Mesenchymal stromal cell ‘licensing’: a multistep process View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2011-05-27

AUTHORS

M Krampera

ABSTRACT

Many in vitro and in vivo data are available supporting the role of mesenchymal stromal cell (MSC) licensing in the induction of a measurable and effective immune regulation. The failure of some MSC-based protocols for immune modulation in animal models and in human clinical trials may be explained by either lack of a proper licensing by inflammatory microenviroment or wrong timing in MSC administration. Thus, optimization of MSC use for immune-regulating purposes is required to maximize their beneficial effects. More... »

PAGES

1408-1414

References to SciGraph publications

  • 2008-08-04. IFNγ and B7-H1 in the immunology of mesenchymal stem cells in CELL RESEARCH
  • 2011-01-18. Human but not murine multipotent mesenchymal stromal cells exhibit broad-spectrum antimicrobial effector function mediated by indoleamine 2,3-dioxygenase in LEUKEMIA
  • 2007-10-04. Mesenchymal stem cells within tumour stroma promote breast cancer metastasis in NATURE
  • 2010-08-04. Inflammatory Cytokine Induced Regulation of Superoxide Dismutase 3 Expression by Human Mesenchymal Stem Cells in STEM CELL REVIEWS AND REPORTS
  • 2007-07-12. Mesenchymal stem cells of cord blood origin are effective at preventing but not treating graft-versus-host disease in LEUKEMIA
  • 2008-07-08. A critical role of IFNγ in priming MSC-mediated suppression of T cell proliferation through up-regulation of B7-H1 in CELL RESEARCH
  • 2010-10-14. Macrophages may promote cancer growth via a GM-CSF/HB-EGF paracrine loop that is enhanced by CXCL12 in MOLECULAR CANCER
  • 2008-07-01. Cancer-related inflammation in NATURE
  • 2007-11-12. Mesenchymal stem cells share molecular signature with mesenchymal tumor cells and favor early tumor growth in syngeneic mice in ONCOGENE
  • 2008-07-29. VEGF expression by mesenchymal stem cells contributes to angiogenesis in pancreatic carcinoma in BRITISH JOURNAL OF CANCER
  • 2005-01. T cell responses to allogeneic human mesenchymal stem cells: immunogenicity, tolerance, and suppression in JOURNAL OF BIOMEDICAL SCIENCE
  • 2007-05-03. Therapeutic targeting of innate immunity with Toll-like receptor agonists and antagonists in NATURE MEDICINE
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/leu.2011.108

    DOI

    http://dx.doi.org/10.1038/leu.2011.108

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1028464217

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/21617697


    Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
    Incoming Citations Browse incoming citations for this publication using opencitations.net

    JSON-LD is the canonical representation for SciGraph data.

    TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

    [
      {
        "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
        "about": [
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Medical and Health Sciences", 
            "type": "DefinedTerm"
          }, 
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1107", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Immunology", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Animals", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Humans", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Inflammation", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Mesenchymal Stem Cells", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Stromal Cells", 
            "type": "DefinedTerm"
          }
        ], 
        "author": [
          {
            "affiliation": {
              "alternateName": "Department of Medicine, Stem Cell Research Laboratory, Section of Hematology, University of Verona, Verona, Italy", 
              "id": "http://www.grid.ac/institutes/grid.5611.3", 
              "name": [
                "Department of Medicine, Stem Cell Research Laboratory, Section of Hematology, University of Verona, Verona, Italy"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Krampera", 
            "givenName": "M", 
            "id": "sg:person.0640531741.61", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0640531741.61"
            ], 
            "type": "Person"
          }
        ], 
        "citation": [
          {
            "id": "sg:pub.10.1038/sj.onc.1210920", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1013590098", 
              "https://doi.org/10.1038/sj.onc.1210920"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/cr.2008.80", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1001799023", 
              "https://doi.org/10.1038/cr.2008.80"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/leu.2010.310", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1027386114", 
              "https://doi.org/10.1038/leu.2010.310"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s12015-010-9178-6", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1048205384", 
              "https://doi.org/10.1007/s12015-010-9178-6"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature06188", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1046203017", 
              "https://doi.org/10.1038/nature06188"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s11373-004-8183-7", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1016243936", 
              "https://doi.org/10.1007/s11373-004-8183-7"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature07205", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1024729982", 
              "https://doi.org/10.1038/nature07205"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/sj.bjc.6604508", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1034223170", 
              "https://doi.org/10.1038/sj.bjc.6604508"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/sj.leu.2404847", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1001692977", 
              "https://doi.org/10.1038/sj.leu.2404847"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nm1589", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1047465928", 
              "https://doi.org/10.1038/nm1589"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/cr.2008.90", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1028089467", 
              "https://doi.org/10.1038/cr.2008.90"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/1476-4598-9-273", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1034314366", 
              "https://doi.org/10.1186/1476-4598-9-273"
            ], 
            "type": "CreativeWork"
          }
        ], 
        "datePublished": "2011-05-27", 
        "datePublishedReg": "2011-05-27", 
        "description": "Many in vitro and in vivo data are available supporting the role of mesenchymal stromal cell (MSC) licensing in the induction of a measurable and effective immune regulation. The failure of some MSC-based protocols for immune modulation in animal models and in human clinical trials may be explained by either lack of a proper licensing by inflammatory microenviroment or wrong timing in MSC administration. Thus, optimization of MSC use for immune-regulating purposes is required to maximize their beneficial effects.", 
        "genre": "article", 
        "id": "sg:pub.10.1038/leu.2011.108", 
        "isAccessibleForFree": false, 
        "isPartOf": [
          {
            "id": "sg:journal.1097065", 
            "issn": [
              "0887-6924", 
              "1476-5551"
            ], 
            "name": "Leukemia", 
            "publisher": "Springer Nature", 
            "type": "Periodical"
          }, 
          {
            "issueNumber": "9", 
            "type": "PublicationIssue"
          }, 
          {
            "type": "PublicationVolume", 
            "volumeNumber": "25"
          }
        ], 
        "keywords": [
          "mesenchymal stromal cells", 
          "stromal cells", 
          "effective immune regulation", 
          "human clinical trials", 
          "MSC administration", 
          "immune modulation", 
          "clinical trials", 
          "immune regulation", 
          "MSC use", 
          "animal models", 
          "beneficial effects", 
          "vivo data", 
          "multistep process", 
          "wrong timing", 
          "cells", 
          "administration", 
          "trials", 
          "microenviroment", 
          "induction", 
          "failure", 
          "modulation", 
          "protocol", 
          "role", 
          "regulation", 
          "lack", 
          "timing", 
          "effect", 
          "use", 
          "purpose", 
          "data", 
          "licensing", 
          "model", 
          "process", 
          "optimization"
        ], 
        "name": "Mesenchymal stromal cell \u2018licensing\u2019: a multistep process", 
        "pagination": "1408-1414", 
        "productId": [
          {
            "name": "dimensions_id", 
            "type": "PropertyValue", 
            "value": [
              "pub.1028464217"
            ]
          }, 
          {
            "name": "doi", 
            "type": "PropertyValue", 
            "value": [
              "10.1038/leu.2011.108"
            ]
          }, 
          {
            "name": "pubmed_id", 
            "type": "PropertyValue", 
            "value": [
              "21617697"
            ]
          }
        ], 
        "sameAs": [
          "https://doi.org/10.1038/leu.2011.108", 
          "https://app.dimensions.ai/details/publication/pub.1028464217"
        ], 
        "sdDataset": "articles", 
        "sdDatePublished": "2022-12-01T06:29", 
        "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
        "sdPublisher": {
          "name": "Springer Nature - SN SciGraph project", 
          "type": "Organization"
        }, 
        "sdSource": "s3://com-springernature-scigraph/baseset/20221201/entities/gbq_results/article/article_540.jsonl", 
        "type": "ScholarlyArticle", 
        "url": "https://doi.org/10.1038/leu.2011.108"
      }
    ]
     

    Download the RDF metadata as:  json-ld nt turtle xml License info

    HOW TO GET THIS DATA PROGRAMMATICALLY:

    JSON-LD is a popular format for linked data which is fully compatible with JSON.

    curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/leu.2011.108'

    N-Triples is a line-based linked data format ideal for batch operations.

    curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/leu.2011.108'

    Turtle is a human-readable linked data format.

    curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/leu.2011.108'

    RDF/XML is a standard XML format for linked data.

    curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/leu.2011.108'


     

    This table displays all metadata directly associated to this object as RDF triples.

