreativeWork
301 https://doi.org/10.1016/j.stem.2010.07.016 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015642068
302 rdf:type schema:CreativeWork
303 https://doi.org/10.1016/s1535-6108(02)00016-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010808082
304 rdf:type schema:CreativeWork
305 https://doi.org/10.1073/pnas.0506580102 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037705714
306 rdf:type schema:CreativeWork
307 https://doi.org/10.1073/pnas.171321298 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019547621
308 rdf:type schema:CreativeWork
309 https://doi.org/10.1073/pnas.95.18.10860 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030002472
310 rdf:type schema:CreativeWork
311 https://doi.org/10.1074/jbc.c000485200 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045371511
312 rdf:type schema:CreativeWork
313 https://doi.org/10.1074/jbc.m501481200 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024003481
314 rdf:type schema:CreativeWork
315 https://doi.org/10.1093/emboj/cdg250 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033929645
316 rdf:type schema:CreativeWork
317 https://doi.org/10.1093/emboj/cdg604 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049428883
318 rdf:type schema:CreativeWork
319 https://doi.org/10.1093/nar/gkl197 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002452850
320 rdf:type schema:CreativeWork
321 https://doi.org/10.1111/j.1365-2141.2009.07749.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1019438267
322 rdf:type schema:CreativeWork
323 https://doi.org/10.1126/science.1097937 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009215838
324 rdf:type schema:CreativeWork
325 https://doi.org/10.1126/science.1201662 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062464428
326 rdf:type schema:CreativeWork
327 https://doi.org/10.1128/mcb.13.10.6336 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044803065
328 rdf:type schema:CreativeWork
329 https://doi.org/10.1128/mcb.18.12.7176 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005099118
330 rdf:type schema:CreativeWork
331 https://doi.org/10.1128/mcb.18.12.7185 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013882269
332 rdf:type schema:CreativeWork
333 https://doi.org/10.1128/mcb.19.5.3635 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019944151
334 rdf:type schema:CreativeWork
335 https://doi.org/10.1128/mcb.21.19.6470-6483.2001 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024889954
336 rdf:type schema:CreativeWork
337 https://doi.org/10.1128/mcb.26.4.1288-1296.2006 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025120345
338 rdf:type schema:CreativeWork
339 https://doi.org/10.1182/blood-2002-04-1199 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018359754
340 rdf:type schema:CreativeWork
341 https://doi.org/10.1182/blood-2002-06-1732 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018996230
342 rdf:type schema:CreativeWork
343 https://doi.org/10.1182/blood-2003-05-1762 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008703469
344 rdf:type schema:CreativeWork
345 https://doi.org/10.1182/blood-2004-08-3115 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030178817
346 rdf:type schema:CreativeWork
347 https://doi.org/10.1182/blood-2007-06-093682 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031806044
348 rdf:type schema:CreativeWork
349 https://doi.org/10.1182/blood-2007-08-110171 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007230674
350 rdf:type schema:CreativeWork
351 https://doi.org/10.1182/blood.v99.1.15 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023618723
352 rdf:type schema:CreativeWork
353 https://doi.org/10.1189/jlb.0209097 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044070500
354 rdf:type schema:CreativeWork
355 https://doi.org/10.1371/journal.pgen.1000275 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051769928
356 rdf:type schema:CreativeWork
357 https://doi.org/10.1371/journal.pone.0001882 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043233231
358 rdf:type schema:CreativeWork
359 https://doi.org/10.1371/journal.pone.0012197 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045831896
360 rdf:type schema:CreativeWork
361 https://www.grid.ac/institutes/grid.239573.9 schema:alternateName Cincinnati Children's Hospital Medical Center
362 schema:name Division of Experimental Hematology and Cancer Biology, Cancer and Blood Diseases Institute, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA
363 rdf:type schema:Organization
364 https://www.grid.ac/institutes/grid.418284.3 schema:alternateName Institut d'Investigació Biomédica de Bellvitge
365 schema:name Chromatin and Disease Group, Cancer Epigenetics and Biology Program (PEBC), Bellvitge Biomedical Research Institute (IDIBELL), Barcelona, Spain
366 rdf:type schema:Organization
367 https://www.grid.ac/institutes/grid.5924.a schema:alternateName University of Navarra
368 schema:name Department of Genetics, University of Navarra, Pamplona, Spain
369 rdf:type schema:Organization
370 https://www.grid.ac/institutes/grid.7719.8 schema:alternateName Spanish National Cancer Research Centre
371 schema:name Bioinformatics Unit, Structural Biology and Biocomputing Programme, Centro Nacional Investigaciones Oncólogicas (CNIO), Madrid, Spain
372 Molecular Cytogenetics Group, Human Cancer Genetics programme, Centro Nacional Investigaciones Oncologicas (CNIO), Centro de Investigaciones de Enfermedades Raras (CIBERER), Madrid, Spain
373 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...