BAG3 regulates epithelial–mesenchymal transition and angiogenesis in human hepatocellular carcinoma View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2013-12-23

AUTHORS

Heng Xiao, Shaobing Cheng, Rongliang Tong, Zheng Lv, Chaofeng Ding, Chengli Du, Haiyang Xie, Lin Zhou, Jian Wu, Shusen Zheng

ABSTRACT

Bcl2-associated athanogene 3 (BAG3) protein is a co-chaperone of heat-shock protein (Hsp) 70 and may regulate major physiological and pathophysiological processes. However, few reports have examined the role of BAG3 in human hepatocellular carcinoma (HCC). In this study, we show that BAG3 regulates epithelial–mesenchymal transition (EMT) and angiogenesis in HCC. BAG3 was overexpressed in HCC tissues and cell lines. BAG3 knockdown resulted in reduction in migration and invasion of HCC cells, which was linked to reversion of EMT by increasing E-cadherin expression and decreasing N-cadherin, vimentin and slug expression, as well as suppressing matrix metalloproteinase 2 (MMP-2) expression. In a xenograft tumorigenicity model, BAG3 knockdown effectively inhibited tumor growth and metastasis through reduction in CD34 and VEGF expression and reversal of the EMT pathway. In conclusion, BAG3 is associated with the invasiveness and angiogenesis in HCC, and the BAG3 gene may be a novel therapeutic approach against HCC. More... »

PAGES

252-261

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/labinvest.2013.151

DOI

http://dx.doi.org/10.1038/labinvest.2013.151

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1038072262

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/24365746


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