Accumulation of CCR5+ T cells around RANTES+ granulomas in Crohn's disease: a pivotal site of Th1-shifted immune response? View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2004-10-11

AUTHORS

Motoji Oki, Haruo Ohtani, Yoshitaka Kinouchi, Eiichi Sato, Shiro Nakamura, Takayuki Matsumoto, Hiroshi Nagura, Osamu Yoshie, Tooru Shimosegawa

ABSTRACT

Immunological abnormalities are implicated in the pathogenesis of inflammatory bowel disease (IBD), that is, Crohn's disease and ulcerative colitis. In particular, Crohn's disease is considered to be a T helper type 1 (Th1)-shifted disease. Chemokines and their receptors are involved in various immune responses including Th1- and Th2 responses. In this study, we analyzed chemokines and their receptors by immunohistochemistry, using frozen sections derived from 33 patients with Crohn's disease and 24 with ulcerative colitis. In inflamed mucosa, small mononuclear cells predominantly expressed CCR5 and CXCR3, the receptors selectively expressed on Th1 cells, without significant differences between Crohn's disease and ulcerative colitis. We then focused on the noncaseating granulomas that are characteristic of Crohn's disease. Granuloma cells, observed in all the layers of intestinal tissues, were positive for RANTES/CCL5 protein along their cell membranes. Lymphocytes surrounding granulomas were mostly CCR5+ and CXCR3+ T cells with CD4+ and CD8+ cells at similar frequencies. Granuloma cells were positive for RANTES mRNA by in situ hybridization. By contrast, lymphoid aggregates in Crohn's disease and lymphoid follicles in the normal intestinal mucosa were characterized by abundant B cells, a predominance of CD4+ T cells over CD8+ T cells, and low frequencies of cells expressing CCR5 or CXCR3. Together with the notion that granuloma cells are possible antigen-presenting cells, our results suggest that the noncaseating granulomas could be one of the crucial sites of Th1-shifted immune responses in Crohn's disease. More... »

