Metal-free imidazolium salts inhibit the growth of hepatocellular carcinoma in a mouse model View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2011-05

AUTHORS

Began Gopalan, Zhiyuan Ke, Chunyan Zhang, Yinling Kng, Nur-Afidah Mohamed Suhaimi, Siti Nurhanna Riduan, Yugen Zhang, Lang Zhuo

ABSTRACT

Imidazolium salts (IMSs) are precursors to N-heterocyclic carbenes (NHCs), which are routinely used as ligands or organo-catalysts in synthetic chemistry. We recently identified several IMSs as anti-fibrotic agents in liver fibrosis, which often has a consequence in the oncogenesis of hepatocellular carcinoma (HCC). Here, we investigate the potential anti-tumor property of three IMSs (named IBN-1, IBN-9, and DPIM) in HCC cell lines and in a xenograft mouse model. Our results showed that both IBN-1 and IBN-9 significantly inhibited the cell proliferation and arrested HCC cells in the G1-phase, whereas DPIM did not have any anti-tumor activity. When tested in a Huh7 HCC xenograft mouse model, IBN-1 reduced the tumor volume by 31% (P<0.05), however accompanied by a 9% loss in body weight (P<0.005), suggesting a general toxicity. In contrast, IBN-9 significantly reduced the tumor volume by 45% (P<0.05) and 60% (P<0.01) at doses of 0.6 and 1.5 g/l in drinking water, respectively, without any loss in body weight. Our in vitro and in vivo data suggested that IBN-1 and IBN-9 inhibited the growth of HCC by suppressing the expression of Survivin and Cyclin-dependent kinases. The current study provides a proof of concept for using the metal-free IMSs to develop novel anti-cancer agents. More... »

