Renin-angiotensin blockade resets podocyte epigenome through Kruppel-like Factor 4 and attenuates proteinuria View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2015-10

AUTHORS

Kaori Hayashi, Hiroyuki Sasamura, Mari Nakamura, Yusuke Sakamaki, Tatsuhiko Azegami, Hideyo Oguchi, Hirobumi Tokuyama, Shu Wakino, Koichi Hayashi, Hiroshi Itoh

ABSTRACT

Proteinuria is a central component of chronic kidney disease and an independent risk factor for cardiovascular disease. Kidney podocytes have an essential role as a filtration barrier against proteinuria. Kruppel-like Factor 4 (KLF4) is expressed in podocytes and decreased in glomerular diseases leading to methylation of the nephrin promoter, decreased nephrin expression and proteinuria. Treatment with an angiotensin receptor blocker (ARB) reduced methylation of the nephrin promoter in murine glomeruli of an adriamycin nephropathy model with recovery of KLF4 expression and a decrease in albuminuria. In podocyte-specific KLF4 knockout mice, the effect of ARB on albuminuria and the nephrin promoter methylation was attenuated. In cultured human podocytes, angiotensin II reduced KLF4 expression and caused methylation of the nephrin promoter with decreased nephrin expression. In patients, nephrin promoter methylation was increased in proteinuric kidney diseases with decreased KLF4 and nephrin expression. KLF4 expression in ARB-treated patients was higher in patients with than without ARB treatment. Thus, angiotensin II can modulate epigenetic regulation in podocytes and ARB inhibits these actions in part via KLF4 in proteinuric kidney diseases. This study provides a new concept that renin-angiotensin system blockade can exert therapeutic effects through epigenetic modulation of the kidney gene expression. More... »