PAGES

137-145

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/labinvest.3700189

DOI

http://dx.doi.org/10.1038/labinvest.3700189

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1026928226

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/15492753


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1107", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Immunology", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Adolescent", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Adult", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Aged", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Biomarkers", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Chemokine CCL5", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Child", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Colitis, Ulcerative", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Colon", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Crohn Disease", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Female", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Fluorescent Antibody Technique, Indirect", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Granuloma", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Ileum", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "In Situ Hybridization", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Male", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Middle Aged", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "RNA, Messenger", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Receptors, CCR5", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Rectum", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "T-Lymphocyte Subsets", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Th1 Cells", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Department of Pathology Division of Histopathology, Tohoku University Graduate School of Medicine, Sendai, Japan", 
          "id": "http://www.grid.ac/institutes/grid.69566.3a", 
          "name": [
            "Department of Internal Medicine Division of Gastroenterology, Tohoku University Graduate School of Medicine, Sendai, Japan", 
            "Department of Pathology Division of Histopathology, Tohoku University Graduate School of Medicine, Sendai, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Oki", 
        "givenName": "Motoji", 
        "id": "sg:person.0576743607.02", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0576743607.02"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Pathology, Mito Medical Center, Ibaraki, Japan", 
          "id": "http://www.grid.ac/institutes/grid.410845.c", 
          "name": [
            "Department of Pathology Division of Histopathology, Tohoku University Graduate School of Medicine, Sendai, Japan", 
            "Department of Pathology, Mito Medical Center, Ibaraki, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Ohtani", 
        "givenName": "Haruo", 
        "id": "sg:person.01213261602.43", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01213261602.43"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Internal Medicine Division of Gastroenterology, Tohoku University Graduate School of Medicine, Sendai, Japan", 
          "id": "http://www.grid.ac/institutes/grid.69566.3a", 
          "name": [
            "Department of Internal Medicine Division of Gastroenterology, Tohoku University Graduate School of Medicine, Sendai, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Kinouchi", 
        "givenName": "Yoshitaka", 
        "id": "sg:person.01145574514.32", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01145574514.32"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Pathology Division of Histopathology, Tohoku University Graduate School of Medicine, Sendai, Japan", 
          "id": "http://www.grid.ac/institutes/grid.69566.3a", 
          "name": [
            "Department of Pathology Division of Histopathology, Tohoku University Graduate School of Medicine, Sendai, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Sato", 
        "givenName": "Eiichi", 
        "id": "sg:person.016462137272.50", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.016462137272.50"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Gastroenterology, Osaka City University Graduate School of Medicine, Osaka City University, Osaka, Japan", 
          "id": "http://www.grid.ac/institutes/grid.261445.0", 
          "name": [
            "Department of Gastroenterology, Osaka City University Graduate School of Medicine, Osaka City University, Osaka, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Nakamura", 
        "givenName": "Shiro", 
        "id": "sg:person.010031712242.89", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.010031712242.89"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Gastroenterology, Osaka City University Graduate School of Medicine, Osaka City University, Osaka, Japan", 
          "id": "http://www.grid.ac/institutes/grid.261445.0", 
          "name": [
            "Department of Gastroenterology, Osaka City University Graduate School of Medicine, Osaka City University, Osaka, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Matsumoto", 
        "givenName": "Takayuki", 
        "id": "sg:person.012162205442.47", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012162205442.47"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Pathology Division of Histopathology, Tohoku University Graduate School of Medicine, Sendai, Japan", 
          "id": "http://www.grid.ac/institutes/grid.69566.3a", 
          "name": [
            "Department of Pathology Division of Histopathology, Tohoku University Graduate School of Medicine, Sendai, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Nagura", 
        "givenName": "Hiroshi", 
        "id": "sg:person.0723362470.15", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0723362470.15"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Solution-Oriented Research for Science and Technology of the Japanese Science and Technology Corporation, Tokyo, Japan", 
          "id": "http://www.grid.ac/institutes/None", 
          "name": [
            "Department of Microbiology, Kinki University School of Medicine, Osaka-Sayama, Japan", 
            "Solution-Oriented Research for Science and Technology of the Japanese Science and Technology Corporation, Tokyo, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Yoshie", 
