The hematopoietic stem cell in chronic phase CML is characterized by a transcriptional profile resembling normal myeloid progenitor cells and ... View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2009-01-22

AUTHORS

I Bruns, A Czibere, J C Fischer, F Roels, R-P Cadeddu, S Buest, D Bruennert, A N Huenerlituerkoglu, N H Stoecklein, R Singh, L F Zerbini, M Jäger, G Kobbe, N Gattermann, R Kronenwett, B Brors, R Haas

ABSTRACT

We found that composition of cell subsets within the CD34+ cell population is markedly altered in chronic phase (CP) chronic myeloid leukemia (CML). Specifically, proportions and absolute cell counts of common myeloid progenitors (CMP) and megakaryocyte–erythrocyte progenitors (MEP) are significantly greater in comparison to normal bone marrow whereas absolute numbers of hematopoietic stem cells (HSC) are equal. To understand the basis for this, we performed gene expression profiling (Affymetrix HU-133A 2.0) of the distinct CD34+ cell subsets from six patients with CP CML and five healthy donors. Euclidean distance analysis revealed a remarkable transcriptional similarity between the CML patients’ HSC and normal progenitors, especially CMP. CP CML HSC were transcriptionally more similar to their progeny than normal HSC to theirs, suggesting a more mature phenotype. Hence, the greatest differences between CP CML patients and normal donors were apparent in HSC including downregulation of genes encoding adhesion molecules, transcription factors, regulators of stem-cell fate and inhibitors of cell proliferation in CP CML. Impaired adhesive and migratory capacities were functionally corroborated by fibronectin detachment analysis and transwell assays, respectively. Based on our findings we propose a loss of quiescence of the CML HSC on detachment from the niche leading to expansion of myeloid progenitors. More... »

