Heterogeneous patterns of amplification of the NUP214-ABL1 fusion gene in T-cell acute lymphoblastic leukemia View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2009-01

AUTHORS

C Graux, M Stevens-Kroef, M Lafage, N Dastugue, C J Harrison, F Mugneret, K Bahloula, S Struski, M J Grégoire, N Nadal, E Lippert, S Taviaux, A Simons, R P Kuiper, A V Moorman, K Barber, A Bosly, L Michaux, P Vandenberghe, I Lahortiga, K De Keersmaecker, I Wlodarska, J Cools, A Hagemeijer, H A Poirel

ABSTRACT

Episomes with the NUP214-ABL1 fusion gene have been observed in 6% of T-ALL. In this multicentric study we collected 27 cases of NUP214-ABL1-positive T-ALL. Median age was 15 years with male predominance. Outcome was poor in 12 patients. An associated abnormality involving TLX1 or TLX3 was found in all investigated cases. Fluorescent in situ hybridization revealed a heterogeneous pattern of NUP214-ABL1 amplification. Multiple episomes carrying the fusion were detected in 24 patients. Episomes were observed in a significant number of nuclei in 18 cases, but in only 1-5% of nuclei in 6. In addition, intrachromosomal amplification (small hsr) was identified either as the only change or in association with episomes in four cases and two T-ALL cell lines (PEER and ALL-SIL). One case showed insertion of apparently non-amplified NUP214-ABL1 sequences at 14q12. The amplified sequences were analyzed using array-based CGH.These findings confirm that the NUP214-ABL1 gene requires amplification for oncogenicity; it is part of a multistep process of leukemogenesis; and it can be a late event present only in subpopulations. Data also provide in vivo evidence for a model of episome formation, amplification and optional reintegration into the genome. Implications for the use of kinase inhibitors are discussed. More... »

PAGES

leu2008278

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/leu.2008.278

DOI

http://dx.doi.org/10.1038/leu.2008.278

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1034699430

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/18923437


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