IL-12 p40 prevents the development of chronic enterocolitis in IL-10-deficient mice View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2004-09-27

AUTHORS

Manabu Shiraki, Hiroyuki Aihara, Yoshitaka Kinouchi, Seiichi Takahashi, Motoji Oki, Mitsunori Noguchi, Kazuma Takahashi, Jun-ichi Miyazaki, Tooru Shimosegawa

ABSTRACT

T-helper-1 (Th1) cytokines play an important role in Crohn's disease, and interleukin-12 (IL-12), which is composed of two subunits, p40 and p35, drives Th1 differentiation. In previous reports, IL-12 p40 was shown to prevent IL-12 from binding to the receptor. We demonstrate here the effect of IL-12 p40 overexpression in intestinal epithelia on enterocolitis mediated by Th1 cells in IL-10-deficient (IL-10−/−) mice on a C57BL/6J background. IL-10 deficient (IL-10−/−)/T3b-IL-12 p40+ (IL-12 p40+) mice and IL-10−/−/T3b-IL-12 p40− (IL-12 p40−) mice were generated by crossing T3b-IL-12 p40 transgenic mice and IL-10−/− mice. At 8 weeks of age, IL-12 p40+ mice did not show any clinical manifestations of colitis. The colon length of IL-12 p40− mice became shorter than that of IL-12 p40+ mice. The histological score of IL-12 p40+ mice was lower. Interferon-gamma (IFN-γ) production was suppressed in both the mesenteric lymph node cell culture and colon tissue culture of IL-12 p40+ mice. There was no significant difference in IL-4 production and tumor necrosis factor-alpha (TNF-α) production between the two groups. These results show that overexpression of IL-12 p40 in intestinal epithelia prevents enterocolitis in IL-10−/− mice by suppressing IFN-γ production, and suggest a potential clinical application of IL-12 p40 for Crohn's disease. Furthermore, these results also suggest that local gene transduction in the intestinal epithelium may be a potent therapeutic approach for Crohn's disease. More... »

PAGES

1491-1500

References to SciGraph publications

  • <error retrieving object. in <ERROR RETRIEVING OBJECT
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/labinvest.3700175

    DOI

    http://dx.doi.org/10.1038/labinvest.3700175

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1044401990

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/15448706


    Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
    Incoming Citations Browse incoming citations for this publication using opencitations.net

    JSON-LD is the canonical representation for SciGraph data.

    TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

    [
      {
        "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
        "about": [
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Medical and Health Sciences", 
            "type": "DefinedTerm"
          }, 
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1107", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Immunology", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Animals", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Body Weight", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Cells, Cultured", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Colon", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Disease Models, Animal", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Enterocolitis", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Fluorescent Antibody Technique, Indirect", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Immunoenzyme Techniques", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Interferon-gamma", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Interleukin-10", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Interleukin-12", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Interleukin-12 Subunit p40", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Lymph Nodes", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Mice", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Mice, Inbred C57BL", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Mice, Knockout", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Protein Subunits", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Th1 Cells", 
            "type": "DefinedTerm"
          }
        ], 
        "author": [
          {
            "affiliation": {
              "alternateName": "Division of Gastroenterology, Tohoku University Graduate School of Medicine, Sendai, Japan", 
              "id": "http://www.grid.ac/institutes/grid.69566.3a", 
              "name": [
                "Division of Gastroenterology, Tohoku University Graduate School of Medicine, Sendai, Japan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Shiraki", 
            "givenName": "Manabu", 
            "id": "sg:person.0776123010.91", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0776123010.91"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Division of Gastroenterology, Tohoku University Graduate School of Medicine, Sendai, Japan", 
              "id": "http://www.grid.ac/institutes/grid.69566.3a", 
              "name": [
                "Division of Gastroenterology, Tohoku University Graduate School of Medicine, Sendai, Japan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Aihara", 
            "givenName": "Hiroyuki", 
            "id": "sg:person.01025452534.43", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01025452534.43"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Division of Gastroenterology, Tohoku University Graduate School of Medicine, Sendai, Japan", 
              "id": "http://www.grid.ac/institutes/grid.69566.3a", 
              "name": [
                "Division of Gastroenterology, Tohoku University Graduate School of Medicine, Sendai, Japan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Kinouchi", 
            "givenName": "Yoshitaka", 
            "id": "sg:person.01145574514.32", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01145574514.32"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Division of Gastroenterology, Tohoku University Graduate School of Medicine, Sendai, Japan", 
              "id": "http://www.grid.ac/institutes/grid.69566.3a", 
              "name": [
                "Division of Gastroenterology, Tohoku University Graduate School of Medicine, Sendai, Japan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Takahashi", 
            "givenName": "Seiichi", 
            "id": "sg:person.01304671035.37", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01304671035.37"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Division of Gastroenterology, Tohoku University Graduate School of Medicine, Sendai, Japan", 
              "id": "http://www.grid.ac/institutes/grid.69566.3a", 
              "name": [
                "Division of Gastroenterology, Tohoku University Graduate School of Medicine, Sendai, Japan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Oki", 
            "givenName": "Motoji", 
            "id": "sg:person.0576743607.02", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0576743607.02"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Sendai Shakaihoken Hospital, Sendai, Japan", 
              "id": "http://www.grid.ac/institutes/grid.415512.6", 
              "name": [
                "Sendai Shakaihoken Hospital, Sendai, Japan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Noguchi", 
            "givenName": "Mitsunori", 
            "id": "sg:person.0613451524.61", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0613451524.61"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Division of Molecular Metabolism and Diabetes, Tohoku University Graduate School of Medicine, Sendai, Japan", 
              "id": "http://www.grid.ac/institutes/grid.69566.3a", 
              "name": [
                "Division of Molecular Metabolism and Diabetes, Tohoku University Graduate School of Medicine, Sendai, Japan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Takahashi", 
            "givenName": "Kazuma", 
            "id": "sg:person.014022231464.05", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.014022231464.05"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Division of Stem Cell Regulation Research (G6), Osaka University Graduate School of Medicine, Osaka, Japan", 
              "id": "http://www.grid.ac/institutes/grid.136593.b", 
              "name": [
                "Division of Stem Cell Regulation Research (G6), Osaka University Graduate School of Medicine, Osaka, Japan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Miyazaki", 
            "givenName": "Jun-ichi", 
            "id": "sg:person.010216313301.83", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.010216313301.83"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Division of Gastroenterology, Tohoku University Graduate School of Medicine, Sendai, Japan", 