        "givenName": "Osamu", 
        "id": "sg:person.01362270415.42", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01362270415.42"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Internal Medicine Division of Gastroenterology, Tohoku University Graduate School of Medicine, Sendai, Japan", 
          "id": "http://www.grid.ac/institutes/grid.69566.3a", 
          "name": [
            "Department of Internal Medicine Division of Gastroenterology, Tohoku University Graduate School of Medicine, Sendai, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Shimosegawa", 
        "givenName": "Tooru", 
        "id": "sg:person.01255535707.76", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01255535707.76"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "sg:pub.10.1038/36129", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1044348755", 
          "https://doi.org/10.1038/36129"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1111/j.1572-0241.1999.01220.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1005305928", 
          "https://doi.org/10.1111/j.1572-0241.1999.01220.x"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/labinvest.3700039", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1003770829", 
          "https://doi.org/10.1038/labinvest.3700039"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/34814", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1011357150", 
          "https://doi.org/10.1038/34814"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2004-10-11", 
    "datePublishedReg": "2004-10-11", 
    "description": "Immunological abnormalities are implicated in the pathogenesis of inflammatory bowel disease (IBD), that is, Crohn's disease and ulcerative colitis. In particular, Crohn's disease is considered to be a T helper type 1 (Th1)-shifted disease. Chemokines and their receptors are involved in various immune responses including Th1- and Th2 responses. In this study, we analyzed chemokines and their receptors by immunohistochemistry, using frozen sections derived from 33 patients with Crohn's disease and 24 with ulcerative colitis. In inflamed mucosa, small mononuclear cells predominantly expressed CCR5 and CXCR3, the receptors selectively expressed on Th1 cells, without significant differences between Crohn's disease and ulcerative colitis. We then focused on the noncaseating granulomas that are characteristic of Crohn's disease. Granuloma cells, observed in all the layers of intestinal tissues, were positive for RANTES/CCL5 protein along their cell membranes. Lymphocytes surrounding granulomas were mostly CCR5+ and CXCR3+ T cells with CD4+ and CD8+ cells at similar frequencies. Granuloma cells were positive for RANTES mRNA by in situ hybridization. By contrast, lymphoid aggregates in Crohn's disease and lymphoid follicles in the normal intestinal mucosa were characterized by abundant B cells, a predominance of CD4+ T cells over CD8+ T cells, and low frequencies of cells expressing CCR5 or CXCR3. Together with the notion that granuloma cells are possible antigen-presenting cells, our results suggest that the noncaseating granulomas could be one of the crucial sites of Th1-shifted immune responses in Crohn's disease.", 
    "genre": "article", 
    "id": "sg:pub.10.1038/labinvest.3700189", 
    "inLanguage": "en", 
    "isAccessibleForFree": true, 
    "isPartOf": [
      {
        "id": "sg:journal.1017964", 
        "issn": [
          "0023-6837", 
          "1530-0307"
        ], 
        "name": "Laboratory Investigation", 
        "publisher": "Springer Nature", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "1", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "85"
      }
    ], 
    "keywords": [
      "Th1-shifted immune responses", 
      "inflammatory bowel disease", 
      "Crohn's disease", 
      "ulcerative colitis", 
      "immune response", 
      "granuloma cells", 
      "noncaseating granulomas", 
      "predominance of CD4", 
      "accumulation of CCR5", 
      "helper type 1", 
      "antigen-presenting cells", 
      "normal intestinal mucosa", 
      "small mononuclear cells", 
      "immunological abnormalities", 
      "inflamed mucosa", 
      "bowel disease", 
      "Th2 responses", 
      "lymphoid aggregates", 
      "lymphoid follicles", 
      "mononuclear cells", 
      "Th1 cells", 
      "intestinal mucosa", 
      "CCL5 protein", 
      "intestinal tissue", 
      "RANTES mRNA", 
      "CCR5", 
      "granulomas", 
      "frozen sections", 
      "colitis", 
      "CXCR3", 
      "type 1", 
      "disease", 
      "CD8", 
      "receptors", 
      "similar frequency", 
      "CD4", 
      "significant differences", 
      "chemokines", 
      "mucosa", 
      "situ hybridization", 
      "cells", 
      "response", 
      "Th1", 
      "patients", 
      "pathogenesis", 
      "lymphocytes", 
      "immunohistochemistry", 
      "cell membrane", 
      "abnormalities", 
      "follicles", 
      "tissue", 
      "pivotal site", 
      "mRNA", 
      "low frequency", 
      "crucial site", 
      "predominance", 
      "frequency", 
      "differences", 
      "sites", 
      "study", 
      "protein", 
      "accumulation", 
      "contrast", 
      "hybridization", 
      "membrane", 
      "sections", 
      "results", 
      "aggregates", 
      "notion", 
      "layer"
    ], 
    "name": "Accumulation of CCR5+ T cells around RANTES+ granulomas in Crohn's disease: a pivotal site of Th1-shifted immune response?", 
    "pagination": "137-145", 
    "productId": [
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1026928226"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1038/labinvest.3700189"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "15492753"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1038/labinvest.3700189", 
      "https://app.dimensions.ai/details/publication/pub.1026928226"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2022-05-20T07:22", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-springernature-scigraph/baseset/20220519/entities/gbq_results/article/article_390.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://doi.org/10.1038/labinvest.3700189"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/labinvest.3700189'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/labinvest.3700189'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/labinvest.3700189'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/labinvest.3700189'


