Identification of MNDA as a new marker for nodal marginal zone lymphoma View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2009-05-28

AUTHORS

G Kanellis, G Roncador, A Arribas, M Mollejo, S Montes-Moreno, L Maestre, Y Campos-Martin, J L Ríos Gonzalez, J L Martinez-Torrecuadrada, L Sanchez-Verde, R Pajares, J C Cigudosa, M C Martin, M A Piris

ABSTRACT

Clinical and biological studies on nodal marginal zone lymphoma (NMZL) are hampered by the lack of specific diagnostic markers and the low reproducibility of this diagnosis. A comparative expression-profiling study has shown a set of markers to be differentially expressed in NMZL compared with follicular lymphoma (FL), including myeloid cell nuclear differentiation antigen (MNDA), a nuclear protein expressed by myeloid cells and a subset of B-cells. The aim of this study was to characterize the expression of MNDA in normal and reactive human tissue, and in a large series of non-Hodgkin's B-cell lymphomas, with particular emphasis on NMZL and FL. Our results showed that MNDA is expressed in normal tissue by a subset of the marginal zone B cells. They also showed MNDA expression in subgroups of chronic lymphocytic leukemia, mantle-cell lymphoma, and diffuse large B-cell lymphoma, but MNDA was especially expressed by lymphomas derived from the marginal zone, such as mucosa-associated lymphoid-tissue lymphoma, splenic marginal-zone lymphoma and NMZL. MNDA expression was rarely observed in FL, a characteristic that is of potential value in distinguishing between NMZL and FL. MNDA expression is thus a useful tool for the recognition of NMZL. More... »

PAGES

1847-1857

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/leu.2009.108

DOI

http://dx.doi.org/10.1038/leu.2009.108

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1010778964

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/19474799


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