Correlation between histone acetylation and expression of Notch1 in human lung carcinoma and its possible role in combined small-cell lung ... View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2017-08

AUTHORS

Wael Abdo Hassan, Shin-Ichiro Takebayashi, Mohamed Osama Ali Abdalla, Kosuke Fujino, Shinji Kudoh, Yamoto Motooka, Yonosuke Sato, Yoshiki Naito, Koichi Higaki, Joeji Wakimoto, Seiji Okada, Mituyoshi Nakao, Yuichi Ishikawa, Takaaki Ito

ABSTRACT

Combined small-cell lung carcinoma (cSCLC) is composed of small-cell lung carcinoma (SCLC) admixed with non-small-cell lung carcinoma (NSCLC). Evaluating the molecular differences between SCLC and NSCLC could lead to a better understanding of the pathogenesis of such neoplasms. Therefore, in this study, we investigated the correlation between histone acetylation and Notch1 expression in lung carcinoma. Using chromatin immunoprecipitation (ChIP) assay, we measured the level of acetylated histone H3 around the promoter region of Notch1 in SCLC and NSCLC cells. We then treated SCLC cells with trichostatin A (TSA) and characterized the level of histone H3 acetylation at Notch1. In addition, TSA-treated cells were injected into immune-compromised mice, for analysis of the ex vivo tumor xenograft phenotype. The level of acetylated histone H3 surrounding the Notch1 promoter was lower in lung cancer cells not expressing Notch1. Tumors originated from TSA-treated SCLC cells occasionally formed an epithelial-like glandular arrangement of cells; with Notch1 expression and decreased expression of neuroendocrine (NE) markers. Histone deacetylation around the promoter region of Notch1 inhibits Notch1 protein expression in SCLC and the restoration of Notch1 expression in SCLC leads to the concurrent appearance of epithelial-like areas within the SCLC, which could provide a possible mechanism for histogenesis of cSCLC. More... »

PAGES

913-921

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/labinvest.2017.36

DOI

http://dx.doi.org/10.1038/labinvest.2017.36

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1084860339

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/28414324


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Turtle is a human-readable linked data format.

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RDF/XML is a standard XML format for linked data.

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308 https://www.grid.ac/institutes/grid.33003.33 schema:alternateName Suez Canal University
309 schema:name Department of Clinical Pathology, Faculty of Medicine, Suez Canal University, Ismailia, Egypt.
310 Department of Medical Cell Biology, Institute of Molecular Embryology and Genetics, Kumamoto University, Japan.
311 Department of Pathology and Experimental Medicine, Graduate School of Medical Sciences, Kumamoto University, Kumamoto, Japan.
312 Department of Pathology, Faculty of Medicine, Suez Canal University, Ismailia, Egypt.
313 rdf:type schema:Organization
314 https://www.grid.ac/institutes/grid.410781.b schema:alternateName Kurume University
315 schema:name Department of Pathology, Kurume University School of Medicine, Kurume, Japan.
316 rdf:type schema:Organization
317 https://www.grid.ac/institutes/grid.486756.e schema:alternateName The Cancer Institute Hospital
318 schema:name Division of Pathology, The Cancer Institute of Japanese Foundation for Cancer Research, Tokyo, Japan.
319 rdf:type schema:Organization
 




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