PAGES

744

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/labinvest.2011.4

DOI

http://dx.doi.org/10.1038/labinvest.2011.4

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1000270369

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/21339744


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1112", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Oncology and Carcinogenesis", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Animals", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Blotting, Western", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Carcinoma, Hepatocellular", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cell Cycle", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cell Division", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cyclin-Dependent Kinases", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Disease Models, Animal", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Imidazoles", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Immunohistochemistry", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "In Situ Nick-End Labeling", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Inhibitor of Apoptosis Proteins", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Liver Neoplasms, Experimental", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Mice", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Mice, Inbred BALB C", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Mice, Nude", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Repressor Proteins", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Salts", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Institute of Bioengineering and Nanotechnology", 
          "id": "https://www.grid.ac/institutes/grid.418830.6", 
          "name": [
            "Institute of Bioengineering and Nanotechnology, Biopolis, Singapore, Singapore"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Gopalan", 
        "givenName": "Began", 
        "id": "sg:person.01372704634.18", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01372704634.18"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Institute of Bioengineering and Nanotechnology", 
          "id": "https://www.grid.ac/institutes/grid.418830.6", 
          "name": [
            "Institute of Bioengineering and Nanotechnology, Biopolis, Singapore, Singapore"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Ke", 
        "givenName": "Zhiyuan", 
        "id": "sg:person.01034410426.80", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01034410426.80"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Institute of Bioengineering and Nanotechnology", 
          "id": "https://www.grid.ac/institutes/grid.418830.6", 
          "name": [
            "Institute of Bioengineering and Nanotechnology, Biopolis, Singapore, Singapore"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Zhang", 
        "givenName": "Chunyan", 
        "id": "sg:person.01317604564.04", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01317604564.04"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Institute of Bioengineering and Nanotechnology", 
          "id": "https://www.grid.ac/institutes/grid.418830.6", 
          "name": [
            "Institute of Bioengineering and Nanotechnology, Biopolis, Singapore, Singapore"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Kng", 
        "givenName": "Yinling", 
        "id": "sg:person.0636375633.71", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0636375633.71"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Institute of Bioengineering and Nanotechnology", 
          "id": "https://www.grid.ac/institutes/grid.418830.6", 
          "name": [
            "Institute of Bioengineering and Nanotechnology, Biopolis, Singapore, Singapore"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Suhaimi", 
        "givenName": "Nur-Afidah Mohamed", 
        "id": "sg:person.0642313664.37", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0642313664.37"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Institute of Bioengineering and Nanotechnology", 
          "id": "https://www.grid.ac/institutes/grid.418830.6", 
          "name": [
            "Institute of Bioengineering and Nanotechnology, Biopolis, Singapore, Singapore"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Riduan", 
        "givenName": "Siti Nurhanna", 
        "id": "sg:person.012313166136.37", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012313166136.37"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Institute of Bioengineering and Nanotechnology", 
          "id": "https://www.grid.ac/institutes/grid.418830.6", 
          "name": [
            "Institute of Bioengineering and Nanotechnology, Biopolis, Singapore, Singapore"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Zhang", 
        "givenName": "Yugen", 
        "id": "sg:person.0576407713.06", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0576407713.06"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Institute of Bioengineering and Nanotechnology", 
          "id": "https://www.grid.ac/institutes/grid.418830.6", 
          "name": [
            "Institute of Bioengineering and Nanotechnology, Biopolis, Singapore, Singapore"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Zhuo", 
        "givenName": "Lang", 
        "id": "sg:person.01361324025.97", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01361324025.97"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.1158/0008-5472.can-07-1343", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1000430897"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nrc2602", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1008867916", 
          "https://doi.org/10.1038/nrc2602"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.bmcl.2009.11.085", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1015481316"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ng0802-339", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1017140614", 
          "https://doi.org/10.1038/ng0802-339"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ng0802-339", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1017140614", 
          "https://doi.org/10.1038/ng0802-339"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ng0802-339", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1017140614", 
          "https://doi.org/10.1038/ng0802-339"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/hep.22082", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1019312922"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/chem.200801992", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1019438061"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nrc2293", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1020411420", 
          "https://doi.org/10.1038/nrc2293"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.onc.1210811", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1022095490", 
