Combined loss of p21waf1/cip1 and p27kip1 enhances tumorigenesis in mice View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2011-08-29

AUTHORS

Rosa A García-Fernández, Pilar García-Palencia, María Á Sánchez, Gabriel Gil-Gómez, Belén Sánchez, Eduardo Rollán, Juan Martín-Caballero, Juana M Flores

ABSTRACT

The cell cycle inhibitors p21Waf1/Cip1 and p27Kip1 are frequently downregulated in many human cancers, and correlate with a worse prognosis. We show here that combined deficiency in p21 and p27 proteins in mice is linked to more aggressive spontaneous tumorigenesis, resulting in a decreased lifespan. The most common tumors developed in p21p27 double-null mice were endocrine, with a higher incidence of pituitary adenomas, pheochromocytomas and thyroid adenomas. The combined absence of p21 and p27 proteins delays the incidence of radiation-induced thymic lymphomas with a higher apoptotic rate, measured by active caspase-3 and cleaved PARP-1 immunoexpresion. These results provide experimental evidence for a cooperation of both cyclin-dependent kinase inhibitors in tumorigenesis in mice. More... »

PAGES

1634-1642

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/labinvest.2011.133

DOI

http://dx.doi.org/10.1038/labinvest.2011.133

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1010851911

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/21876534


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