PAGES

892-899

Journal

TITLE

Leukemia

ISSUE

5

VOLUME

23

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/leu.2008.392

DOI

http://dx.doi.org/10.1038/leu.2008.392

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1021573817

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/19158832


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1103", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Clinical Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1112", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Oncology and Carcinogenesis", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cell Adhesion", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cell Differentiation", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cell Movement", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cell Proliferation", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Fluorescent Antibody Technique", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Gene Expression Profiling", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Gene Expression Regulation, Leukemic", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Hematopoietic Stem Cells", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Leukemia, Myelogenous, Chronic, BCR-ABL Positive", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Myeloid Progenitor Cells", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Neoplastic Stem Cells", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Oligonucleotide Array Sequence Analysis", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "RNA, Messenger", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Reverse Transcriptase Polymerase Chain Reaction", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Department of Hematology, Oncology and Clinical Immunology, Heinrich-Heine-University D\u00fcsseldorf, Duesseldorf, Germany", 
          "id": "http://www.grid.ac/institutes/grid.411327.2", 
          "name": [
            "Department of Hematology, Oncology and Clinical Immunology, Heinrich-Heine-University D\u00fcsseldorf, Duesseldorf, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Bruns", 
        "givenName": "I", 
        "id": "sg:person.01327547615.34", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01327547615.34"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Hematology, Oncology and Clinical Immunology, Heinrich-Heine-University D\u00fcsseldorf, Duesseldorf, Germany", 
          "id": "http://www.grid.ac/institutes/grid.411327.2", 
          "name": [
            "Department of Hematology, Oncology and Clinical Immunology, Heinrich-Heine-University D\u00fcsseldorf, Duesseldorf, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Czibere", 
        "givenName": "A", 
        "id": "sg:person.01032642115.04", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01032642115.04"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Institute for Transplantation Diagnostics and Cell Therapeutics, Heinrich-Heine-University D\u00fcsseldorf, Duesseldorf, Germany", 
          "id": "http://www.grid.ac/institutes/grid.411327.2", 
          "name": [
            "Institute for Transplantation Diagnostics and Cell Therapeutics, Heinrich-Heine-University D\u00fcsseldorf, Duesseldorf, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Fischer", 
        "givenName": "J C", 
        "id": "sg:person.01007114665.38", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01007114665.38"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Theoretical Bioinformatics, German Cancer Research Center, Heidelberg, Germany", 
          "id": "http://www.grid.ac/institutes/grid.7497.d", 
          "name": [
            "Theoretical Bioinformatics, German Cancer Research Center, Heidelberg, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Roels", 
        "givenName": "F", 
        "id": "sg:person.01003110062.40", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01003110062.40"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Hematology, Oncology and Clinical Immunology, Heinrich-Heine-University D\u00fcsseldorf, Duesseldorf, Germany", 
          "id": "http://www.grid.ac/institutes/grid.411327.2", 
          "name": [
            "Department of Hematology, Oncology and Clinical Immunology, Heinrich-Heine-University D\u00fcsseldorf, Duesseldorf, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Cadeddu", 
        "givenName": "R-P", 
        "id": "sg:person.0725427333.92", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0725427333.92"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Hematology, Oncology and Clinical Immunology, Heinrich-Heine-University D\u00fcsseldorf, Duesseldorf, Germany", 
          "id": "http://www.grid.ac/institutes/grid.411327.2", 
          "name": [
            "Department of Hematology, Oncology and Clinical Immunology, Heinrich-Heine-University D\u00fcsseldorf, Duesseldorf, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Buest", 
        "givenName": "S", 
        "id": "sg:person.01363307652.29", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01363307652.29"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Hematology, Oncology and Clinical Immunology, Heinrich-Heine-University D\u00fcsseldorf, Duesseldorf, Germany", 
          "id": "http://www.grid.ac/institutes/grid.411327.2", 
          "name": [
            "Department of Hematology, Oncology and Clinical Immunology, Heinrich-Heine-University D\u00fcsseldorf, Duesseldorf, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Bruennert", 
        "givenName": "D", 
        "id": "sg:person.01351227431.29", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01351227431.29"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "St\u00e4dtische Kliniken Neuss, Lukaskrankenhaus, Neuss, Germany", 
          "id": "http://www.grid.ac/institutes/grid.416164.0", 
          "name": [
            "St\u00e4dtische Kliniken Neuss, Lukaskrankenhaus, Neuss, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Huenerlituerkoglu", 
        "givenName": "A N", 