          "https://doi.org/10.1038/sj.onc.1210811"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1200/jco.2005.03.196", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1023556043"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1158/1078-0432.ccr-08-1946", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1026154465"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.0609757104", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1027158008"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/onc.2008.448", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1027217991", 
          "https://doi.org/10.1038/onc.2008.448"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.onc.1203665", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1027293885", 
          "https://doi.org/10.1038/sj.onc.1203665"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.onc.1203665", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1027293885", 
          "https://doi.org/10.1038/sj.onc.1203665"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1152/physrev.00013.2007", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1028143968"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1158/0008-5472.can-09-0301", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037872980"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/jcb.1228", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1038777271"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.0405407101", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1043089695"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.ijrobp.2008.02.011", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1047795230"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/1479-5876-6-24", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1048809078", 
          "https://doi.org/10.1186/1479-5876-6-24"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1053/he.2000.6496", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1051555850"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature03096", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1051657854", 
          "https://doi.org/10.1038/nature03096"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature03096", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1051657854", 
          "https://doi.org/10.1038/nature03096"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/cad.0b013e328327994e", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1052081198"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/cad.0b013e328327994e", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1052081198"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/cad.0b013e328327994e", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1052081198"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1056/nejmoa0708857", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1053513212"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1021/cr800500u", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1053815852"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1021/cr800500u", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1053815852"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1021/ci900398f", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1055404856"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1021/ci900398f", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1055404856"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1021/ja075889z", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1055845939"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1021/ja075889z", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1055845939"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1021/ja8037883", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1055858726"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1021/ja8037883", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1055858726"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1053/j.humpath.2003.07.016", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1057076256"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1055/s-1996-4293", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1057397038"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3892/ijmm.18.6.1141", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1071506492"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2011-05", 
    "datePublishedReg": "2011-05-01", 
    "description": "Imidazolium salts (IMSs) are precursors to N-heterocyclic carbenes (NHCs), which are routinely used as ligands or organo-catalysts in synthetic chemistry. We recently identified several IMSs as anti-fibrotic agents in liver fibrosis, which often has a consequence in the oncogenesis of hepatocellular carcinoma (HCC). Here, we investigate the potential anti-tumor property of three IMSs (named IBN-1, IBN-9, and DPIM) in HCC cell lines and in a xenograft mouse model. Our results showed that both IBN-1 and IBN-9 significantly inhibited the cell proliferation and arrested HCC cells in the G1-phase, whereas DPIM did not have any anti-tumor activity. When tested in a Huh7 HCC xenograft mouse model, IBN-1 reduced the tumor volume by 31% (P<0.05), however accompanied by a 9% loss in body weight (P<0.005), suggesting a general toxicity. In contrast, IBN-9 significantly reduced the tumor volume by 45% (P<0.05) and 60% (P<0.01) at doses of 0.6 and 1.5 g/l in drinking water, respectively, without any loss in body weight. Our in vitro and in vivo data suggested that IBN-1 and IBN-9 inhibited the growth of HCC by suppressing the expression of Survivin and Cyclin-dependent kinases. The current study provides a proof of concept for using the metal-free IMSs to develop novel anti-cancer agents.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1038/labinvest.2011.4", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": true, 
    "isPartOf": [
      {
        "id": "sg:journal.1017964", 
        "issn": [
          "0023-6837", 
          "1530-0307"
        ], 
        "name": "Laboratory Investigation", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "5", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "91"
      }
    ], 
    "name": "Metal-free imidazolium salts inhibit the growth of hepatocellular carcinoma in a mouse model", 
    "pagination": "744", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "01491184918eee7f7da5a66d298ee2d37974b7e8e9efe9b53aefa943ffa757ef"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "21339744"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "0376617"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1038/labinvest.2011.4"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1000270369"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1038/labinvest.2011.4", 
      "https://app.dimensions.ai/details/publication/pub.1000270369"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-11T00:05", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8695_00000436.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://www.nature.com/articles/labinvest20114"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/labinvest.2011.4'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/labinvest.2011.4'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/labinvest.2011.4'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/labinvest.2011.4'