PAGES

745-753

References to SciGraph publications

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/ki.2015.178

DOI

http://dx.doi.org/10.1038/ki.2015.178

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1012852744

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/26108068


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1103", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Clinical Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Albuminuria", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Angiotensin II", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Angiotensin II Type 1 Receptor Blockers", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Animals", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Benzimidazoles", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Biphenyl Compounds", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cell Line", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "DNA Methylation", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Disease Models, Animal", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Dose-Response Relationship, Drug", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Doxorubicin", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Epigenesis, Genetic", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Kruppel-Like Transcription Factors", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Male", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Membrane Proteins", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Mice, Inbred C57BL", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Mice, Knockout", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Podocytes", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Promoter Regions, Genetic", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Renal Insufficiency, Chronic", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Renin-Angiotensin System", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Signal Transduction", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Tetrazoles", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Time Factors", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Transfection", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Keio University", 
          "id": "https://www.grid.ac/institutes/grid.26091.3c", 
          "name": [
            "Department of Internal Medicine, School of Medicine, Keio University, Tokyo, Japan."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Hayashi", 
        "givenName": "Kaori", 
        "id": "sg:person.01177220753.46", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01177220753.46"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Keio University", 
          "id": "https://www.grid.ac/institutes/grid.26091.3c", 
          "name": [
            "Department of Internal Medicine, School of Medicine, Keio University, Tokyo, Japan."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Sasamura", 
        "givenName": "Hiroyuki", 
        "id": "sg:person.01106247335.03", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01106247335.03"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Keio University", 
          "id": "https://www.grid.ac/institutes/grid.26091.3c", 
          "name": [
            "Department of Internal Medicine, School of Medicine, Keio University, Tokyo, Japan."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Nakamura", 
        "givenName": "Mari", 
        "id": "sg:person.01227316446.78", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01227316446.78"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Keio University", 
          "id": "https://www.grid.ac/institutes/grid.26091.3c", 
          "name": [
            "Department of Internal Medicine, School of Medicine, Keio University, Tokyo, Japan."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Sakamaki", 
        "givenName": "Yusuke", 
        "id": "sg:person.01222475735.80", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01222475735.80"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Keio University", 
          "id": "https://www.grid.ac/institutes/grid.26091.3c", 
          "name": [
            "Department of Internal Medicine, School of Medicine, Keio University, Tokyo, Japan."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Azegami", 
        "givenName": "Tatsuhiko", 
        "id": "sg:person.01115562045.18", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01115562045.18"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Keio University", 
          "id": "https://www.grid.ac/institutes/grid.26091.3c", 
          "name": [
            "Department of Internal Medicine, School of Medicine, Keio University, Tokyo, Japan."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Oguchi", 
        "givenName": "Hideyo", 
        "id": "sg:person.01343545046.60", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01343545046.60"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Keio University", 
          "id": "https://www.grid.ac/institutes/grid.26091.3c", 
          "name": [
            "Department of Internal Medicine, School of Medicine, Keio University, Tokyo, Japan."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Tokuyama", 
        "givenName": "Hirobumi", 
        "id": "sg:person.01225050715.66", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01225050715.66"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Keio University", 
          "id": "https://www.grid.ac/institutes/grid.26091.3c", 
          "name": [
            "Department of Internal Medicine, School of Medicine, Keio University, Tokyo, Japan."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Wakino", 
        "givenName": "Shu", 
        "id": "sg:person.0612032115.31", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0612032115.31"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Keio University", 
          "id": "https://www.grid.ac/institutes/grid.26091.3c", 
          "name": [
            "Department of Internal Medicine, School of Medicine, Keio University, Tokyo, Japan."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Hayashi", 
        "givenName": "Koichi", 
        "id": "sg:person.016614403402.57", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.016614403402.57"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Keio University", 
          "id": "https://www.grid.ac/institutes/grid.26091.3c", 
          "name": [
            "Department of Internal Medicine, School of Medicine, Keio University, Tokyo, Japan."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Itoh", 
        "givenName": "Hiroshi", 
        "id": "sg:person.012712207547.35", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012712207547.35"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.1681/asn.2012111078", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1001335780"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1681/asn.2012111078", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1001335780"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1111/j.1523-1755.2004.00636.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1001764216", 
          "https://doi.org/10.1111/j.1523-1755.2004.00636.x"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.cell.2011.03.022", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1001775952"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0140-6736(11)60178-5", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1002346808"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.bbrc.2011.02.007", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1003459524"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.jep.2011.06.031", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1005395365"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1158/1541-7786.mcr-07-0159", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1006237880"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1046/j.1523-1755.2000.00342.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1009024340", 
          "https://doi.org/10.1046/j.1523-1755.2000.00342.x"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.2353/jmoldx.2009.080126", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1010142913"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/mnh.0b013e32835200df", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1010581311"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/mnh.0b013e32835200df", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1010581311"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/mnh.0b013e32835200df", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1010581311"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/gene.10164", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1011304736"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1056/nejmoa060838", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1011919761"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ki.2010.81", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1014368341", 
          "https://doi.org/10.1038/ki.2010.81"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1159/000327564", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1015956018"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1172/jci114846", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1017158440"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1172/jci69557", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1018244097"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ki.2011.142", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1018321039", 