              "id": "http://www.grid.ac/institutes/grid.69566.3a", 
              "name": [
                "Division of Gastroenterology, Tohoku University Graduate School of Medicine, Sendai, Japan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Shimosegawa", 
            "givenName": "Tooru", 
            "id": "sg:person.01255535707.76", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01255535707.76"
            ], 
            "type": "Person"
          }
        ], 
        "citation": [
          {
            "id": "sg:pub.10.1038/sj.gt.3301841", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1036288093", 
              "https://doi.org/10.1038/sj.gt.3301841"
            ], 
            "type": "CreativeWork"
          }
        ], 
        "datePublished": "2004-09-27", 
        "datePublishedReg": "2004-09-27", 
        "description": "T-helper-1 (Th1) cytokines play an important role in Crohn's disease, and interleukin-12 (IL-12), which is composed of two subunits, p40 and p35, drives Th1 differentiation. In previous reports, IL-12 p40 was shown to prevent IL-12 from binding to the receptor. We demonstrate here the effect of IL-12 p40 overexpression in intestinal epithelia on enterocolitis mediated by Th1 cells in IL-10-deficient (IL-10\u2212/\u2212) mice on a C57BL/6J background. IL-10 deficient (IL-10\u2212/\u2212)/T3b-IL-12 p40+ (IL-12 p40+) mice and IL-10\u2212/\u2212/T3b-IL-12 p40\u2212 (IL-12 p40\u2212) mice were generated by crossing T3b-IL-12 p40 transgenic mice and IL-10\u2212/\u2212 mice. At 8 weeks of age, IL-12 p40+ mice did not show any clinical manifestations of colitis. The colon length of IL-12 p40\u2212 mice became shorter than that of IL-12 p40+ mice. The histological score of IL-12 p40+ mice was lower. Interferon-gamma (IFN-\u03b3) production was suppressed in both the mesenteric lymph node cell culture and colon tissue culture of IL-12 p40+ mice. There was no significant difference in IL-4 production and tumor necrosis factor-alpha (TNF-\u03b1) production between the two groups. These results show that overexpression of IL-12 p40 in intestinal epithelia prevents enterocolitis in IL-10\u2212/\u2212 mice by suppressing IFN-\u03b3 production, and suggest a potential clinical application of IL-12 p40 for Crohn's disease. Furthermore, these results also suggest that local gene transduction in the intestinal epithelium may be a potent therapeutic approach for Crohn's disease.", 
        "genre": "article", 
        "id": "sg:pub.10.1038/labinvest.3700175", 
        "inLanguage": "en", 
        "isAccessibleForFree": true, 
        "isPartOf": [
          {
            "id": "sg:journal.1017964", 
            "issn": [
              "0023-6837", 
              "1530-0307"
            ], 
            "name": "Laboratory Investigation", 
            "publisher": "Springer Nature", 
            "type": "Periodical"
          }, 
          {
            "issueNumber": "11", 
            "type": "PublicationIssue"
          }, 
          {
            "type": "PublicationVolume", 
            "volumeNumber": "84"
          }
        ], 
        "keywords": [
          "IL-12 p40", 
          "IL-10-deficient mice", 
          "Crohn's disease", 
          "IL-12", 
          "intestinal epithelium", 
          "tumor necrosis factor-alpha production", 
          "mesenteric lymph node cell cultures", 
          "necrosis factor-alpha production", 
          "helper 1 cytokines", 
          "lymph node cell cultures", 
          "IL-4 production", 
          "interferon-gamma production", 
          "potent therapeutic approach", 
          "weeks of age", 
          "chronic enterocolitis", 
          "colon length", 
          "IL-10", 
          "potential clinical applications", 
          "clinical manifestations", 
          "interleukin-12", 
          "Th1 cells", 
          "histological scores", 
          "Th1 differentiation", 
          "therapeutic approaches", 
          "transgenic mice", 
          "enterocolitis", 
          "C57BL/6J background", 
          "disease", 
          "mice", 
          "p40", 
          "significant differences", 
          "clinical applications", 
          "gene transduction", 
          "previous reports", 
          "epithelium", 
          "IL", 
          "cell cultures", 
          "overexpression", 
          "tissue culture", 
          "colitis", 
          "cytokines", 
          "IFN", 
          "important role", 
          "weeks", 
          "receptors", 
          "manifestations", 
          "age", 
          "scores", 
          "p35", 
          "report", 
          "cells", 
          "group", 
          "prevents", 
          "culture", 
          "differentiation", 
          "production", 
          "differences", 
          "role", 
          "background", 
          "transduction", 
          "effect", 
          "results", 
          "subunits", 
          "development", 
          "length", 
          "approach", 
          "applications"
        ], 
        "name": "IL-12 p40 prevents the development of chronic enterocolitis in IL-10-deficient mice", 
        "pagination": "1491-1500", 
        "productId": [
          {
            "name": "dimensions_id", 
            "type": "PropertyValue", 
            "value": [
              "pub.1044401990"
            ]
          }, 
          {
            "name": "doi", 
            "type": "PropertyValue", 
            "value": [
              "10.1038/labinvest.3700175"
            ]
          }, 
          {
            "name": "pubmed_id", 
            "type": "PropertyValue", 
            "value": [
              "15448706"
            ]
          }
        ], 
        "sameAs": [
          "https://doi.org/10.1038/labinvest.3700175", 
          "https://app.dimensions.ai/details/publication/pub.1044401990"
        ], 
        "sdDataset": "articles", 
        "sdDatePublished": "2022-05-20T07:22", 
        "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
        "sdPublisher": {
          "name": "Springer Nature - SN SciGraph project", 
          "type": "Organization"
        }, 
        "sdSource": "s3://com-springernature-scigraph/baseset/20220519/entities/gbq_results/article/article_390.jsonl", 
        "type": "ScholarlyArticle", 
        "url": "https://doi.org/10.1038/labinvest.3700175"
      }
    ]
     

