Murine cardiac mtDNA: effects of transgenic manipulation of nucleoside phosphorylation View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2009-02

AUTHORS

James J Kohler, Seyed H Hosseini, Ioan Cucoranu, Amy Hoying-Brandt, Elgin Green, David Johnson, Bree Wittich, Jaya Srivastava, Kristopher Ivey, Earl Fields, Rodney Russ, C Michael Raper, Robert Santoianni, William Lewis

ABSTRACT

Mitochondrial toxicity results from pyrimidine nucleoside reverse transcriptase inhibitors (NRTIs) for HIV/AIDS. In the heart, this can deplete mitochondrial (mt) DNA and cause cardiac dysfunction (eg, left ventricle hypertrophy, LVH). Four unique transgenic, cardiac-targeted overexpressors (TGs) were generated to determine their individual impact on native mitochondrial biogenesis and effects of NRTI administration on development of mitochondrial toxicity. TGs included cardiac-specific overexpression of native thymidine kinase 2 (TK2), two pathogenic TK2 mutants (H121N and I212N), and a mutant of mtDNA polymerase, pol-gamma (Y955C). Each was treated with antiretrovirals (AZT-HAART, 3 or 10 weeks, zidovudine (AZT) + lamivudine (3TC) + indinavir, or vehicle control). Parameters included left ventricle (LV) performance (echocardiography), LV mtDNA abundance (real-time PCR), and mitochondrial fine structure (electron microscopy, EM) as a function of duration of treatment and presence of TG. mtDNA abundance significantly decreased in Y955C TG, increased in TK2 native and I212N TGs, and was unchanged in H121N TGs at 10 weeks regardless of treatment. Y955C and I212N TGs exhibited LVH during growth irrespective of treatment. Y955C TGs exhibited cardiomyopathy (CM) at 3 and 10 weeks irrespective of treatment, whereas H121N and I212N TGs exhibited CM only after 10 weeks AZT-HAART. EM features were consistent with cardiac dysfunction. mtDNA abundance and cardiac functional changes were related to TG expression of mitochondrially related genes, mutations thereof, and NRTIs. More... »

PAGES

labinvest2008121

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/labinvest.2008.121

DOI

http://dx.doi.org/10.1038/labinvest.2008.121

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1003771516

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/19079325


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