        "id": "sg:person.0706016752.45", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0706016752.45"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of General and Visceral Surgery, Heinrich-Heine-University D\u00fcsseldorf, Duesseldorf, Germany", 
          "id": "http://www.grid.ac/institutes/grid.411327.2", 
          "name": [
            "Department of General and Visceral Surgery, Heinrich-Heine-University D\u00fcsseldorf, Duesseldorf, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Stoecklein", 
        "givenName": "N H", 
        "id": "sg:person.01075327323.75", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01075327323.75"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Hematology, Oncology and Clinical Immunology, Heinrich-Heine-University D\u00fcsseldorf, Duesseldorf, Germany", 
          "id": "http://www.grid.ac/institutes/grid.411327.2", 
          "name": [
            "Department of Hematology, Oncology and Clinical Immunology, Heinrich-Heine-University D\u00fcsseldorf, Duesseldorf, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Singh", 
        "givenName": "R", 
        "id": "sg:person.01275305074.11", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01275305074.11"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "BIDMC Genomics Center, Harvard Institutes of Medicine, Boston, MA, USA", 
          "id": "http://www.grid.ac/institutes/grid.38142.3c", 
          "name": [
            "BIDMC Genomics Center, Harvard Institutes of Medicine, Boston, MA, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Zerbini", 
        "givenName": "L F", 
        "id": "sg:person.01347644163.62", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01347644163.62"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Orthopedic Surgery, Heinrich-Heine-University D\u00fcsseldorf, Duesseldorf, Germany", 
          "id": "http://www.grid.ac/institutes/grid.411327.2", 
          "name": [
            "Department of Orthopedic Surgery, Heinrich-Heine-University D\u00fcsseldorf, Duesseldorf, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "J\u00e4ger", 
        "givenName": "M", 
        "id": "sg:person.0711746412.32", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0711746412.32"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Hematology, Oncology and Clinical Immunology, Heinrich-Heine-University D\u00fcsseldorf, Duesseldorf, Germany", 
          "id": "http://www.grid.ac/institutes/grid.411327.2", 
          "name": [
            "Department of Hematology, Oncology and Clinical Immunology, Heinrich-Heine-University D\u00fcsseldorf, Duesseldorf, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Kobbe", 
        "givenName": "G", 
        "id": "sg:person.01164073234.53", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01164073234.53"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Hematology, Oncology and Clinical Immunology, Heinrich-Heine-University D\u00fcsseldorf, Duesseldorf, Germany", 
          "id": "http://www.grid.ac/institutes/grid.411327.2", 
          "name": [
            "Department of Hematology, Oncology and Clinical Immunology, Heinrich-Heine-University D\u00fcsseldorf, Duesseldorf, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Gattermann", 
        "givenName": "N", 
        "id": "sg:person.01273447501.34", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01273447501.34"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Hematology, Oncology and Clinical Immunology, Heinrich-Heine-University D\u00fcsseldorf, Duesseldorf, Germany", 
          "id": "http://www.grid.ac/institutes/grid.411327.2", 
          "name": [
            "Department of Hematology, Oncology and Clinical Immunology, Heinrich-Heine-University D\u00fcsseldorf, Duesseldorf, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Kronenwett", 
        "givenName": "R", 
        "id": "sg:person.01266717124.24", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01266717124.24"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Theoretical Bioinformatics, German Cancer Research Center, Heidelberg, Germany", 
          "id": "http://www.grid.ac/institutes/grid.7497.d", 
          "name": [
            "Theoretical Bioinformatics, German Cancer Research Center, Heidelberg, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Brors", 
        "givenName": "B", 
        "id": "sg:person.0670067053.30", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0670067053.30"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Hematology, Oncology and Clinical Immunology, Heinrich-Heine-University D\u00fcsseldorf, Duesseldorf, Germany", 
          "id": "http://www.grid.ac/institutes/grid.411327.2", 
          "name": [
            "Department of Hematology, Oncology and Clinical Immunology, Heinrich-Heine-University D\u00fcsseldorf, Duesseldorf, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Haas", 
        "givenName": "R", 
        "id": "sg:person.01127414674.14", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01127414674.14"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "sg:pub.10.1038/nm1579", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1045933044", 
          "https://doi.org/10.1038/nm1579"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.leu.2403626", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030519744", 
          "https://doi.org/10.1038/sj.leu.2403626"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature04247", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1003673253", 
          "https://doi.org/10.1038/nature04247"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nrc2368", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1020611190", 
          "https://doi.org/10.1038/nrc2368"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature04747", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1012527227", 
          "https://doi.org/10.1038/nature04747"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nm740", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1011527446", 