    Download the RDF metadata as:  json-ld nt turtle xml License info

    HOW TO GET THIS DATA PROGRAMMATICALLY:

    JSON-LD is a popular format for linked data which is fully compatible with JSON.

    curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/labinvest.3700175'

    N-Triples is a line-based linked data format ideal for batch operations.

    curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/labinvest.3700175'

    Turtle is a human-readable linked data format.

    curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/labinvest.3700175'

    RDF/XML is a standard XML format for linked data.

    curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/labinvest.3700175'


     

    This table displays all metadata directly associated to this object as RDF triples.

    269 TRIPLES      22 PREDICATES      112 URIs      103 LITERALS      25 BLANK NODES

    Subject Predicate Object
    1 sg:pub.10.1038/labinvest.3700175 schema:about N0c4ffa1891bb4f1ba42ccda5ffb3b569
    2 N0d59a80fe59c441ba850b437bd5b86c6
    3 N14ac959fdf96492f9adede75e5441dda
    4 N18fd7aecd3484331b8365dcf6220a887
    5 N1920a17ca99245db978337df31f3fc8a
    6 N1c781ccffa4145958501b3a7b5bfc0aa
    7 N1cc4e0d682574a76af4c7125eab33294
    8 N30d042730cab47949f53fccc1ab5fb32
    9 N41d8a36735c9407681f9c5a85c8d4818
    10 N4982b0a07fcb480cb6ed4d2b265a8bec
    11 N4be37756e2144a929adfc5921000f7ac
    12 N61e4cbc82a0a47fc8d58e5987389fabc
    13 N6a896682314c4d2a9dc82bafe660b132
    14 N926b7c60aff94ef0a99158a711dbce7d
    15 Nc4b9fc130ef842c6bd64df4fdb799d1b
    16 Nc5348501e877482aaeb06732ab2b5d9a
    17 Nd5174db05c744bc7861ed0e75782e959
    18 Nd518051588324bf2abca63a698c01c2d
    19 anzsrc-for:11
    20 anzsrc-for:1107
    21 schema:author N3e57f058ca3a4a86a89d937ba453f862
    22 schema:citation sg:pub.10.1038/sj.gt.3301841
    23 schema:datePublished 2004-09-27
    24 schema:datePublishedReg 2004-09-27
    25 schema:description T-helper-1 (Th1) cytokines play an important role in Crohn's disease, and interleukin-12 (IL-12), which is composed of two subunits, p40 and p35, drives Th1 differentiation. In previous reports, IL-12 p40 was shown to prevent IL-12 from binding to the receptor. We demonstrate here the effect of IL-12 p40 overexpression in intestinal epithelia on enterocolitis mediated by Th1 cells in IL-10-deficient (IL-10−/−) mice on a C57BL/6J background. IL-10 deficient (IL-10−/−)/T3b-IL-12 p40+ (IL-12 p40+) mice and IL-10−/−/T3b-IL-12 p40− (IL-12 p40−) mice were generated by crossing T3b-IL-12 p40 transgenic mice and IL-10−/− mice. At 8 weeks of age, IL-12 p40+ mice did not show any clinical manifestations of colitis. The colon length of IL-12 p40− mice became shorter than that of IL-12 p40+ mice. The histological score of IL-12 p40+ mice was lower. Interferon-gamma (IFN-γ) production was suppressed in both the mesenteric lymph node cell culture and colon tissue culture of IL-12 p40+ mice. There was no significant difference in IL-4 production and tumor necrosis factor-alpha (TNF-α) production between the two groups. These results show that overexpression of IL-12 p40 in intestinal epithelia prevents enterocolitis in IL-10−/− mice by suppressing IFN-γ production, and suggest a potential clinical application of IL-12 p40 for Crohn's disease. Furthermore, these results also suggest that local gene transduction in the intestinal epithelium may be a potent therapeutic approach for Crohn's disease.
    26 schema:genre article
    27 schema:inLanguage en
    28 schema:isAccessibleForFree true
    29 schema:isPartOf N3153f1f9e4764b649a42f8f9400e7f6a
    30 N98fbd307299d4d97b8f73dff4ca8da66
    31 sg:journal.1017964
    32 schema:keywords C57BL/6J background