 

This table displays all metadata directly associated to this object as RDF triples.

305 TRIPLES      22 PREDICATES      122 URIs      110 LITERALS      29 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1038/labinvest.3700189 schema:about N05c7588e9bf84bc9be06b92c7cf922a1
2 N1721d0829ab24eefad51fa28596d88e5
3 N189f008a016f4468bdce19470c3109d9
4 N1afcb46269c4455ea048789dfc8cceaf
5 N30c28ba90d0340b5a7a34312fdb8cc53
6 N38f8330003ed402e8659ef10e7f22fda
7 N8b6953e61a444ab1b3523905cb7614f1
8 N8e7fe56c0c73468480ad169e956f0281
9 N8ebc0a0277db410f8967257bedfc7cb4
10 N98dcbf12db06473181c69e78990768b5
11 Na03a0d5f1df740b1a601127451b7e92c
12 Nad0999b7a9c446bfb7e881d4ec7f346c
13 Nada8e31b52744ac894ba5086ba6e008d
14 Nba56b6d76a4249279b81240898a35412
15 Nc50527d6bb8746a88acab32d3e99572d
16 Ncccffd4bd1cd4e4f99cff2c912e8fe6f
17 Ncce290b85b0b43739913766a7cf80ad2
18 Nd1a318689fbf4885815ad6212d4abc70
19 Nd2e218ba401d4ab8983408e469468850
20 Nd429626dabda4744b08d39e9781cc09f
21 Ne61210549f3f455cb2cfd1a92a44b4f2
22 Nf4099c554b8143b09395fae7481c0af5
23 anzsrc-for:11
24 anzsrc-for:1107
25 schema:author N196c143f19444dbab826ea6f125a2b3e
26 schema:citation sg:pub.10.1038/34814
27 sg:pub.10.1038/36129
28 sg:pub.10.1038/labinvest.3700039
29 sg:pub.10.1111/j.1572-0241.1999.01220.x
30 schema:datePublished 2004-10-11
31 schema:datePublishedReg 2004-10-11
32 schema:description Immunological abnormalities are implicated in the pathogenesis of inflammatory bowel disease (IBD), that is, Crohn's disease and ulcerative colitis. In particular, Crohn's disease is considered to be a T helper type 1 (Th1)-shifted disease. Chemokines and their receptors are involved in various immune responses including Th1- and Th2 responses. In this study, we analyzed chemokines and their receptors by immunohistochemistry, using frozen sections derived from 33 patients with Crohn's disease and 24 with ulcerative colitis. In inflamed mucosa, small mononuclear cells predominantly expressed CCR5 and CXCR3, the receptors selectively expressed on Th1 cells, without significant differences between Crohn's disease and ulcerative colitis. We then focused on the noncaseating granulomas that are characteristic of Crohn's disease. Granuloma cells, observed in all the layers of intestinal tissues, were positive for RANTES/CCL5 protein along their cell membranes. Lymphocytes surrounding granulomas were mostly CCR5+ and CXCR3+ T cells with CD4+ and CD8+ cells at similar frequencies. Granuloma cells were positive for RANTES mRNA by in situ hybridization. By contrast, lymphoid aggregates in Crohn's disease and lymphoid follicles in the normal intestinal mucosa were characterized by abundant B cells, a predominance of CD4+ T cells over CD8+ T cells, and low frequencies of cells expressing CCR5 or CXCR3. Together with the notion that granuloma cells are possible antigen-presenting cells, our results suggest that the noncaseating granulomas could be one of the crucial sites of Th1-shifted immune responses in Crohn's disease.
33 schema:genre article
34 schema:inLanguage en
35 schema:isAccessibleForFree true
36 schema:isPartOf N0772bdfa6f4147a8b4499f2619e44d4d
37 N6afdb18ff29947869b9a5c42a5d8ff79
38 sg:journal.1017964
39 schema:keywords CCL5 protein
40 CCR5
41 CD4
42 CD8
43 CXCR3
44 Crohn's disease
45 RANTES mRNA
46 Th1
47 Th1 cells
48 Th1-shifted immune responses
49 Th2 responses
50 abnormalities
51 accumulation
52 accumulation of CCR5
53 aggregates
54 antigen-presenting cells
55 bowel disease
56 cell membrane
57 cells
58 chemokines
59 colitis
60 contrast
61 crucial site
62 differences
63 disease
64 follicles
65 frequency
66 frozen sections
67 granuloma cells
68 granulomas
69 helper type 1
70 hybridization
71 immune response
72 immunohistochemistry
73 immunological abnormalities
