Angiotensin-converting enzyme affects the presentation of MHC class II antigens View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2017-04-10

AUTHORS

Tuantuan Zhao, Kenneth E Bernstein, Jianmin Fang, Xiao Z Shen

ABSTRACT

Antigen processing and presentation through the MHC class II pathway is critical for activating T helper cells. Angiotensin-converting enzyme (ACE) is a carboxyl peptidase expressed by antigen-presenting cells. By analysis of ACE null (knockout), wild-type, and ACE-overexpressing (ACE10) mice and the antigen-presenting cells derived from these mice, we found that ACE has a physiological role in the processing of peptides for MHC class II presentation. The efficiency of presenting MHC class II epitopes from ovalbumin (OVA) and hen egg lysosome is markedly affected by cellular ACE levels. Mice overexpressing ACE in myeloid cells have a much more vigorous CD4+ T-cell and antibody response when immunized with OVA. ACE is present in the endosomal pathway where MHC class II peptide processing and loading occur. The efficiency of MHC class II antigen presentation can be altered by ACE overexpression or ACE pharmacological inhibition. Thus, ACE is a dynamic participant in processing MHC class II peptides. Manipulation of ACE expression by antigen-presenting cells may prove to be a novel strategy to alter the immune response. More... »

PAGES

764-771

References to SciGraph publications

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/labinvest.2017.32

DOI

http://dx.doi.org/10.1038/labinvest.2017.32

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1084767526

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/28394320


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215 schema:name Department of Biomedical Sciences, Cedars-Sinai Medical Center, Los Angeles, CA, USA
216 Laboratory of Molecular Medicine, Shanghai Key Laboratory of Signaling and Disease Research, School of Life Sciences and Technology, Tongji University, Shanghai, China
217 rdf:type schema:Organization
 




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