    33 Crohn's disease
    34 IFN
    35 IL
    36 IL-10
    37 IL-10-deficient mice
    38 IL-12
    39 IL-12 p40
    40 IL-4 production
    41 Th1 cells
    42 Th1 differentiation
    43 age
    44 applications
    45 approach
    46 background
    47 cell cultures
    48 cells
    49 chronic enterocolitis
    50 clinical applications
    51 clinical manifestations
    52 colitis
    53 colon length
    54 culture
    55 cytokines
    56 development
    57 differences
    58 differentiation
    59 disease
    60 effect
    61 enterocolitis
    62 epithelium
    63 gene transduction
    64 group
    65 helper 1 cytokines
    66 histological scores
    67 important role
    68 interferon-gamma production
    69 interleukin-12
    70 intestinal epithelium
    71 length
    72 lymph node cell cultures
    73 manifestations
    74 mesenteric lymph node cell cultures
    75 mice
    76 necrosis factor-alpha production
    77 overexpression
    78 p35
    79 p40
    80 potent therapeutic approach
    81 potential clinical applications
    82 prevents
    83 previous reports
    84 production
    85 receptors
    86 report
    87 results
    88 role
    89 scores
    90 significant differences
    91 subunits
    92 therapeutic approaches
    93 tissue culture
    94 transduction
    95 transgenic mice
    96 tumor necrosis factor-alpha production
    97 weeks
    98 weeks of age
    99 schema:name IL-12 p40 prevents the development of chronic enterocolitis in IL-10-deficient mice
    100 schema:pagination 1491-1500
    101 schema:productId N0ca55a180d5a440bb98825844bd510cd
    102 N1d18c2119e89438eb44ab1743584681f
    103 Nd4d394e7fbef4f4fae91e9b91ca0c797
    104 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044401990
    105 https://doi.org/10.1038/labinvest.3700175
    106 schema:sdDatePublished 2022-05-20T07:22
    107 schema:sdLicense https://scigraph.springernature.com/explorer/license/
    108 schema:sdPublisher N15ea29db90b74bdfa00148ad4e8c522b
    109 schema:url https://doi.org/10.1038/labinvest.3700175
    110 sgo:license sg:explorer/license/
    111 sgo:sdDataset articles
    112 rdf:type schema:ScholarlyArticle
    113 N0c4ffa1891bb4f1ba42ccda5ffb3b569 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    114 schema:name Body Weight
    115 rdf:type schema:DefinedTerm
    116 N0ca55a180d5a440bb98825844bd510cd schema:name doi
    117 schema:value 10.1038/labinvest.3700175
    118 rdf:type schema:PropertyValue
    119 N0d59a80fe59c441ba850b437bd5b86c6 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    120 schema:name Th1 Cells
    121 rdf:type schema:DefinedTerm
    122 N14ac959fdf96492f9adede75e5441dda schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    123 schema:name Protein Subunits
    124 rdf:type schema:DefinedTerm
    125 N15ea29db90b74bdfa00148ad4e8c522b schema:name Springer Nature - SN SciGraph project
    126 rdf:type schema:Organization
    127 N180f6b5532fd413f9171f275adba69a9 rdf:first sg:person.010216313301.83
    128 rdf:rest Nc1d2905143a849bfa6bc04cabb45ed0f
    129 N18fd7aecd3484331b8365dcf6220a887 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    130 schema:name Lymph Nodes
    131 rdf:type schema:DefinedTerm
    132 N1920a17ca99245db978337df31f3fc8a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    133 schema:name Interferon-gamma
    134 rdf:type schema:DefinedTerm
    135 N1c781ccffa4145958501b3a7b5bfc0aa schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    136 schema:name Colon
    137 rdf:type schema:DefinedTerm
    138 N1cc4e0d682574a76af4c7125eab33294 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    139 schema:name Interleukin-12 Subunit p40
    140 rdf:type schema:DefinedTerm