          "https://doi.org/10.1038/nm740"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/gb-2001-2-10-reports0032", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1085169177", 
          "https://doi.org/10.1186/gb-2001-2-10-reports0032"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/gb-2001-2-8-research0032", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1015228558", 
          "https://doi.org/10.1186/gb-2001-2-8-research0032"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/35090591", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1007018909", 
          "https://doi.org/10.1038/35090591"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.leu.2404274", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1018722873", 
          "https://doi.org/10.1038/sj.leu.2404274"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.leu.2404549", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1043862344", 
          "https://doi.org/10.1038/sj.leu.2404549"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2009-01-22", 
    "datePublishedReg": "2009-01-22", 
    "description": "We found that composition of cell subsets within the CD34+ cell population is markedly altered in chronic phase (CP) chronic myeloid leukemia (CML). Specifically, proportions and absolute cell counts of common myeloid progenitors (CMP) and megakaryocyte\u2013erythrocyte progenitors (MEP) are significantly greater in comparison to normal bone marrow whereas absolute numbers of hematopoietic stem cells (HSC) are equal. To understand the basis for this, we performed gene expression profiling (Affymetrix HU-133A 2.0) of the distinct CD34+ cell subsets from six patients with CP CML and five healthy donors. Euclidean distance analysis revealed a remarkable transcriptional similarity between the CML patients\u2019 HSC and normal progenitors, especially CMP. CP CML HSC were transcriptionally more similar to their progeny than normal HSC to theirs, suggesting a more mature phenotype. Hence, the greatest differences between CP CML patients and normal donors were apparent in HSC including downregulation of genes encoding adhesion molecules, transcription factors, regulators of stem-cell fate and inhibitors of cell proliferation in CP CML. Impaired adhesive and migratory capacities were functionally corroborated by fibronectin detachment analysis and transwell assays, respectively. Based on our findings we propose a loss of quiescence of the CML HSC on detachment from the niche leading to expansion of myeloid progenitors.", 
    "genre": "article", 
    "id": "sg:pub.10.1038/leu.2008.392", 
    "isAccessibleForFree": false, 
    "isPartOf": [
      {
        "id": "sg:journal.1097065", 
        "issn": [
          "0887-6924", 
          "1476-5551"
        ], 
        "name": "Leukemia", 
        "publisher": "Springer Nature", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "5", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "23"
      }
    ], 
    "keywords": [
      "common myeloid progenitors", 
      "hematopoietic stem cells", 
      "loss of quiescence", 
      "megakaryocyte-erythrocyte progenitors", 
      "myeloid progenitors", 
      "stem cell fate", 
      "stem cells", 
      "downregulation of genes", 
      "gene expression profiling", 
      "normal myeloid progenitor cells", 
      "myeloid progenitor cells", 
      "transcription factors", 
      "transcriptional profiles", 
      "distinct CD34", 
      "expression profiling", 
      "transcriptional similarity", 
      "Euclidean distance analysis", 
      "distance analysis", 
      "normal hematopoietic stem cells", 
      "transwell assays", 
      "progenitors", 
      "progenitor cells", 
      "cell proliferation", 
      "CP CML", 
      "cell populations", 
      "normal progenitors", 
      "migratory capacity", 
      "adhesion molecules", 
      "normal bone marrow", 
      "mature phenotype", 
      "cells", 
      "quiescence", 
      "bone marrow", 
      "genes", 
      "niche", 
      "progeny", 
      "regulator", 
      "phenotype", 
      "chronic phase chronic myeloid leukemia", 
      "profiling", 
      "downregulation", 
      "fate", 
      "cell subsets", 
      "proliferation", 
      "CD34", 
      "assays", 
      "inhibitors", 
      "similarity", 
      "great differences", 
      "chronic myeloid leukemia", 
      "subset", 
      "CML patients", 
      "molecules", 
      "myeloid leukemia", 
      "loss", 
      "population", 
      "marrow", 
      "chronic-phase CML", 
      "phase chronic myeloid leukemia", 
      "analysis", 
      "normal donors", 
      "composition", 
      "CP-CML patients", 
      "healthy donors", 
      "absolute cell counts", 
      "donors", 
      "basis", 
      "leukemia", 
      "factors", 
      "expansion", 
      "profile", 
      "cell count", 
      "proportion", 
      "patients", 
      "absolute number", 
      "number", 
      "findings", 
      "capacity", 
      "differences", 
      "comparison", 
      "detachment", 
      "count"
    ], 
    "name": "The hematopoietic stem cell in chronic phase CML is characterized by a transcriptional profile resembling normal myeloid progenitor cells and reflecting loss of quiescence", 
    "pagination": "892-899", 
    "productId": [
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1021573817"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1038/leu.2008.392"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "19158832"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1038/leu.2008.392", 
      "https://app.dimensions.ai/details/publication/pub.1021573817"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2022-08-04T16:57", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-springernature-scigraph/baseset/20220804/entities/gbq_results/article/article_488.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://doi.org/10.1038/leu.2008.392"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/leu.2008.392'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/leu.2008.392'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/leu.2008.392'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/leu.2008.392'