74 inflamed mucosa
75 inflammatory bowel disease
76 intestinal mucosa
77 intestinal tissue
78 layer
79 low frequency
80 lymphocytes
81 lymphoid aggregates
82 lymphoid follicles
83 mRNA
84 membrane
85 mononuclear cells
86 mucosa
87 noncaseating granulomas
88 normal intestinal mucosa
89 notion
90 pathogenesis
91 patients
92 pivotal site
93 predominance
94 predominance of CD4
95 protein
96 receptors
97 response
98 results
99 sections
100 significant differences
101 similar frequency
102 sites
103 situ hybridization
104 small mononuclear cells
105 study
106 tissue
107 type 1
108 ulcerative colitis
109 schema:name Accumulation of CCR5+ T cells around RANTES+ granulomas in Crohn's disease: a pivotal site of Th1-shifted immune response?
110 schema:pagination 137-145
111 schema:productId N5e81d8a0559542979817110e0f35508f
112 Nec922c29438744df9e8738330d7f602a
113 Nfecf6311f0ee400ea79631c911e7064f
114 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026928226
115 https://doi.org/10.1038/labinvest.3700189
116 schema:sdDatePublished 2022-05-20T07:22
117 schema:sdLicense https://scigraph.springernature.com/explorer/license/
118 schema:sdPublisher N04b5505fed7f416e840694b7e822d040
119 schema:url https://doi.org/10.1038/labinvest.3700189
120 sgo:license sg:explorer/license/
121 sgo:sdDataset articles
122 rdf:type schema:ScholarlyArticle
123 N04b5505fed7f416e840694b7e822d040 schema:name Springer Nature - SN SciGraph project
124 rdf:type schema:Organization
125 N05c7588e9bf84bc9be06b92c7cf922a1 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
126 schema:name Adult
127 rdf:type schema:DefinedTerm
128 N0772bdfa6f4147a8b4499f2619e44d4d schema:volumeNumber 85
129 rdf:type schema:PublicationVolume
130 N1721d0829ab24eefad51fa28596d88e5 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
131 schema:name Biomarkers
132 rdf:type schema:DefinedTerm
133 N1746cd63909c4203a297a8290028be2e rdf:first sg:person.0723362470.15
134 rdf:rest Nf12bfb13d87b454d8077ce3a28ae4aca
135 N189f008a016f4468bdce19470c3109d9 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
136 schema:name Male
137 rdf:type schema:DefinedTerm
138 N196c143f19444dbab826ea6f125a2b3e rdf:first sg:person.0576743607.02
139 rdf:rest Nf909266eb99845c287ada9d39a22e117
140 N1afcb46269c4455ea048789dfc8cceaf schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
141 schema:name Aged
142 rdf:type schema:DefinedTerm
143 N30c28ba90d0340b5a7a34312fdb8cc53 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
144 schema:name Chemokine CCL5
145 rdf:type schema:DefinedTerm
146 N38f8330003ed402e8659ef10e7f22fda schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
147 schema:name Female
148 rdf:type schema:DefinedTerm
149 N413f672b4d64407dab687e1b9c56084e rdf:first sg:person.012162205442.47
150 rdf:rest N1746cd63909c4203a297a8290028be2e
151 N5e81d8a0559542979817110e0f35508f schema:name pubmed_id
152 schema:value 15492753
153 rdf:type schema:PropertyValue
154 N6afdb18ff29947869b9a5c42a5d8ff79 schema:issueNumber 1
155 rdf:type schema:PublicationIssue
156 N8b6953e61a444ab1b3523905cb7614f1 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
157 schema:name Child
158 rdf:type schema:DefinedTerm
159 N8e7fe56c0c73468480ad169e956f0281 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
160 schema:name Rectum
161 rdf:type schema:DefinedTerm
162 N8ebc0a0277db410f8967257bedfc7cb4 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
163 schema:name T-Lymphocyte Subsets
164 rdf:type schema:DefinedTerm
165 N983138d2b216449e946d8bbf8ac92f7b rdf:first sg:person.01145574514.32
166 rdf:rest Nb46924bf95c34079b998895cf0cd78c5
167 N98dcbf12db06473181c69e78990768b5 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
168 schema:name Th1 Cells
169 rdf:type schema:DefinedTerm