    141 N1d18c2119e89438eb44ab1743584681f schema:name dimensions_id
    142 schema:value pub.1044401990
    143 rdf:type schema:PropertyValue
    144 N30d042730cab47949f53fccc1ab5fb32 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    145 schema:name Disease Models, Animal
    146 rdf:type schema:DefinedTerm
    147 N3153f1f9e4764b649a42f8f9400e7f6a schema:volumeNumber 84
    148 rdf:type schema:PublicationVolume
    149 N3e57f058ca3a4a86a89d937ba453f862 rdf:first sg:person.0776123010.91
    150 rdf:rest Nae9be657e2e9488984524972e7edc493
    151 N41d8a36735c9407681f9c5a85c8d4818 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    152 schema:name Immunoenzyme Techniques
    153 rdf:type schema:DefinedTerm
    154 N42c12ed50e42451e93626988e4030408 rdf:first sg:person.0613451524.61
    155 rdf:rest N6897301eb5484fee84bf7f33f1b0b7f5
    156 N4982b0a07fcb480cb6ed4d2b265a8bec schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    157 schema:name Enterocolitis
    158 rdf:type schema:DefinedTerm
    159 N4be37756e2144a929adfc5921000f7ac schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    160 schema:name Mice, Knockout
    161 rdf:type schema:DefinedTerm
    162 N61e4cbc82a0a47fc8d58e5987389fabc schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    163 schema:name Interleukin-10
    164 rdf:type schema:DefinedTerm
    165 N6897301eb5484fee84bf7f33f1b0b7f5 rdf:first sg:person.014022231464.05
    166 rdf:rest N180f6b5532fd413f9171f275adba69a9
    167 N6a896682314c4d2a9dc82bafe660b132 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    168 schema:name Animals
    169 rdf:type schema:DefinedTerm
    170 N761128cf4b02407a83f461d2f49fb635 rdf:first sg:person.0576743607.02
    171 rdf:rest N42c12ed50e42451e93626988e4030408
    172 N89c9a39854ca4ab8af59bda5dda99af5 rdf:first sg:person.01145574514.32
    173 rdf:rest Ndb64d0a8611740588b7bbb3358cb823f
    174 N926b7c60aff94ef0a99158a711dbce7d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    175 schema:name Interleukin-12
    176 rdf:type schema:DefinedTerm
    177 N98fbd307299d4d97b8f73dff4ca8da66 schema:issueNumber 11
    178 rdf:type schema:PublicationIssue
    179 Nae9be657e2e9488984524972e7edc493 rdf:first sg:person.01025452534.43
    180 rdf:rest N89c9a39854ca4ab8af59bda5dda99af5
    181 Nc1d2905143a849bfa6bc04cabb45ed0f rdf:first sg:person.01255535707.76
    182 rdf:rest rdf:nil
    183 Nc4b9fc130ef842c6bd64df4fdb799d1b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    184 schema:name Mice, Inbred C57BL
    185 rdf:type schema:DefinedTerm
    186 Nc5348501e877482aaeb06732ab2b5d9a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    187 schema:name Cells, Cultured
    188 rdf:type schema:DefinedTerm
    189 Nd4d394e7fbef4f4fae91e9b91ca0c797 schema:name pubmed_id
    190 schema:value 15448706
    191 rdf:type schema:PropertyValue
    192 Nd5174db05c744bc7861ed0e75782e959 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    193 schema:name Fluorescent Antibody Technique, Indirect
    194 rdf:type schema:DefinedTerm
    195 Nd518051588324bf2abca63a698c01c2d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    196 schema:name Mice
    197 rdf:type schema:DefinedTerm
    198 Ndb64d0a8611740588b7bbb3358cb823f rdf:first sg:person.01304671035.37
    199 rdf:rest N761128cf4b02407a83f461d2f49fb635
    200 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
    201 schema:name Medical and Health Sciences
    202 rdf:type schema:DefinedTerm
    203 anzsrc-for:1107 schema:inDefinedTermSet anzsrc-for:
    204 schema:name Immunology
    205 rdf:type schema:DefinedTerm
    206 sg:journal.1017964 schema:issn 0023-6837
    207 1530-0307
    208 schema:name Laboratory Investigation