 

This table displays all metadata directly associated to this object as RDF triples.

284 TRIPLES      21 PREDICATES      76 URIs      38 LITERALS      26 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1038/labinvest.2011.4 schema:about N011dc3f9c18c4da9b6de1a9eb591ab34
2 N0f7e910982aa45c0b98ac941e1f22524
3 N2406feb81d144e6bb72097735c5c10d0
4 N26b08e321d734d3ca5eef678463580d9
5 N4268613c8ce74ae383bc3ab814356da2
6 N49c240e263534f60b9e91a7566183ea5
7 N55acd16311f848a4834e8950eb93dde8
8 N5d5da4eb26624632a3c6b75c8b836c72
9 N617c434db12749dcb5d81b257668cd9a
10 N711db1a07f154eaa88215acbd40bd40a
11 Na87ada2bb7a643898df02fcab04ab169
12 Ncec132281f464e848189bd1d0f700dc5
13 Nd77e91102384447b917c7407b0374719
14 Ndfe1146c38b749afbddc17f3c90a7f94
15 Ne151b4e52d69402db4794a018d052dfa
16 Ne9d6d8652e7b4e28a5d9189e3f685c6c
17 Nedcbe85a07224562b5124832fd1ed0cb
18 anzsrc-for:11
19 anzsrc-for:1112
20 schema:author Ndd7b0500048249559f7a4a93ed8ee93b
21 schema:citation sg:pub.10.1038/nature03096
22 sg:pub.10.1038/ng0802-339
23 sg:pub.10.1038/nrc2293
24 sg:pub.10.1038/nrc2602
25 sg:pub.10.1038/onc.2008.448
26 sg:pub.10.1038/sj.onc.1203665
27 sg:pub.10.1038/sj.onc.1210811
28 sg:pub.10.1186/1479-5876-6-24
29 https://doi.org/10.1002/chem.200801992
30 https://doi.org/10.1002/hep.22082
31 https://doi.org/10.1002/jcb.1228
32 https://doi.org/10.1016/j.bmcl.2009.11.085
33 https://doi.org/10.1016/j.ijrobp.2008.02.011
34 https://doi.org/10.1021/ci900398f
35 https://doi.org/10.1021/cr800500u
36 https://doi.org/10.1021/ja075889z
37 https://doi.org/10.1021/ja8037883
38 https://doi.org/10.1053/he.2000.6496
39 https://doi.org/10.1053/j.humpath.2003.07.016
40 https://doi.org/10.1055/s-1996-4293
41 https://doi.org/10.1056/nejmoa0708857
42 https://doi.org/10.1073/pnas.0405407101
43 https://doi.org/10.1073/pnas.0609757104
44 https://doi.org/10.1097/cad.0b013e328327994e
45 https://doi.org/10.1152/physrev.00013.2007
46 https://doi.org/10.1158/0008-5472.can-07-1343
47 https://doi.org/10.1158/0008-5472.can-09-0301
48 https://doi.org/10.1158/1078-0432.ccr-08-1946
49 https://doi.org/10.1200/jco.2005.03.196
50 https://doi.org/10.3892/ijmm.18.6.1141
51 schema:datePublished 2011-05
52 schema:datePublishedReg 2011-05-01
53 schema:description Imidazolium salts (IMSs) are precursors to N-heterocyclic carbenes (NHCs), which are routinely used as ligands or organo-catalysts in synthetic chemistry. We recently identified several IMSs as anti-fibrotic agents in liver fibrosis, which often has a consequence in the oncogenesis of hepatocellular carcinoma (HCC). Here, we investigate the potential anti-tumor property of three IMSs (named IBN-1, IBN-9, and DPIM) in HCC cell lines and in a xenograft mouse model. Our results showed that both IBN-1 and IBN-9 significantly inhibited the cell proliferation and arrested HCC cells in the G1-phase, whereas DPIM did not have any anti-tumor activity. When tested in a Huh7 HCC xenograft mouse model, IBN-1 reduced the tumor volume by 31% (P<0.05), however accompanied by a 9% loss in body weight (P<0.005), suggesting a general toxicity. In contrast, IBN-9 significantly reduced the tumor volume by 45% (P<0.05) and 60% (P<0.01) at doses of 0.6 and 1.5 g/l in drinking water, respectively, without any loss in body weight. Our in vitro and in vivo data suggested that IBN-1 and IBN-9 inhibited the growth of HCC by suppressing the expression of Survivin and Cyclin-dependent kinases. The current study provides a proof of concept for using the metal-free IMSs to develop novel anti-cancer agents.
54 schema:genre research_article
55 schema:inLanguage en
56 schema:isAccessibleForFree true
57 schema:isPartOf Nd792a45001324b789571e55920136c22
58 Nfcc4bf184f7248499b17fcacaa8a2146
59 sg:journal.1017964
60 schema:name Metal-free imidazolium salts inhibit the growth of hepatocellular carcinoma in a mouse model
61 schema:pagination 744
62 schema:productId N083b4c255bfb42939c8dfabc4882c0b2
63 N0a5c161f1b4d462e996310f1e3e845b8
64 N75a79e9e64b842d6b3806ddc03a0160b
65 Nb9ed09dc24b84bd594367c456c1e44a0
66 Nf28249f66ec643af802b49e4905adca7