 

This table displays all metadata directly associated to this object as RDF triples.

378 TRIPLES      21 PREDICATES      134 URIs      114 LITERALS      22 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1038/leu.2008.392 schema:about N0576bdf286394367b020a02371bbd217
2 N0b2f37b843ff4f9c9dd6598258266187
3 N26de2c1110ee44a09b9e0f042324031d
4 N2bd12c8ec19448dfaf39f77e9b4849fb
5 N461bbd21fe9840508674838cde249a3e
6 N5c28396bb7334564a1fdd7b49ba3c4b3
7 N66cea921af5d467780651c0adfefa8f5
8 N6b84cd7da3024c9e8b08897736d930a1
9 N7d65ea92dda14abeaa9f3c645ad89dc0
10 N7e31372794cb4d93977a456bdbd60cbd
11 N7e798dff78ff488da1371877e7b0893e
12 Na71d09a3931445ca8009186a3244833d
13 Nc624c10c65bf4512b6a345bbd03ac348
14 Ne44a5db7d27f4055974536adba661cad
15 Ne9c75bfbfc6f4baf85ff830cf3623acd
16 anzsrc-for:11
17 anzsrc-for:1103
18 anzsrc-for:1112
19 schema:author N586f21c8e00d45979061a0c31d88b8e6
20 schema:citation sg:pub.10.1038/35090591
21 sg:pub.10.1038/nature04247
22 sg:pub.10.1038/nature04747
23 sg:pub.10.1038/nm1579
24 sg:pub.10.1038/nm740
25 sg:pub.10.1038/nrc2368
26 sg:pub.10.1038/sj.leu.2403626
27 sg:pub.10.1038/sj.leu.2404274
28 sg:pub.10.1038/sj.leu.2404549
29 sg:pub.10.1186/gb-2001-2-10-reports0032
30 sg:pub.10.1186/gb-2001-2-8-research0032
31 schema:datePublished 2009-01-22
32 schema:datePublishedReg 2009-01-22
33 schema:description We found that composition of cell subsets within the CD34+ cell population is markedly altered in chronic phase (CP) chronic myeloid leukemia (CML). Specifically, proportions and absolute cell counts of common myeloid progenitors (CMP) and megakaryocyte–erythrocyte progenitors (MEP) are significantly greater in comparison to normal bone marrow whereas absolute numbers of hematopoietic stem cells (HSC) are equal. To understand the basis for this, we performed gene expression profiling (Affymetrix HU-133A 2.0) of the distinct CD34+ cell subsets from six patients with CP CML and five healthy donors. Euclidean distance analysis revealed a remarkable transcriptional similarity between the CML patients’ HSC and normal progenitors, especially CMP. CP CML HSC were transcriptionally more similar to their progeny than normal HSC to theirs, suggesting a more mature phenotype. Hence, the greatest differences between CP CML patients and normal donors were apparent in HSC including downregulation of genes encoding adhesion molecules, transcription factors, regulators of stem-cell fate and inhibitors of cell proliferation in CP CML. Impaired adhesive and migratory capacities were functionally corroborated by fibronectin detachment analysis and transwell assays, respectively. Based on our findings we propose a loss of quiescence of the CML HSC on detachment from the niche leading to expansion of myeloid progenitors.
34 schema:genre article
35 schema:isAccessibleForFree false
36 schema:isPartOf N3981bdd33c3a4a9aabe49b7309dafac5
37 N66fe90ed32c44aec9338d7fe1ddf654b
38 sg:journal.1097065
39 schema:keywords CD34
40 CML patients
41 CP CML
42 CP-CML patients
43 Euclidean distance analysis
44 absolute cell counts
45 absolute number
46 adhesion molecules
47 analysis
48 assays
49 basis
50 bone marrow
51 capacity
52 cell count
53 cell populations
54 cell proliferation
55 cell subsets
56 cells
57 chronic myeloid leukemia
58 chronic phase chronic myeloid leukemia
59 chronic-phase CML
60 common myeloid progenitors
61 comparison
62 composition
63 count
64 detachment
65 differences
66 distance analysis
67 distinct CD34
68 donors
69 downregulation
70 downregulation of genes
71 expansion
72 expression profiling
73 factors
74 fate
75 findings
76 gene expression profiling
77 genes
78 great differences
79 healthy donors
80 hematopoietic stem cells
81 inhibitors
82 leukemia
83 loss
84 loss of quiescence
85 marrow
86 mature phenotype
87 megakaryocyte-erythrocyte progenitors
88 migratory capacity
89 molecules
90 myeloid leukemia
91 myeloid progenitor cells
92 myeloid progenitors
93 niche
94 normal bone marrow
95 normal donors
96 normal hematopoietic stem cells
97 normal myeloid progenitor cells
98 normal progenitors
99 number
100 patients
101 phase chronic myeloid leukemia
102 phenotype
103 population
104 profile
105 profiling
106 progenitor cells
107 progenitors
108 progeny
109 proliferation
110 proportion
111 quiescence
112 regulator
113 similarity
114 stem cell fate
115 stem cells
116 subset
117 transcription factors
118 transcriptional profiles
119 transcriptional similarity
120 transwell assays
121 schema:name The hematopoietic stem cell in chronic phase CML is characterized by a transcriptional profile resembling normal myeloid progenitor cells and reflecting loss of quiescence