    163 TRIPLES      21 PREDICATES      76 URIs      56 LITERALS      12 BLANK NODES

    Subject Predicate Object
    1 sg:pub.10.1038/leu.2011.108 schema:about N0ac39b767a0d431fa41cbfeb5c949841
    2 N262c8add8a3d4b58858875a01ed866b0
    3 N3932fa8b61e24feb9bc19fc02779c6a3
    4 N7d4e0894d3514709a19bbb53c8778fe4
    5 Nefec2f9cefc440b98e06aec44e03ac6d
    6 anzsrc-for:11
    7 anzsrc-for:1107
    8 schema:author N839888802835429986e0ce329291fa05
    9 schema:citation sg:pub.10.1007/s11373-004-8183-7
    10 sg:pub.10.1007/s12015-010-9178-6
    11 sg:pub.10.1038/cr.2008.80
    12 sg:pub.10.1038/cr.2008.90
    13 sg:pub.10.1038/leu.2010.310
    14 sg:pub.10.1038/nature06188
    15 sg:pub.10.1038/nature07205
    16 sg:pub.10.1038/nm1589
    17 sg:pub.10.1038/sj.bjc.6604508
    18 sg:pub.10.1038/sj.leu.2404847
    19 sg:pub.10.1038/sj.onc.1210920
    20 sg:pub.10.1186/1476-4598-9-273
    21 schema:datePublished 2011-05-27
    22 schema:datePublishedReg 2011-05-27
    23 schema:description Many in vitro and in vivo data are available supporting the role of mesenchymal stromal cell (MSC) licensing in the induction of a measurable and effective immune regulation. The failure of some MSC-based protocols for immune modulation in animal models and in human clinical trials may be explained by either lack of a proper licensing by inflammatory microenviroment or wrong timing in MSC administration. Thus, optimization of MSC use for immune-regulating purposes is required to maximize their beneficial effects.
    24 schema:genre article
    25 schema:isAccessibleForFree false
    26 schema:isPartOf N03dfb1eb1563475da4bc020c88e1954e
    27 N7f0c2670506d49c8a9e181b5e0ca8b34
    28 sg:journal.1097065
    29 schema:keywords MSC administration
    30 MSC use
    31 administration
    32 animal models
    33 beneficial effects
    34 cells
    35 clinical trials
    36 data
    37 effect
    38 effective immune regulation
    39 failure
    40 human clinical trials
    41 immune modulation
    42 immune regulation
    43 induction
    44 lack
    45 licensing
    46 mesenchymal stromal cells
    47 microenviroment
    48 model
    49 modulation
    50 multistep process
    51 optimization
    52 process
    53 protocol
    54 purpose
    55 regulation
    56 role
    57 stromal cells
    58 timing
    59 trials
    60 use
    61 vivo data
    62 wrong timing
    63 schema:name Mesenchymal stromal cell ‘licensing’: a multistep process
    64 schema:pagination 1408-1414
    65 schema:productId N1f88fb74e5324a7e8fe7a67b11e7f296
    66 N261e04f4a2ad4767ac9f761b9de5557d
    67 Naf798625ed25498582cbba43aaff785c
    68 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028464217
    69 https://doi.org/10.1038/leu.2011.108
    70 schema:sdDatePublished 2022-12-01T06:29
    71 schema:sdLicense https://scigraph.springernature.com/explorer/license/
    72 schema:sdPublisher N61077646e84e492982d14bc56a8ab3e3
    73 schema:url https://doi.org/10.1038/leu.2011.108
    74 sgo:license sg:explorer/license/
    75 sgo:sdDataset articles
    76 rdf:type schema:ScholarlyArticle
    77 N03dfb1eb1563475da4bc020c88e1954e schema:volumeNumber 25
    78 rdf:type schema:PublicationVolume
    79 N0ac39b767a0d431fa41cbfeb5c949841 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    80 schema:name Animals
    81 rdf:type schema:DefinedTerm
    82 N1f88fb74e5324a7e8fe7a67b11e7f296 schema:name dimensions_id
    83 schema:value pub.1028464217
    84 rdf:type schema:PropertyValue
    85 N261e04f4a2ad4767ac9f761b9de5557d schema:name doi
    86 schema:value 10.1038/leu.2011.108
    87 rdf:type schema:PropertyValue
    88 N262c8add8a3d4b58858875a01ed866b0 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    89 schema:name Inflammation
    90 rdf:type schema:DefinedTerm
    91 N3932fa8b61e24feb9bc19fc02779c6a3 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    92 schema:name Humans
    93 rdf:type schema:DefinedTerm
    94 N61077646e84e492982d14bc56a8ab3e3 schema:name Springer Nature - SN SciGraph project