67 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000270369
68 https://doi.org/10.1038/labinvest.2011.4
69 schema:sdDatePublished 2019-04-11T00:05
70 schema:sdLicense https://scigraph.springernature.com/explorer/license/
71 schema:sdPublisher N4d49488c7cc94ed6bc51926f91b762a5
72 schema:url https://www.nature.com/articles/labinvest20114
73 sgo:license sg:explorer/license/
74 sgo:sdDataset articles
75 rdf:type schema:ScholarlyArticle
76 N011dc3f9c18c4da9b6de1a9eb591ab34 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
77 schema:name Blotting, Western
78 rdf:type schema:DefinedTerm
79 N083b4c255bfb42939c8dfabc4882c0b2 schema:name readcube_id
80 schema:value 01491184918eee7f7da5a66d298ee2d37974b7e8e9efe9b53aefa943ffa757ef
81 rdf:type schema:PropertyValue
82 N0a5c161f1b4d462e996310f1e3e845b8 schema:name dimensions_id
83 schema:value pub.1000270369
84 rdf:type schema:PropertyValue
85 N0f7e910982aa45c0b98ac941e1f22524 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
86 schema:name Animals
87 rdf:type schema:DefinedTerm
88 N1db19368a8864659a795291ac6cd610c rdf:first sg:person.0576407713.06
89 rdf:rest Nc6d2d7b7654a4cb2b203f82cc531fdab
90 N2406feb81d144e6bb72097735c5c10d0 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
91 schema:name Salts
92 rdf:type schema:DefinedTerm
93 N26b08e321d734d3ca5eef678463580d9 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
94 schema:name Immunohistochemistry
95 rdf:type schema:DefinedTerm
96 N298fd1994abb4bae9c484549f5e860b8 rdf:first sg:person.0636375633.71
97 rdf:rest Nc2f94676b055459281bd835901140bc5
98 N36ed06960ae8495c81d8484877ffc7c7 rdf:first sg:person.01034410426.80
99 rdf:rest Ne8f0a925038c4c9a9902e6bba4118389
100 N4268613c8ce74ae383bc3ab814356da2 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
101 schema:name Inhibitor of Apoptosis Proteins
102 rdf:type schema:DefinedTerm
103 N49c240e263534f60b9e91a7566183ea5 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
104 schema:name Mice, Inbred BALB C
105 rdf:type schema:DefinedTerm
106 N4d49488c7cc94ed6bc51926f91b762a5 schema:name Springer Nature - SN SciGraph project
107 rdf:type schema:Organization
108 N55acd16311f848a4834e8950eb93dde8 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
109 schema:name Cell Cycle
110 rdf:type schema:DefinedTerm
111 N5d5da4eb26624632a3c6b75c8b836c72 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
112 schema:name Cell Division
113 rdf:type schema:DefinedTerm
114 N617c434db12749dcb5d81b257668cd9a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
115 schema:name Cyclin-Dependent Kinases
116 rdf:type schema:DefinedTerm
117 N711db1a07f154eaa88215acbd40bd40a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
118 schema:name Imidazoles
119 rdf:type schema:DefinedTerm
120 N75a79e9e64b842d6b3806ddc03a0160b schema:name doi
121 schema:value 10.1038/labinvest.2011.4
122 rdf:type schema:PropertyValue
123 N7c44a671ddb747bcaebd0f4d86016385 rdf:first sg:person.012313166136.37
124 rdf:rest N1db19368a8864659a795291ac6cd610c
125 Na87ada2bb7a643898df02fcab04ab169 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
126 schema:name Mice, Nude
127 rdf:type schema:DefinedTerm
128 Nb9ed09dc24b84bd594367c456c1e44a0 schema:name pubmed_id
129 schema:value 21339744
130 rdf:type schema:PropertyValue
131 Nc2f94676b055459281bd835901140bc5 rdf:first sg:person.0642313664.37
132 rdf:rest N7c44a671ddb747bcaebd0f4d86016385
133 Nc6d2d7b7654a4cb2b203f82cc531fdab rdf:first sg:person.01361324025.97
134 rdf:rest rdf:nil
135 Ncec132281f464e848189bd1d0f700dc5 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
136 schema:name Liver Neoplasms, Experimental
137 rdf:type schema:DefinedTerm
138 Nd77e91102384447b917c7407b0374719 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
139 schema:name Carcinoma, Hepatocellular
140 rdf:type schema:DefinedTerm
141 Nd792a45001324b789571e55920136c22 schema:volumeNumber 91
142 rdf:type schema:PublicationVolume
143 Ndd7b0500048249559f7a4a93ed8ee93b rdf:first sg:person.01372704634.18
144 rdf:rest N36ed06960ae8495c81d8484877ffc7c7