          "https://doi.org/10.1038/ki.2011.142"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.cell.2011.06.020", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1018622449"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1161/hy0102.100536", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1022804895"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1111/j.1523-1755.2004.00787.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1023312828", 
          "https://doi.org/10.1111/j.1523-1755.2004.00787.x"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1161/01.res.0000126049.79800.ca", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1024129967"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1161/01.res.0000126049.79800.ca", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1024129967"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1161/01.res.0000126049.79800.ca", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1024129967"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1161/hypertensionaha.108.122721", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1024514941"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1161/hypertensionaha.108.122721", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1024514941"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1046/j.1523-1755.2002.00112.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1027415230", 
          "https://doi.org/10.1046/j.1523-1755.2002.00112.x"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1681/asn.2011060629", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1028494657"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1681/asn.2011060629", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1028494657"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ki.2010.40", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1032435011", 
          "https://doi.org/10.1038/ki.2010.40"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1152/ajprenal.00475.2004", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1033058461"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1152/ajprenal.00475.2004", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1033058461"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1681/asn.2009010019", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1033221599"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1681/asn.2009010019", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1033221599"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1152/ajprenal.00423.2006", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1033898285"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nrendo.2010.188", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1036939887", 
          "https://doi.org/10.1038/nrendo.2010.188"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nrendo.2010.188", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1036939887", 
          "https://doi.org/10.1038/nrendo.2010.188"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1681/asn.2012060590", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037189981"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1681/asn.2012060590", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037189981"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1161/01.cir.0000095676.90936.80", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1038647312"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.molcel.2011.11.031", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1042599176"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ki.2013.387", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1042962412", 
          "https://doi.org/10.1038/ki.2013.387"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/ndt/14.5.1234", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1046498483"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1152/ajprenal.00266.2007", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1046794677"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1371/journal.pone.0006721", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1048422203"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1046/j.1523-1755.2001.00049.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1052571186", 
          "https://doi.org/10.1046/j.1523-1755.2001.00049.x"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature08752", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1053322224", 
          "https://doi.org/10.1038/nature08752"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature08752", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1053322224", 
          "https://doi.org/10.1038/nature08752"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1046/j.1523-1755.2000.00824.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1053579289", 
          "https://doi.org/10.1046/j.1523-1755.2000.00824.x"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/ajh/hpt105", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1059382169"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/01.asn.0000026610.48842.cb", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1060318868"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/01.asn.0000078803.53165.c9", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1060319258"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/01.asn.0000127988.42710.a7", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1060319600"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/01.asn.0000127988.42710.a7", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1060319600"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/01.asn.0000127988.42710.a7", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1060319600"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1074512813", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1075001367", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1075053566", 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2015-10", 
    "datePublishedReg": "2015-10-01", 
    "description": "Proteinuria is a central component of chronic kidney disease and an independent risk factor for cardiovascular disease. Kidney podocytes have an essential role as a filtration barrier against proteinuria. Kruppel-like Factor 4 (KLF4) is expressed in podocytes and decreased in glomerular diseases leading to methylation of the nephrin promoter, decreased nephrin expression and proteinuria. Treatment with an angiotensin receptor blocker (ARB) reduced methylation of the nephrin promoter in murine glomeruli of an adriamycin nephropathy model with recovery of KLF4 expression and a decrease in albuminuria. In podocyte-specific KLF4 knockout mice, the effect of ARB on albuminuria and the nephrin promoter methylation was attenuated. In cultured human podocytes, angiotensin II reduced KLF4 expression and caused methylation of the nephrin promoter with decreased nephrin expression. In patients, nephrin promoter methylation was increased in proteinuric kidney diseases with decreased KLF4 and nephrin expression. KLF4 expression in ARB-treated patients was higher in patients with than without ARB treatment. Thus, angiotensin II can modulate epigenetic regulation in podocytes and ARB inhibits these actions in part via KLF4 in proteinuric kidney diseases. This study provides a new concept that renin-angiotensin system blockade can exert therapeutic effects through epigenetic modulation of the kidney gene expression.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1038/ki.2015.178", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": false, 
    "isFundedItemOf": [
      {
        "id": "sg:grant.6148415", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.6126564", 
        "type": "MonetaryGrant"
      }
    ], 
    "isPartOf": [
      {
        "id": "sg:journal.1015319", 
        "issn": [
          "0085-2538", 
          "1523-1755"
        ], 
        "name": "Kidney International", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "4", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "88"
      }
    ], 
    "name": "Renin-angiotensin blockade resets podocyte epigenome through Kruppel-like Factor 4 and attenuates proteinuria", 
    "pagination": "745-753", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "3d3ab509e3c30c0bd62c3cfe83cb803084a97b764144da2bc4f043ca5238c501"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "26108068"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "0323470"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1038/ki.2015.178"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1012852744"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1038/ki.2015.178", 
      "https://app.dimensions.ai/details/publication/pub.1012852744"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-10T17:35", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8672_00000531.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "http://www.nature.com/ki/journal/v88/n4/full/ki2015178a.html"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/ki.2015.178'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/ki.2015.178'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/ki.2015.178'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/ki.2015.178'