122 schema:pagination 892-899
123 schema:productId N6804d9f12a514b559106e60303cccb71
124 N84ab91cd1c024ac3a5d35eaf8e6b84f6
125 Na2eefe2f48d74d9f9c44f47d9ec03fda
126 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021573817
127 https://doi.org/10.1038/leu.2008.392
128 schema:sdDatePublished 2022-08-04T16:57
129 schema:sdLicense https://scigraph.springernature.com/explorer/license/
130 schema:sdPublisher N244729169c20469d83951cef4b47722a
131 schema:url https://doi.org/10.1038/leu.2008.392
132 sgo:license sg:explorer/license/
133 sgo:sdDataset articles
134 rdf:type schema:ScholarlyArticle
135 N03859a19e2054791a17a05a7c584b4a7 rdf:first sg:person.0670067053.30
136 rdf:rest N87633736b0614fa0b2ad7b53ee54f6d4
137 N0576bdf286394367b020a02371bbd217 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
138 schema:name Fluorescent Antibody Technique
139 rdf:type schema:DefinedTerm
140 N0b2f37b843ff4f9c9dd6598258266187 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
141 schema:name Reverse Transcriptase Polymerase Chain Reaction
142 rdf:type schema:DefinedTerm
143 N163e942823e94b2fbde8bedd2ba6a3aa rdf:first sg:person.01164073234.53
144 rdf:rest Nc1700d3796e44b56908de41cb32d2d3a
145 N1bc1a140e9734543b640c003491cf929 rdf:first sg:person.01266717124.24
146 rdf:rest N03859a19e2054791a17a05a7c584b4a7
147 N244729169c20469d83951cef4b47722a schema:name Springer Nature - SN SciGraph project
148 rdf:type schema:Organization
149 N24b2e72c8cc24f229b5b6007604b9dc0 rdf:first sg:person.01032642115.04
150 rdf:rest N9a1b437c359b43599a91dac49c192e15
151 N26de2c1110ee44a09b9e0f042324031d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
152 schema:name RNA, Messenger
153 rdf:type schema:DefinedTerm
154 N2b6d6ac121c3489b970a2092c6127fb8 rdf:first sg:person.0725427333.92
155 rdf:rest N440e83c6be994504afcc00cacd1cd329
156 N2bd12c8ec19448dfaf39f77e9b4849fb schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
157 schema:name Cell Proliferation
158 rdf:type schema:DefinedTerm
159 N31b7521f66824d3ea20b9aa579518651 rdf:first sg:person.01003110062.40
160 rdf:rest N2b6d6ac121c3489b970a2092c6127fb8
161 N3981bdd33c3a4a9aabe49b7309dafac5 schema:volumeNumber 23
162 rdf:type schema:PublicationVolume
163 N440e83c6be994504afcc00cacd1cd329 rdf:first sg:person.01363307652.29
164 rdf:rest Nfd092dec9949434b8d43b1708defc46c
165 N461bbd21fe9840508674838cde249a3e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
166 schema:name Gene Expression Profiling
167 rdf:type schema:DefinedTerm
168 N55f442ab14d3490fa64df71daaa117df rdf:first sg:person.0711746412.32
169 rdf:rest N163e942823e94b2fbde8bedd2ba6a3aa
170 N586f21c8e00d45979061a0c31d88b8e6 rdf:first sg:person.01327547615.34
171 rdf:rest N24b2e72c8cc24f229b5b6007604b9dc0
172 N5aad5d602b62454fac5c63a09d0781e0 rdf:first sg:person.01275305074.11
173 rdf:rest N9fff28abc3604739807981179c107851
174 N5c28396bb7334564a1fdd7b49ba3c4b3 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
175 schema:name Cell Adhesion
176 rdf:type schema:DefinedTerm
177 N66cea921af5d467780651c0adfefa8f5 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
178 schema:name Cell Movement
179 rdf:type schema:DefinedTerm
180 N66fe90ed32c44aec9338d7fe1ddf654b schema:issueNumber 5
181 rdf:type schema:PublicationIssue
182 N6804d9f12a514b559106e60303cccb71 schema:name dimensions_id
183 schema:value pub.1021573817
184 rdf:type schema:PropertyValue
185 N6b84cd7da3024c9e8b08897736d930a1 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
186 schema:name Cell Differentiation
187 rdf:type schema:DefinedTerm
188 N7d65ea92dda14abeaa9f3c645ad89dc0 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
189 schema:name Hematopoietic Stem Cells
190 rdf:type schema:DefinedTerm
191 N7e31372794cb4d93977a456bdbd60cbd schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
192 schema:name Leukemia, Myelogenous, Chronic, BCR-ABL Positive
193 rdf:type schema:DefinedTerm
194 N7e798dff78ff488da1371877e7b0893e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
195 schema:name Gene Expression Regulation, Leukemic
196 rdf:type schema:DefinedTerm
197 N84ab91cd1c024ac3a5d35eaf8e6b84f6 schema:name doi
198 schema:value 10.1038/leu.2008.392
199 rdf:type schema:PropertyValue
200 N87633736b0614fa0b2ad7b53ee54f6d4 rdf:first sg:person.01127414674.14
201 rdf:rest rdf:nil
202 N97516de03a744620a6e665b48c0add79 rdf:first sg:person.0706016752.45
203 rdf:rest Ne00e66017b1e4c2db4df8666c79b315e
204 N9a1b437c359b43599a91dac49c192e15 rdf:first sg:person.01007114665.38
205 rdf:rest N31b7521f66824d3ea20b9aa579518651
206 N9fff28abc3604739807981179c107851 rdf:first sg:person.01347644163.62