145 Ndfe1146c38b749afbddc17f3c90a7f94 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
146 schema:name In Situ Nick-End Labeling
147 rdf:type schema:DefinedTerm
148 Ne151b4e52d69402db4794a018d052dfa schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
149 schema:name Mice
150 rdf:type schema:DefinedTerm
151 Ne8f0a925038c4c9a9902e6bba4118389 rdf:first sg:person.01317604564.04
152 rdf:rest N298fd1994abb4bae9c484549f5e860b8
153 Ne9d6d8652e7b4e28a5d9189e3f685c6c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
154 schema:name Repressor Proteins
155 rdf:type schema:DefinedTerm
156 Nedcbe85a07224562b5124832fd1ed0cb schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
157 schema:name Disease Models, Animal
158 rdf:type schema:DefinedTerm
159 Nf28249f66ec643af802b49e4905adca7 schema:name nlm_unique_id
160 schema:value 0376617
161 rdf:type schema:PropertyValue
162 Nfcc4bf184f7248499b17fcacaa8a2146 schema:issueNumber 5
163 rdf:type schema:PublicationIssue
164 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
165 schema:name Medical and Health Sciences
166 rdf:type schema:DefinedTerm
167 anzsrc-for:1112 schema:inDefinedTermSet anzsrc-for:
168 schema:name Oncology and Carcinogenesis
169 rdf:type schema:DefinedTerm
170 sg:journal.1017964 schema:issn 0023-6837
171 1530-0307
172 schema:name Laboratory Investigation
173 rdf:type schema:Periodical
174 sg:person.01034410426.80 schema:affiliation https://www.grid.ac/institutes/grid.418830.6
175 schema:familyName Ke
176 schema:givenName Zhiyuan
177 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01034410426.80
178 rdf:type schema:Person
179 sg:person.012313166136.37 schema:affiliation https://www.grid.ac/institutes/grid.418830.6
180 schema:familyName Riduan
181 schema:givenName Siti Nurhanna
182 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012313166136.37
183 rdf:type schema:Person
184 sg:person.01317604564.04 schema:affiliation https://www.grid.ac/institutes/grid.418830.6
185 schema:familyName Zhang
186 schema:givenName Chunyan
187 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01317604564.04
188 rdf:type schema:Person
189 sg:person.01361324025.97 schema:affiliation https://www.grid.ac/institutes/grid.418830.6
190 schema:familyName Zhuo
191 schema:givenName Lang
192 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01361324025.97
193 rdf:type schema:Person
194 sg:person.01372704634.18 schema:affiliation https://www.grid.ac/institutes/grid.418830.6
195 schema:familyName Gopalan
196 schema:givenName Began
197 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01372704634.18
198 rdf:type schema:Person
199 sg:person.0576407713.06 schema:affiliation https://www.grid.ac/institutes/grid.418830.6
200 schema:familyName Zhang
201 schema:givenName Yugen
202 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0576407713.06
203 rdf:type schema:Person
204 sg:person.0636375633.71 schema:affiliation https://www.grid.ac/institutes/grid.418830.6
205 schema:familyName Kng
206 schema:givenName Yinling
207 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0636375633.71
208 rdf:type schema:Person
209 sg:person.0642313664.37 schema:affiliation https://www.grid.ac/institutes/grid.418830.6
210 schema:familyName Suhaimi
211 schema:givenName Nur-Afidah Mohamed
212 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0642313664.37
213 rdf:type schema:Person
214 sg:pub.10.1038/nature03096 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051657854
215 https://doi.org/10.1038/nature03096
216 rdf:type schema:CreativeWork
217 sg:pub.10.1038/ng0802-339 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017140614
218 https://doi.org/10.1038/ng0802-339
219 rdf:type schema:CreativeWork
220 sg:pub.10.1038/nrc2293 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020411420
221 https://doi.org/10.1038/nrc2293
222 rdf:type schema:CreativeWork
223 sg:pub.10.1038/nrc2602 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008867916
224 https://doi.org/10.1038/nrc2602
225 rdf:type schema:CreativeWork
226 sg:pub.10.1038/onc.2008.448 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027217991