 

This table displays all metadata directly associated to this object as RDF triples.

383 TRIPLES      21 PREDICATES      100 URIs      46 LITERALS      34 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1038/ki.2015.178 schema:about N0120142f59ec4afe891e0ded5193033c
2 N089bb8c8f40d4187a679c8544404146b
3 N1754c72759cf44388f70701da48e5208
4 N1be5d1942c7742e1893660fdb3c79198
5 N224b40a5e99b4cb1a25de8484d978ccd
6 N33a94d5c1300413c94913ee971760aa1
7 N53fb10c9b661466dbe1c675574df3614
8 N5946e91773b448118d8dbea0c3211318
9 N5ad3e4c71f374d81a07b3e076ae99726
10 N629606328f4d4db5816b07ca28602d7c
11 N629feb90281e4e1a98cf8f3207bacd7b
12 N6b4894fc0f8a4a8b80427c2cde1ea68a
13 N7189180681d74a89aad93e1629420eb6
14 N817e34937bae412e9564771f06afe750
15 N8a236b9c525d418181777c01d744cda9
16 N8a6b9d16ab82431c81d9e716135b4199
17 N8a9a0d72f5b843c0b13bff7de6c3d148
18 Na6954da3db984c1f839a96014c59a88f
19 Nb0a8390ea48c4ea7b2ebfb33e080380d
20 Nb2fee34b47b14c63b22abea61c99ae01
21 Nbd1de72cf0744bc08339c90cb87a1d09
22 Nbdaa000f2bce49578b740bf52a23c14f
23 Nd9fcdd21040e420fb35af619afaf8d5b
24 Nf7b6a8cb5a574b1d84f5b84a2ee6789d
25 Nf870911ebd894b869be7e38d07add69e
26 anzsrc-for:11
27 anzsrc-for:1103
28 schema:author Ndccb0bd1058d426da345d4b979f123ae
29 schema:citation sg:pub.10.1038/ki.2010.40
30 sg:pub.10.1038/ki.2010.81
31 sg:pub.10.1038/ki.2011.142
32 sg:pub.10.1038/ki.2013.387
33 sg:pub.10.1038/nature08752
34 sg:pub.10.1038/nrendo.2010.188
35 sg:pub.10.1046/j.1523-1755.2000.00342.x
36 sg:pub.10.1046/j.1523-1755.2000.00824.x
37 sg:pub.10.1046/j.1523-1755.2001.00049.x
38 sg:pub.10.1046/j.1523-1755.2002.00112.x
39 sg:pub.10.1111/j.1523-1755.2004.00636.x
40 sg:pub.10.1111/j.1523-1755.2004.00787.x
41 https://app.dimensions.ai/details/publication/pub.1074512813
42 https://app.dimensions.ai/details/publication/pub.1075001367
43 https://app.dimensions.ai/details/publication/pub.1075053566
44 https://doi.org/10.1002/gene.10164
45 https://doi.org/10.1016/j.bbrc.2011.02.007
46 https://doi.org/10.1016/j.cell.2011.03.022
47 https://doi.org/10.1016/j.cell.2011.06.020
48 https://doi.org/10.1016/j.jep.2011.06.031
49 https://doi.org/10.1016/j.molcel.2011.11.031
50 https://doi.org/10.1016/s0140-6736(11)60178-5
51 https://doi.org/10.1056/nejmoa060838
52 https://doi.org/10.1093/ajh/hpt105
53 https://doi.org/10.1093/ndt/14.5.1234
54 https://doi.org/10.1097/01.asn.0000026610.48842.cb
55 https://doi.org/10.1097/01.asn.0000078803.53165.c9
56 https://doi.org/10.1097/01.asn.0000127988.42710.a7
57 https://doi.org/10.1097/mnh.0b013e32835200df
58 https://doi.org/10.1152/ajprenal.00266.2007
59 https://doi.org/10.1152/ajprenal.00423.2006
60 https://doi.org/10.1152/ajprenal.00475.2004
61 https://doi.org/10.1158/1541-7786.mcr-07-0159
62 https://doi.org/10.1159/000327564
63 https://doi.org/10.1161/01.cir.0000095676.90936.80
64 https://doi.org/10.1161/01.res.0000126049.79800.ca
65 https://doi.org/10.1161/hy0102.100536
66 https://doi.org/10.1161/hypertensionaha.108.122721
67 https://doi.org/10.1172/jci114846
68 https://doi.org/10.1172/jci69557
69 https://doi.org/10.1371/journal.pone.0006721
70 https://doi.org/10.1681/asn.2009010019
71 https://doi.org/10.1681/asn.2011060629
72 https://doi.org/10.1681/asn.2012060590
73 https://doi.org/10.1681/asn.2012111078
74 https://doi.org/10.2353/jmoldx.2009.080126
75 schema:datePublished 2015-10
76 schema:datePublishedReg 2015-10-01
77 schema:description Proteinuria is a central component of chronic kidney disease and an independent risk factor for cardiovascular disease. Kidney podocytes have an essential role as a filtration barrier against proteinuria. Kruppel-like Factor 4 (KLF4) is expressed in podocytes and decreased in glomerular diseases leading to methylation of the nephrin promoter, decreased nephrin expression and proteinuria. Treatment with an angiotensin receptor blocker (ARB) reduced methylation of the nephrin promoter in murine glomeruli of an adriamycin nephropathy model with recovery of KLF4 expression and a decrease in albuminuria. In podocyte-specific KLF4 knockout mice, the effect of ARB on albuminuria and the nephrin promoter methylation was attenuated. In cultured human podocytes, angiotensin II reduced KLF4 expression and caused methylation of the nephrin promoter with decreased nephrin expression. In patients, nephrin promoter methylation was increased in proteinuric kidney diseases with decreased KLF4 and nephrin expression. KLF4 expression in ARB-treated patients was higher in patients with than without ARB treatment. Thus, angiotensin II can modulate epigenetic regulation in podocytes and ARB inhibits these actions in part via KLF4 in proteinuric kidney diseases. This study provides a new concept that renin-angiotensin system blockade can exert therapeutic effects through epigenetic modulation of the kidney gene expression.
