Combined loss of p21waf1/cip1 and p27kip1 enhances tumorigenesis in mice View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2011-11

AUTHORS

Rosa A García-Fernández, Pilar García-Palencia, María Á Sánchez, Gabriel Gil-Gómez, Belén Sánchez, Eduardo Rollán, Juan Martín-Caballero, Juana M Flores

ABSTRACT

The cell cycle inhibitors p21(Waf1/Cip1) and p27(Kip1) are frequently downregulated in many human cancers, and correlate with a worse prognosis. We show here that combined deficiency in p21 and p27 proteins in mice is linked to more aggressive spontaneous tumorigenesis, resulting in a decreased lifespan. The most common tumors developed in p21p27 double-null mice were endocrine, with a higher incidence of pituitary adenomas, pheochromocytomas and thyroid adenomas. The combined absence of p21 and p27 proteins delays the incidence of radiation-induced thymic lymphomas with a higher apoptotic rate, measured by active caspase-3 and cleaved PARP-1 immunoexpresion. These results provide experimental evidence for a cooperation of both cyclin-dependent kinase inhibitors in tumorigenesis in mice. More... »

PAGES

1634

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/labinvest.2011.133

DOI

http://dx.doi.org/10.1038/labinvest.2011.133

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1010851911

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/21876534


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Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

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N-Triples is a line-based linked data format ideal for batch operations.

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Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/labinvest.2011.133'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/labinvest.2011.133'


 

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