170 Na03a0d5f1df740b1a601127451b7e92c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
171 schema:name Adolescent
172 rdf:type schema:DefinedTerm
173 Na56a52370b634b0f9a5de2e5cdfad63b rdf:first sg:person.010031712242.89
174 rdf:rest N413f672b4d64407dab687e1b9c56084e
175 Nad0999b7a9c446bfb7e881d4ec7f346c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
176 schema:name In Situ Hybridization
177 rdf:type schema:DefinedTerm
178 Nad6548493fb146799283aa7627f604e1 rdf:first sg:person.01255535707.76
179 rdf:rest rdf:nil
180 Nada8e31b52744ac894ba5086ba6e008d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
181 schema:name Granuloma
182 rdf:type schema:DefinedTerm
183 Nb46924bf95c34079b998895cf0cd78c5 rdf:first sg:person.016462137272.50
184 rdf:rest Na56a52370b634b0f9a5de2e5cdfad63b
185 Nba56b6d76a4249279b81240898a35412 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
186 schema:name Ileum
187 rdf:type schema:DefinedTerm
188 Nc50527d6bb8746a88acab32d3e99572d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
189 schema:name RNA, Messenger
190 rdf:type schema:DefinedTerm
191 Ncccffd4bd1cd4e4f99cff2c912e8fe6f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
192 schema:name Middle Aged
193 rdf:type schema:DefinedTerm
194 Ncce290b85b0b43739913766a7cf80ad2 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
195 schema:name Colon
196 rdf:type schema:DefinedTerm
197 Nd1a318689fbf4885815ad6212d4abc70 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
198 schema:name Receptors, CCR5
199 rdf:type schema:DefinedTerm
200 Nd2e218ba401d4ab8983408e469468850 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
201 schema:name Colitis, Ulcerative
202 rdf:type schema:DefinedTerm
203 Nd429626dabda4744b08d39e9781cc09f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
204 schema:name Fluorescent Antibody Technique, Indirect
205 rdf:type schema:DefinedTerm
206 Ne61210549f3f455cb2cfd1a92a44b4f2 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
207 schema:name Crohn Disease
208 rdf:type schema:DefinedTerm
209 Nec922c29438744df9e8738330d7f602a schema:name dimensions_id
210 schema:value pub.1026928226
211 rdf:type schema:PropertyValue
212 Nf12bfb13d87b454d8077ce3a28ae4aca rdf:first sg:person.01362270415.42
213 rdf:rest Nad6548493fb146799283aa7627f604e1
214 Nf4099c554b8143b09395fae7481c0af5 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
215 schema:name Humans
216 rdf:type schema:DefinedTerm
217 Nf909266eb99845c287ada9d39a22e117 rdf:first sg:person.01213261602.43
218 rdf:rest N983138d2b216449e946d8bbf8ac92f7b
219 Nfecf6311f0ee400ea79631c911e7064f schema:name doi
220 schema:value 10.1038/labinvest.3700189
221 rdf:type schema:PropertyValue
222 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
223 schema:name Medical and Health Sciences
224 rdf:type schema:DefinedTerm
225 anzsrc-for:1107 schema:inDefinedTermSet anzsrc-for:
226 schema:name Immunology
227 rdf:type schema:DefinedTerm
228 sg:journal.1017964 schema:issn 0023-6837
229 1530-0307
230 schema:name Laboratory Investigation
231 schema:publisher Springer Nature
232 rdf:type schema:Periodical
233 sg:person.010031712242.89 schema:affiliation grid-institutes:grid.261445.0
234 schema:familyName Nakamura
235 schema:givenName Shiro
236 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.010031712242.89
237 rdf:type schema:Person
238 sg:person.01145574514.32 schema:affiliation grid-institutes:grid.69566.3a
239 schema:familyName Kinouchi
240 schema:givenName Yoshitaka
241 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01145574514.32
242 rdf:type schema:Person
243 sg:person.01213261602.43 schema:affiliation grid-institutes:grid.410845.c
244 schema:familyName Ohtani
245 schema:givenName Haruo
246 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01213261602.43
247 rdf:type schema:Person