78 schema:genre research_article
79 schema:inLanguage en
80 schema:isAccessibleForFree false
81 schema:isPartOf Nb582c03f57454122ba2e9e43fb1c29e6
82 Nb9c52e79bb7848f28f520f7b6dd1e428
83 sg:journal.1015319
84 schema:name Renin-angiotensin blockade resets podocyte epigenome through Kruppel-like Factor 4 and attenuates proteinuria
85 schema:pagination 745-753
86 schema:productId N022752e89c004f0e8dcfa8ecf480d284
87 N3948afdb4b544a1492f207a4d6d33c88
88 N3f9dac82a6ca406ab3a4d159b3806b84
89 N7aa58cf6ab0f48458c2467b983e7e8f7
90 Ne4f6110dce024cfc8529c44620d5eeba
91 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012852744
92 https://doi.org/10.1038/ki.2015.178
93 schema:sdDatePublished 2019-04-10T17:35
94 schema:sdLicense https://scigraph.springernature.com/explorer/license/
95 schema:sdPublisher Naba7262bc92e4dceb15af046dab1c5f2
96 schema:url http://www.nature.com/ki/journal/v88/n4/full/ki2015178a.html
97 sgo:license sg:explorer/license/
98 sgo:sdDataset articles
99 rdf:type schema:ScholarlyArticle
100 N0120142f59ec4afe891e0ded5193033c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
101 schema:name Angiotensin II
102 rdf:type schema:DefinedTerm
103 N022752e89c004f0e8dcfa8ecf480d284 schema:name doi
104 schema:value 10.1038/ki.2015.178
105 rdf:type schema:PropertyValue
106 N089bb8c8f40d4187a679c8544404146b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
107 schema:name Mice, Inbred C57BL
108 rdf:type schema:DefinedTerm
109 N1754c72759cf44388f70701da48e5208 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
110 schema:name Time Factors
111 rdf:type schema:DefinedTerm
112 N1be5d1942c7742e1893660fdb3c79198 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
113 schema:name Doxorubicin
114 rdf:type schema:DefinedTerm
115 N224b40a5e99b4cb1a25de8484d978ccd schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
116 schema:name Biphenyl Compounds
117 rdf:type schema:DefinedTerm
118 N33a94d5c1300413c94913ee971760aa1 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
119 schema:name Podocytes
120 rdf:type schema:DefinedTerm
121 N3948afdb4b544a1492f207a4d6d33c88 schema:name readcube_id
122 schema:value 3d3ab509e3c30c0bd62c3cfe83cb803084a97b764144da2bc4f043ca5238c501
123 rdf:type schema:PropertyValue
124 N3f9dac82a6ca406ab3a4d159b3806b84 schema:name pubmed_id
125 schema:value 26108068
126 rdf:type schema:PropertyValue
127 N4070201d79804d6c86461f4b15f57b0c rdf:first sg:person.012712207547.35
128 rdf:rest rdf:nil
129 N53fb10c9b661466dbe1c675574df3614 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
130 schema:name Tetrazoles
131 rdf:type schema:DefinedTerm
132 N5946e91773b448118d8dbea0c3211318 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
133 schema:name Benzimidazoles
134 rdf:type schema:DefinedTerm
135 N5976fd55d2bc4a7b81ee873eb34c39fe rdf:first sg:person.01115562045.18
136 rdf:rest Nbd98b5e4ec5249ef96c4941fd4ba7533
137 N5ad3e4c71f374d81a07b3e076ae99726 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
138 schema:name Mice, Knockout
139 rdf:type schema:DefinedTerm
140 N607aceffbf034a9097231f5ddd0c9509 rdf:first sg:person.016614403402.57
141 rdf:rest N4070201d79804d6c86461f4b15f57b0c
142 N629606328f4d4db5816b07ca28602d7c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
143 schema:name Renal Insufficiency, Chronic
144 rdf:type schema:DefinedTerm
145 N629feb90281e4e1a98cf8f3207bacd7b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
146 schema:name Dose-Response Relationship, Drug
147 rdf:type schema:DefinedTerm
148 N6b4894fc0f8a4a8b80427c2cde1ea68a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
149 schema:name Epigenesis, Genetic
150 rdf:type schema:DefinedTerm
151 N6d6758fe9a09419783d2078bf6b880b7 rdf:first sg:person.01225050715.66
152 rdf:rest N955f2adf3fd743e9b7f1d3fee08324e1
153 N7189180681d74a89aad93e1629420eb6 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
154 schema:name Renin-Angiotensin System
155 rdf:type schema:DefinedTerm
156 N75db3c11eff646658bf2453438196a96 rdf:first sg:person.01227316446.78
157 rdf:rest N9fe4b1d0702649e3bd1c31a0c6825872