    209 schema:publisher Springer Nature
    210 rdf:type schema:Periodical
    211 sg:person.010216313301.83 schema:affiliation grid-institutes:grid.136593.b
    212 schema:familyName Miyazaki
    213 schema:givenName Jun-ichi
    214 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.010216313301.83
    215 rdf:type schema:Person
    216 sg:person.01025452534.43 schema:affiliation grid-institutes:grid.69566.3a
    217 schema:familyName Aihara
    218 schema:givenName Hiroyuki
    219 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01025452534.43
    220 rdf:type schema:Person
    221 sg:person.01145574514.32 schema:affiliation grid-institutes:grid.69566.3a
    222 schema:familyName Kinouchi
    223 schema:givenName Yoshitaka
    224 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01145574514.32
    225 rdf:type schema:Person
    226 sg:person.01255535707.76 schema:affiliation grid-institutes:grid.69566.3a
    227 schema:familyName Shimosegawa
    228 schema:givenName Tooru
    229 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01255535707.76
    230 rdf:type schema:Person
    231 sg:person.01304671035.37 schema:affiliation grid-institutes:grid.69566.3a
    232 schema:familyName Takahashi
    233 schema:givenName Seiichi
    234 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01304671035.37
    235 rdf:type schema:Person
    236 sg:person.014022231464.05 schema:affiliation grid-institutes:grid.69566.3a
    237 schema:familyName Takahashi
    238 schema:givenName Kazuma
    239 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.014022231464.05
    240 rdf:type schema:Person
    241 sg:person.0576743607.02 schema:affiliation grid-institutes:grid.69566.3a
    242 schema:familyName Oki
    243 schema:givenName Motoji
    244 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0576743607.02
    245 rdf:type schema:Person
    246 sg:person.0613451524.61 schema:affiliation grid-institutes:grid.415512.6
    247 schema:familyName Noguchi
    248 schema:givenName Mitsunori
    249 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0613451524.61
    250 rdf:type schema:Person
    251 sg:person.0776123010.91 schema:affiliation grid-institutes:grid.69566.3a
    252 schema:familyName Shiraki
    253 schema:givenName Manabu
    254 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0776123010.91
    255 rdf:type schema:Person
    256 sg:pub.10.1038/sj.gt.3301841 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036288093
    257 https://doi.org/10.1038/sj.gt.3301841
    258 rdf:type schema:CreativeWork
    259 grid-institutes:grid.136593.b schema:alternateName Division of Stem Cell Regulation Research (G6), Osaka University Graduate School of Medicine, Osaka, Japan
    260 schema:name Division of Stem Cell Regulation Research (G6), Osaka University Graduate School of Medicine, Osaka, Japan
    261 rdf:type schema:Organization
    262 grid-institutes:grid.415512.6 schema:alternateName Sendai Shakaihoken Hospital, Sendai, Japan
    263 schema:name Sendai Shakaihoken Hospital, Sendai, Japan
    264 rdf:type schema:Organization
    265 grid-institutes:grid.69566.3a schema:alternateName Division of Gastroenterology, Tohoku University Graduate School of Medicine, Sendai, Japan
    266 Division of Molecular Metabolism and Diabetes, Tohoku University Graduate School of Medicine, Sendai, Japan
    267 schema:name Division of Gastroenterology, Tohoku University Graduate School of Medicine, Sendai, Japan
    268 Division of Molecular Metabolism and Diabetes, Tohoku University Graduate School of Medicine, Sendai, Japan
    269 rdf:type schema:Organization
     




    Preview window. Press ESC to close (or click here)


    ...