248 sg:person.012162205442.47 schema:affiliation grid-institutes:grid.261445.0
249 schema:familyName Matsumoto
250 schema:givenName Takayuki
251 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012162205442.47
252 rdf:type schema:Person
253 sg:person.01255535707.76 schema:affiliation grid-institutes:grid.69566.3a
254 schema:familyName Shimosegawa
255 schema:givenName Tooru
256 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01255535707.76
257 rdf:type schema:Person
258 sg:person.01362270415.42 schema:affiliation grid-institutes:None
259 schema:familyName Yoshie
260 schema:givenName Osamu
261 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01362270415.42
262 rdf:type schema:Person
263 sg:person.016462137272.50 schema:affiliation grid-institutes:grid.69566.3a
264 schema:familyName Sato
265 schema:givenName Eiichi
266 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.016462137272.50
267 rdf:type schema:Person
268 sg:person.0576743607.02 schema:affiliation grid-institutes:grid.69566.3a
269 schema:familyName Oki
270 schema:givenName Motoji
271 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0576743607.02
272 rdf:type schema:Person
273 sg:person.0723362470.15 schema:affiliation grid-institutes:grid.69566.3a
274 schema:familyName Nagura
275 schema:givenName Hiroshi
276 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0723362470.15
277 rdf:type schema:Person
278 sg:pub.10.1038/34814 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011357150
279 https://doi.org/10.1038/34814
280 rdf:type schema:CreativeWork
281 sg:pub.10.1038/36129 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044348755
282 https://doi.org/10.1038/36129
283 rdf:type schema:CreativeWork
284 sg:pub.10.1038/labinvest.3700039 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003770829
285 https://doi.org/10.1038/labinvest.3700039
286 rdf:type schema:CreativeWork
287 sg:pub.10.1111/j.1572-0241.1999.01220.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1005305928
288 https://doi.org/10.1111/j.1572-0241.1999.01220.x
289 rdf:type schema:CreativeWork
290 grid-institutes:None schema:alternateName Solution-Oriented Research for Science and Technology of the Japanese Science and Technology Corporation, Tokyo, Japan
291 schema:name Department of Microbiology, Kinki University School of Medicine, Osaka-Sayama, Japan
292 Solution-Oriented Research for Science and Technology of the Japanese Science and Technology Corporation, Tokyo, Japan
293 rdf:type schema:Organization
294 grid-institutes:grid.261445.0 schema:alternateName Department of Gastroenterology, Osaka City University Graduate School of Medicine, Osaka City University, Osaka, Japan
295 schema:name Department of Gastroenterology, Osaka City University Graduate School of Medicine, Osaka City University, Osaka, Japan
296 rdf:type schema:Organization
297 grid-institutes:grid.410845.c schema:alternateName Department of Pathology, Mito Medical Center, Ibaraki, Japan
298 schema:name Department of Pathology Division of Histopathology, Tohoku University Graduate School of Medicine, Sendai, Japan
299 Department of Pathology, Mito Medical Center, Ibaraki, Japan
300 rdf:type schema:Organization
301 grid-institutes:grid.69566.3a schema:alternateName Department of Internal Medicine Division of Gastroenterology, Tohoku University Graduate School of Medicine, Sendai, Japan
302 Department of Pathology Division of Histopathology, Tohoku University Graduate School of Medicine, Sendai, Japan
303 schema:name Department of Internal Medicine Division of Gastroenterology, Tohoku University Graduate School of Medicine, Sendai, Japan
304 Department of Pathology Division of Histopathology, Tohoku University Graduate School of Medicine, Sendai, Japan
305 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...