158 N7aa58cf6ab0f48458c2467b983e7e8f7 schema:name nlm_unique_id
159 schema:value 0323470
160 rdf:type schema:PropertyValue
161 N817e34937bae412e9564771f06afe750 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
162 schema:name Angiotensin II Type 1 Receptor Blockers
163 rdf:type schema:DefinedTerm
164 N8a236b9c525d418181777c01d744cda9 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
165 schema:name Animals
166 rdf:type schema:DefinedTerm
167 N8a6b9d16ab82431c81d9e716135b4199 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
168 schema:name Transfection
169 rdf:type schema:DefinedTerm
170 N8a9a0d72f5b843c0b13bff7de6c3d148 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
171 schema:name Albuminuria
172 rdf:type schema:DefinedTerm
173 N955f2adf3fd743e9b7f1d3fee08324e1 rdf:first sg:person.0612032115.31
174 rdf:rest N607aceffbf034a9097231f5ddd0c9509
175 N9fe4b1d0702649e3bd1c31a0c6825872 rdf:first sg:person.01222475735.80
176 rdf:rest N5976fd55d2bc4a7b81ee873eb34c39fe
177 Na496ffe6ab794903ae6239904ba0ef54 rdf:first sg:person.01106247335.03
178 rdf:rest N75db3c11eff646658bf2453438196a96
179 Na6954da3db984c1f839a96014c59a88f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
180 schema:name Disease Models, Animal
181 rdf:type schema:DefinedTerm
182 Naba7262bc92e4dceb15af046dab1c5f2 schema:name Springer Nature - SN SciGraph project
183 rdf:type schema:Organization
184 Nb0a8390ea48c4ea7b2ebfb33e080380d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
185 schema:name Signal Transduction
186 rdf:type schema:DefinedTerm
187 Nb2fee34b47b14c63b22abea61c99ae01 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
188 schema:name DNA Methylation
189 rdf:type schema:DefinedTerm
190 Nb582c03f57454122ba2e9e43fb1c29e6 schema:volumeNumber 88
191 rdf:type schema:PublicationVolume
192 Nb9c52e79bb7848f28f520f7b6dd1e428 schema:issueNumber 4
193 rdf:type schema:PublicationIssue
194 Nbd1de72cf0744bc08339c90cb87a1d09 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
195 schema:name Membrane Proteins
196 rdf:type schema:DefinedTerm
197 Nbd98b5e4ec5249ef96c4941fd4ba7533 rdf:first sg:person.01343545046.60
198 rdf:rest N6d6758fe9a09419783d2078bf6b880b7
199 Nbdaa000f2bce49578b740bf52a23c14f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
200 schema:name Kruppel-Like Transcription Factors
201 rdf:type schema:DefinedTerm
202 Nd9fcdd21040e420fb35af619afaf8d5b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
203 schema:name Promoter Regions, Genetic
204 rdf:type schema:DefinedTerm
205 Ndccb0bd1058d426da345d4b979f123ae rdf:first sg:person.01177220753.46
206 rdf:rest Na496ffe6ab794903ae6239904ba0ef54
207 Ne4f6110dce024cfc8529c44620d5eeba schema:name dimensions_id
208 schema:value pub.1012852744
209 rdf:type schema:PropertyValue
210 Nf7b6a8cb5a574b1d84f5b84a2ee6789d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
211 schema:name Cell Line
212 rdf:type schema:DefinedTerm
213 Nf870911ebd894b869be7e38d07add69e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
214 schema:name Male
215 rdf:type schema:DefinedTerm
216 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
217 schema:name Medical and Health Sciences
218 rdf:type schema:DefinedTerm
219 anzsrc-for:1103 schema:inDefinedTermSet anzsrc-for:
220 schema:name Clinical Sciences
221 rdf:type schema:DefinedTerm
222 sg:grant.6126564 http://pending.schema.org/fundedItem sg:pub.10.1038/ki.2015.178
223 rdf:type schema:MonetaryGrant
224 sg:grant.6148415 http://pending.schema.org/fundedItem sg:pub.10.1038/ki.2015.178
225 rdf:type schema:MonetaryGrant
226 sg:journal.1015319 schema:issn 0085-2538
227 1523-1755
228 schema:name Kidney International
229 rdf:type schema:Periodical
230 sg:person.01106247335.03 schema:affiliation https://www.grid.ac/institutes/grid.26091.3c
231 schema:familyName Sasamura
232 schema:givenName Hiroyuki
233 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01106247335.03
234 rdf:type schema:Person
235 sg:person.01115562045.18 schema:affiliation https://www.grid.ac/institutes/grid.26091.3c
236 schema:familyName Azegami
237 schema:givenName Tatsuhiko
238 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01115562045.18
239 rdf:type schema:Person
240 sg:person.01177220753.46 schema:affiliation https://www.grid.ac/institutes/grid.26091.3c
241 schema:familyName Hayashi
242 schema:givenName Kaori
243 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01177220753.46
244 rdf:type schema:Person