207 rdf:rest N55f442ab14d3490fa64df71daaa117df
208 Na2eefe2f48d74d9f9c44f47d9ec03fda schema:name pubmed_id
209 schema:value 19158832
210 rdf:type schema:PropertyValue
211 Na71d09a3931445ca8009186a3244833d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
212 schema:name Humans
213 rdf:type schema:DefinedTerm
214 Nc1700d3796e44b56908de41cb32d2d3a rdf:first sg:person.01273447501.34
215 rdf:rest N1bc1a140e9734543b640c003491cf929
216 Nc624c10c65bf4512b6a345bbd03ac348 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
217 schema:name Neoplastic Stem Cells
218 rdf:type schema:DefinedTerm
219 Ne00e66017b1e4c2db4df8666c79b315e rdf:first sg:person.01075327323.75
220 rdf:rest N5aad5d602b62454fac5c63a09d0781e0
221 Ne44a5db7d27f4055974536adba661cad schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
222 schema:name Oligonucleotide Array Sequence Analysis
223 rdf:type schema:DefinedTerm
224 Ne9c75bfbfc6f4baf85ff830cf3623acd schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
225 schema:name Myeloid Progenitor Cells
226 rdf:type schema:DefinedTerm
227 Nfd092dec9949434b8d43b1708defc46c rdf:first sg:person.01351227431.29
228 rdf:rest N97516de03a744620a6e665b48c0add79
229 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
230 schema:name Medical and Health Sciences
231 rdf:type schema:DefinedTerm
232 anzsrc-for:1103 schema:inDefinedTermSet anzsrc-for:
233 schema:name Clinical Sciences
234 rdf:type schema:DefinedTerm
235 anzsrc-for:1112 schema:inDefinedTermSet anzsrc-for:
236 schema:name Oncology and Carcinogenesis
237 rdf:type schema:DefinedTerm
238 sg:journal.1097065 schema:issn 0887-6924
239 1476-5551
240 schema:name Leukemia
241 schema:publisher Springer Nature
242 rdf:type schema:Periodical
243 sg:person.01003110062.40 schema:affiliation grid-institutes:grid.7497.d
244 schema:familyName Roels
245 schema:givenName F
246 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01003110062.40
247 rdf:type schema:Person
248 sg:person.01007114665.38 schema:affiliation grid-institutes:grid.411327.2
249 schema:familyName Fischer
250 schema:givenName J C
251 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01007114665.38
252 rdf:type schema:Person
253 sg:person.01032642115.04 schema:affiliation grid-institutes:grid.411327.2
254 schema:familyName Czibere
255 schema:givenName A
256 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01032642115.04
257 rdf:type schema:Person
258 sg:person.01075327323.75 schema:affiliation grid-institutes:grid.411327.2
259 schema:familyName Stoecklein
260 schema:givenName N H
261 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01075327323.75
262 rdf:type schema:Person
263 sg:person.01127414674.14 schema:affiliation grid-institutes:grid.411327.2
264 schema:familyName Haas
265 schema:givenName R
266 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01127414674.14
267 rdf:type schema:Person
268 sg:person.01164073234.53 schema:affiliation grid-institutes:grid.411327.2
269 schema:familyName Kobbe
270 schema:givenName G
271 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01164073234.53
272 rdf:type schema:Person
273 sg:person.01266717124.24 schema:affiliation grid-institutes:grid.411327.2
274 schema:familyName Kronenwett
275 schema:givenName R
276 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01266717124.24
277 rdf:type schema:Person
278 sg:person.01273447501.34 schema:affiliation grid-institutes:grid.411327.2
279 schema:familyName Gattermann
280 schema:givenName N
281 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01273447501.34
282 rdf:type schema:Person
283 sg:person.01275305074.11 schema:affiliation grid-institutes:grid.411327.2
284 schema:familyName Singh
285 schema:givenName R
286 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01275305074.11
287 rdf:type schema:Person
288 sg:person.01327547615.34 schema:affiliation grid-institutes:grid.411327.2
289 schema:familyName Bruns
290 schema:givenName I
291 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01327547615.34
292 rdf:type schema:Person
293 sg:person.01347644163.62 schema:affiliation grid-institutes:grid.38142.3c
294 schema:familyName Zerbini
295 schema:givenName L F
296 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01347644163.62
297 rdf:type schema:Person
298 sg:person.01351227431.29 schema:affiliation grid-institutes:grid.411327.2
299 schema:familyName Bruennert
300 schema:givenName D
301 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01351227431.29
302 rdf:type schema:Person
303 sg:person.01363307652.29 schema:affiliation grid-institutes:grid.411327.2
304 schema:familyName Buest
305 schema:givenName S