227 https://doi.org/10.1038/onc.2008.448
228 rdf:type schema:CreativeWork
229 sg:pub.10.1038/sj.onc.1203665 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027293885
230 https://doi.org/10.1038/sj.onc.1203665
231 rdf:type schema:CreativeWork
232 sg:pub.10.1038/sj.onc.1210811 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022095490
233 https://doi.org/10.1038/sj.onc.1210811
234 rdf:type schema:CreativeWork
235 sg:pub.10.1186/1479-5876-6-24 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048809078
236 https://doi.org/10.1186/1479-5876-6-24
237 rdf:type schema:CreativeWork
238 https://doi.org/10.1002/chem.200801992 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019438061
239 rdf:type schema:CreativeWork
240 https://doi.org/10.1002/hep.22082 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019312922
241 rdf:type schema:CreativeWork
242 https://doi.org/10.1002/jcb.1228 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038777271
243 rdf:type schema:CreativeWork
244 https://doi.org/10.1016/j.bmcl.2009.11.085 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015481316
245 rdf:type schema:CreativeWork
246 https://doi.org/10.1016/j.ijrobp.2008.02.011 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047795230
247 rdf:type schema:CreativeWork
248 https://doi.org/10.1021/ci900398f schema:sameAs https://app.dimensions.ai/details/publication/pub.1055404856
249 rdf:type schema:CreativeWork
250 https://doi.org/10.1021/cr800500u schema:sameAs https://app.dimensions.ai/details/publication/pub.1053815852
251 rdf:type schema:CreativeWork
252 https://doi.org/10.1021/ja075889z schema:sameAs https://app.dimensions.ai/details/publication/pub.1055845939
253 rdf:type schema:CreativeWork
254 https://doi.org/10.1021/ja8037883 schema:sameAs https://app.dimensions.ai/details/publication/pub.1055858726
255 rdf:type schema:CreativeWork
256 https://doi.org/10.1053/he.2000.6496 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051555850
257 rdf:type schema:CreativeWork
258 https://doi.org/10.1053/j.humpath.2003.07.016 schema:sameAs https://app.dimensions.ai/details/publication/pub.1057076256
259 rdf:type schema:CreativeWork
260 https://doi.org/10.1055/s-1996-4293 schema:sameAs https://app.dimensions.ai/details/publication/pub.1057397038
261 rdf:type schema:CreativeWork
262 https://doi.org/10.1056/nejmoa0708857 schema:sameAs https://app.dimensions.ai/details/publication/pub.1053513212
263 rdf:type schema:CreativeWork
264 https://doi.org/10.1073/pnas.0405407101 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043089695
265 rdf:type schema:CreativeWork
266 https://doi.org/10.1073/pnas.0609757104 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027158008
267 rdf:type schema:CreativeWork
268 https://doi.org/10.1097/cad.0b013e328327994e schema:sameAs https://app.dimensions.ai/details/publication/pub.1052081198
269 rdf:type schema:CreativeWork
270 https://doi.org/10.1152/physrev.00013.2007 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028143968
271 rdf:type schema:CreativeWork
272 https://doi.org/10.1158/0008-5472.can-07-1343 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000430897
273 rdf:type schema:CreativeWork
274 https://doi.org/10.1158/0008-5472.can-09-0301 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037872980
275 rdf:type schema:CreativeWork
276 https://doi.org/10.1158/1078-0432.ccr-08-1946 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026154465
277 rdf:type schema:CreativeWork
278 https://doi.org/10.1200/jco.2005.03.196 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023556043
279 rdf:type schema:CreativeWork
280 https://doi.org/10.3892/ijmm.18.6.1141 schema:sameAs https://app.dimensions.ai/details/publication/pub.1071506492
281 rdf:type schema:CreativeWork
282 https://www.grid.ac/institutes/grid.418830.6 schema:alternateName Institute of Bioengineering and Nanotechnology
283 schema:name Institute of Bioengineering and Nanotechnology, Biopolis, Singapore, Singapore
284 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...