245 sg:person.01222475735.80 schema:affiliation https://www.grid.ac/institutes/grid.26091.3c
246 schema:familyName Sakamaki
247 schema:givenName Yusuke
248 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01222475735.80
249 rdf:type schema:Person
250 sg:person.01225050715.66 schema:affiliation https://www.grid.ac/institutes/grid.26091.3c
251 schema:familyName Tokuyama
252 schema:givenName Hirobumi
253 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01225050715.66
254 rdf:type schema:Person
255 sg:person.01227316446.78 schema:affiliation https://www.grid.ac/institutes/grid.26091.3c
256 schema:familyName Nakamura
257 schema:givenName Mari
258 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01227316446.78
259 rdf:type schema:Person
260 sg:person.012712207547.35 schema:affiliation https://www.grid.ac/institutes/grid.26091.3c
261 schema:familyName Itoh
262 schema:givenName Hiroshi
263 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012712207547.35
264 rdf:type schema:Person
265 sg:person.01343545046.60 schema:affiliation https://www.grid.ac/institutes/grid.26091.3c
266 schema:familyName Oguchi
267 schema:givenName Hideyo
268 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01343545046.60
269 rdf:type schema:Person
270 sg:person.016614403402.57 schema:affiliation https://www.grid.ac/institutes/grid.26091.3c
271 schema:familyName Hayashi
272 schema:givenName Koichi
273 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.016614403402.57
274 rdf:type schema:Person
275 sg:person.0612032115.31 schema:affiliation https://www.grid.ac/institutes/grid.26091.3c
276 schema:familyName Wakino
277 schema:givenName Shu
278 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0612032115.31
279 rdf:type schema:Person
280 sg:pub.10.1038/ki.2010.40 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032435011
281 https://doi.org/10.1038/ki.2010.40
282 rdf:type schema:CreativeWork
283 sg:pub.10.1038/ki.2010.81 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014368341
284 https://doi.org/10.1038/ki.2010.81
285 rdf:type schema:CreativeWork
286 sg:pub.10.1038/ki.2011.142 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018321039
287 https://doi.org/10.1038/ki.2011.142
288 rdf:type schema:CreativeWork
289 sg:pub.10.1038/ki.2013.387 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042962412
290 https://doi.org/10.1038/ki.2013.387
291 rdf:type schema:CreativeWork
292 sg:pub.10.1038/nature08752 schema:sameAs https://app.dimensions.ai/details/publication/pub.1053322224
293 https://doi.org/10.1038/nature08752
294 rdf:type schema:CreativeWork
295 sg:pub.10.1038/nrendo.2010.188 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036939887
296 https://doi.org/10.1038/nrendo.2010.188
297 rdf:type schema:CreativeWork
298 sg:pub.10.1046/j.1523-1755.2000.00342.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1009024340
299 https://doi.org/10.1046/j.1523-1755.2000.00342.x
300 rdf:type schema:CreativeWork
301 sg:pub.10.1046/j.1523-1755.2000.00824.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1053579289
302 https://doi.org/10.1046/j.1523-1755.2000.00824.x
303 rdf:type schema:CreativeWork
304 sg:pub.10.1046/j.1523-1755.2001.00049.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1052571186
305 https://doi.org/10.1046/j.1523-1755.2001.00049.x
306 rdf:type schema:CreativeWork
307 sg:pub.10.1046/j.1523-1755.2002.00112.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1027415230
308 https://doi.org/10.1046/j.1523-1755.2002.00112.x
309 rdf:type schema:CreativeWork
310 sg:pub.10.1111/j.1523-1755.2004.00636.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1001764216
311 https://doi.org/10.1111/j.1523-1755.2004.00636.x
312 rdf:type schema:CreativeWork
313 sg:pub.10.1111/j.1523-1755.2004.00787.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1023312828
314 https://doi.org/10.1111/j.1523-1755.2004.00787.x
315 rdf:type schema:CreativeWork
316 https://app.dimensions.ai/details/publication/pub.1074512813 schema:CreativeWork
317 https://app.dimensions.ai/details/publication/pub.1075001367 schema:CreativeWork
318 https://app.dimensions.ai/details/publication/pub.1075053566 schema:CreativeWork
319 https://doi.org/10.1002/gene.10164 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011304736
320 rdf:type schema:CreativeWork
321 https://doi.org/10.1016/j.bbrc.2011.02.007 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003459524
322 rdf:type schema:CreativeWork
