Smad3 knockout mice exhibit impaired intestinal mucosal healing View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2008-10

AUTHORS

Cheri R Owen, Lisi Yuan, Marc D Basson

ABSTRACT

Altered transforming growth factor-beta (TGFbeta) expression may contribute to inflammatory bowel disease and modulate epithelial cell restitution. Interference with TGFbeta-mediated signaling inhibits excisional skin wound healing, but accelerates healing of incisional cutaneous wounds and wounds in some other tissues. Therefore, we sought to clarify the potential role of Smad3-dependent TGFbeta signaling in intestinal mucosal healing in Smad3 null mice. Jejunal serosal application of filter disks saturated with 75% acetic acid yielded a circumscribed reproducible ischemic mucosal ulcer 1 day later. We compared ulcer area at 3 and 5 days to day 1 in Smad3 knockout mice and syngeneic wild-type mice, and evaluated mucosal immunoreactivity at the ulcer edge for TGFbeta, phosphorylated (activated) focal adhesion kinase (pFAK), phosphorylated extracellular signal-related kinase (pERK), proliferating cell nuclear antigen and apoptosis by TUNEL. Ulcer healing in Smad3 null mice was 17% less at day 3 (n=14, P=0.022) and 15% less at day 5 (n=14, P=0.004) than in wild-type littermates. In wild-type mice, pFAK, pERK and TGFbeta immunoreactivity were elevated in epithelium immediately adjacent to the ulcer compared with more distant mucosa. However, this pattern of immunoreactivity for pFAK, pERK and TGFbeta was not observed in Smad3 null mice. Smad3 null mice exhibited increased epithelial proliferation and no differences in apoptotic cell death compared with wild types, suggesting that ulcer healing may reflect differences in restitutive cell migration. Thus, Smad3-dependent disruption of the TGFbeta signaling pathway impairs the healing of murine intestinal mucosal ulcers and alters patterns of activated FAK and ERK immunoreactivity important for cell migration at the ulcer edge. These studies suggest a significant role for Smad3-dependent TGFbeta signaling in intestinal mucosal healing. More... »

PAGES

1101

References to SciGraph publications

  • 1995-12. Abnormal lung development and cleft palate in mice lacking TGF–β3 indicates defects of epithelial–mesenchymal interaction in NATURE GENETICS
  • 2005-02. Protein Microarray Analysis of Disease Activity in Pediatric Inflammatory Bowel Disease Demonstrates Elevated Serum PLGF, IL-7, TGF-β1, and IL-12p40 Levels in Crohn's Disease and Ulcerative Colitis Patients in Remission versus Active Disease in THE AMERICAN JOURNAL OF GASTROENTEROLOGY
  • 2008-04. Smad3 deficiency inhibits v-ras-induced transformation by suppression of JNK MAPK signaling and increased farnesyl transferase inhibition in ONCOGENE
  • 2000-12. How cells read TGF-β signals in NATURE REVIEWS MOLECULAR CELL BIOLOGY
  • 1992-10. Targeted disruption of the mouse transforming growth factor-β1 gene results in multifocal inflammatory disease in NATURE
  • 2006-02. Hair cycle and wound healing in mice with a keratinocyte-restricted deletion of FAK in ONCOGENE
  • 2003-10. Smad-dependent and Smad-independent pathways in TGF-β family signalling in NATURE
  • 1995-12. Transforming growth factor–β3 is required for secondary palate fusion in NATURE GENETICS
  • 2004-04. HST-1/FGF-4 plays a critical role in crypt cell survival and facilitates epithelial cell restitution and proliferation in ONCOGENE
  • 1988-03. Role of inflammatory mediators in colonic smooth muscle function in ulcerative colitis in DIGESTIVE DISEASES AND SCIENCES
  • 2005-06. Smad3 and Extracellular Signal-Regulated Kinase 1/2 Coordinately Mediate Transforming Growth Factor-β-Induced Expression of Connective Tissue Growth Factor in Human Fibroblasts in JOURNAL OF INVESTIGATIVE DERMATOLOGY
  • 2005-02. Accelerated re-epithelialization in β3-integrin-deficient- mice is associated with enhanced TGF-β1 signaling in NATURE MEDICINE
  • 2005-10. Cellular and Molecular Mechanisms of the Epithelial Repair in IBD in DIGESTIVE DISEASES AND SCIENCES
  • 1998-03. Hepatocyte growth factor accelerates restitution of intestinal epithelial cells in JOURNAL OF GASTROENTEROLOGY
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/labinvest.2008.77

    DOI

    http://dx.doi.org/10.1038/labinvest.2008.77

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1041147228

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/18711354


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