    95 rdf:type schema:Organization
    96 N7d4e0894d3514709a19bbb53c8778fe4 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    97 schema:name Mesenchymal Stem Cells
    98 rdf:type schema:DefinedTerm
    99 N7f0c2670506d49c8a9e181b5e0ca8b34 schema:issueNumber 9
    100 rdf:type schema:PublicationIssue
    101 N839888802835429986e0ce329291fa05 rdf:first sg:person.0640531741.61
    102 rdf:rest rdf:nil
    103 Naf798625ed25498582cbba43aaff785c schema:name pubmed_id
    104 schema:value 21617697
    105 rdf:type schema:PropertyValue
    106 Nefec2f9cefc440b98e06aec44e03ac6d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    107 schema:name Stromal Cells
    108 rdf:type schema:DefinedTerm
    109 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
    110 schema:name Medical and Health Sciences
    111 rdf:type schema:DefinedTerm
    112 anzsrc-for:1107 schema:inDefinedTermSet anzsrc-for:
    113 schema:name Immunology
    114 rdf:type schema:DefinedTerm
    115 sg:journal.1097065 schema:issn 0887-6924
    116 1476-5551
    117 schema:name Leukemia
    118 schema:publisher Springer Nature
    119 rdf:type schema:Periodical
    120 sg:person.0640531741.61 schema:affiliation grid-institutes:grid.5611.3
    121 schema:familyName Krampera
    122 schema:givenName M
    123 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0640531741.61
    124 rdf:type schema:Person
    125 sg:pub.10.1007/s11373-004-8183-7 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016243936
    126 https://doi.org/10.1007/s11373-004-8183-7
    127 rdf:type schema:CreativeWork
    128 sg:pub.10.1007/s12015-010-9178-6 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048205384
    129 https://doi.org/10.1007/s12015-010-9178-6
    130 rdf:type schema:CreativeWork
    131 sg:pub.10.1038/cr.2008.80 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001799023
    132 https://doi.org/10.1038/cr.2008.80
    133 rdf:type schema:CreativeWork
    134 sg:pub.10.1038/cr.2008.90 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028089467
    135 https://doi.org/10.1038/cr.2008.90
    136 rdf:type schema:CreativeWork
    137 sg:pub.10.1038/leu.2010.310 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027386114
    138 https://doi.org/10.1038/leu.2010.310
    139 rdf:type schema:CreativeWork
    140 sg:pub.10.1038/nature06188 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046203017
    141 https://doi.org/10.1038/nature06188
    142 rdf:type schema:CreativeWork
    143 sg:pub.10.1038/nature07205 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024729982
    144 https://doi.org/10.1038/nature07205
    145 rdf:type schema:CreativeWork
    146 sg:pub.10.1038/nm1589 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047465928
    147 https://doi.org/10.1038/nm1589
    148 rdf:type schema:CreativeWork
    149 sg:pub.10.1038/sj.bjc.6604508 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034223170
    150 https://doi.org/10.1038/sj.bjc.6604508
    151 rdf:type schema:CreativeWork
    152 sg:pub.10.1038/sj.leu.2404847 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001692977
    153 https://doi.org/10.1038/sj.leu.2404847
    154 rdf:type schema:CreativeWork
    155 sg:pub.10.1038/sj.onc.1210920 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013590098
    156 https://doi.org/10.1038/sj.onc.1210920
    157 rdf:type schema:CreativeWork
    158 sg:pub.10.1186/1476-4598-9-273 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034314366
    159 https://doi.org/10.1186/1476-4598-9-273
    160 rdf:type schema:CreativeWork
    161 grid-institutes:grid.5611.3 schema:alternateName Department of Medicine, Stem Cell Research Laboratory, Section of Hematology, University of Verona, Verona, Italy
    162 schema:name Department of Medicine, Stem Cell Research Laboratory, Section of Hematology, University of Verona, Verona, Italy
    163 rdf:type schema:Organization
     




    Preview window. Press ESC to close (or click here)


    ...