323 https://doi.org/10.1016/j.cell.2011.03.022 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001775952
324 rdf:type schema:CreativeWork
325 https://doi.org/10.1016/j.cell.2011.06.020 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018622449
326 rdf:type schema:CreativeWork
327 https://doi.org/10.1016/j.jep.2011.06.031 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005395365
328 rdf:type schema:CreativeWork
329 https://doi.org/10.1016/j.molcel.2011.11.031 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042599176
330 rdf:type schema:CreativeWork
331 https://doi.org/10.1016/s0140-6736(11)60178-5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002346808
332 rdf:type schema:CreativeWork
333 https://doi.org/10.1056/nejmoa060838 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011919761
334 rdf:type schema:CreativeWork
335 https://doi.org/10.1093/ajh/hpt105 schema:sameAs https://app.dimensions.ai/details/publication/pub.1059382169
336 rdf:type schema:CreativeWork
337 https://doi.org/10.1093/ndt/14.5.1234 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046498483
338 rdf:type schema:CreativeWork
339 https://doi.org/10.1097/01.asn.0000026610.48842.cb schema:sameAs https://app.dimensions.ai/details/publication/pub.1060318868
340 rdf:type schema:CreativeWork
341 https://doi.org/10.1097/01.asn.0000078803.53165.c9 schema:sameAs https://app.dimensions.ai/details/publication/pub.1060319258
342 rdf:type schema:CreativeWork
343 https://doi.org/10.1097/01.asn.0000127988.42710.a7 schema:sameAs https://app.dimensions.ai/details/publication/pub.1060319600
344 rdf:type schema:CreativeWork
345 https://doi.org/10.1097/mnh.0b013e32835200df schema:sameAs https://app.dimensions.ai/details/publication/pub.1010581311
346 rdf:type schema:CreativeWork
347 https://doi.org/10.1152/ajprenal.00266.2007 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046794677
348 rdf:type schema:CreativeWork
349 https://doi.org/10.1152/ajprenal.00423.2006 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033898285
350 rdf:type schema:CreativeWork
351 https://doi.org/10.1152/ajprenal.00475.2004 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033058461
352 rdf:type schema:CreativeWork
353 https://doi.org/10.1158/1541-7786.mcr-07-0159 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006237880
354 rdf:type schema:CreativeWork
355 https://doi.org/10.1159/000327564 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015956018
356 rdf:type schema:CreativeWork
357 https://doi.org/10.1161/01.cir.0000095676.90936.80 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038647312
358 rdf:type schema:CreativeWork
359 https://doi.org/10.1161/01.res.0000126049.79800.ca schema:sameAs https://app.dimensions.ai/details/publication/pub.1024129967
360 rdf:type schema:CreativeWork
361 https://doi.org/10.1161/hy0102.100536 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022804895
362 rdf:type schema:CreativeWork
363 https://doi.org/10.1161/hypertensionaha.108.122721 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024514941
364 rdf:type schema:CreativeWork
365 https://doi.org/10.1172/jci114846 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017158440
366 rdf:type schema:CreativeWork
367 https://doi.org/10.1172/jci69557 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018244097
368 rdf:type schema:CreativeWork
369 https://doi.org/10.1371/journal.pone.0006721 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048422203
370 rdf:type schema:CreativeWork
371 https://doi.org/10.1681/asn.2009010019 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033221599
372 rdf:type schema:CreativeWork
373 https://doi.org/10.1681/asn.2011060629 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028494657
374 rdf:type schema:CreativeWork
375 https://doi.org/10.1681/asn.2012060590 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037189981
376 rdf:type schema:CreativeWork
377 https://doi.org/10.1681/asn.2012111078 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001335780
378 rdf:type schema:CreativeWork
379 https://doi.org/10.2353/jmoldx.2009.080126 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010142913
380 rdf:type schema:CreativeWork
381 https://www.grid.ac/institutes/grid.26091.3c schema:alternateName Keio University
382 schema:name Department of Internal Medicine, School of Medicine, Keio University, Tokyo, Japan.
383 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...