306 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01363307652.29
307 rdf:type schema:Person
308 sg:person.0670067053.30 schema:affiliation grid-institutes:grid.7497.d
309 schema:familyName Brors
310 schema:givenName B
311 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0670067053.30
312 rdf:type schema:Person
313 sg:person.0706016752.45 schema:affiliation grid-institutes:grid.416164.0
314 schema:familyName Huenerlituerkoglu
315 schema:givenName A N
316 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0706016752.45
317 rdf:type schema:Person
318 sg:person.0711746412.32 schema:affiliation grid-institutes:grid.411327.2
319 schema:familyName Jäger
320 schema:givenName M
321 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0711746412.32
322 rdf:type schema:Person
323 sg:person.0725427333.92 schema:affiliation grid-institutes:grid.411327.2
324 schema:familyName Cadeddu
325 schema:givenName R-P
326 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0725427333.92
327 rdf:type schema:Person
328 sg:pub.10.1038/35090591 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007018909
329 https://doi.org/10.1038/35090591
330 rdf:type schema:CreativeWork
331 sg:pub.10.1038/nature04247 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003673253
332 https://doi.org/10.1038/nature04247
333 rdf:type schema:CreativeWork
334 sg:pub.10.1038/nature04747 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012527227
335 https://doi.org/10.1038/nature04747
336 rdf:type schema:CreativeWork
337 sg:pub.10.1038/nm1579 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045933044
338 https://doi.org/10.1038/nm1579
339 rdf:type schema:CreativeWork
340 sg:pub.10.1038/nm740 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011527446
341 https://doi.org/10.1038/nm740
342 rdf:type schema:CreativeWork
343 sg:pub.10.1038/nrc2368 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020611190
344 https://doi.org/10.1038/nrc2368
345 rdf:type schema:CreativeWork
346 sg:pub.10.1038/sj.leu.2403626 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030519744
347 https://doi.org/10.1038/sj.leu.2403626
348 rdf:type schema:CreativeWork
349 sg:pub.10.1038/sj.leu.2404274 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018722873
350 https://doi.org/10.1038/sj.leu.2404274
351 rdf:type schema:CreativeWork
352 sg:pub.10.1038/sj.leu.2404549 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043862344
353 https://doi.org/10.1038/sj.leu.2404549
354 rdf:type schema:CreativeWork
355 sg:pub.10.1186/gb-2001-2-10-reports0032 schema:sameAs https://app.dimensions.ai/details/publication/pub.1085169177
356 https://doi.org/10.1186/gb-2001-2-10-reports0032
357 rdf:type schema:CreativeWork
358 sg:pub.10.1186/gb-2001-2-8-research0032 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015228558
359 https://doi.org/10.1186/gb-2001-2-8-research0032
360 rdf:type schema:CreativeWork
361 grid-institutes:grid.38142.3c schema:alternateName BIDMC Genomics Center, Harvard Institutes of Medicine, Boston, MA, USA
362 schema:name BIDMC Genomics Center, Harvard Institutes of Medicine, Boston, MA, USA
363 rdf:type schema:Organization
364 grid-institutes:grid.411327.2 schema:alternateName Department of General and Visceral Surgery, Heinrich-Heine-University Düsseldorf, Duesseldorf, Germany
365 Department of Hematology, Oncology and Clinical Immunology, Heinrich-Heine-University Düsseldorf, Duesseldorf, Germany
366 Department of Orthopedic Surgery, Heinrich-Heine-University Düsseldorf, Duesseldorf, Germany
367 Institute for Transplantation Diagnostics and Cell Therapeutics, Heinrich-Heine-University Düsseldorf, Duesseldorf, Germany
368 schema:name Department of General and Visceral Surgery, Heinrich-Heine-University Düsseldorf, Duesseldorf, Germany
369 Department of Hematology, Oncology and Clinical Immunology, Heinrich-Heine-University Düsseldorf, Duesseldorf, Germany
370 Department of Orthopedic Surgery, Heinrich-Heine-University Düsseldorf, Duesseldorf, Germany
371 Institute for Transplantation Diagnostics and Cell Therapeutics, Heinrich-Heine-University Düsseldorf, Duesseldorf, Germany
372 rdf:type schema:Organization
373 grid-institutes:grid.416164.0 schema:alternateName Städtische Kliniken Neuss, Lukaskrankenhaus, Neuss, Germany
374 schema:name Städtische Kliniken Neuss, Lukaskrankenhaus, Neuss, Germany
375 rdf:type schema:Organization
376 grid-institutes:grid.7497.d schema:alternateName Theoretical Bioinformatics, German Cancer Research Center, Heidelberg, Germany
377 schema:name Theoretical Bioinformatics, German Cancer Research Center, Heidelberg, Germany
378 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...