Mesenchymal stromal cell ‘licensing’: a multistep process View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2011-05-27

AUTHORS

M Krampera

ABSTRACT

Many in vitro and in vivo data are available supporting the role of mesenchymal stromal cell (MSC) licensing in the induction of a measurable and effective immune regulation. The failure of some MSC-based protocols for immune modulation in animal models and in human clinical trials may be explained by either lack of a proper licensing by inflammatory microenviroment or wrong timing in MSC administration. Thus, optimization of MSC use for immune-regulating purposes is required to maximize their beneficial effects. More... »

PAGES

1408-1414

References to SciGraph publications

  • 2008-08-04. IFNγ and B7-H1 in the immunology of mesenchymal stem cells in CELL RESEARCH
  • 2011-01-18. Human but not murine multipotent mesenchymal stromal cells exhibit broad-spectrum antimicrobial effector function mediated by indoleamine 2,3-dioxygenase in LEUKEMIA
  • 2007-10-04. Mesenchymal stem cells within tumour stroma promote breast cancer metastasis in NATURE
  • 2010-08-04. Inflammatory Cytokine Induced Regulation of Superoxide Dismutase 3 Expression by Human Mesenchymal Stem Cells in STEM CELL REVIEWS AND REPORTS
  • 2007-07-12. Mesenchymal stem cells of cord blood origin are effective at preventing but not treating graft-versus-host disease in LEUKEMIA
  • 2008-07-08. A critical role of IFNγ in priming MSC-mediated suppression of T cell proliferation through up-regulation of B7-H1 in CELL RESEARCH
  • 2010-10-14. Macrophages may promote cancer growth via a GM-CSF/HB-EGF paracrine loop that is enhanced by CXCL12 in MOLECULAR CANCER
  • 2008-07-01. Cancer-related inflammation in NATURE
  • 2007-11-12. Mesenchymal stem cells share molecular signature with mesenchymal tumor cells and favor early tumor growth in syngeneic mice in ONCOGENE
  • 2008-07-29. VEGF expression by mesenchymal stem cells contributes to angiogenesis in pancreatic carcinoma in BRITISH JOURNAL OF CANCER
  • 2005-01. T cell responses to allogeneic human mesenchymal stem cells: immunogenicity, tolerance, and suppression in JOURNAL OF BIOMEDICAL SCIENCE
  • 2007-05-03. Therapeutic targeting of innate immunity with Toll-like receptor agonists and antagonists in NATURE MEDICINE
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/leu.2011.108

    DOI

    http://dx.doi.org/10.1038/leu.2011.108

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1028464217

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/21617697


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